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| 1 | GENETIC ENGINEERING NEURAL STEM CELL MODIFIED BY LENTIVIRUS FOR REPAIR OF SPINAL CORD INJURY IN RATS显示文摘Objective To explore the feasibility for therapy of spinal cord injury (SCI) by genetic engineering neural stem cell (NSC) modified by lentiviral vector. Methods Following the construction of the genetic engineering NSC modified by lentivirus to secrete both neurotrophic factor-3 (NT-3) and green fluorescence protein (GFP), hemisection of spinal cord at the level of T_ 10 was performed in 56 adult Wistar rats that were randomly divided into 4 groups (n=14), namely 3 therapeutic groups and 1 control group. The therapeutic groups were dealed with NSC, genetic engineering NSC, and concentrated lentiviral supernatant which carries both GFP and NT-3, respectively. Then used fluorescence microscope to detect the transgenic expression in vitro and in vivo, migration of the grafted cells in vivo, and used the Basso, Beattie, and Bresnahan (BBB) open-field locomotor test to assess the recovery of function. Results The transplanted cells could survive for long time in vivo and migrate for long distance. The stable transgenic expression could be detected in vivo. The hindlimb function of the injured rats in 3 therapeutic groups, especially those dealed with genetic engineering NSC, improved obviously. Conclusion It is feasible to combine NSC with lentivirus for the repair of SCI. NSC modified by lentivirus to deliver NT-3, acting as a source of neurotrophic factors and function cell in vivo, has the potential to participate in spinal cord repair. | Xun Tang Pei-qiang Cai Yue-qiu Lin Martin Oudega Bas Blits Ling Xu Yun-kang Yang Tian-hua Zhou | 2006 | Chinese Medical Sciences Journal2006，21，2： | 8 |
| 2 | MicroRNAs as novel predictive biomarkers and therapeutic targets in colorectal cancer显示文摘Colorectal cancer(CRC) is the third most common cancer in western countries. Despite significant improvement in available treatment options, CRC still remains the second leading cause of cancer-related death. Traditionally, 5-fluorouracil has been used as the main chemotherapy drug for treatment of metastatic CRC(mCRC). However, during the last two decades more effective chemotherapeutic agents such as oxaliplatin, irinotecan and the monoclonal antibodies cetuximab, panitumumab and bevacizumab have been used in clinical practice. More recently, the therapeutic armamentarium has been supplemented by the monoclonal antibodies bevacizumab, cetuximab and panitumumab as well as the protein-trap aflibercept and the smallmolecule multi-kinase inhibitor regorafenib. One of the major problems for the management of CRC is the inherent or acquired resistance to therapeutic approaches. The discovery of microRNAs(miRNAs), a class of small, endogenous, non-coding, single-stranded RNAs that play a role as post-transcriptional regulators, has added new dimensions to the diagnosis and treatment of cancer. Because miRNAs are important regulators of carcinogenesis, progression, invasion, angiogenesis and metastases in CRC, they might serve as potential predictive and prognostic factors and even as therapeutic targets themselves. Several miRNAs are already known to be dysregulated in CRCs and have been linked to biological processes involved in tumor progression and response to anti-cancer therapies. This review summarizes current therapeutic approaches for treating CRC and highlights the role of miRNAs as novel predictive biomarkers and potential drug targets in CRC patients. | Verena Stiegelbauer Samantha Perakis Alexander Deutsch Hui Ling Armin Gerger Martin Pichler | 2014 | World Journal of Gastroenterology2014，20，33： | 7 |
