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| 1 | Hepatic glycogenosis: An underdiagnosed complication of diabetes mellitus?显示文摘Hepatic glycogenosis(HG) is characterized by excessive glycogen accumulation in hepatocytes and represents a hepatic complication of diabetes that particularly occurs in patients with longstanding poorly controlled type 1 diabetes(T1D). HG has been reported to be a very rare disease, although it is believed to be extremely underdiagnosed because it is not possible to distinguish it from non-alcoholic fatty liver disease(NAFLD) unless a liver biopsy is performed. In contrast to HG, NAFLD is characterized by liver fat accumulation and is the more likely diagnosis for patients with type 2 diabetes and metabolic syndrome. The pathogenesis of HG involves the concomitant presence of insulin and excess glucose, which increases glycogen storage in the liver. HG is characterized by a transient elevation in liver transaminases and hepatomegaly. Differentiating between these two conditions is of the utmost importance because HG is a benign disease that is potentially reversible by improving glycemic control, whereas NAFLD can progress to cirrhosis. Therefore, HG should be suspected when liver dysfunction occurs in patients with poorly controlled T1 D. The aim of this article is to review the epidemiology, clinical characteristics, pathogenesis and histology of HG. | María Teresa Julián Núria Alonso Isabel Ojanguren Eduarda Pizarro Enric Ballestar Manel Puig-Domingo | 2015 | World Journal of Diabetes2015，6，2： | 4 |
| 2 | Heuristics of node selection criteria to assess robustness of world airport network显示文摘The world airport network(WAN) is one of the networked infrastructures that shape today's economic and social activity, so its resilience against incidents affecting the WAN is an important problem. In this paper, the robustness of air route networks is extended by defining and testing several heuristics to define selection criteria to detect the critical nodes of the WAN.In addition to heuristics based on genetic algorithms and simulated annealing, custom heuristics based on node damage and node betweenness are defined. The most effective heuristic is a multiattack heuristic combining both custom heuristics. Results obtained are of importance not only for advance in the understanding of the structure of complex networks, but also for critical node detection. | Manel SORIA Oriol LORDAN JosMaría SALLAN | 2017 | Chinese Journal of Aeronautics2017，30，4： | 3 |
| 3 | Risk Factors for Preeclampsia:Results from a Cohort of Over 5000 Pregnancies in Spain显示文摘Objective:To determine the incidence of preeclampsia(PE)and preterm PE in Spain and to identify the risk factors for developing the disease.Methods:This is a multicenter prospective cohort study performed at six maternity units across Spain.Women with singleton pregnancies attending their first-trimester routine visit at the hospital were offered participation.Maternal and pregnancy characteristics,including mean arterial pressure,as well as ultrasound findings were recorded.Univariate and multivariate logistic regression analyses were performed to identify independent risk factors for subsequent development of PE.Results:A total of 5868 pregnancies were recruited for this study,including 174(3.0%)cases of PE,47(0.8%)cases of preterm PE and 127(2.2%)cases of term PE.Median maternal age was 33.9 years(interquartile range:30.1 to 36.9)and median gestational age at the routine visit was 12.7 weeks(interquartile range:12.3 to 13.0).However,293(5.0%)of the women were on aspirin treatment during pregnancy,likely reducing the true incidence of the disease.As expected,increasing body mass index(P<0.001),uterine artery pulsatility index(P=0.011)and mean arterial pressure(P<0.001),assisted conception(P=0.013),previous personal(P<0.001)or family history of PE(P=0.024)and chronic hypertension(P=0.001)were identified as independent risk factors for developing subsequent PE during pregnancy.Screening for PE by maternal factors alone leads to a detection rate of 36.8%(64/174)at 10.0%(587/5868)screen positive rate.Conclusion:In Spain,3.0%of singleton pregnancies are complicated by PE and 0.8%require delivery before term due to its severity.Screening of PE by risk factors alone is only able to detect about 40%of total PE at 10%screen-positive rate. | Diana Cuenca Valeria Rolle Katy de Paco Matallana Nuria Valiño Rocio Revello Begoña Adiego Manel Mendoza Belen Santacruz Maria del Mar Gil | 2021 | Maternal-Fetal Medicine2021，3，2： | 1 |
