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| 1 | Trends of foodborne diseases in China: lessons from laboratory- based surveillance since 2011显示文摘Foodborne 疾病是世界范围的最重要的公共健康问题之一。中国在食物链的所有方面面对各种各样、崭新的挑战。从从 2013 ~ 2016 的基于实验室的 foodborne 疾病监视系统的数据,以及不同区域和年龄,能在与多样的特征检测的病原体的模式与差别一起被发现。Vibrio parahaemolyticus 是在中国的传染腹泻的领先的原因,特别在在沿海的区域的成年人之中。沙门氏菌是为实质的社会经济的负担负责的严肃、广泛地分布式的病原体。Shigella 主要在 5 年下面在孩子之中与开发更少的区域在西北中国和内陆省(河南省) 被识别。从从 2011 ~ 2016 报导系统的 foodborne 疾病爆发的数据证明有毒的动物和为大多数死亡负责的植物因素在在西南区域的遥远的区域是有毒的蘑菇(54.7%) 。引起了报导的大多数案例(42.3%) 的生物危险被归因于 V。parahaemolyticus, foodborne 爆发的领先的原因。在这评论,我们在中国总结最近的监视途径到 foodborne 疾病并且在发达国家把结果与那些作比较。 | Jikai Liu Li Bai Weiwei Li Haihong Han Ping Fu Xiaochen Ma Zhenwang Bi Xiaorong Yang Xiuli Zhang Shiqi Zhen Xiaoling Deng Xiumei Liu Yunchang Guo | 2018 | Frontiers of Medicine2018，12，1： | 55 |
| 2 | Effect of six kinds of scale inhibitors on calcium carbonate precipitation in high salinity wastewater at high temperatures显示文摘Precipitation of calcium carbonate(Ca CO3) scale on heat transfer surfaces is a serious and expensive problem widely occurring in numerous industrial processes. In this study, we compared the scale inhibition effect of six kinds of commercial scale inhibitors and screened out the best one(scale inhibitor SQ-1211) to investigate its scale inhibition performance in highly saline conditions at high temperature through static scale inhibition tests. The influences of scale inhibitor dosage, temperature, heating time and p H on the inhibition efficiency of the optimal scale inhibitor were investigated. The morphologies and crystal structures of the precipitates were characterized by Scanning Electron Microscopy and X-ray Diffraction analysis. Results showed that the scale inhibition efficiency of the optimal scale inhibitor decreased with the increase of the reaction temperature. When the concentration of Ca2+was 1600 mg/L, the scale inhibition rate could reach 90.7% at 80°C at p H 8. The optimal scale inhibitor could effectively retard scaling at high temperature. In the presence of the optimal scale inhibitor, the main crystal structure of Ca CO3 changed from calcite to aragonite. | Xiaochen Li Baoyu Gao Qinyan Yue Defang Ma Hongyan Rong Pin Zhao Pengyou Teng | 2015 | Journal of Environmental Sciences2015，27，3： | 15 |
| 3 | Community structure of macrobenthos in coastal water off Rushan, southern Shandong Peninsula, and the relationships with environmental factors显示文摘To understand the present actuality of the marine ecosystem in the southern coastal water region of the Shandong Peninsula and the impact of the global change and the human activities to the marine ecosystem of the region, the macrobenthic community structure was researched based on data from 26 sampling stations carried out on four seasonal cruises from December 2006 to November 2007. The data was analyzed using PRIMER 6.0 and SPSS 15.0 software packages. The results showed that 236 macrobenthic species in total were collected from the research region by the field works. Most of the species belong to Polychaeta (76 species), Mollusca (75) and Crustacea (60). Of which, 33 species were common species by the four cruises. The dominant species were different among the four seasons, however, the polychaete species Nephtys oligobranchia and Sternaspis scutata were always dominant in the four seasons. The abundances and biomasses of the macrobenthos from the research region were variable in the four seasons. The results of CLUSTER and MDS analysis showed that the similarities of macrobenthic structures among the stations were low, most of the similarities were at about 40% of similarity values, only that of two stations were up to 60%. In accordance with the similarity values of the macrobenthic structures, the 26 stations were clustered as six groups at arbitrary similarity level of 30%. The ABC curve indicated that the marcofauna communities in the research region had not been disturbed distinctly. The results of BIOENV and BVSTEP (Spearman) analysis implied that the concentrations of organic matter in bottom water and heavy metal copper in sediment, water depth and temperature of bottom were the most significant environmental factors to affect the macrobentic community. | LI Xinzheng LI Baoquan WANG Hongfa WANG Jinbao WANG Xiaochen ZHOU Jin HAN Qingxi MA Lin DONG Chao ZHANG Baolin | 2009 | Acta Oceanologica Sinica2009，28，5： | 14 |