| 3 | The Involvement of Lipids in Alzheimer's Disease显示文摘It has been estimated that Alzheimer's disease(AD), the most common form of dementia, will affect approximately 81 million individuals by 2040. To date, the actual cause and cascade of events in the progression of this disease have not been fully determined.Furthermore, there is currently no definitive blood test or simple diagnostic method for AD. Considerable efforts have been put into proteomic approaches to develop a diagnostic blood test, but to date these efforts have not been successful. More recently, there has been a stronger focus on lipidomic studies in the hope of increasing our understanding of the underlying mechanisms leading to AD and developing an AD blood test. It is well known that the strongest genetic risk factor for AD is the ε4 variant of apolipoprotein E(APOE).Evidence suggests that the ApoE protein, a major lipid transporter, plays a key role in the pathogenesis of AD, and its role in both normal and aberrant lipid metabolism warrants further extensive investigation. Here, we review ApoE-lipid interactions, as well as the roles that lipids may play in the pathogenesis of AD. | Wei Ling Florence Lim Ian James Martins Ralph Nigel Martins | 2014 | Journal of Genetics and Genomics2014，41，5： | 6 |
| 4 | Characterization of artificial spherical particles for DEM validation studies显示文摘This paper describes a study in which advanced particle-scale characterization was carried out on spherical particles that can be used in experimental tests to validate discrete element method (DEM) simulations. Two types of particle, alkaline and borosilicate glass beads, made from two different materials, were considered. The particle shape, stiffness, contact friction properties and surface roughness were measured. The influences of hardness and roughness on the mechanical response of the particles were carefully considered. Compared to the alkaline beads, the borosilicate beads were more spherical and more uniform in size, and they exhibited mechanical characteristics closer to natural quartz sand. While only two material types were studied, the work has the broader implication as a methodology for selecting particles suitable for use in DEM studies and the key parameters that should be considered in the selection process are highlighted. | Ignazio Cavarretta Catherine O'Sullivan Erdin Ibraim Martin Lings Simon Hamlin David Muir Wood | 2012 | Particuology2012，10，2： | 3 |
| 5 | Functionalized Hydrogels for Articular Cartilage Tissue Engineering显示文摘Articular cartilage(AC)is an avascular and flexible connective tissue located on the bone surface in the diarthrodial joints.AC defects are common in the knees of young and physically active individuals.Because of the lack of suitable tissue-engineered artificial matrices,current therapies for AC defects,espe-cially full-thickness AC defects and osteochondral interfaces,fail to replace or regenerate damaged carti-lage adequately.With rapid research and development advancements in AC tissue engineering(ACTE),functionalized hydrogels have emerged as promising cartilage matrix substitutes because of their favor-able biomechanical properties,water content,swelling ability,cytocompatibility,biodegradability,and lubricating behaviors.They can be rationally designed and conveniently tuned to simulate the extracel-lular matrix of cartilage.This article briefly introduces the composition,structure,and function of AC and its defects,followed by a comprehensive review of the exquisite(bio)design and(bio)fabrication of func-tionalized hydrogels for AC repair.Finally,we summarize the challenges encountered in functionalized hydrogel-based strategies for ACTE both in vivo and in vitro and the future directions for clinical translation. | Liangbin Zhou Peng Guo Matteo D’Este Wenxue Tong Jiankun Xu Hao Yao Martin J.Stoddart Gerjo J.V.M.van Osch Kevin Ki-Wai Ho Zhen Li Ling Qin | 2022 | Engineering2022，8，6： | 1 |
