|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Weaning stress and gastrointestinal barrier development:Implications for lifelong gut health in pigs显示文摘The gastrointestinal(GI) barrier serves a critical role in survival and overall health of animals and humans. Several layers of barrier defense mechanisms are provided by the epithelial, immune and enteric nervous systems. Together they act in concert to control normal gut functions(e.g., digestion,absorption, secretion, immunity, etc.) whereas at the same time provide a barrier from the hostile conditions in the luminal environment. Breakdown of these critical GI functions is a central pathophysiological mechanism in the most serious GI disorders in pigs. This review will focus on the development and functional properties of the GI barrier in pigs and how common early life production stressors, such as weaning, can alter immediate and long-term barrier function and disease susceptibility.Specific stress-related pathophysiological mechanisms responsible for driving GI barrier dysfunction induced by weaning and the implications to animal health and performance will be discussed. | Adam J.Moeser Calvin S.Pohl Mrigendra Rajput | 2017 | Animal Nutrition2017，，4： | 33 |
| 2 | Geochemical characteristics of mafic and ultramafic rocks from the Naga Hills Ophiolite, India:Implications for petrogenesis显示文摘The Naga Hills Ophiolite(NHO) represents one of the fragments of Tethyan oceanic crust in the Himalayan Orogenic system which is exposed in the Phek and Kiphire districts of Nagaland, India. The NHO is composed of partially serpentinized dunite, peridotite, gabbro, basalt, minor plagiogranite,diorite dyke and marine sediments. The basalts are mainly composed of fine grained plagioclase feldspar, clinopyroxene and orthopyroxene and show quenching and variolitic textures. The gabbros are characterized by medium to coarse grained plagioclase, orthopyroxene and clinopyroxene with ophitic to sub-ophitic textures. The ultramafic cumulates are represented by olivine, Cpx and Opx.Geochemically, the basalts and gabbros are sub-alkaline to alkaline and show tholeiitic features.The basalts are characterized by 44.1-45.6 wt.% of SiO_2 with 28-38 of Mg#, and the gabbros by38.7-43.7 wt.% of SiO_2, and 26-79 of Mg#. The ultramafic rocks are characterized by 37.4-52.2 wt.% of SiO_2, and 80-88 of Mg#. In multi-element diagrams(spidergrams) both basalts and gabbros show fractionated trends with strong negative anomalies of Zr. Nb. Sr and a gentle negative anomaly of P.However, the rare earth element(REE) plots of the basalts and gabbros show two distinct patterns. The first pattern, represented by light REE(LREE) depletion, suggests N-MORB features and can be interpreted as a signature of Paleo-Tethyan oceanic crust. The second pattern, represented by LREE enrichment with negligible negative Eu anomaly, conforms to E-MORB, and may be related to an arc tectonic setting. In V vs. Ti/1000, Cr vs. Y and AFM diagrams, the basalts and gabbros plot within Island Arc Tholeiite(IAT) and MORB fields suggesting both ridge and arc related settings. The ultramafic rocks exhibit two distinct patterns both in spidergrams and in REE plots. In the spidergram, one group displays highly enriched pattern, whereas the other group shows near flat pattern compared to primordial mantle. In the REE plot, one group displays steeper slopes [(La/Yb)N = 4.340-4.341], whereas the other displays moderate to flat slopes [(La/Yb)N = 0.97-1.67] and negative Eu-anomalies. Our study suggests that the ultramafic rocks represent two possible mantle sources(fertile and refractory). | Ajoy Dey M.Faruque Hussain Mrigendra N.Barman | 2018 | Geoscience Frontiers2018，9，2： | 7 |
| 3 | Reasoning and Rehabilitation cognitive skills programme for mentally disordered offenders: Predictors of outcome显示文摘AIM To investigate factors predicting treatment completion and treatment outcome of the Reasoning and Rehabilitation Mental Health Programme(R&R2MHP) cognitive skills programme for mentally disordered offenders. METHODS Secondary analysis of data previously obtained from 97 male patients who were sectioned and detained under the United Kingdom Mental Health Act in low, medium and high security hospitals and who had completed R&R2MHP. Predictors of treatment completion included background variables and five outcome measures: Four self-reported measures of violent attitudes, social problem-solving skills, reactive anger and locus of control and an objective measure of behaviour on theward that was completed by staff. Completion of the 16 session programme, which was delivered on a weekly basis, was classified as ≥ 12 sessions.RESULTS It was found that the R&R2MHP is appropriate for delivery to participants of different ages, ethnic background, and at different levels of security without the completion rate or treatment effectiveness being compromised. Participants taking oral typical psychotropic medication were over seven times more likely to complete the programme than other participants. Behavioural disturbance on the ward prior to commencing the programme predicted non-completion(medium effect size). As far as treatment completion was concerned, none of the background factors predicted treatment effectiveness(age, ethnic background, level of security, number of previous convictions and number of previous hospital admissions). The best predictor of treatment effectiveness was attitude towards violence suggesting that this should be the primary outcome measure in future research evaluating outcomes of the R&R2MHP cognitive skills program. CONCLUSION The findings suggest that a stable mental state is a key factor that predicts treatment completion. | Susan Young Mrigendra Das Gisli H Gudjonsson | 2016 | World Journal of Psychiatry2016，6，4： | 1 |
| 4 | Volumetric structural brain abnormalities in men with schizophrenia or antisocial personality disorder显示文摘 | Ian Barkataki Veena Kumari Mrigendra Das Pamela Taylor Tonmoy Sharma | 2006 | Behavioural Brain Research2006，，2： | 1 |
| 5 | Mucinous cystadenoma of the appendix with enterocutaneous fistula:a therapeutic dilemma显示文摘Mucinous cystadenoma of appendix is a rare clinical entity with very few reported cases in the literature.Consensus on optimal surgical management has not been reached.We report the case of a 65-year-old female patient who presented with fistula over the right iliac fossa.Computed tomography(CT)of the abdomen suggested abscess of the parietal wall.Upon exploration,a mass was found to be arising from the tip of the retroperitoneal appendix and the retroperitoneum was studded with mucoid material.Appendectomy was carried out and final histopathology revealed mucinous cystadenoma with no evidence of malignancy.The patient was discharged uneventfully.The unusual presentation of this disease,as retroperitoneal psuedomyxoma without any intraperitoneal pathology,prompted us to report this case. | Nawal K.Jha Dipendra K.Sinha Abhinav Anand Mrigendra K.Rai Anjana Gandhi Jitin Yadav Sanjay K.Yadav | 2015 | Gastroenterology Report2015，3，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员