| 4 | Epidermal growth factor receptor (EGFR) T790M mutation identified in plasma indicates failure sites and predicts clinical prognosis in non-small cell lung cancer progression during first-generation tyrosine kinase inhibitor therapy: a prospective observational study显示文摘Introduction:Plasma circulating tumor DNA(ctDNA)is an ideal approach to detecting the epidermal growth factor receptor(EGFR)T790M mutation,which is a major mechanism of resistance to first-generation EGFR-tyrosine kinase inhibitor(TKI)therapy.The present study aimed to explore the association of ctDNA-identified T790M mutation with disease failure sites and clinical prognosis in non-small cell lung cancer(NSCLC)patients.Methods:Patients who progressed on first-generation TKIs were categorized into failure site groups of chest limited(CF),brain limited(BF)and other(OF).Amplification refractory mutation system(ARMS)and droplet digital PCR(ddPCR)were used to identify the T790M mutation in ctDNA.Prognosis was analyzed with Kaplan-Meier methods.Results:Overall concordance between the two methods was 78.3%.According to both ARMS and ddPCR,patients in the OF group had a significantly higher rate of T790M mutation than did patients in the BF and CF groups(P<0.001),and a significantly higher T790M mutation rate was also observed in OF-group patients than in those in the CF and BF groups(P<0.001).AZD9291 was found to be an excellent treatment option and yielded the longest survival for T790M+patients in all groups who had progressed on EGFR-TKIs;for other treatments,the prognosis of T790M−patient subgroups varied.Conclusions:The present study demonstrates that T790M mutation in ctDNA is associated with failure sites for NSCLC patients after EGFR-TKI therapy and indicates that both failure site and T790M mutational status greatly influ-ence treatment selection and prognosis. | Shirong Zhang Lucheng Zhu Bing Xia Enguo Chen Qiong Zhao Xiaochen Zhang Xueqin Chen Xufeng Chen Shenglin Ma | 2018 | Cancer Communications2018，38，1： | 12 |
| 5 | Exposure to polycyclic aromatic hydrocarbons and risk for premature ovarian failure and reproductive hormones imbalance显示文摘Polycyclic aromatic hydrocarbons(PAHs)are a typical class of persistent organic pollutants that is ubiquitous worldwide.Previous animal studies suggested that PAHs had adverse effects on female reproduction.However,the human data regarding relationship of PAHs exposure with women reproductive health,such as ovarian dysfunction,are scarce.In this case-control study,the associations of serum levels of PAHs with the risk of premature ovarian failure(POF)and reproductive hormones in Chinese women were investigated,with recruiting 157 POF patients and 217 healthy women.The serum levels of 12 types of PAHs,as well as reproductive hormones,including follicle-stimulating hormone,luteinizing hormone and anti-mullerian hormone,were determined.In the logistic regression models,most individual PAH congeners showed significantly positive correlations with the risk of POF(p<0.05),except for fluorine and pyrene.Benzo(a)pyrene(BaP),as the most carcinogenic PAH congener,was observed to be significantly positively associated with the risk of POF.After adjustment for age,body mass index,educational levels and household income,per one-unit increase in the log-transformed BaP concentration was significantly correlated with 2.191-fold increased risk of POF(OR=2.191,95%CI:1.634-2.938,p<0.05).To the best of our knowledge,this is the first study to report an association between internal exposure levels of PAHs and the increased risk of POF in women. | Xiaoqing Ye Wuye Pan Chunming Li Xiaochen Ma Shanshan Yin Jianhong Zhou Jing Liu | 2020 | Journal of Environmental Sciences2020，32，5： | 10 |
| 6 | Retrieval and Analysis of Coal Fire Temperature in Wuda Coalfield, Inner Mongolia, China显示文摘Coal fire burning around the world is an environmental catastrophe characterized by the emission of noxious gases, particulate matter, and condensation by-products. In this study, coal fire temperature is retrieved based on Landsat 5 TM images and Generalized Single-Channel Algorithm (GSCA), in Wuda coalfield, Inner Mongolia, China. Then coal fire zones are extracted by Jenks′ natural breaks and threshold methods based on temperature images. Changes of coal fire zones are analyzed from 1989 to 2008. The results are summarized as follows: 1) The coal fire temperature retrieval method based on Landsat 5 TM and the GSCA model is effective and feasible, because the temperature error is relatively small (from –2.9℃ to +2.6℃) between the measured temperature and the retrieved temperature. 2) The accuracy is relatively high to extract coal fire zones through the Jenks′ natural breaks and threshold methods, because 83.56% of surveyed area is located in the coal fire zones extracted in 2005. 3) The coal fire area increased 9.81 × 10 5 m 2 from 1989 to 2005, and the annual growth is about 6.1 × 10 4 m 2 , with an annual increasing rate of 2.48%. The area of coal fire decreased by 8.1 × 10 5 m 2 from 2005 to 2008. | JIANG Weiguo ZHU Xiaohua WU Jianjun GU Lei MA Guobin LIU Xiaochen | 2011 | Chinese Geographical Science2011，21，2： | 7 |
