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| 1 | Azathioprine-induced fever in autoimmune hepatitis显示文摘Underdiagnosis of drug-induced fever leads to extensive investigation and prolongation of hospitalization, and may lead to multiple unnecessary invasive procedures and a wrong diagnosis. Azathioprine is a widely used immunosuppressive drug. We report a case of a 53-year-old female patient diagnosed with autoimmune hepatitis treated with azathioprine, who presented to the emergency room with a 6-wk history of fever and chills without other associated symptoms. Since the patient's fever was of unknown origin, she was hospitalized. All treatment was stopped and an extensive workup to explore the source of fever and chills was performed. Results of chest X-ray, viral, urine, and blood cultures, autoimmune serology, transthoracic and transesophageal echocardiography, and abdominal ultrasound revealed no source of infection. A rechallenge test of azathioprine was performed and the fever and chills returned within a few hours. Azathioprine was established as the definite cause following rechallenge. Fever as an adverse drug reaction is often unrecognized. Azathioprine has been reported to cause druginduced fever in patients with inflammatory bowel disease, rheumatoid arthritis, and sarcoidosis. To the bestof our knowledge there have been no previous reports documenting azathioprine-induced fever in patients with autoimmune hepatitis. The occurrence of fever following the readministration of azathioprine suggests the diagnosis of drug-induced fever, particularly after the exclusion of other causes. A careful rechallenge is recommended to confirm the diagnosis. | Tawfik Khoury Jacob E Ollech Shmuel Chen Meir Mizrahi Meir Shalit | 2013 | World Journal of Gastroenterology2013，19，25： | 3 |
| 2 | J Am Chem Soc显示文摘 | Meir Landau E Grayer Wolf S Levanon M | 1989 | 111:1 4361989，111，： | 1 |
| 3 | Dynamics of biogenic Siin freshwater tidal marshes:Si regeneration and retention inmarsh sediments (Scheldt estuary) 显示文摘 | Struyf E Temmerman S Meire P | 2007 | Biogeochemistry2007，82，： | 1 |
| 4 | The Outcome of Closed, Intramedullary Exchange Nailing With Reamed Insertion in the Treatment of Femoral Shaft Nonunions显示文摘 | Josh E Shroeder Rami Mosheiff Amal Khoury Meir Liebergall Yoram A Weil | 2009 | Journal of Orthopaedic Trauma2009，，9： | 1 |
| 5 | How useful is sentiment index?显示文摘 | Michael E Solt Meir Statman | 1988 | Financial Analysts Journal1988，，910： | 1 |
| 6 | Circulating angiogenic factors in monochorionic twin pregnancies complicated by twin to twin transfusion syndrome and selective intra-uterine growth restriction显示文摘 | Yinon Y Ben Meir E Berezowsky A | | 0，，13： | 1 |
| 7 | Person-environment congruence and holland's theory: a review and reconsid- eration 显示文摘 | SPOKANE A R MEIR E CATALANO M | 2000 | Journal of Vocational Behavior2000，57，3： | 1 |
| 8 | Ethylene-enhanced senescence of leafy vegetables and fresh herbs显示文摘 | HADAS S P PESIS E MEIR S | 1989 | Acta Hort1989，258，： | 1 |
| 9 | Human glioblastoma cells release interleukin 6 in vivo and in vitro显示文摘 | Van Meir E Sawamura Y Diserens AC | 1990 | Cancer Res1990，50，20： | 1 |
| 10 | Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia,necrosis,and accelerated growth in glioblastoma显示文摘 | Brat D J Van Meir E G | 2004 | Lab Invest2004，84，4： | 1 |
| 11 | Photosynthetic pa- rameters from two contrasting woody vegetation types in West Af- rica 显示文摘 | Meir P Levy P E Grace J | 2007 | Plant Ecology2007，192，2： | 1 |
| 12 | Glioblas- toma cancer stem-like cells: Implications for pathogenesis and treatment 显示文摘 | NDUOM E K HADJIPANAYIS C G VAN MEIR E G | 2012 | Cancer J2012，18，1： | 1 |
| 13 | Hepatitis C infection and lymphoproliferative disease:Accidental comorbidities?显示文摘Chronic hepatitis C virus(HCV)infection has been associated with liver cancer and cirrhosis,autoimmune disorders such as thyroiditis and mixed cryoglobulinema,and alterations in immune function and chronic inflammation,both implicated in B cell lymphoproliferative diseases that may progress to non-Hodgkin lymphoma(NHL).HCV bound to B cell surface receptors can induce lymphoproliferation,leading to DNA mutations and/or lower antigen response thresholds.These findings and epidemiological reports suggest an association between HCV infection and NHL.We performed a systematic review of the literature to clarify this potential relationship.We searched the English-language literature utilizing Medline,Embase,Paper First,Web ofScience,Google Scholar,and the Cochrane Database of Systematic Reviews,with search terms broadly defined to capture discussions of HCV and its relationship with NHL and/or lymphoproliferative diseases.References were screened to further identify relevant studies and literature in the basic sciences.A total of 62 reports discussing the relationship between HCV,NHL,and lymphoproliferative diseases were identified.Epidemiological studies suggest that at least a portion of NHL may be etiologically attributable to HCV,particularly in areas with high HCV prevalence.Studies that showed a lack of association between HCV infection and lymphoma may have been influenced by small sample size,short follow-up periods,and database limitations.The association appears strongest with the B-cell lymphomas relative to other lymphoproliferative diseases.Mechanisms by which chronic HCV infection promotes lymphoproliferative disease remains unclear.Lymphomagenesis is a multifactorial process involving genetic,environmental,and infectious factors.HCV most probably have a role in the lymphomagenesis but further study to clarify the association and underlying mechanisms is warranted. | Tawfik Khoury Shmuel Chen Tomer Adar E Ollech Jacob Meir Mizrahi | 2014 | World Journal of Gastroenterology2014，20，43： | 1 |
| 14 | The segment polarity network is a robust developmental module显示文摘 | Von Dassow G Meir E Munro EM | 2000 | Nature2000，406，： | 1 |
| 15 | Atherosclerosis in the apolipopro- tein E-deficient mouse: a decade of progress 显示文摘 | Meir KS Leitersdorf E | 2004 | Arterio- scler Thromb Vasc Biol2004，24，10： | 1 |
| 16 | Robustness,flexibility,and the role of lateral inhibition in the neurogenic network显示文摘 | Meir E yon Dassow G Munro EM | 2002 | Curr Biol2002，12，： | 1 |
| 17 | The effect of aqueous transport of CO2 in xylem sap on gas exchange in woody plants显示文摘 | Levy P E Meir P Allen S J | 1999 | Tree Physiology1999，19，： | 1 |
| 18 | Human glioblastoma cells release IL-6 in vivo and in vitro 显示文摘 | Van Meir E Sawamura Y Diserens AC | 1990 | Cancer Res1990，35，20： | 1 |
| 19 | Person-envi- ronment Congruence and Holland's Theory: A Re- view and Reconsideration 显示文摘 | Spokane A R Meir E I Catalano M | 2000 | Journal of Vocational Behavior2000，57，1： | 1 |
| 20 | Atherosclerosis in the apolipoprotein E-deficient mouse a decade of progress显示文摘 | Leitersdorf E | 2004 | Arterioscler Thromb Vasc Biol2004，24，6： | 1 |
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