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| 1 | Truncated Human LMP-1 Triggers Differentiation of C2C12 Cells to an Osteoblastic Phenotype in vitro显示文摘秘鲁利玛机场之代号矿化作用 protein-1 (LMP-1 ) 是被显示了在 vitro 并且在 vivo.LMP-1 导致骨头形成的新奇细胞内部的 osteoinductiveprotein 包含 anN 终端 PDZ 领域和三个 C 终端秘鲁利玛机场之代号领域。在这研究,我们调查了是否人的 LMP-1 的一种截断的形式( hLMP-l [ t ]),缺乏三个C终端秘鲁利玛机场之代号领域, weretransiently 触发 pluripotent myoblastic C2C12 房间的区别到造骨细胞 lineage.C2C12 房间有 Ad5-hLMP-l (t)绿色的 transduced 荧光灯的蛋白质和截断的蛋白质被检验。结果证明 thathLMP-l (t) 在 C2C12 文化堵住了 myotube 形成并且显著地提高了碱性磷酸酶(高山) 活动。另外,形态基因的蛋白质(BMP )-2 和 BMP-7 基因也是的高山, osteocalcin,和骨头的表情增加了。这些关键 osteogenic 标记的正式就职建议 hLMP-l (t)能触发 pluripotent myoblastic C2C12 房间区分 intoosteoblastic 系,因此扩大我们 LMP-1 和 LMP-1 (t)提高的以前的观察在房间的文化的 theosteoblastic 显型已经承诺了 osteoblasticlineage.Therefore , C2C12 房间是为 osteoblastic 显型和 LMP-1 行动的机制的学习感应的 LMP-1 的考试的一个适当模型系统。 | Qinming FEI | 2007 | Acta Biochimica et Biophysica Sinica2007，39，9： | 8 |
| 2 | 失独者抑郁的心理弹性多因素作用模型显示文摘目的:中国失独家庭已多达百万个,65.6%的失独者存在严重而持久的抑郁情绪,需要及时干预。本研究旨在探索心理弹性与其影响因素的交互作用,比较心理弹性及其影响因素对于失独者抑郁的效应。方法:采用Connor-Davidson心理弹性量表、Zung抑郁自评量表、简易应对方式问卷、艾森克简式量表中国版、社会支持评定量表、一般自我效能感量表对长沙市9个行政区域212名失独者进行入户调查。基于Kumpfer心理弹性框架和心理应激多因素作用过程的理论模式构建假设模型并进行验证。结果:心理弹性的影响因素有:积极应对(总效应值为0.480)、支持利用(总效应值为0.359)、精神质(总效应值为-0.326)、消极应对(总效应值为0.279)、内外倾(总效应值为0.219)、客观支持(总效应值为0.077)。心理弹性对抑郁的影响以直接效应为主(总效应值为-0.344,占67.1%),也通过自我效能感发挥间接效应(总效应值为-0.169),心理弹性的总效应值占所有变量总效应的20.1%。结论:心理弹性受到人格、积极应对、社会支持等应激中介变量的直接和间接作用;心理弹性对抑郁主要产生直接负性效应,是定位于自我效能感之前的重要应激中介变量。个体-环境互动作用过程对心理弹性的影响较大,人格和支持利用通过影响消极应对、积极应对进而间接影响心理弹性。提高心理弹性应当关注个体-环境作用过程,即利用支持、积极应对、适当的消极应对,进而影响个体对自我的积极评价,这将是开发心理弹性干预方案以改善失独者抑郁的重要内容。 | 王安妮 张雯 郭玉芳 Wendy Cross Virginia Plummer Louisa Lam 张静平 | 2021 | 中南大学学报(医学版)2021，46，1： | 7 |
| 3 | Interventional strategies in infected necrotizing pancreatitis:Indications,timing,and outcomes显示文摘Acute pancreatitis(AP)is one of the most common gastrointestinal diseases and remains a life-threatening condition.Although AP resolves to restitutio ad integrum in approximately 80%of patients,it can progress to necrotizing pancreatitis(NP).NP is associated with superinfection in a third of patients,leading to an increase in mortality rate of up to 40%.Accurate and early diagnosis of NP and associated complications,as well as state-of-the-art therapy are essential to improve patient prognoses.The emerging role of endoscopy and recent trials on multidisciplinary management of NP established the“step-up approach”.This approach starts with endoscopic interventions and can be escalated to other interventional and ultimately surgical procedures if required.Studies showed that this approach decreases the incidence of new multiple-organ failure as well as the risk of interventional complications.However,the optimal interventional sequence and timing of interventional procedures remain controversial.This review aims to summarize the indications,timing,and treatment outcomes for infected NP and to provide guidance on multidisciplinary decision-making. | Birte Purschke Louisa Bolm Max Nikolaus Meyer Hiroki Sato | 2022 | World Journal of Gastroenterology2022，28，27： | 4 |
