4篇
您的检索式：作者名="Marianne Fillet"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Simultaneous determination of amino acids in different teas using supercritical fluid chromatography coupled with single quadrupole mass spectrometry显示文摘Tea is a widely consumed beverage and has many important physiological properties and potential health benefits. In this study, a novel method based on supercritical fluid chromatography coupled with mass spectrometry (SFC-MS) was developed to simultaneously determine 11 amino acids in different types of tea (green teas, Oolong tea, black tea and Pu-erh tea). The separation conditions for the analysis of the selected amino acids including the column type, temperature and backpressure as well as the type of additive, were carefully optimized. The best separation of the 11 amino acids was obtained by adding water (5%, v/v) and trifluoroacetic acid (0.4%, v/v) to the organic modifier (methanol). Finally, the developed SFC-MS method was fully validated and successfully applied to the determination of these amino acids in six different tea samples. Good linearity (r ≥ 0.993), precision (RSDs≤ 2.99%), accuracy (91.95%-107.09%) as well as good sample stability were observed. The limits of detection ranged from 1.42 to 14.69 ng/mL, while the limits of quantification were between 4.53 and 47.0 ng/mL. The results indicate that the contents of the 11 amino acids in the six different tea samples are greatly influenced by the degree of fermentation. The proposed SFC-MS method shows a great potential for further investigation of tea varieties. | Yang Huang Tiejie Wang Marianne Fillet Jacques Crommen Zhengjin Jiang | 2019 | Journal of Pharmaceutical Analysis2019，9，4： | 7 |
| 2 | Biomarker discovery for inflammatory bowel disease, using proteomic serum profiling显示文摘 | Marie-Alice Meuwis Marianne Fillet Pierre Geurts Dominique de Seny Laurence Lutteri Jean-Paul Chapelle Vincent Bours Louis Wehenkel Jacques Belaiche Michel Malaise Edouard Louis Marie-Paule Merville | 2007 | Biochemical Pharmacology2007，，9： | 2 |
| 3 | Biomarker discovery for inflammatory bowel disease,using proteomic serum profiling显示文摘 | Marie-Alice Meuwis Marianne Fillet | | 0，，8： | 1 |
| 4 | Determination of iohexol by capillary blood microsampling and UHPLC-MS/MS显示文摘One of the most important tools used to evaluate kidney function in the context of chronic kidney disease or other renal function related pathologies is the exploration of glomerular filtration rate (GFR). Iohexol is up to this moment a good candidate molecule for the GFR assessment since it exhibits minimum protein binding rates and minimum extra-renal clearance, being neither secreted nor reabsorbed at the tubular level. This study proposes and evaluates a new LC-MS/MS method for the iohexol determination from capillary blood, prelevated using volumetric absorbative microsampling (VAMS) systems. As an alternative to VAMS, a brand new HemaPEN■ device for micro-prelevation was also tested. A new high throughput sample preparation protocol adapted for iohexol quantification from whole blood VAMS samples was developed. The medium term stability study of iohexol in dried whole blood VAMS samples that was conducted showed a good stability of this molecule for up to 12 days. By collecting only 10 mL of blood, iohexol can be analyzed from dried whole blood VAMS samples for concentration ranges between 1 and 250 mg/mL. Due to the analyte stability in VAMS for up to 12 days, this approach might be successfully applied for GFR assessment for clinical cases allowing minimum invasiveness and even delayed analysis. | Valentin Ion Caroline Legoff Etienne Cavalier Pierre Delanaye Anne-Catherine Servais Daniela-Lucia Muntean Marianne Fillet | 2019 | Journal of Pharmaceutical Analysis2019，9，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员