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| 1 | PPIs are not associated with a lower incidence of portal-hypertension-related bleeding in cirrhosis显示文摘AIM:To determine if proton pump inhibitor use in cirrhotic patients with endoscopic findings of portal hypertension is associated with a lower frequency of gastrointestinal bleeding.METHODS:Patients with cirrhosis and endoscopic findings related to portal hypertension,receiving or not receiving proton pump inhibitor (PPI) therapy,were included retrospectively.We assigned patients to two groups:group 1 patients underwent PPI therapy and group 2 patients did not undergo PPI therapy.RESULTS:One hundred and five patients with a median age of 58 (26-87) years were included,57 (54.3%) of which were women.Esophageal varices were found in 82 (78%) patients,portal hypertensive gastropathy in 72 (68.6%) patients,and gastric varices in 15 (14.3%) patients.PPI therapy was used in 45.5% of patients (n=48).Seventeen (16.1%) patients presented with upper gastrointestinal bleeding;in 14/17 (82.3%) patients,bleeding was secondary to esophageal varices,and in 3/17 patients bleeding was attributed to portal hypertensive gastropathy.Bleeding related to portal hypertension according to PPI therapy occurred in 18.7% (n=9) of group 1 and in 14% (n=8) of group 2 (odds ratio:0.83,95% confidence interval:0.5-1.3,P=0.51).CONCLUSION:Portal hypertension bleeding is not associated with PPI use.These findings do not support the prescription of PPIs in patients with chronic liver disease with no currently accepted indication. | Mauricio Garcia-Saenz-de-Sicilia Francisco Sanchez-Avila Norberto C Chavez-Tapia Gustavo Lopez-Arce Sandra Garcia-Osogobio Roberto Ruiz-Cordero Felix I Tellez-Avila | 2010 | World Journal of Gastroenterology2010，16，46： | 6 |
| 2 | Prevalence of metabolic syndrome, obesity and diabetes type 2 in cryptogenic cirrhosis显示文摘AIM: To evaluate the prevalence of metabolic syndrome (MS), obesity and type 2 diabetes mellitus (T2DM) in a group of Mexican Mestizo patients with cryptogenic cirrhosis (CC) and to compare this group with patients with cirrhosis secondary to other causes (disease controls). METHODS: Patients with CC, diagnosed between January, 1990 and April, 2005, were included in a retrospective study. Patients with cirrhosis caused by chronic hepatitis C, alcohol abuse or autoimmune hepatitis (AIH) served as disease controls. RESULTS: A total of 134 patients with CC were analyzed. Disease controls consisted of 81 patients with chronic hepatitis C, 33 with alcohol abuse and 20 with AIH. The median age of patients with CC was 57 years (range, 16-87); 83 (61.9%) patients were female; 53 (39.6%) were Child A, 65 (48.5%) Child B, and 16 (11.9%) were Child C cirrhosis. The prevalence of MS (29.1% vs 6%; P < 0.001), obesity (16.4% vs 8.2%; P = 0.04) and T2DM (40% vs 22.4%; P = 0.013) was higher in CC patients than in disease controls. There were no differences in sex, age or liver function tests between the two groups. CONCLUSION: The prevalence of MS, obesityand T2DM were higher in patients with CC than in patients with cirrhosis secondary to others causes. Our findings support the hypothesis that non-alcoholic steatohepatitis (NASH) plays an under-recognized role in CC. | Felix I Tellez-Avila Francisco Sanchez-Avila Mauricio García-Saenz-de-Sicilia Norberto C Chavez-Tapia Ada M Franco-Guzman Gustavo Lopez-Arce Eduardo Cerda-Contreras Misael Uribe | 2008 | World Journal of Gastroenterology2008，14，30： | 6 |
