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40篇 您的检索式:作者名="Maria T E"
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1Expression of HER2 and bradykinin B_1 receptors in precursor lesions of gallbladder carcinoma显示文摘AIM:To determine the expression of HER2 and bradykinin B 1 receptors(B 1 R) in the two pathogenic models of gallbladder cancer:the metaplasia-dysplasia-carcinoma and the adenoma-carcinoma pathways.METHODS:Receptor proteins were visualized by immunohistochemistry on 5-μm sections of paraffin-embedded tissue.Expression of both receptors was studied in biopsy samples from 92 patients(6 males and 86 females;age ranging from 28 to 86 years,mean 56 years).High HER2 expression in specimens was additionally investigated by fluorescence in situ hybridiza-tion.Cell proliferation in each sample was assessed by using the Ki-67 proliferation marker.RESULTS:HER2 receptor protein was absent in adenomas and in normal gallbladder epithelium.On the contrary,there was intense staining for HER2 on the basolateral membrane of epithelial cells of intestinal metaplasia(22/24;91.7%) and carcinoma in situ(9/10;90%),the lesions that displayed a significantly high proliferation index.Protein up-regulation of HER2 in the epithelium with metaplasia or carcinoma in situ was not accompanied by HER2 gene amplification.A similar result was observed in invasive carcinomas(0/12).The B 1 R distribution pattern mirrored that of HER2 except that B 1 R was additionally observed in the adenomas.The B 1 R appeared either as cytoplasmic dots or labeling on the apical cell membrane of the cells composing the epithelia with intestinal metaplasia(24/24;100%) and carcinoma in situ(10/10;100%) and in the epithelial cells of adenomas.In contrast,both HER2(4/12;33%) and B 1 R(1/12;8.3%) showed a low expression in invasive gallbladder carcinomas.CONCLUSION:The up-regulation of HER2 and B1R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis.Cesar Toledo Carola E Matus Ximena Barraza Pamela Arroyo Pamela Ehrenfeld Carlos D Figueroa Kanti D Bhoola Maeva del Pozo Maria T Poblete 2012World Journal of Gastroenterology2012,18,11:6
2Langerhans cells utilize CDla and langerin to efficiently present nonpeptide antigens to T cells显示文摘Robert E H Peter A S Maria T 2004J Clin Invest2004,113,5:1
3Analyzing a fLrm' s In- ternational Portfolio of Technological Knowledge: A Declarative Ontology-based OWL Approach for Patent Documents显示文摘Maria B E Manuel N Nuria H T 2013Ad- vanced Engineering Informatics2013,27,3:1
4Supported monolayers containing preformed binding sites synthesis and interfacial binding properties of a thiolated β-cyclodextrin derivative显示文摘Maria T Rojas Rainer Koniger J Fraser Stoddart Angel E Kaifer 1995J Am Chem Soc1995,117,:1
5Preparation of griseofulvin nanoparticles from water-dilutable microemulsions显示文摘Michele T Marina G Maria E C 2003Int J Pharm2003,254,2:1
6Ankle-brachial index as a predictor of the extent of coronary atherosclerosis and cardiovascular events in patients with coronary artery disease显示文摘Christos M Papamichael John P Lekakis Kimon S Stamatelopoulos Theodoros G Papaioannou Maria K Alevizaki Adriana T Cimponeriu John E Kanakakis Aggeliki Papapanagiotou Anastasios Th Kalofoutis Stamatios F Stamatelopoulos 2000The American Journal of Cardiology2000,,6:1
7Dendritic cells of immune thrombocytopenic purpura show increased capacity to present apoptotic platelet to T lymphocytes显示文摘CATANIL L MARIA E F PIER L T 2006Experimental hematology2006,34,:1
8Grafting raises the salt tolerance of tomato through limiting the transport of sodium and chloride to the shoot显示文摘Maria T E Maria M M R Francisco P A 2005Journal of Experimental Botany2005,412,56:1
9Two-Way Laser Link over Interplanetary Distance显示文摘David E Smith Maria T Zuber Xiaoli Sun 2006Science(S0036-8075)2006,311,:1
10Protein degradation in C3 and C4 plants with particular reference to ribulose bisphosphate carboxylase and glycolate oxidase显示文摘MARIA G E RICARDO B F ARTUR R T 1998Journal of Experimental Botany1998,49,:1
11Morphlolgical,anatomical and physiological responses related to differential shoot vs root growth inhibition an low temperature in spring and winter wheat 显示文摘Maria A E Juan P M Jorge A T 2001Annals of Botany2001,87,:1
12Meat intake,preparation methods,mutagens and colorectal adenoma recurrence显示文摘MARIA E M JACOBS E T ASHBECK E L 2007Carcinogenesis2007,28,9:1
13Grafting raises the salt tolerance of tomato through limiting the transport of sodium and chloride to the shoot 显示文摘Maria T E Maria M Martinez-Rodriguez 2005Joumal of Experimental Botany2005,56,412:1
14Solid-liquid equilibrium of K2 SO4 in solvent mixtures at different temperatures 显示文摘Yecid P J Maria E T H6ctor R G 2009Fluid Phase Equilibria2009,284,2:1
15Hydrogen production by ethanol steam reforming over a commercial Pd/γ-Al2O3 catalyst显示文摘Maria A G Sotiria K Panagiotis E T 2004Applied Catalysis B: Environmental2004,49,2:1
16Grafting raises the salt tolerance of tomato through limiting the transport of sodium and chloride to the shoot显示文摘MARIA T E MARIA M M R FRANCISCO P A 2005Journal of Experimental Botany2005,56,412:1
17Diagnosing correctness of semantic workflow models 显示文摘Diana B Rik E Maria T 2013Data & Knowledge Engineering2013,87,3:1
18Determination of methimazole and carbimazole by flow-injection with chemiluminescence detection based on the inhibition of the Cu (11) - catalysed luminol - hydrogen peroxide reaction 显示文摘Anastasios E Paraskevas D T Maria N 2004Anal Chim Aeta2004,505,:1
19Synthesis and effects on cell viability of- flavonols and 3-methyl ether derivatives on human leukemia cells显示文摘Olga B Maria T M Sara E 2014European Journal of Medicinal Chemistry2014,84,:1
20Atmospheric density during the aerobraking of Mars Odyssey from radio tracking data显示文摘Mazarico Erwan Zuber Maria T Lemoine Frank G Smith David E 2007Journal of Spacecraft and Rockets2007,44,5:1
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