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| 1 | Adalimumab Induces and Maintains Clinical Remission in Patients With Moderate-to-Severe Ulcerative Colitis显示文摘 | William J. Sandborn Gert van Assche Walter Reinisch Jean–Frederic Colombel Geert D’Haens Douglas C. Wolf Martina Kron Mary Beth Tighe Andreas Lazar Roopal B. Thakkar | 2012 | Gastroenterology2012，，2： | 9 |
| 2 | 5-ASA colonic mucosal concentrations resulting from different pharmaceutical formulations in ulcerative colitis显示文摘AIM:To compare the mucosal concentrations of 5-aminosalicylic acid(5-ASA)resulting from different pharmaceutical formulations and analyse the influence of inflammation on the mucosal concentrations.METHODS:The study included 130 inflammatory bowel disease(IBD)patients receiving 5-ASA as pH-dependent-release formulations(73 patients),time-dependent-release formulations(11 patients),or pro-drugs(18patients).In addition,28 patients were receiving topical treatment(2-4 g/d)with pH-dependent-release formulations.Endoscopic biopsies were obtained from the sigmoid region during the colonoscopy.The 5-ASA concentrations(ng/mg)were measured in tissue homogenatesusing high-pressure liquid chromatography with electrochemical detection.The t test and Mann-Whitney test,when appropriate,were used for statistical analysis.RESULTS:Patients receiving pH-dependent-release formulations showed significantly higher mucosal concentrations of 5-ASA(51.75±5.72 ng/mg)compared with patients receiving pro-drugs(33.35±5.78 ng/mg,P=0.01)or time-dependent-release formulations(38.24±5.53 ng/mg,P=0.04).Patients with endoscopic remission had significantly higher mucosal concentrations of5-ASA than patients with active disease(60.14±7.95ng/mg vs 35.66±5.68 ng/mg,P=0.02).Similar results were obtained when we compared patients with the histological appearance of remission and patients with active histological inflammation(67.53±9.22 ng/mg vs 35.53±5.63 ng/mg,P<0.001).Significantly higher mucosal concentrations of 5-ASA were detected in patients treated with both oral and topical treatments in combination compared with patients who received oral treatment with pH-dependent-release formulations alone(72.33±11.23 ng/mg vs 51.75±5.72 ng/mg,P=0.03).CONCLUSION:IBD patients showed significant variability in mucosal 5-ASA concentrations depending on the type of formulation,and the highest mean concentration was achieved using pH-dependent-release formulations. | Renata D’Incà Martina Paccagnella Romilda Cardin Surajit Pathak Vincenzo Baldo Maria Cecilia Giron Giacomo Carlo Sturniolo | 2013 | World Journal of Gastroenterology2013，19，34： | 4 |
| 3 | Orthostatic hypotension,an often-neglected problem in community-dwelling older people:discrepancies between studies and real life显示文摘Orthostatic hypotension (OH)is a common condition in older persons.According to the 2011criteria,OH is defined by a sustained reduction of systolic blood pressure of 20 mmHg or a 10mmHg-fall of diastolic blood pressure,[1] Its prevalence increases with age and according to a recent systematic review the pooled prevalence in community dwelling older people is 22.2%.[2]Although OH is largely explained by concurrent clinical conditions (in particular, hypertension,diabetes,malnutrition,vascular encephalopa- thy,anemia,Parkinson's disease)[3],aging per se determines a series of physiological dysfunctions potentially representing its biological substratum (e.g.,reduction in barore- flex-mediated cardiovascular function,altered salt and water balance at renal level,impaired cardiac diastolic filling).It is also noteworthy that age-related changes in pharmacokinetic and pharmacodynamic mechanisms of drugs (especially in the context of polypharmacy)also increase the risk of OH. | Sarah Damanti Dario Consormi Annalisa Valentini Benedetta Cerasoli Martina Biotto Federica Conti Marta Clerici Pasqualina Iannuzzi Emanuela Manzo Paolo D Rossi Simona Ciccone Matteo Cesari | 2018 | Journal of Geriatric Cardiology2018，15，10： | 2 |