| 3 | Treatment of highgrade glioma patients with the humanized anti - epidermal growth factor receptor (EGFR) antibody h - R3 : Report from a phase I/Ⅱ trial显示文摘 | Tania C R Javier F Mauricio C | 2006 | Cancer Biol Ther2006，5，4： | 1 |
| 4 | Diabetic neuropathy is associated with activation of the TNF-α system in subjects with type 1 diabetes mellitus 显示文摘 | Gonzalez-Clemente JM Mauricio D Richart C | 2005 | Clin Endocrinol ( Oxf)2005，63，5： | 1 |
| 5 | Alcoho and aldehyde dehydrogenase from Saccharomyces cerevisiae: specific activity and influence on the production of acetic acid, ethanol and higher alcohols in the first 48h of fermentation of grape must 显示文摘 | Millán C Mauricio J C Ortege J M | 1990 | Mcrobios1990，64，： | 1 |
| 6 | A brief discussion on (pure mode I ) fatigue crack growth rate data in 5HS weave fabric composites: evaluation of empirical relations显示文摘 | MARCOS Y S REYNDERT C A MAURICIO V D | 2015 | International Journal of Fatigue2015，84，： | 1 |
| 7 | Parallel scalability and efficiency of HEVC parallelization approaches 显示文摘 | Chi C C Mauricio A M Juurlink B | 2012 | IEEE Trans on Circuits and Systems for Video Technology2012，22，12： | 1 |
| 8 | Minimum Entro Pydeconvolution with Frequency-domain Constraints显示文摘 | Mauricio D S Danilo R V Alberta H C | 1994 | Geophysics1994，59，6： | 1 |
| 9 | Attack taxonomies for the Modbus protocols显示文摘 | Peter H Rodrigo C Mauricio P | 2008 | Critical Infrastructure Protection2008，1，： | 1 |
| 10 | Diabetic neuropathy is associated with activation of the TNF-alpha system in subjects with type 1 diabetes mellitus显示文摘 | Gonzalez-Clemente J M Mauricio D Richart C | 2005 | Clin Endocrinol (Oxf)2005，63，5： | 1 |
| 11 | Closed-Loop Job Release Control for VLSI Circuit Manufacturing 显示文摘 | Glassey C R Mauricio G C | 1988 | IEEE Transactions Semiconductor Manufacturing1988，1，1： | 1 |
| 12 | Nasopharyngeal nonossifying variant of ossifying fibromyxoid tumor: CT and MR findings显示文摘 | Jill T Mauricio C Robert LR | 1995 | AJNR1995，16，5： | 1 |
| 13 | Clinical applica- tions of proton MR spectroscopy显示文摘 | Mauricio C Leater K Suresh KM | 1996 | AJNR1996，17，： | 1 |
| 14 | The choice of policy instruments to control pollution under costly enforcement and incomplete information显示文摘 | Carlos A C Mauricio G V Stranlund J K | 2009 | Journal of Applied Economics2009，12，2： | 1 |
| 15 | Comparison between clinical examination, transvaginal sonography and magnetic resonance ima- ging for the diagnosis of deep endometriosis 显示文摘 | Mauricio S Abrao Manoel C | 2007 | Hum Reprod2007，22，12： | 1 |
| 16 | Changes in nitrogen compounds in must and wine during fermentation and biological aging by flor yeasts显示文摘 | Mauricio J C Valero E Millán C | 2001 | Journal of Agricultural and Food Chemistry2001，49，7： | 1 |
| 17 | Channel estimation using implicit training显示文摘 | Orozco-Lugo A G Mauricio L M McLernon D C | 2004 | IEEE Transactions on Signal Processing2004，52，1： | 1 |
| 18 | Comparison betweenclinical examination,transvaginal sonography and magneticresonance imaging for the diagnosis of deep endometriosis显示文摘 | Mauricio S Abrao Manoel C | 2007 | Hum Reprod2007，22，12： | 1 |
| 19 | Polyaniline/lignin belens: FTIR, MEV and electrochemical characterization 显示文摘 | Panula C Mauricio P Paulo J | 2002 | European Polymer Journal2002，38，2： | 1 |
| 20 | Acute Marchiafava-Big-nami disease: MR findings in two patients 显示文摘 | Andres A Adriana P Mauricio C | 2003 | Ara J Neu-roradiol2003，24，10： | 1 |
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