|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Metabolic syndrome as a risk factor for gallstone disease显示文摘AIM: To establish an association between the presence of metabolic syndrome and the development of gallstone disease.METHOIDS: We carried out a cross-sectional study in a check-up unit in a university hospital in Mexico City. We enrolled 245 subjects, comprising 65 subjects with gallstones (36 women, 29 men) and 180 controls (79women and 101 men without gallstones). Body mass index, waist circumference, blood pressure, plasma insulin, and serum lipids and lipoproteins levels were measured. Insulin resistance was calculated by homeostasis model assessment. Unconditional logistic regressionanalysis (univariate and multivariate) was used to calculate the risk of gallstone disease associated with the presence of at least three of the criteria (Adult Treatment Panel Ⅲ). Analyses were adjusted for age and sex.RESULTS: Among 245 subjects, metabolic syndrome was present in 40% of gallstone disease subjects, compared with 17.2% of the controls, adjusted by age and gender (odds ratio (OR) = 2.79; 95%CI, 1.46-5.33; P = 0.002),a dose-dependent effect was observed with each component of metabolic syndrome (OR = 2.36, 95%CI, 0.72-7.71;P = 0.16 with one component and OR = 5.54, 95%CI,1.35-22.74; P = 0.02 with four components of metabolic syndrome). Homeostasis model assessment was significantly associated with gallstone disease (adjusted OR = 2.25;95%CI, 1.08-4.69; P = 0.03).CONCLUSION: We conclude that as for cardiovascular disease and diabetes mellitus, gallstone disease appears to be strongly associated with metabolic syndrome. | Nahum Méndez-Sánchez Norberto C. Chavez-Tapia Daniel Motola-Kuba Karla Sanchez-Lara Guadalupe Ponciano-Rodríguez Héctor Baptista Martha H. Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，11： | 32 |
| 2 | Adiponectin as a protective factor in hepatic steatosis显示文摘AIM: Obesityand insulin resistance (IR) are closely related to hepatic steatosis (HS), and adiponectin is a hepatic insulin sensitizer that has important effects in liver function.This study aims at investigating the relationship between serum adiponectin concentration and the presence of HS.METHODS: We carried out a cross-sectional study in a check-up unit of a University Hospital in Mexico City. We enrolled 196 subjects, comprising 98 subjects with HS (27 women, 71 men) and 98 controls (37 women and 61men). Anthropometric, metabolic and biochemical variables were measured in the two groups. Serum adiponectin and leptin concentrations were determined,their association with grade of HS tested, and concentrations,according to quartiles, compared between cases and controls. χ2 analysis for linear trends was used to test for a dose-response relationship and logistic regression analysis was conducted to test for a protective effect of adiponectin.RESULTS: The HS subjects were older and more obese than controls, with a central obesity pattern. In the fourth quartile of adiponectin concentrations, HS was less common and severe. In a multivariate model of the fourth quartile of the adiponectin concentrations, we observed a protective effect (OR = 0.17, 95%CI: 0.04-0.67, P= 0.01).In subjects with more severe HS, we observed higher leptin concentrations, and caloric intakes, total fat and iron consumption were higher than in controls.CONCLUSION: The results of the present study suggest that a high serum concentration of adiponectin is associated with a protective effect against HS. | Nahum Méndez-Sánchez Norberto C.Chávez-Tapia Antonio R.Villa Karla Sánchez-Lara Daniel Zamora-Valdés Martha H.Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，12： | 12 |
| 3 | New gene therapy strategies for hepatic fibrosis显示文摘The liver is the largest internal organ of the body, which may suffer acute or chronic injury induced by many factors, leading to cirrhosis and hepatocarcinoma. Cirrhosis is the irreversible end result of fibrous scarring and hepatocellular regeneration, characterized by diffuse disorganization of the normal hepatic structure, regenerative nodules and fibrotic tissue. Cirrhosis is associated with a high co-morbidity and mortality without effective treatment, and much research has been aimed at developing new therapeutic strategies to guarantee recovery. Liver-based gene therapy has been used to downregulate specific genes, to block the expression of deleterious genes, to delivery therapeutic genes, to prevent allograft rejection and to augment liver regeneration. Viral and non-viral vectors have been used, with viral vectors proving to be more efficient. This review provides an overview of the main strategies used in liver-gene therapy represented by non-viral vectors, viral vectors, novel administration methods like hydrodynamic injection, hybrids of two viral vectors and blocking molecules, with the hope of translating findings from the laboratory to the patient′s bed-side. | Adriana M Salazar-Montes Luis D Hernández-Ortega Martha S Lucano-Landeros Juan Armendariz-Borunda | 2015 | World Journal of Gastroenterology2015，21，13： | 12 |
