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| 1 | Natural Variation in CCD4 Promoter Underpins Species-Specific Evolution of Red Coloration in Citrus Peel显示文摘Carotenoids and apocarotenoids act as phytohormones and volatile precursors that influence plant development and confer aesthetic and nutritional value critical to consumer preference.Citrus fruits display considerable natural variation in carotenoid and apocarotenoid pigments.In this study,using an integrated genetic approach we revealed that a 5;c/s-regulatory change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C3 0 apocarotenoids responsible for red coloration of citrus peel.Functional analyses demonstrated that in addition the known role in synthesizing 3-citraurin,CCD4b is also responsible for the production of another important C3 0 apocarotenoid pigment,p-citraurinene.Furthermore,analyses of the CCD4b promoter and transcripts from various citrus germplasm accessions established a tight correlation between the presence of a putative 5'c/s-regulatory enhancer within an MITE transposon and the enhanced allelic expression of CCD4b in C3 0 apocarotenoid-rich red-peeled accessions.Phylogenetic analysis provided further evidence that functional diversification of CCD4b and naturally occurring variation of the CCD4b promoter resulted in the stepwise evolution of red peels in mandarins and their hybrids.Taken together,our findings provide new insights into the genetic and evolutionary basis of apocarotenoid diversity in plants,and would facilitate breeding efforts that aim to improve the nutritional and aesthetic value of citrus and perhaps other fruit crops. | Xiongjie Zheng Kaijie Zhu Quan Sun Weiyi Zhang Xia Wang Hongbo Cao Meilian Tan Zongzhou Xie Yunliu Zeng Junli Ye Lijun Chai Qiang Xu Zhiyong Pan Shunyuan Xiao Paul D.Fraser Xiuxin Deng | 2019 | Molecular Plant2019，12，9： | 18 |
| 2 | Self-cleaving ribozymes enable the production of guide RNAs from unlimited choices of promoters for CRISPR/Cas9 mediated genome editing显示文摘Development of tools for targeted modifications of specific DNA sequences in plants is of great importance to basic plant biology research as well as crop improvement.The ability to cut DNA at specific locations in the genome to generate doublestrand breaks(DSBs)in vivo is a prerequisite for any genome editing efforts.Several engineered nucleases including zinc finger nucleases(ZFNs)and transcriptional activator-like nucleases(TALENs)have been successfully used to edit genomes.However, | Yubing He Tao Zhang Ning Yang Meilian Xu Lang Yan Lihao Wang Rongchen Wang Yunde Zhao | 2017 | Journal of Genetics and Genomics2017，44，9： | 14 |
| 3 | Adiponectin:a versatile player of innate immunity显示文摘Adiponectin acts as a key regulator of the innate immune system and plays a major role in the progression of inflammation and metabolic disorders.Macrophages and monocytes are representative components of the innate immune system,and their proliferation,plasticity,and polarization are a key component of metabolic adaption.Innate-like lymphocytes such as group 2 innate lymphoid cells(ILC2s),natural killer T(NKT)cells,and gamma delta T(gd T)cells are also members of the innate immune system and play important roles in the development of obesity and its related diseases.Adiponectin senses metabolic stress and modulates metabolic adaption by targeting the innate immune system under physiological and pathological conditions.Defining the mechanisms underlying the role of adiponectin in regulating innate immunity is crucial to adiponectin-based therapeutic intervention. | Yan Luo Meilian Liu | 2016 | Journal of Molecular Cell Biology2016，8，2： | 6 |
| 4 | PacBio Sequencing Reveals Transposable Elements as a Key Contributor to Genomic Plasticity and Virulence Variation in Magnaporthe oryzae显示文摘 | Jiandong Bao Meilian Chen Zhenhui Zhong Wei Tang Lianyu Lin Xingtan Zhang Haolang Jiang Deyu Zhang Chenyong Miao Haibao Tang Jisen Zhang Guodong Lu Ray Ming Justice Norvienyeku Baohua Wang Zonghua Wang | 2017 | Molecular Plant2017，10，11： | 5 |
