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| 1 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 2 | Miniature gastrointestinal endoscopy: Now and the future显示文摘Since its original application,gastrointestinal(GI)endoscopy has undergone many innovative transformations aimed at expanding the scope,safety,accuracy,acceptability and cost-effectiveness of this area of clinical practice.One method of achieving this has been to reduce the caliber of endoscopic devices.We propose the collective term“Miniature GI Endoscopy”.In this Opinion Review,the innovations in this field are explored and discussed.The progress and clinical use of the three main areas of miniature GI endoscopy(ultrathin endoscopy,wireless endoscopy and scanning fiber endoscopy)are described.The opportunities presented by these technologies are set out in a clinical context,as are their current limitations.Many of the positive aspects of miniature endoscopy are clear,in that smaller devices provide access to potentially all of the alimentary canal,while conferring high patient acceptability.This must be balanced with the costs of new technologies and recognition of device specific challenges.Perspectives on future application are also considered and the efforts being made to bring new innovations to a clinical platform are outlined.Current devices demonstrate that miniature GI endoscopy has a valuable place in investigation of symptoms,therapeutic intervention and screening.Newer technologies give promise that the potential for enhancing the investigation and management of GI complaints is significant. | John J McGoran Mark E McAlindon Prasad G Iyer Eric J Seibel Rehan Haidry Laurence B Lovat Sarmed S Sami | 2019 | World Journal of Gastroenterology2019，25，30： | 4 |
| 3 | 弹性散射光谱法可准确鉴别Barrett食管的高度不典型增生与癌变 | Lovat L.B. Johnson K. Mackenzie G.D. 廖新华 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，12： | 2 |
| 4 | MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer显示文摘 | Nicola Valeri Chiara Braconi Pierluigi Gasparini Claudio Murgia Andrea Lampis Viola Paulus-Hock Jonathan R. Hart Lynn Ueno Sergei I. Grivennikov Francesca Lovat Alessio Paone Luciano Cascione Khlea M. Sumani Angelo Veronese Muller Fabbri Stefania Carasi H | 2014 | Cancer Cell2014，，： | 2 |
| 5 | Frequency response characterization of acid sites in zeolite catalgsts using NH3 as the probe molecule显示文摘 | Lovat V C Rees Gyorgy Onyestyak | 1999 | Microporous and Mesoporous Materials1999，28，： | 1 |
| 6 | Formation of zeolite from the system Na2O-Al2O3-H2O in alkaline medium (pH>10) 显示文摘 | Lovat V C Ree s Sathy Chandrasekhar | 1993 | Zeolites1993，13，： | 1 |
| 7 | Concentration-dependent effects of 9-cisretinoic acid on neuroblastoma differentiation and proliferation in vitro显示文摘 | Lovat P E Lsmis S P Pearson A D | 1994 | Neurosci Lett1994，182，1： | 1 |
| 8 | Study of fast diffusion in zeolites using a higher harmonic frequncy response methodc 显示文摘 | Dongmin shen Lovat V CRees | 1994 | Chem Soc Faraday Trans1994，90，19： | 1 |
| 9 | Analysis and Optimization of Leaky-Wave Radiation at Broadside From a Class of 1-D Periodic Structures显示文摘 | Burghignoli Lovat Jackson | 2006 | IEEE Transactions on An- tennas and propagation2006，54，9： | 1 |
| 10 | Effects of gestational diabetes on junction adhesion molecules in human term placental vascula- ture显示文摘 | Babawale S Lovat TM | 2000 | Diabetologia September2000，43，9： | 1 |
| 11 | Equivalent circuit for electromagnetic interaction and transmission through graphene sheets显示文摘 | LOVAT G | 2012 | IEEE Transactions on Electromagnetic Compatibility2012，54，1： | 1 |
| 12 | Increasing melanoma cell death using inhibitors of pro-tein disulfide isomerases to abrogate survival responses to endoplas-mic reticulum stress 显示文摘 | Lovat PE | 2008 | Cancer Res2008，68，： | 1 |
| 13 | The NF-kappaB pathway mediates fenretinide-induced apoptosis in SH-SY5Y neuro blastoma cells显示文摘 | Hewson QD Lovat PE Corazzari M | 2005 | Apoptosis2005，10，3： | 1 |
| 14 | Concentration dependent effects of 9-cis retinoic acid on neuroblastoma cell differentiation and proliferation in vitro显示文摘 | Lovat PE Lowis SP Pearson ADJ | 1994 | Neurosci Lett1994，182，1： | 1 |
| 15 | Effector mechanisms of fenretinide - induced apoptosis in neuroblastoma 显示文摘 | Lovat PE Ranalli M Annichiarrico- Petruzzelli M | 2000 | Exp Cell Res2000，260，1： | 1 |
| 16 | An efficient MoM formulation for the evaluation of the shielding effectiveness of rectangular enclosures with thin and thick apertures显示文摘 | Araneo R Lovat G | 2008 | IEEE Transactions on Electromagnetic Compatibility2008，50，2： | 1 |
| 17 | Experimental and molecular simulation studies of adsorption and diffusion of cyclic hydrocarbons in siliealite-1显示文摘 | SONG L J SUN Z L LOVAT V C | 2002 | Microporous and Mesoporous Materials2002，55，1： | 1 |
| 18 | Frequency response characterization of acid sites in zeolite catalgsts using NH3 as the probe molecule 显示文摘 | LOVAT V C REES GYORGY ONYESTYAK | 1999 | Microporous and Mesoporous Materials1999，28，： | 1 |
| 19 | Analysis of bimodal frequency response behaviour of p-xylene diffusion in silicalite-1 显示文摘 | DONGMIN SHEN LOVAT V C REES | 1995 | Chem Soc Faraday Trans1995，91，13： | 1 |
| 20 | Surface-wave suppression in a double-negative metamaterial grounded slab显示文摘 | Baccarelli P Burghignoli P Lovat G | 2003 | IEEE Antennas Wireless Propag Lett2003，2，19： | 1 |
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