| 7 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 8 | s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide显示文摘Hand-foot skin reaction(HFSR),among the most significant adverse effects of sorafenib,has been limiting the clinical benefits of this frontline drug in treating various malignant tumors.The mechanism underlying such toxicity remains poorly understood,hence the absence of effective intervention strategies.In the present study,we show that vascular endothelial cells are the primary cellular target of sorafenib-induced HFSR wherein soluble heparin-binding epidermal growth factor(s-HBEGF)mediates the crosstalk between vascular endothelial cells and keratinocytes.Mechanistically,s-HBEGF released from vascular endothelial cells activates the epidermal growth factor receptor(EGFR)on keratinocytes and promotes the phosphorylation of c-Jun N-terminal kinase 2(JNK2),which stabilizes sirtuin 1(SIRT1),an essential keratinization inducer,and ultimately gives rise to HFSR.The administration of s-HBEGF in vivo could sufficiently induce hyper-keratinization without sorafenib treatment.Furthermore,we report that HBEGF neutralization antibody,Sirtl knockdown,and a classic SIRTI inhibitor nicotinamide could all significantly reduce the sorafenib-induced HFSR in the mouse model.It is noteworthy that nicotinic acid,a prodrug of nicotinamide,could substantially reverse the sorafenib-induced HFSR in ten patients in a preliminary clinical study.Collectively,our findings reveal the mechanism of vascular endothelial cell-promoted keratinization in keratinocytes and provide a potentially promising therapeutic strategy for the treatment of sorafenib-induced HFSR. | Peihua Luo Hao Yan Xueqin Chen Ying Zhang Ziying Zhao Ji Cao Yi Zhu Jiangxia Du Zhifei Xu Xiaochen Zhang Su Zeng Bo Yang Shenglin Ma Qiaojun He | 2020 | Cell Research2020，30，9： | 5 |
| 9 | 第一代酪氨酸激酶抑制剂治疗中发生进展的非小细胞肺癌血浆表皮生长因子受体(EGFR)T790M突变提示了失败部位并预测了临床预后:一项前瞻性观察研究显示文摘背景与目的血浆循环肿瘤DNA(circulating tumor DNA,ctDNA)是检测表皮生长因子受体(epidermal growth factor receptor,EGFR)T790M突变的理想方法。T790M突变是第一代EGFR酪氨酸激酶抑制剂(tyrosine kinase inhibitor,TKI)耐药的主要机制。本研究旨在探讨ctDNA来源的T790M突变与非小细胞肺癌(non-small cell lung cancer,NSCLC)患者疾病失败部位及临床预后的关系。方法第一代TKI治疗发生进展的患者被分为局限胸内进展(chest limited,CF)、局限颅内进展(brain limited,BF)和其他部位进展(other,OF)组。采用扩增阻滞突变系统(amplification refractory mutation system,ARMS)和微滴式数字PCR(droplet digital PCR,ddPCR)对ctDNA中T790M突变进行了检测。采用Kaplan-Meier法分析了预后。结果 2种方法的总体一致性为78.3%。根据ARMS和ddPCR,OF组患者的T790M突变率明显高于BF组和CF组(P <0.001),OF组的T790M突变丰度也明显高于CF组和BF组(P <0.001)。AZD9291是T790M+患者最佳治疗选择,为EGFR-TKI治疗后进展的所有组中T790M+患者提供了最长的生存期;接受其他治疗的T790M-患者亚组的预后各不相同。结论本研究表明ctDNA中T790M突变与NSCLC患者EGFR-TKI治疗失败部位相关,失败部位和T790M突变状态对治疗选择和预后都有很大影响。 | Shirong Zhang Lucheng Zhu Bing Xia Enguo Chen Qiong Zhao Xiaochen Zhang Xueqin Chen Xufeng Chen Shenglin Ma | 2018 | 癌症2018，37，9： | 4 |
| 10 | Provenance Analyses of Lower Cretaceous Strata in the Liupanshan Basin: From Paleocurrents Indicators, Conglomerate Clast Compositions, and Zircon U-Pb Geochronology显示文摘The Liupanshan Basin constitutes a major portion of the northern North-South tectonic belt. The Lower Cretaceous strata in the Liupanshan Basin recorded the tectono-sedimentary evolution processes of this area and are pivotal for understanding the original sedimentary appearance of the Liupanshan Basin. In this work, we present a study of provenance and tectono-sedimentary evolution of the Liupanshan Basin during the Early Cretaceous. Integrated-paleocurrent directions, gravel clast compositions, and detrital zircon U-Pb isotopic analysis of the Lower Cretaceous Sanqiao and Heshangpu formations were applied to determine the provenance. The gravel clast compositions of Sanqiao Formation conglomerates(mainly including magmatic rocks, metamorphic rocks and limestones) display various features in different places, revealing different rock