| 4 | Update on management of gastric varices显示文摘Gastric varices(GV) have different physiology and clinical characteristics compared to oesophageal varices(OV). There is little information about the management of GV. Most part of the recommendations is extrapolated from studies where the majority of participants had OV. Thus, most recommendations lack of strong evidence. This is a comprehensive review on all aspects of management of GV, i.e., primary, secondary prophylaxis and management of acute bleeding. The papers on which international societies' recommendations are based are scrutinised in this review and areas of research are identified. | Louisa J Vine Mohsan Subhani Juan G Acevedo | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 5 | Promising xenograft animal model recapitulating the features of human pancreatic cancer显示文摘BACKGROUND Multiple sites of metastasis and desmoplastic reactions in the stroma are key features of human pancreatic cancer(PC).There are currently no simple and reliable animal models that can mimic these features for accurate disease modeling.AIM To create a new xenograft animal model that can faithfully recapitulate the features of human PC.METHODS Interleukin 2 receptor subunit gamma(IL2RG)gene knockout Syrian hamster was created and characterized.A panel of human PC cell lines were transplanted into IL2RG knockout Syrian hamsters and severe immune-deficient mice subcutaneously or orthotopically.Tumor growth,local invasion,remote organ metastasis,histopathology,and molecular alterations of tumor cells and stroma were compared over time.RESULTS The Syrian hamster with IL2RG gene knockout(named ZZU001)demonstrated an immune-deficient phenotype and function.ZZU001 hamsters faithfully recapitulated most features of human PC,in particular,they developed metastasis at multiple sites.PC tissues derived from ZZU001 hamsters displayed desmoplastic reactions in the stroma and epithelial to mesenchymal transition phenotypes,whereas PC tissues derived from immune-deficient mice did not present such features.CONCLUSION ZZU001 hamsters engrafted with human PC cells are a superior animal model compared to immune-deficient mice.ZZU001 hamsters can be a valuable animal model for better understanding the molecular mechanism of tumorigenesis and metastasis and the evaluation of new drugs targeting human PC. | Jin-Xin Miao Jian-Yao Wang Hao-Ze Li Hao-Ran Guo Louisa S Chard Dunmall Zhong-Xian Zhang Zhen-Guo Cheng Dong-Ling Gao Jian-Zeng Dong Zhong-De Wang Yao-He Wang | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 6 | Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial显示文摘 | John Primrose Stephen Falk Meg Finch-Jones Juan Valle Derek O’Reilly Ajith Siriwardena Joanne Hornbuckle Mark Peterson Myrddin Rees Tim Iveson Tamas Hickish Rachel Butler Louise Stanton Elizabeth Dixon Louisa Little Megan Bowers Sian Pugh O James Garden D | 2014 | Lancet Oncology2014，，6： | 2 |
| 7 | Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews显示文摘 | Paul K Nelson Bradley M Mathers Benjamin Cowie Holly Hagan Don Des Jarlais Danielle Horyniak Louisa Degenhardt | 2011 | The Lancet . 2011 (9791)2011，，： | 2 |
| 8 | Expression, purification and mass spectrometric analysis of LIM mineralization protein-1 in human lung epithelial cells显示文摘秘鲁利玛机场之代号矿化作用 protein-1 (LMP-1 ) 是被克隆并且出现在 vitro 并且在 vivo 导致骨头形成的新奇 osteoin-ductive 蛋白质。在 LMP-1 的糖类结构的可能的存在的察觉和评估是为 recombinantly 表示的蛋白质的治疗学的使用的重要规章的考虑。LMP-1 的顺序包含一个高度保存的 N 终端 PDZ 领域和三个 C 终端秘鲁利玛机场之代号领域。LMP-1 的顺序分析预言二个潜在的 N-glycosylation 地点和几个 O-glycosylation 地点。这里,我们报导克隆并且在在人的肺癌(A549 ) 的 LMP-1 的表示上房间。尽管我们的组已经报导了 LMP-1 cDNA 的顺序,我们拿了这个工作澄清是否过去表示蛋白质在 vivo 经历任何 glycosylation。表示全身的 recombinant 蛋白质被净化并且使遭到了到化学分析并且内部定序。在 LMP-1 蛋白质的化学作文分析的任何 hexosamines (N 乙酰 glucosamine 或 N 乙酰 galactosamine ) 的缺席表明有很少或在肺癌房间(A549 ) 的 LMP-1 多肽的没有 translational 以后 glycosylation。我们在净化的 LMP-1,和产生的肽上执行了在里面胶化胰岛素消化文摘被分析进一步的使用为肽质量的帮助矩阵的激光解吸附作用和电离团 spectrometry 手指打印,它与相应 LMP-1 肽生产了几准确匹配。由高效液体层析和定序的 N 终端跟随的需要的肽的纯化的分离为几净化的肽导致了许多准确 LMP-1 火柴,因此作为 LMP-1 建立净化的蛋白质的身份。 | Sreedhara Sangadala Louisa Titus Scott D. Boden | 2008 | Acta Biochimica et Biophysica Sinica2008，40，11： | 2 |