| 5 | Competing endogenous RNAs in lung cancer显示文摘Competing endogenous RNAs(ce RNAs)containing micro RNA response elements can competitively interact with micro RNA via mi RNA response elements,which can combine non-coding RNAs with protein-coding RNAs through complex ce RNA networks.Ce RNAs include non-coding RNAs(long non-coding RNAs,circular RNAs,and transcribed pseudogenes)and protein-coding RNAs(m RNAs).Molecular interactions in ce RNA networks can coordinate many biological processes;however,they may also lead to ce RNA network imbalance and thus contribute to cancer occurrence when disturbed.Recent studies indicate that many dysregulated RNAs derived from lung cancer may function as ce RNAs to regulate multitudinous biological functions for lung cancer,including tumor cell proliferation,apoptosis,growth,invasion,migration,and metastasis.This study therefore reviewed the research progress in the field of non-coding and protein-coding RNAs as ce RNAs in lung cancer,and highlighted validated ce RNAs involved in biological lung cancer functions.Furthermore,the roles of ce RNAs as novel prognostic and diagnostic biomarkers were also discussed.Interpreting the involvement of ce RNAs networks in lung cancer will provide new insight into cancer pathogenesis and treatment strategies. | Meilian Zhao Jianguo Feng Liling Tang | 2021 | Cancer Biology & Medicine2021，18，1： | 5 |
| 6 | Recommending Authors and Papers Based on ACTTM Community and Bilayer Citation Network显示文摘Citation network is often used for academic recommendation. However, it is difficult to achieve high recommendation accuracy and low time complexity because it is often very large and sparse and different citations have different purposes. What's more, some citations include unreasonable information, such as in case of intentional self-citation. To improve the accuracy of citation network-based academic recommendation and reduce the time complexity, we propose an academic recommendation method for recommending authors and papers. In which, an author-paper bilayer citation network is built, then an enhanced topic model, Author Community Topic Time Model(ACTTM) is proposed to detect high quality author communities in the author layer, and a set of attributes are proposed to comprehensively depict the author/paper nodes in the bilayer citation network. Experimental results prove that the proposed ACTTM can detect high quality author communities and facilitate low time complexity, and the proposed academic recommendation method can effectively improve the recommendation accuracy. | Meilian Lu Zhihe Qu Mengxing Wang Zhen Qin | 2018 | China Communications2018，15，7： | 4 |
| 7 | The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells显示文摘Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect(80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-L-cysteine(NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum(ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation(ERAD) ubiquitinates anddownregulates YAP to enhance ER stress via destruction complex(YAP-Axin-GSK-βTr CP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate. | Junxia Wang Minghua Chen Mengyan Wang Wenxia Zhao Conghui Zhang Xiujun Liu Meilian Cai Yuhan Qiu Tianshu Zhang Huimin Zhou Wuli Zhao Shuyi Si Rongguang Shao | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 8 | Regulation of adiponectin multimerization, signaling and function显示文摘 | Meilian Liu Feng Liu | 2013 | Best Practice & Research Clinical Endocrinology & Metabolism2013，，： | 2 |
| 9 | Plant genome editing using xCas9 with expanded PAM compatibility显示文摘CRISPR/Cas enables robust genome editing and has revolution-ized both functional genomics and crop breeding.The specificity of Cas-directed DNA cleavage is strictly determined by a chimeric single guide RNA(SgRNA)and a short protospacer adjacent motif(PAM)in the genome(Cong et al,2013;Zetsche et al,2015).The widely used Cas9 from Streptococcus pyogenes(SpCas9)generally recognizes the canonical NGG PAM(where N indicates any nucleicacid base)(Miao et al.,2013;Ma et al,2015),making many regionsuntargetable by Cas9.SpCas9 VQR and VRER variants,which recog-nize the non-canonical PAM sequences of NGA and NGCG,respectively,have been used to expand targetable sequences in plants(Hu et al.,2016).In addition,the applications of other Cas endonucleases such as SaCas9(Staphylococcus aureus Cas9)(Ran et al..2015). | Jingying Li Jinman Luo Meilian Xu Shaoya Li Jiahui Zhang Huiyuan Li Lei Yan Yunde Zhao Lanqin Xia | 2019 | Journal of Genetics and Genomics2019，46，5： | 2 |