components of source areas. The paleocurrent directions of the Sanqiao and Heshangpu formations suggest that the sediments were transported from the basin margin to the center. Detrital zircons of two samples from the Huoshizhai Section(northwestern Liupanshan Basin) yield a dominant unimodal distribution from 420 to 500 Ma, suggesting a single-sourced provenance. Based on the above analyses, comparing to the magmatic records in the Qilian-Qinling orogenic belt, the detritus of the Sanqiao and Heshangpu formations were mainly from the proximal metamorphic and magmatic rocks of the Qilian-Qinling orogenic belt and the limestones of the archaic uplift. Combined with sedimentary characteristics, we concluded that the Liupanshan Basin experienced multi-stage evolution history:(1) the early rifting extension stage(Sanqiao Period),(2) the middle spanning and depression stage(Heshangpu–Early Naijiahe Period), and(3) the late extinction stage(Late Naijiahe Period). The evolution of Liupanshan Basin is closely related to that of Ordos Basin and it is further associated with tectonic transition of the northern North-South tectonic belt. | Xiaochen Zhao Chiyang Liu Jianqiang Wang Wei Luo Fangpeng Du Li Ma | 2020 | Journal of Earth Science2020，31，4： | 3 |
| 11 | Kinematics analysis of a novel all-attitude flight simulator显示文摘To overcome the kinematic singularity limitation of simulator, which is unavoidable in a three-axis architecture, an all-attitude flight simulator in a four-axis architecture is proposed. The simulator can always provide 3DOF motion by applying redundant manipulator mechanism. For direct kinematics of the manipulator, a dual-Euler method is adopted to solve the expressions of attitude angles; thus computation singularity of all- attitude angles is overcome. For inverse kinematics of the manipulator, pseudo-inverse gradient projection method is used to obtain optimal velocity solution. Then, based on dynamic control method, optimal position solution is obtained. The proposed inverse kinematics algorithm can achieve desired attitudes, as well as can avoid kinematics singularity and axis angle limits. The simulation results show that the kinematic performance of the four-axis all-attitude flight simulator is superior to that of a three-axis simulator. | WANG XiaoChen , ZHAO Hui, MA KeMao, HUO Xin & YAO Yu Control and Simulation Center, Harbin Institute of Technology, Harbin 150080, China | 2010 | Science China(Information Sciences)2010，53，2： | 3 |
| 12 | Development of a Label-Free Colorimetric Aptasensor with Rationally Utilized Aptamer for Rapid Detection of Okadaic Acid显示文摘Okadaic acid(OA)is a typical marine toxin with strong toxicity causing diarrheic shellfish poisoning(DSP).Aptamers show great advantages in toxin detection and attract increasing attentions in the field of food analysis.In this study,a label-free col-orimetric aptasensor was constructed for visual and rapid detection of OA in shellfish.To exploit the binding capability of the anti-OA aptamer,the inherent molecular recognition mechanism of aptamer and OA was studied,based on molecular docking,fluorescent assay,and biolayer interferometry.Consistent results showed that the stem-loop near the 3’terminal of the aptamer exhibit dominate binding capacity.Based on the revealed recognition information,the aptamer was thus rationally utilized and combined with AuNPs and cationic polymer polydiallyl dimethyl ammonium chloride(PDDA)for the development of the label-free colorimetric aptasensor,in which the 3’terminal was thoroughly exposed to OA.The aptasensor provided robust performance with a linear detection range of 100-1200 nmol L-1,a limit of detection of 41.30 nmol L-1,recovery rates of 91.6%-106.2%,as well as a high selectivity towards OA in shellfish samples.The whole detection process can be completed within 1 h.To our best knowledge,this is the first time that the anti-OA aptamer was thoroughly studied,and a label-free colorimetric aptasensor was rationally designed in this way.This study not only provides a rapid detection method for highly sensitive and specific detection of OA,but also serves as a reference for the design of efficient aptasensors in the future. | YAN Xiaochen QI Xiaoyan ZHAO Yinglin LI Ling MA Rui WANG Lele WANG Sai MAO Xiangzhao | 2022 | Journal of Ocean University of China2022，21，2： | 2 |