| 4 | LDL-cholesterol predicts negative coronary artery remodelling in diabetic patients:an intravascular ultrasound study显示文摘 | Pilar JQ Manel S Dominick A | 2005 | European Heart Journal2005，26，： | 1 |
| 5 | Statistical analysis of amplified fragment length polymorphism data: a toolbox for molecular ecologists and evolutionists显示文摘 | Bonin A Ehrich D Manel S | 2007 | Mol Ecol2007，16，18： | 1 |
| 6 | Tubular and interstitial expression of ICAM - 1 as a marker of renal injury in IGA nephropathy显示文摘 | Pilar A Manel S | 2003 | Am J Neph rol2003，23，1： | 1 |
| 7 | Game theory for energy efficiency in wireless sensor networks: Latest trends显示文摘 | TAREK A MANEL G Z BORIS B | 2015 | Journal of Network and Computer Applications2015，54，： | 1 |
| 8 | CD4^+T lymphocytopenia-a frequent finding in anti-SSA antibody serupositive patients with primary Sjogren's syndrome显示文摘 | Manel T Bredberg A Jacobsson LT | 2004 | J Rheumatol2004，31，4： | 1 |
| 9 | Homocysteine enhances LDL fatty acid peroxidation, promoting microalbuminuria in type 2 diabetes显示文摘 | Asma K Thouraya A Manel I | 2008 | Ann Clin Biochem2008，45，5： | 1 |
| 10 | Rigid ureteros-copy in the case of suspected tumor of the upper urinary tract:re-port of 63 cases显示文摘 | Morel-Journel N Manel A Chaffanges P | 2002 | Prog Urol2002，12，1： | 1 |
| 11 | Questionnaire-based second-hand smoke assessment in adults显示文摘 | Mó nica Pé rez-Rí os Anna Schiaffino Marí a José Ló pez Manel Nebot I? aki Galá n Marcela Fu José Marí a Martí nez-Sá nchez Albert Moncada Agustí n Montes Carles Ariza Esteve Ferná ndez | 2013 | The European Journal of Public Health2013，，5： | 1 |
| 12 | Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis 显示文摘 | Sims TJ Lemmark A Manel LA | 2002 | J Clin Periodontol2002，29，： | 1 |
| 13 | Tissue engineering techniques for the treatment of a complex knee injury显示文摘 | Ronga M Grassi FA Manel i A | | 0，，05： | 1 |
| 14 | Notch Signaling Is Essential for Ventricular Chamber Development显示文摘 | Joaquín Grego-Bessa Luis Luna-Zurita Gonzalo del Monte Victoria Bolós Pedro Melgar Alejandro Arandilla Alistair N. Garratt Heesuk Zang Yoh-suke Mukouyama Hanying Chen Weinian Shou Esteban Ballestar Manel Esteller Ana Rojas José María Pérez-Pomares José Lu | 2007 | Developmental Cell2007，，： | 1 |
| 15 | CD4 + T |ym- phoeytopenia - a frequent finding in anti - SSA antibody seru- positive patients with primary Sjogren' s syndrome 显示文摘 | Manel T Bredberg A Jaeobsson L T | 2004 | J Rheumatol2004，31，4： | 1 |
| 16 | Statistical analysis of amplifiedfragment length polymorphism data: a toolbox for molecularecologists and evolutionists显示文摘 | Bonin A Ehrich D Manel S | 2007 | Molecular ecology2007，16，18： | 1 |
| 17 | Serunr IgG to heat shock protein and Porphyromonas gingivalis antigens in diabetic patients with periodontitis 显示文摘 | Sims TJ Lemmark A Manel LA | 2002 | J Clin Periodontol2002，29，6： | 1 |
| 18 | Evalution of an intergrated system for pig slurry treatment显示文摘 | Xavier F Nuria A Manel P | 2000 | Environmental Science2000，，5： | 1 |
| 19 | A clinical comparison of two vinyl polysiloxane impression materials using the one-step technique 显示文摘 | Raiqrodski A J Doqan S Manel LA | 2009 | J Prosthet Dent2009，102，3： | 1 |
| 20 | Support vector machines for nonlinear kernel ARMA system identification 显示文摘 | Manel M R Jose L R A | 2006 | IEEE Transactions on Neural Networks2006，17，6： | 1 |
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