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| 1 | Tumor-associated macrophage-derived CCL20 enhances the growth and metastasis of pancreatic cancer显示文摘胰腺的癌症是有导致世界范围的高死亡率的一个高变形的潜力的好攻击的恶意。尽管巨噬细胞有潜力杀死肿瘤房间并且对肿瘤得到有免疫力的回答,有证据,联系肿瘤的巨噬细胞(TAM ) 支持肿瘤前进并且压制 T 房间回答。CC-chemokine ligand 20 (CCL20 ) 并且它的唯一的受体 CC-chemokine 受体(CCR6 ) 6 被癌症房间为移植和转移利用并且在癌症的发展和前进起重要作用。最近的研究证明了 CCL20 的表示是在胰腺的癌症的 upregulated;然而, CCL20 的行动的机制尚待充分被阐明。在这研究,包括变形胰腺的癌症织物,在胰腺的癌症织物的 TAM 的 CCL20 的异常表示被检测。CCL20 表示比在胰腺的癌症房间排队的在巨噬细胞是更加更高的,特别地在 interleukin-4-treated (M2 ) 巨噬细胞。用胰腺的癌症房间的 Boyden 房间试金,我们发现 M2 巨噬细胞分泌的 CCL20 支持了胰腺的癌症房间的迁居,上皮间充质的转变,和侵略。RNA 干扰结果证明 CCR6 是为在胰腺的癌症房间的 CCL20 的受体,调停这些房间的增加的侵略性质由 CCL20 支持了。用一个老鼠模型,我们在在 vivo 支持胰腺的癌症生长和肝转移证实了 CCR6/CCL20 的角色。我们的调查结果在胰腺的癌症提供卓见进藏匿巨噬细胞的 CCL20 的重要角色并且含有 CCR6/CCL20 同样潜在的治疗学的目标。 | Bingyan Liu Yiping Jia Jun Ma Shaoqiu Wu Haosheng Jiang Yan Cao Xianjun Sun Xiang Yin Shuo Yan Mingyi Shang Aiwu Mao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 13 |
| 2 | Exogenous cAMP upregulates the expression of glnII and glnK-amtB genes in Sinorhizobium meliloti 1021显示文摘The existence of multiple adenylate cy- clase encoding genes implies the importance of cAMP in Sinorhizobium meliloti 1021. In this study, as a pioneer step of understanding cAMP roles, mi- croarray analysis on S. meliloti was carried out for the function of exogenous cAMP. To our surprise, the result showed that the transcriptions of glnII and glnK genes were significantly upshifted in the presence of exogenous cAMP in S. meliloti. This phenomenon is further confirmed in S. meliloti that the expression of either glnII or glnK promoter-lacZ translational fusion is higher in the presence of exogenous cAMP. Therefore, for the first time, we have identified genes from S. meliloti whose expression is activated by cAMP. The potential physiological role of upregula- tion of glnII and glnK by cAMP is discussed. | TIAN Zhexian MAO Xianjun SU Wei LI Jian BECKER Anke WANG Yiping | 2006 | Chinese Science Bulletin2006，51，16： | 1 |
| 3 | Lysophosphatidic acid is a bioactive mediator in ovarian cancer显示文摘 | Xianjun Fang Michel Schummer Muling Mao Shuangxing Yu Fazal Haq Tabassam Ramona Swaby Yutaka Hasegawa Janos L Tanyi Ruthie LaPushin Astrid Eder Robert Jaffe Jim Erickson Gordon B Mills | 2002 | BBA - Molecular and Cell Biology of Lipids2002，，1： | 1 |
| 4 | cAMP receptor protein (CRP) downregulates Klebsiella pneumoniae nif promoters in Escherichia coli显示文摘In enteric bacteria, in response to the PTS system, the cAMP receptor protein (CRP) mediates the glucose effect, via regulating σ70-dependent catabolic genes at transcriptional level. In this study, it is observed that the nitrogen fixation capacity of Klebsiella pneumoniae varies strongly when cells are grown on different carbohydrates, and this carbon effect occurs at the level of nif gene expression. Here we show that CRP can repress σ54-dependent nif promoters (nifB, nifE, nifF, nifH, nifJ, nifLA and nifU), in a cAMP dependent fashion, in closed related E. coll background. Sequence analysis of these nif promoters indicates that there is no direct correlation between the fold of CRP-cAMP-mediated inhibition and the upstream cis elements at the promoters. In addition, the crp gene of K. pneumoniae has been isolated and sequenced, which is structural and functional highly homologous to that of E. coli. This suggests that CRP-cAMP-mediated inhibition on the nif promoters could be the reason for | Zhiting Li Yicheng Sun Xianjun Mao Yiping Wang | 2002 | Chinese Science Bulletin2002，47，19： | 1 |
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