| 13 | Neglected Rural Public Health Issue:The Case of Intestinal Roundworms显示文摘Despite increasing institutional and financial support,certain public health issues are still neglected by the Chinese Government.The present paper examines the soil-transmitted helminth(STH)infection and reinfection rates by conducting a survey on 1724 children in Guizhou Province,China.Our results indicate that 37.5 percent of children had been infected with one or more of the three types of tested STH.However,only 50.4 percent of children reported having taken deworming medicine during the 18-month period before the survey.Of those who reported being dewormed,34.6 percent tested positive for STH infections.Poverty and number of siblings are significantly and positively correlated with infection and reinfection,and parental education is significantly and negatively correlated with infection and reinfection.Given the ineffectiveness of treatment in these areas to date,for anthelmintic campaigns to actually succeed,China must pay more attention to locallevel incentives to improve children's health. | Linxiu Zhang Yingping Cai Xiaobing Wang Xiaochen Ma Alexis Medina D.Scott Smith Scott Rozelle | 2013 | China & World Economy2013，21，3： | 2 |
| 14 | Variations of the thermal growing season during the period 1961–2015 in northern China显示文摘Researching into changes in thermal growing season has been one of the most important scientific issues in studies of the impact of global climate change on terrestrial ecosystems. However, few studies investigated the differences under various definitions of thermal growing season and compared the trends of thermal growing season in different parts of China. Based on the daily mean air temperatures collected from 877 meteorological stations over northern China from 1961 to 2015, we investigated the variations of the thermal growing season parameters including the onset, ending and duration of the growing season using the methods of differential analysis, trend analysis, comparative analysis, and Kriging interpolation technique. Results indicate that the differences of the maximum values of those indices for the thermal growing season were significant, while they were insignificant for the mean values. For indices with the same length of the spells exceeding 5°C, frost criterion had a significant effect on the differences of the maximum values. The differences of the mean values between frost and non-frost indices were also slight, even smaller than those from the different lengths of the spells. Temporally, the starting date of the thermal growing season advanced by 10.0–11.0 days, while the ending dates delayed by 5.0–6.0 days during the period 1961–2015. Consequently, the duration of the thermal growing season was prolonged 15.0–16.0 days. Spatially, the advanced onset of the thermal growing season occurred in the southwestern, eastern, and northeastern parts of northern China, whereas the delayed ending of the thermal growing season appeared in the western part, and the length of the thermal growing season was prolonged significantly in the vast majority of northern China. The trend values of the thermal growing season were affected by altitude. The magnitude of the earlier onset of the thermal growing season decreased, and that of the later ending increased rapidly as the altitude increased, causing the magnitude of the prolonged growing season increased correspondingly. Comparing the applicability of selected indices and considering the impacts of frost on the definitions are important and necessary for determining the timing and length of the thermal growing season in northern China. | CUI Linli SHI Jun MA Yue LIU Xiaochen | 2018 | Journal of Arid Land2018，10，2： | 2 |
| 15 | Point Cloud Classification and Accuracy Analysis Based on Feature Fusion显示文摘A method for land-cover classification was proposed based on the fusion of features generated from waveform data and point cloud respectively.It aims to partially overcome the ineffectiveness of many traditional classifiers caused by the fact that point cloud is lacking spectral information.The whole flowchart of the method is as follows:Firstly,Gaussian decomposition was applied to fit an echo full-waveform.The parameters associated with the Gaussian function were optimized by LM(Levenberg-Marquard)algorithm.Six and thirteen features were generated to describe the waveform characteristics and the local geometry of point cloud,respectively.Secondly,a random forest was selected as the classifier to which the generated features were input.Relief-F was used