| 10 | The effect of anodizing temperature on the structure and electrical properties of Al-Ti composite oxide film显示文摘The Al-Ti composite oxide films with high dielectric constant were prepared by hydrolysis precipitation and anodizing. The growth, structure and electrical properties of the Al-Ti composite oxide films formed at different anodizing temperatures from 25℃ to 85℃ have been studied by dissolution of anodic oxide films, Auger electron spectroscopy (AES), and electrical measurements. With the anodizing temperature increasing, the film growth rate increases, the structure of two layers in the Al-Ti composite oxide film converts into three layers, I-V characteristics change evidently, and the specific capacitance achieves a peak value at about 75℃. The local breakdown in the composite oxide films formed at 50℃ occurs obviously, which may be contributed to the lowest leakage current and the highest withstanding voltage. | CHEN Jinju YANG Bangchao JIANG Meilian FENG Zhesheng | 2005 | Science China(Technological Sciences)2005，48，6： | 2 |
| 11 | Rheb promotes brown fat thermogenesis by Notch-dependent activation of the PKA signaling pathway显示文摘Increasing brown and beige fat thermogenesis have an anti-obesity effect and thus great metabolic benefits.However,the molecular mechanisms regulating brown and beige fat thermogenesis remain to be further elucidated.We recently found that fat-specific knockout of Rheb promoted beige fat thermogenesis.In the current study,we show that Rheb has distinct effects on thermogenic gene expression in brown and beige fat.Fat-specific knockout of Rheb decreased protein kinase A(PKA)activity and thermogenic gene expression in brown adipose tissue of high-fat diet-fed mice.On the other hand,overexpression of Rheb activated PKA and increased uncoupling protein 1 expression in brown adipocytes.Mechanistically,Rheb overexpression in brown adipocytes increased Notch expression,leading to disassociation of the regulatory subunit from the catalytic subunit of PKA and subsequent PKA activation.Our study demonstrates that Rheb,by selectively modulating thermogenic gene expression in brown and beige adipose tissues,plays an important role in regulating energy homeostasis. | Wen Meng Xiuci Liang Ting Xiao Jing Wang Jie Wen Hairong Luo Jianhui Teng Yanquan Fei Qinghai Zhang Bilian Liu Fang Hu juli Bai Meilian Liu Zhiguang Zhou Feng Liu | 2019 | Journal of Molecular Cell Biology2019，11，9： | 2 |
| 12 | Mineralogical and geochemical constraints on environmental impacts from waste rock at Taojiang Mn-ore deposit, central Hunan, China显示文摘 | Bo Peng Adam Piestrzynski Jadwiga Pieczonka Meilian Xiao Yaozhu Wang Shurong Xie Xiaoyan Tang Changxun Yu Zhi Song | 2007 | Environmental Geology2007，，7： | 2 |
| 13 | Using multi-source data to assess livability in Hong Kong at the community-based level:A combined subjective-objective approach显示文摘With the emergence of new types of data(e.g.social media data)and cutting-edge computer technology(e.g.Natural Language Processing),the shortcomings of traditional methods(subjective and objective ways)for de-tecting urban livability can be overcome by an integrated approach.This study aims to develop a comprehensive approach to measure urban livability based on statistic data,geo-data(e.g.points of interest),questionnaires survey,and social media data(Instagram),from both objective and subjective angles.Hong Kong,as a city with a high level of urbanization and contrasting urban environments,is chosen as the study area in this research.Through this study,the question“which area of Hong Kong is more suitable for living”is answered by the visu-alization of GIS-based analysis.Also,the correlation between livability scores and individuals’sentiment scores are explored.Specifically,the results show that central areas of Hong Kong with a higher level of urbanization are relatively more livable than suburban regions.However,through sentiment analysis,individuals who post Instagram in suburban areas of Hong Kong usually express more positive content and happier emotion than those who post Instagram in central urban areas.The study could offer useful information for the policy action of authorities as well as the residential location choices of citizens. | Jianxiao LIU Han BI Meilian Wang | 2020 | Geography and Sustainability2020，1，4： | 2 |
