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| 1 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 2 | Carbon-based nanozymes for biomedical applications显示文摘Nanozymes are nanomaterials with enzyme-like properties that have attracted significant interest owing to their capability to address the limitations of traditional enzymes such as fragility,high cost,and impossible mass production.Over the past decade,a broad variety of nanomaterials have been found to mimic the enzyme-like activity by engineering the active centers of natural enzymes or developing multivalent elements within nanostructures.Carbon nanomaterials with well-defined electronic and geometric structures have served as favorable surrogates of traditional enzymes by mimicking the highly evolved catalytic center of natural enzymes.In particular,by combining the unique electronic,optical,thermal,and mechanical properties,carbon nanomaterials-based nanozymes can offer a variety of multifunctional platforms for biomedical applications.In this review,we will introduce the enzymatic characteristics and recent advances of carbon nanozymes,and summarize their significant applications in biomedicine. | Hui Ding Bing Hu Bin Zhang Han Zhang Xiyun Yan Guohui Nie Minmin Liang | 2021 | Nano Research2021，14，3： | 4 |
| 3 | Analysis of Aroma Volatile Compounds in Fuji Apple Using SPME with Different Fiber Coatings显示文摘The aroma volatile compounds in Fuji apple were isolated by solid-phase microextraction( SPME),and detected by gas chromatography-mass spectrometry( GC-MS). The results showed that the optimal retention time of the heating up of capillary columns was 5 min. Of the seven fibers used in this work,DVB/CAR/PDMS was found to be the most suitable to extract the aroma volatile compounds in Fuji apple. A total number of 43 volatile compounds were identified according to their retention time on capillary columns and their mass spectra,including eleven esters,ten alcohols,ten aldehydes,seven alkenes,two anhydrides,one ketone,one phenol and one ether. This detection method will provide a new foundation for analysis of volatile compounds in apple were identified. | Jie LI Jicheng HAN Haie ZHANG Chaohong ZHANG Minmin LI Yu WANG | 2020 | Agricultural Biotechnology2020，9，3： | 4 |
| 4 | Tuning the luminous properties and optical thermometry of Cs_(2)SnCl_(6) phosphor microcrystals via Bi and Sb codoping显示文摘The toxicity and instability of lead halide perovskite seriously limit its commercial application in lighting,although it has high photoluminescence(PL)efficiency and adjustable emission.Here,lead-free bismuth(Bi)and antimony(Sb)codoped Cs_(2)SnCl_(6)(BSCSC)microcrystals(MCs)are prepared successfully by a solvothermal method.The PL spectrum is composed of dual emission bands with the peak at 485 and 650 nm,of which relative intensity can be tunable through the change of Bi and Sb feeding contents,respectively.Because of the phonon–electron interaction,the PL intensity is enhanced as the temperature rises within the range of 80–260 K.Then,the nonradiative transition is intensified until 380 K,which results in decrease in PL intensity.Simultaneously,combining with time-resolved PL,it is concluded that the emission peak at 485 nm is attributed to the[Bi_(Sn)+V_(Cl)]as the luminescent centers with the lifetime of hundreds of nanoseconds,and the emission peak at 650 nm is attributed to microsecond-timescale self-trapped excitons.The maximum values of relative sensitivity(S_(R))and absolute sensitivity(S_(A))values obtained are 3.82%K^(-1) and 5.11 ns·K^(-1),which for the first time to our knowledge demonstrate that BSCSC MCs can be novel luminescent materials for developing better optical thermometry.Whitelight-emitting diodes(WLEDs)are constructed using BSCSC MCs only combined with an LED chip,the Commission Internationale de L’Eclairage color coordinates of which are(0.30,0.37).It provides a novel scheme for the lighting field to realize WLEDs without adding additional commercial phosphors. | SHUNFA GONG RUIRUI WU SEN YANG LIFANG WU MINMIN ZHANG QIUJU HAN WENZHI WU | 2021 | Photonics Research2021，9，11： | 2 |
| 5 | Effects of petroleum contamination on soil microbial numbers, metabolic activity and urease activity显示文摘 | Huan Guo Jun Yao Minmin Cai Yiguang Qian Yue Guo Hans H. Richnow Ruth E. Blake Serena Doni Brunello Ceccanti | 2012 | Chemosphere2012，，11： | 1 |
| 6 | Potential for aerobic and methanogenic oil biodegradation in a water flooded oil field (Dagang oil field)显示文摘 | Minmin Cai Núria Jiménez Martin Krüger Huan Guo Yao Jun Nontje Straaten Hans H. Richnow | 2014 | Fuel2014，，： | 1 |
| 7 | Fast example-based surface texture synthesis via discrete optimization显示文摘 | Jianwei Han Kun Zhou Li-Yi Wei Minmin Gong Hujun Bao Xinming Zhang Baining Guo | 2006 | The Visual Computer (-)2006，，9： | 1 |
| 8 | Fast example-based surface texture synthesis via discrete optimization显示文摘 | Jianwei Han Kun Zhou Li-Yi Wei Minmin Gong Hujun Bao Xinming Zhang Baining Guo | 2006 | The Visual Computer (-)2006，，9： | 1 |
| 9 | Loss of CO_2 sensing by the olfactory system of CNGA3 knockout mice显示文摘Atmospheric CO_2 can signal the presence of food, predators or environmental stress and trigger stereotypical behaviorsin both vertebrates and invertebrates. Recent studies have shown that the necklace olfactory system in mice sensitively detectsCO_2 in the air. Olfactory CO_2 neurons are believed to rely on cyclic guanosine monophosphate (cGMP) as the key secondmessenger; however, the specific ion channel underlying CO2 responses remains unclear. Here we show that CO_2-evoked neuronaland behavioral responses require cyclic nucleotide-gated (CNG) channels consisting of the CNGA3 subunit. ThroughCa^(2+)-imaging, we found that CO_2-triggered Ca^(2+) influx was abolished in necklace olfactory sensory neurons (OSNs) ofCNGA3-knockout mice. Olfactory detection tests using a Go/No-go paradigm showed that these knockout mice failed to detect0.5% CO_2. Thus, sensitive detection of atmospheric CO_2 depends on the function of CNG channels consisting of the CNGA3subunit in necklace OSNs. These data support the important role of the necklace olfactory system in CO_2 sensing and extend ourunderstanding of the signal transduction pathway mediating CO_2 detection in | Jinlong HAN Minmin LUO | 2010 | Current Zoology2010，56，6： | 0 |