to rank the weights of all the features generated.Finally,features were input to the classifier one by one according to the weights calculated from feature ranking,where classification accuracies were evaluated.The experimental results show that the effectiveness of the fusion of features generated from waveform and point cloud for LiDAR data classification,with 95.4%overall accuracy,0.90 kappa coefficient,which outperform the results obtained by a single class of features,no matter whether they were generated from point cloud or waveform data. | Xiaochen WANG Hongchao MA Liang ZHANG Zhan CAI Haichi MA | 2021 | Journal of Geodesy and Geoinformation Science2021，4，3： | 2 |
| 16 | Epidemiology of foodborne disease outbreaks caused by Vibrio parahaemolyticus , China, 2003–2008显示文摘 | Yongning Wu Jian Wen Yi Ma Xiaochen Ma Yan Chen | 2014 | Food Control2014，，： | 2 |
| 17 | Catalytic pyrolysis of microalgae and their three major components: carbohydrates, proteins, and lipids显示文摘 | DU Zhenyi HU Bing MA Xiaochen | 2013 | Bioresource Technology2013，130，： | 1 |
| 18 | A 2-step GPS carrier tracking loop for urban vehicle applications显示文摘Global positioning system(GPS) for vehicle applications in the urban area is challenged by low signal intensity. The carrier loop based on fast Fourier transform(FFT) can obtain a high signal to noise ratio(SNR) gain by increasing the observation time. However, this leads to a major problem that the acceleration cannot be ignored. The performance of the FFT-based loop will decline with the acceleration increasing. This paper discusses the effect of the dynamic on FFT first. Then a high performance carrier tracking loop for weak GPS L5 signals is proposed. It combines discrete chirp-Fourier transform(DCFT) and the phase fitting method to estimate Doppler frequency and Doppler rate simultaneously.First, a sequence of integration results is used to perform DCFT to estimate coarse Doppler frequency and Doppler rate. Second, the phase of the sequence is calculated and used to perform linear fitting. By the phase fitting method, the fine Doppler frequency and Doppler rate can be estimated. The computation cost is small because the integration results are used and the phase fitting method needs only coarse estimates of Doppler frequency and Doppler rate. Compared with FFT and DCFT, the precision of the phase fitting method is not limited by the resolution. Thus the proposed loop can get high precision and low carrier to noise ratio(C/N0) tracking threshold. Simulation results show this loop has a great improvement than conventional loops for urban weak-signal applications. | Hongyang Zhang Luping Xu Yue Jian Xiaochen Ma | 2017 | Journal of Systems Engineering and Electronics2017，28，5： | 1 |
| 19 | Pre-ribosomal RNA reorganizes DNA damage repair factors in nucleus during meiotic prophase and DNA damage response显示文摘In response to DNA double strand breaks(DSBs),DNA damage repair factors are recruited to DNA lesions and form nuclear foci.However,the underlying molecular mechanism remains largely elusive.Here,by analyzing the localization of DSB repair factors in the XY body and DSB foci,we demonstrate that pre-ribosomal RNA(pre-rRNA)mediates the recruitment of DSB repair factors around DNA lesions.Pre-rRNA exists in the XY body,a DSB repair hub,during meiotic prophase,and colocalizes with DSB repair factors,such as MDC1,BRCA1 and TopBP1.Moreover,pre-rRNA-associated proteins and RNAs,such as ribosomal protein subunits,RNase MRP and snoRNAs,also localize in the XY body.Similar to those in the XY body,pre-rRNA and ribosomal proteins also localize at DSB foci and associate with DSB repair factors.RNA polymerase I inhibitor treatment that transiently suppresses transcription of rDNA but does not affect global protein translation abolishes foci formation of DSB repair factors as well as DSB repair.The FHA domain and PST repeats of MDC1 recognize pre-rRNA and mediate phase separation of DSB repair factors,which may be the molecular basis for the foci formation of DSB repair factors during DSB response. | Xiaochen Gai Di Xin Duo Wu Xin Wang Linlin Chen Yiqing Wang Kai Ma Qilin Li Peng Li Xiaochun Yu | 2022 | Cell Research2022，32，3： | 1 |
| 20 | Production of aromatic hydrocarbons by catalytic pyrolysis of microalgae with zeolites: catalyst screening in a pyroprobe 显示文摘 | Du Zhenyi Ma Xiaochen Li Yun | 2013 | Bioresource Technology2013，139，： | 1 |
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