| 9 | A Model and Treatment for Autism at the Convergence of Chinese Medicine and Western Science:First 130 Cases显示文摘为显示出那个缺陷的孤独性介绍一个模型的目的感觉并且自动调节是在孤独性在聚会 / 语言的技巧和反常行为位于延期下面的核心赤字;并且基于中国药为孤独性表明治疗的功效。有不到 6 岁的孤独性的方法孩子被分到治疗或等待表条件。130 个孩子的一个总数被对待并且结果与 45 等待表控制相比。治疗是针对感觉 impairmentKai Qiao Tuina 的 tuina 方法论。处理是是经由训练支持职员的实现的每日的 by trained 父母的一个五月的协议。主要症状上的处理的效果, autistic 行为,聚会 / 语言的延期,感觉、自我规章的缺陷,以及在抚育应力上,被观察并且比较。结果处理有一种大效果尺寸(P < 0.0001 ) 在措施上感觉并且自动调节。幼儿园教师做的评估在孤独性的措施表明了改进(P < 0.003 ) ,并且被父母做的评估证实(P < 0.0001 ) 。有大减少(P < 0.0001 ) 在抚育应力。结论感觉、自我规章的缺陷是在孤独性的发展和严厉的一个主要因素。有有 Kai Qiao Tuina 的孤独性的小孩子的处理在孤独性的措施的严厉在感觉、自我规章的缺陷和减小导致了减少。 | Louisa M.T.Silva Mark Schalock Robert Ayres | 2011 | Chinese Journal of Integrative Medicine2011，17，6： | 2 |
| 10 | Remote sensing and human health:New sensors and new opportunities 显示文摘 | Louisa R Buadley M Byron L | 2000 | Emerging Inf Dis2000，6，： | 1 |
| 11 | Preparation of vanadium phosphate catalysts from VOPO4·2 H2O:effect of VOPO4·2 H2O preparation on catalyst performance显示文摘 | LOUISA G JONATHAN K RICHARD P K | 2004 | Journal of Molecular Catalysis A:Chemical2004，220，1： | 1 |
| 12 | Parametric land cover and land-use classifications as tools for environmental change detection显示文摘 | Louisa J M Jansen Antonio Di Gregorio | 2002 | Agriculture Ecosystems and Environment2002，91，： | 1 |
| 13 | Mesenchymal stem cells for the treatment of neurodegenerative disease显示文摘 | Nanette Joyce Geralyn Annett Louisa Wirthlin Scott Olson Gerhard Bauer Jan A Nolta | 2010 | Regen Med2010，，6： | 1 |
| 14 | Understanding the Shopping Motivation ofMainland Chinese Tourists in Hong Kong 显示文摘 | NELSON K F TSANG LOUISA YEE - SUM LEE CAR-RIE K L LIU | 2014 | Journal ofChina Tourism Research2014，10，3： | 1 |
| 15 | What makes surgical tumor resection feasible in Broca' s area? Insights into intraoperative brain mapping显示文摘 | Vincent L Louisa D Franck-Emmanuel R | 2010 | Neurosurgery2010，66，： | 1 |
| 16 | Parametric land cover and land-use classifications as tools for environmental change detection显示文摘 | Louisa J M Jansen Antonio Di Gregorio | 2002 | Agriculture Ecosystems &Environment2002，91，： | 1 |
| 17 | Interactivity reexamined: A baseline analysis of early business web sites显示文摘 | Louisa Ha E. Lincoln James | 1998 | Journal of Broadcasting & Electronic Media1998，，4： | 1 |
| 18 | Antibacterial metabolites from Australia macrofungi from the genus显示文摘 | Karren DB Razina R Louisa G | 2010 | Phytochemistry2010，71，89： | 1 |
| 19 | Romate sensing and human health : new senseors and new opportunities 显示文摘 | Louisa R B Bradley M L Byron L W | 2000 | Emerg Infect Dis2000，，6： | 1 |
| 20 | Enhancing Memory in Late-Life Depression: The Effects of a Combined Psychoeducation and Cognitive Training Program显示文摘 | Sharon L. Naismith Keri Diamond Phoebe E. Carter Louisa M. Norrie Marie Antoinette Redoblado-Hodge Simon J.G. Lewis Ian B. Hickie | 2011 | American Journal of Geriatric Psychiatry2011，，3： | 1 |
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