| 14 | Optimization anal- ysis of the tridimensional container terminal transmission sys- tem显示文摘 | Liang Meilian Wang Junli Zhao Weidong | 2012 | Applied Mechanics and Materials2012，，： | 1 |
| 15 | Construction and Algorithm Analysis of a Social Network System Structure Based on P2P显示文摘 | He Fei Chen Meilian Tang Rong | 2014 | Applied Mechanics and Materials2014，443，8： | 1 |
| 16 | Light-induced expression of genes involved in phenylpropanoid biosynthetic pathways in callus of tea ( Camellia sinensis (L.) O. Kuntze)显示文摘 | YunSheng Wang LiPing Gao ZhengRong Wang YaJun Liu MeiLian Sun DongQing Yang ChaoLing Wei Yu Shan Tao Xia | 2011 | Scientia Horticulturae2011，，： | 1 |
| 17 | Immunomodulatory effect of ethanol-soluble polypeptides from Atlantic cod (Gadus morhua)显示文摘There are many active substances in Atlantic cod(Gadus morhua)explaining the variety of biological activities.In order to study the immunomodulatory activity and the mechanism of Atlantic cod peptides at the cellular level.In this study,cod peptides were isolated by 80%ethanol extraction method,the isolated ethanol-soluble cod peptides(CP-ES)were investigated and their immunomodulatory activity was verified.Additionally,CP-ES showed lower molecular weight and more hydrophobic amino acids.CP-ES could promote the proliferation of spleen lymphocytes and T lymphocytes in mice,suggesting that CP-ES may regulate adaptive immunity.It promoted the release of NO and the expression of iNOS,TNF-α,IL-6 and IL-1βgenes in macrophages,suggesting that CP-ES may regulate innate immunity.CP-ES could promote the expression of TLR2 gene,and the peptides identified in CP-ES were docked with TLR2 to predict the peptides playing a major role in CP-ES.These results suggested that CP-ES may regulate the immune activity of both innate and adaptive lines. | Zhen Yuan Meilian Yang Dongyang Zhu Di Wu Shuzhen Cheng Chao Wu Hesham R.El-Seedi Ming Du | 2023 | Food Science and Human Wellness2023，12，4： | 1 |
| 18 | Theroretical analysis on the variation of value of travel time saving显示文摘 | JIANG Meilian | 2004 | Transportation Research Part A2004，38，8： | 1 |
| 19 | Hydrothermal synthesis of hierarchical SnO_(2)nanomaterials for high-efficiency detection of pesticide residue显示文摘Acephate pesticide contamination in agricultural production has caused serious human health problems.Metal oxide semiconductor(MOS)gas sensor can be used as a portable and promising alternative tool for efficiently detection of acephate.In this study,hierarchical assembled SnO_(2)nanosphere,SnO_(2)hollow nanosphere and SnO_2 nanoflower were synthesized respectively as high efficiency sensing materials to build rapid and selective acephate pesticide residues sensors.The morphologies of different SnO_(2)3 D nanostructures were characterized by various material characterization technology.The sensitive performance test results of the 3 D SnO_(2)nanomaterials towards acephate show that hollow nanosphere SnO_(2)based sensor displayed preferable sensitivity,selectivity,and rapid response(9 s)properties toward acephate at the optimal working temperature(300℃).This SnO_(2)hollow nanosphere based gas sensor represents a useful tool for simple and highly effective monitoring of acephate pesticide residues in food and environment.According to the characterization results,particularly Brunauer-Emmett-Teller(BET)and Ultraviolet-Visible Spectroscopy(UV-vis),the obvious and fast response can be attributed to the mesoporous hollow nanosphere structure and appropriate band gap of SnO_2 hollow nanosphere. | Haijie Cai Xiaopeng Qiao Meilian Chen Dongsheng Feng Abdulaziz AAlghamdi Fahad A.Alharthi Yingjie Pan Yong Zhao Yongheng Zhu Yonghui Deng | 2021 | Chinese Chemical Letters2021，32，4： | 1 |
| 20 | Myeloid adrenerglc signaling via CaMKII forms a feedforward loop of catecholarnine biosynthesis显示文摘 | Yan Luo Bilian Liu Xin Yang Xiaoxiao Ma Xing Zhang Denis E. Bragin Xuexian O. Yang Wendong Huang Meilian Liu | 2017 | Journal of Molecular Cell Biology2017，9，5： | 1 |
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