| 4 | Production of a chimeric enzyme tool associating the Trichoderma reesei swollenin with the Aspergillus niger feruloyl esterase A for release of ferulic acid显示文摘 | Anthony Levasseur Markku Saloheimo David Navarro Martina Andberg Frédéric Monot Tiina Nakari-Set?l? Marcel Asther Eric Record | 2006 | Applied Microbiology and Biotechnology2006，，4： | 1 |
| 5 | The role of physical activity in the prevention of osteoporosis in postmenopausal women—An update显示文摘 | Natalie M. Schmitt Jochen Schmitt Martina D?ren | 2009 | Maturitas2009，，1： | 1 |
| 6 | ABCC8 and ABCC9: ABC transporters that regulate K+ channels显示文摘 | Joseph Bryan Alvaro Mu?oz Xinna Zhang Martina Düfer Gisela Drews Peter Krippeit-Drews Lydia Aguilar-Bryan | 2007 | Pflügers Archiv - European Journal of Physiology2007，，5： | 1 |
| 7 | Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study显示文摘 | Martina Goffredo Sonia Caprio Ariel E. Feldstein Ebe D’Adamo Melissa M. Shaw Bridget Pierpont Mary Savoye Hongyu Zhao Allen E. Bale Nicola Santoro | 2016 | Hepatology2016，，1： | 1 |
| 8 | Star-polymer Synthesis via Radical Reversible Addition-Fragmentation Chain-Transfer Polymerization 显示文摘 | Martina S R Thomas R D Vicki C | 2001 | Polym Sci Part A: Polyps Chem2001，39，16： | 1 |
| 9 | Adalimumab Induces and Maintains Clinical Remission in Patients With Moderate-to-Severe Ulcerative Colitis显示文摘 | William J. Sandborn Gert van Assche Walter Reinisch Jean–Frederic Colombel Geert D’Haens Douglas C. Wolf Martina Kron Mary Beth Tighe Andreas Lazar Roopal B. Thakkar | 2012 | Gastroenterology2012，，2： | 1 |
| 10 | Journal of polyer science part A 显示文摘 | Martina H S Thomas P D | 2002 | Polymer Chemisty2002，24，： | 1 |
| 11 | Biodegradable polymers applied in tissue engineering research: a review 显示文摘 | Martina M Hutmacher D W | 2007 | Polym lnt2007，56，2： | 1 |
| 12 | Tracking in multistatic passive radar systems using DAB/DVB-T illumination显示文摘 | Martina D Ulrich N and Wolfgang K | 2012 | Signal Processing2012，92，6： | 1 |
| 13 | Carbon source dependence and photostimulation of conidiatiou in Hypocrea atroviridis显示文摘 | MARTINA A F CHRISTIAN P K IRINA S D | 2008 | Applied and Enviroumental Microbiology2008，74，1： | 1 |
| 14 | Heterosis manifestation during early Arabidopsis seedling development is characterized by intermediate gene expression and enhanced metabolic activity in the hybrids显示文摘 | Rhonda C. Meyer Hanna Witucka‐Wall Martina Becher Anna Blacha Anastassia Boudichevskaia Peter D?rmann Oliver Fiehn Svetlana Friedel Maria von Korff Jan Lisec Michael Melzer Dirk Repsilber Renate Schmidt Matthias Scholz Joachim Selbig Lothar Willmitzer Tho | 2012 | The Plant Journal2012，，4： | 1 |
| 15 | Effect of dietary con-jugated linoleic acid and monounsaturated fatty acids on produc-tive,carcass and meat quality traits of pigs显示文摘 | Martina D Muriela E Gonzalezb E | 2008 | Livest Sci2008，117，23： | 1 |
| 16 | Lithium bis(fluorosulfonyI)imide-PYR14TFSI ionic liquid electrolyte compatible with graphite显示文摘 | Martina N Jakub R Robert D | 2011 | Journal of power sources2011，196，： | 1 |
| 17 | The mycosubtilin synthetase of Bacillus subtilis ATCC6633:A multifunctional hybrid between a peptide synthetase,an amino transferase,and a fatty acid synthase显示文摘 | ERWIN H D LEENDERT W H MARTINA R | 1999 | Proc Natl Acad Sci USA1999，96，13： | 1 |
| 18 | SO2 and NOx removal by electron beam and electrical discharge induced non-thermal plasmas 显示文摘 | IGHIGEANUA O MARTINA D ZISSULESCUB E | 2005 | Vacuum2005，77，4： | 1 |
| 19 | Absorption andtranslocation of polybrominated diphenyl ethers(PBDEs)by plantsfrom contaminated sewage sludge显示文摘 | JANA V KATERINA D MARTINA M | 2010 | Chemosphere2010，81，3： | 1 |
| 20 | Adalimumab Induces and Maintains Clinical Remission in Patients With Moderate-to-Severe Ulcerative Colitis显示文摘 | William J. Sandborn Gert van Assche Walter Reinisch Jean–Frederic Colombel Geert D’Haens Douglas C. Wolf Martina Kron Mary Beth Tighe Andreas Lazar Roopal B. Thakkar | 2012 | Gastroenterology2012，，2： | 1 |
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