| 4 | Serum leptin levels and insulin resistance are associated with gallstone disease in overweight subjects显示文摘AIM: To establish an association between the serum leptin levels and the development of gallstone disease (GD).METHODS: We carried out a non-matched case-controlled study in a university hospital in Mexico City. Two hundred and eighty-seven subjects were included: 97 cases with gallstones and 190 controls. Body mass index (BMI), fasting plasma leptin, insulin, serum lipid, and lipoprotein levels were measured. Insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Unconditional logistic regression analysis (univariate and multivariate)stratified by BMI was used to calculate the risk of GD.RESULTS: The multivariate conditional regression analysis revealed a model for those patients with BMI <30. The selected variables in the model were HOMA-IR index with OR = 1.31, P= 0.02 and leptin higher than median with OR = 2.11, P= 0.05. In the stratum of BMI ≥30, we did not find a useful model.CONCLUSION: We concluded that insulin resistance and the development of GD appears to be associated with serum leptin levels in subjects with overweight, but not in obese subjects with similar metabolic profiles. | Nahum Méndez-Sánchez Luisa B Bermejo-Martínez Yolanda Vi(n|~)als Norberto C Chavez-Tapia Irina Vander Graff Guadalupe Ponciano-Rodríguez Martha H Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，39： | 11 |
| 5 | Cerebral palsy: introduction and diagnosis (Part I)显示文摘 | Martha WJ Elaine M Jean ES | 2007 | J Pediatr Health Care2007，21，： | 1 |
| 6 | Longitudinal associations between blood lead concentrations lower than 10μg/dL and neurohehavioral development in environmentally exposed children in Mexico City显示文摘 | Martha M Tellez-Rojo David C | 2006 | Pediatrics2006，118，2： | 1 |
| 7 | Solar reflectance values for concrete: intrinsic materical properties can minimize the heat island effect 显示文摘 | MEDGAR L M MARTHA G V | 2008 | Concrete International2008，30，8： | 1 |
| 8 | CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients显示文摘 | Savoldo Barbara Ramos Carlos Almeida Liu Enli Mims Martha P Keating Michael J Carrum George Kamble Rammurti T Bollard Catherine M Gee Adrian P Mei Zhuyong Liu Hao Grilley Bambi Rooney Cliona M Heslop Helen E Brenner Malcolm K Dotti Gianpie | 2011 | Journal of Clinical Investigation2011，，5： | 1 |
| 9 | Issues in supply chain manage- ment 显示文摘 | Douglas M Lambert Martha C Cooper | 2000 | Industrial Marketing Management2000，29，： | 1 |
| 10 | Starch synthesis in the cereal endosperm显示文摘 | MARTHA G J KAY D ALAN M M | 2003 | Current Opinion in Plant Biology2003，6，： | 1 |
| 11 | Op- timizing disinfection pretreatment using excitation-emis- sion matrix fluorescence spectroscope 显示文摘 | Katherine Y Bell Juan SOnez and Martha J M Wells | 2012 | Ozone: Science & Engineering: The Journal of the International Ozone Association2012，34，： | 1 |
| 12 | Expression of NOTCH-1 and Its Ligands, Delta-Like-1 and Jagged-1, Is Critical for Glioma Cell Survival and Proliferation显示文摘 | Benjamin W P Raqeeb M H Martha W N etal | 2005 | Cancer Res2005，65，6： | 1 |
| 13 | Toward a Model of Environmental Scanning显示文摘 | Martha M L | | 0，，03： | 1 |
| 14 | Facile synthesis of highly active g-C3 N4 for efficient hydrogen production under visible light显示文摘 | Martha S Nashim A Pafida K M | 2013 | Journal of Materials Chemistry A2013，26，1： | 1 |
| 15 | Issues in supply chain management 显示文摘 | Cooper Martha C | 2000 | Industrial Marketing Management2000，29，： | 1 |
| 16 | Cytologic Features of Metastatic Sebaceous Carcinoma: Report of Two Cases With Comparison to Three Cases of Basal Cell Carcinoma显示文摘 | Saha Sadeghi Martha B Pilman Michele M Weir | 1999 | 21(5) :340 -3451999，21，5： | 1 |
| 17 | The response ot sod ero- sion and sediment export to land-use change in four areas of Europe : the importance of landscape pattern 显示文摘 | Martha M B Gerard G Anne V D | 2008 | Geomorphology2008，98，34： | 1 |
| 18 | Viral determinants of simian immunodeficiency virus (SIV) virulence in rhesus macaques assessed by using attenuated and pathogenic molecular clones of SIVmac 显示文摘 | Marthas M L Ramos R A Lohman B L | 1993 | J Virol1993，67，10： | 1 |
| 19 | Global leaders are team players: developing global leaders through membership on global teams 显示文摘 | Martha L M Joseph J D | 2000 | Human Resource Management2000，39，23： | 1 |
| 20 | Mutations affecting starch synthase III in arabidopsis alter leaf starch structure and increase the rate of starch synthesisl显示文摘 | Zhang X L Alan M M Martha G | 2005 | Plant Physiology2005，138，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员