| 6 | Total synthesis of a functional designer eukaryotic chromosome 显示文摘 | Annaluru N Muller H Mitchell L A Ramalingam S Stracquadanio G Richardson S M Dymond J S Kuang Z Scheifele L Z Cooper E M Cai Y Z Zeller K Agmon N Han J S Hadjithomas M Tullman J Caravelli K Cirelli K Guo Z Y London V Yeluru A Murugan S Kandavelou K Agier N Fischer G Yang K Martin J A Bilgel M Bohutski P Boulier K M Capaldo B J Chang J Charoen K Choi W J Deng P Dicarlo J E Doong J Dunn J Feinberg J I Fernandez C Floria C E Gladowski D Hadidi P Ishizuka I Jabbari J Lau C Y L Lee P A Li S Lin D Linder M E Ling J Liu J Liu J London M Ma H Mao J Mcdade J E Mcmillan A Moore A M Oh W C Ouyang Y Patel R Paul M Paulsen L C Qiu J Rhee A Rubashkin M G Soh I Y Sotuyo N E Srinivas V Suarez A Wong A Wong R Xie W R Xu Y J Yu A T Koszul R Bader J S Boeke J D Chandrasegaran S | 2014 | Science2014，344，6179： | 1 |
| 7 | Expansion of the red cell distribution width and evolving iron deficiency as predictors of poor outcome in chronic heart failure显示文摘 | Nay Aung Hua Zen Ling Adrian S. Cheng Suneil Aggarwal Julia Flint Michelle Mendonca Mohammed Rashid Swan Kang Susanne Weissert Caroline J. Coats Toby Richards Martin Thomas Simon Woldman Darlington O. Okonko | 2013 | International Journal of Cardiology2013，，： | 1 |
| 8 | Testing the iron hypothesis in ecosystems of the equatorial Pacific Ocean 显示文摘 | Martin J H CoMe K H Johnson K S Fitzwater S E Gordon R M Tanner S J Hunter C N Elrod V A Nowicki J L Coley T L Barber R T Lindley S Watson A J Van Scoy K Law C S Liddicoat M I Ling R Stanton T Stoekel J Collins C Anderson A Bidigare R Ondrusek M Latasa M Millero F J Lee K Yao W Zhang J Z Friederich G Sakamoto C Chavez F Buck K Kolber Z Greene R Falkowski P Chisholm S W Hoge F Swift R Yangel J Turner S Nightingale P Hatton A Liss P Tindale N W | 1994 | Nature1994，371，6493： | 1 |
| 9 | Comparative study between core–shell and interpenetrating network structure polyurethane/polyacrylate composite emulsions显示文摘 | Shu Ling Chai Martin Ming Jin Hui Min Tan | 2008 | European Polymer Journal2008，，10： | 1 |
| 10 | Expression of growth factor receptors and tageting of EGFR in cholangiocarcinoma cell lines显示文摘 | Ling Xu Martin H Wolfgang D | 2010 | BMC Cancer2010，18，10： | 1 |
| 11 | Graphenes Prepared by Hummers, Staudenmaier and Hofmann Methods for Analysis of TNT‐Based Nitroaromatic Explosives in Seawater显示文摘 | Beng Khong Ong Hwee Ling Poh Chun Kiang Chua Martin Pumera | 2012 | Electroanalysis2012，，11： | 1 |
| 12 | Flow injection analysis of water vapour based on a fluorosensor 显示文摘 | Martin M F choi Qi ling Tse | 2000 | Analytica Chimica Acta2000，423，： | 1 |
| 13 | Comparative study between core-shell and interpenetrating network structure polyurethane-polyacrylate composite emulsions显示文摘 | Shu Ling Chai Martin Ming Jin Hui Min Tan | 2008 | European Poly- mer Journal2008，44，10： | 1 |
| 14 | Effects of Modeling Soil Nonlinearity and Wall Installation on Back-Analysis of Deep Excavation in Stiff Clay显示文摘 | Charles W w Ng Martin L Lings | 1995 | Journal of Geotechnical Engineering ASCE1995，121，10： | 1 |
| 15 | FGFR1 Signaling Stimulates Proliferation of Human Mesenchymal Stem Cells by Inhibiting the Cyclin‐Dependent Kinase Inhibitors p21Waf1 and p27Kip1显示文摘 | Christian Dombrowski Torben Helledie Ling Ling Martin Grünert Claire A. Canning C. Michael Jones James H. Hui Victor Nurcombe Andre J. van Wijnen Simon M. Cool | 2013 | Stem Cells2013，，： | 1 |
| 16 | Amyloid beta antagonizes insulin promoted secretion of the amyloid beta-protein precursor显示文摘 | Ling X Martins RN Racchi M | 2002 | J Alzheimers Dis2002，4，5： | 1 |
| 17 | ESL students’ experiences of online peer feedback显示文摘 | Martin Guardado Ling Shi | 2007 | Computers and Composition2007，，4： | 1 |
| 18 | Morphology and Particle Size ofNanograde Polyurethane/Polyacrylate Hybrid Emulsions显示文摘 | SHU LING CHAI MARTIN MING JIN | 2009 | Journal of Applied Polymer Science2009，，114： | 1 |
| 19 | A phase I study of prolonged infusion of triapine in combination with fixed dose rate gemcitabine in patients with advanced solid tumors显示文摘 | Mortazavi A Ling Y Martin LK | 2013 | Invest New Drugs2013，31，3： | 1 |
| 20 | Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation显示文摘 | Jumei Shi Junru Wang Huaien Zheng Wen Ling Jacob Joseph Dayuan Li Jawahar L Mehta Usha Ponnappan Pei Lin Louis M Fink Martin Hauer-Jensen | 2003 | Blood Coagulation & Fibrinolysis2003，，6： | 1 |
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