| 10 | Atomic insights of electronic states engineering of GaN nanowires by Cu cation substitution for highly efficient lithium ion battery显示文摘Electronic engineering of gallium nitride(Ga N) is critical for enhancement of its electrode performance.In this work, copper(Cu) cation substituted Ga N(Cu-Ga N) nanowires were fabricated to understand the electronically engineered electrochemical performance for Li ion storage. Cu cation substitution was revealed at atomic level by combination of X-ray photoelectron spectroscopy(XPS), X-ray absorption fine structure(XAFS), density functional theory(DFT) simulation, and so forth. The Cu-Ga N electrode delivered high capacity of 813.2 m A h g^(-1) at 0.1 A g^(-1) after 200 cycles, increased by 66% relative to the unsubstituted Ga N electrode. After 2000 cycles at 10 A g^(-1),the reversible capacity was still maintained at326.7 m A h g^(-1). The DFT calculations revealed that Cu substitution introduced the impurity electronic states and efficient interatomic electron migration, which can enhance the charge transfer efficiency and reduce the Li ion adsorption energy on the Cu-Ga N electrode. The ex-situ SEM, TEM, HRTEM, and SAED analyses demonstrated the reversible intercalation Li ion storage mechanism and good structural stability. The concept of atomic-arrangement-assisted electronic engineering strategy is anticipated to open up opportunities for advanced energy storage applications. | Zhenjiang Li Kesheng Gao Ying Han Shiqi Ding Yanglansen Cui Minmin Hu Jian Zhao Meng Zhang Alan Meng Jimmy Yun Zhiming Liu Da-Wei Wang Changlong Sun | 2022 | Journal of Energy Chemistry2022，31，4： | 0 |
| 11 | An Improved Coupled Dynamic Modelling for Exploring Gearbox Vibrations Considering Local Defects显示文摘Gearbox is a key part in machinery,in which gear,shaft and bearing operate together to transmit motion and power.The wide usage and high failure rate of gearbox make it attract much attention on its health monitoring and fault diagnosis.Dynamic modelling can study the mechanism under different faults and provide theoretical foundation for fault detection.However,current commonly used gear dynamic model usually neglects the influence of bearing and shaft,resulting in incomplete understanding of gearbox fault diagnosis especially under the effect of local defects on gear and shaft.To address this problem,an improved gear-shaft-bearing-housing dynamic model is proposed to reveal the vibration mechanism and responses considering shaft whirling and gear local defects.Firstly,an eighteen degree-of-freedom gearbox dynamic model is proposed,taking into account the interaction among gear,bearing and shaft.Secondly,the dynamic model is iteratively solved.Then,vibration responses are expounded and analysed considering gear spalling and shaft crack.Numerical results show that the gear mesh frequency and its harmonics have higher amplitude through the spectrum.Vibration RMS and the shaft rotating frequency increase with the spalling size and shaft crack angle in general.An experiment is designed to verify the rationality of the proposed gearbox model.Lastly,comprehensive analysis under different spalling size and shaft crack angle are analysed.Results show that when spalling size and crack angle are larger,RMS and the amplitude of shaft rotating frequency will not increase linearly.The dynamic model can accurately simulate the vibration of gear transmission system,which is helpful for gearbox fault diagnosis. | Yaoyao Han Xiaohui Chen Jiawei Xiao James Xi Gu Minmin Xu | 2023 | Journal of Dynamics, Monitoring and Diagnostics2023，2，4： | 0 |
| 12 | The neuroprotective efects of peracetylated chitosan oligosaccharides againstβ‑amyloid‑induced cognitive defcits in rats显示文摘Chitosan oligosaccharides(COSs)have been reported to possess a broad range of activities such as antitumor,antioxidant and neuroprotective activities.In this study,the protective efects and mechanisms of peracetylated chitosan oligosaccharides(PACOs)against Aβ-induced cognitive defcits were investigated in Sprague–Dawley(SD)rats.PACOs treatment signifcantly improved the learning and memory function of Alzheimer’s disease(AD)rats and attenuated the neuron cell damage caused by Aβ.PACOs also markedly reduced the levels of lactate dehydrogenase(LDH)and Malondialdehyde(MDA)and decreased the phosphorylation of Tau protein to inhibit oxidative injury and infammatory responses in AD rats.Further studies indicated that PACOs may promote the repair of Aβinduced nerve damage and inhibit neuronal apoptosis mainly through regulating PI3K/Akt/GSK3βsignaling pathway.Consistently,the transcriptome analysis verifed that the diferentially expressed genes(DEGs)were mainly involved in neuron development and the PI3K-Akt signaling pathway.Taken together,peracetylated chitosan oligosaccharides(PACOs)have the potential to be developed into novel anti-AD agents targeting the cellular PI3K/Akt/GSK3βsignaling pathway. | Cui Hao Minmin Han Wei Wang Cheng Yang Jigang Wang Yunliang Guo Tao Xu Lijuan Zhang Chunxia Li | 2023 | Marine Life Science & Technology2023，5，2： | 0 |
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