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| 1 | Folic acid supplementation inhibits recurrence of colorectal adenomas:A randomized chemoprevention trial显示文摘AIM: To determine whether folic acid supplementation will reduce the recurrence of colorectal adenomas, the precursors of colorectal cancer, we performed a double-blind placebo-controlled trial in patients with adenomatous polyps. METHODS: In the current double-blind, placebo-controlled trial at this VA Medical Center, patients with colorectal adenomas were randomly assigned to receive either a daily 5 mg dose of folic acid or a matched identical placebo for 3 years. All polyps were removed at baseline colonoscopy and each patient had a follow up colonoscopy at 3 years. The primary endpoint was a reduction in the number of recurrent adenomas at 3 years. RESULTS: Of 137 subjects, who were eligible after confirmation of polyp histology and run-in period to conform compliance, 94 completed the study; 49 in folic acid group and 45 in placebo group. Recurrence of adenomas at 3-year was compared between the two groups. The mean number of recurrent polyps at 3-year was 0.36 (SD, 0.69) for folic acid treated patients compared to 0.82 (SD, 1.17) for placebo treated subjects, resulting in a 3-fold increase in polyp recurrence in the placebo group. Patients below 70 years of age and those with left-sided colonicadenomas or advanced adenomas responded better to folic acid supplementation. CONCLUSION: High dose folic acid supplementation is associated with a signif icant reduction in the recurrence of colonic adenomas suggesting that folic acid may be an effective chemopreventive agent for colorectal neoplasia. | Richard Jaszewski Sabeena Misra Martin Tobi Nadeem Ullah Jo Ann Naumoff Omer Kucuk Edi Levi Bradley N Axelrod Bhaumik B Patel Adhip PN Majumdar | 2008 | World Journal of Gastroenterology2008，14，28： | 10 |
| 2 | Energy transfer in triton -X 100 micelles : a fluorescence study 显示文摘 | Saha D C Ray K Misra T N | 2000 | Spectrochimica Acta A2000，56，： | 1 |
| 3 | Graft copolymerization of 4-vinylpyridine and methyl acrylate onto polyethylene film by radiochemical method显示文摘 | MISRA B N GUPTA A | 1998 | J Appl Polym Sci1998，69，： | 1 |
| 4 | Cutting edge:human CD4^+CD25^+ T cells restrain the maturation and antigen-presenting function of dendritic cells显示文摘 | Misra N Bayry J Lacroix-Desmazes S | 2004 | J Immunol2004，172，8： | 1 |
| 5 | Changes in nucleic acids and protein content of Tilapia mossambica exposed to dichlorvos显示文摘 | Rath S Misra B N | 1980 | Indian Journal of Fisheries1980，27，： | 1 |
| 6 | Grafting:A versatile means to modify polymers Techniques,factors and applications显示文摘 | BHATTACHARYA A MISRA B N | 2004 | Progress in Polymer Science2004，29，： | 1 |
| 7 | Pyrroloquinoline quinone:a reactive oxygen species scavenger in bacteria显示文摘 | MISRA H S KJAIRNAR N P BARIK A | 2004 | FEBS Lett2004，578，12： | 1 |
| 8 | Cutting edge:human CD4^+CD25^+ T cells restrain the maturation and antigen-presenting function of dendritic cells显示文摘 | Misra N Bayry J Lacroix-Desmazes S | 2004 | J Immunol2004，172，： | 1 |
| 9 | Consistent Estimation of Regression Coef- ficients in Ultrastructural Measurement Error model Using Stochastic Prior Information显示文摘 | Shalabh Garg G Misra N | 2010 | Statistical Papers2010，，51： | 1 |
| 10 | Advancement and current status of wear debris analysis for machine condition monitoring: a review显示文摘 | M Kumar P S Mukherjee N M Misra | 2013 | Industrial Lubrication and Tribology2013，65，1： | 1 |
| 11 | Complex proximal humeral fractures in adults-a systematic review of management显示文摘 | Misra A Kapur R Mafmlli N | 2001 | Injury2001，32，： | 1 |
| 12 | Energy dynamics in sananna ecosystem in India 显示文摘 | Singh A K Misra K N Ambasht R S | 1980 | Japan Journal Ecology1980，3，： | 1 |
| 13 | Use of aggregates from recy- cled construction and demolition waste in concrete 显示文摘 | Rao A Jha K N Misra S | 2007 | Resources Conservation and Recycling2007，50，1： | 1 |
| 14 | Alkoxides of lanthanide elements显示文摘 | Misra S N Misra T N Kapoor R N | 1963 | Chem & Ind1963，，3： | 1 |
| 15 | Extraction of molybdenum from spent catalyst by salt-roasting 显示文摘 | Kar B B Murthy B V R Misra V N | 2005 | In- ternational Journal of Mineral Processing2005，76，3： | 1 |
| 16 | Stochastic comparisons of multivariate frailty models显示文摘 | NEERAJ MISRA N G GUPTA R D | 2008 | Journal of Statistical Planning and Inference2008，138，： | 1 |
| 17 | Immunoglobulin-dependent regulation of dendritic cells in the context of autoimmune responses显示文摘 | Ephrem A Bayry J Misra N | 2005 | Transfus Med Hemother2005，32，6： | 1 |
| 18 | Effect of salt stress on proline metabolism in two high yielding genotypes of green gram显示文摘 | Misra N Gupta A K | 2005 | Plant Science2005，169，： | 1 |
| 19 | A clinical,magnetic resonance imaging,and survival motorneuron gene deletion study of Hirayama disease显示文摘 | Misra U K Kalita J Mishra V N | 2005 | Arch Neurol2005，62，1： | 1 |
| 20 | An overview ofutilization of slag and sludge from steel industries 显示文摘 | Das B Prakash S Reddy P S R Misra V N | 2007 | Resources Conservation and Recycling2007，50，1： | 1 |
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