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| 1 | Targeting chronic lymphocytic leukemia cells in the tumor microenviroment: A review of the in vitro and clinical trials to date显示文摘Chronic lymphocytic leukemia(CLL) is the most common leukemia in the western world. Despite significantadvances in therapy over the last decade CLL remains incurable. Current front-line therapy often consists of chemoimmunotherapy-based regimens, most commonly the fludarabine, cyclophosphamide plus rituximab combination, but rates of relapse and refractory disease are high among these patients. Several key signaling pathways are now known to mediate the survival and proliferation of CLL cells in vivo, the most notable of which are the pathways mediated by the B-cell receptor(BCR) and cytokine receptors. A better understanding of the pathogenesis of the disease, the underlying biology of the CLL-cell and the roles of the tumour microenvironment has provided the rationale for trials of a range of novel, more targeted therapeutic agents. In particular, clinical trials of ibrutinib and idelalisib, which target the Brutons tyrosine kinase and the delta isoform of phosphoinositol-3 kinase components of the BCR signaling pathway respectively, have shown extremely promising results. Here we review the current literature on the key signaling pathways and interactions of CLL cells that mediate the survival and proliferation of the leukemic cells. For each we describe the results of the recent clinical trials and in vitro studies of novel therapeutic agents. | Kyle Crassini Stephen P Mulligan O Giles Best | 2015 | World Journal of Clinical Cases2015，3，8： | 5 |
| 2 | Alkyl hydroperoxide reductase: A candidate Helicobacter pylori vaccine显示文摘 | Avril A. O’Riordan Veronica Athie Morales Linda Mulligan Nazia Faheem Henry J. Windle Dermot P. Kelleher | 2012 | Vaccine2012，，26： | 4 |
| 3 | Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice – an evidence‐based international guide显示文摘 | A. P. S. Hungin C. Mulligan B. Pot P. Whorwell L. Agréus P. Fracasso C. Lionis J. Mendive J.‐M. Philippart de Foy G. Rubin C. Winchester N. Wit | 2013 | Aliment Pharmacol Ther2013，，8： | 4 |
| 4 | Incorporating spatial variation in housing attribute prices: a comparison of geographically weighted regression and the spatial expansion method显示文摘 | Christopher Bitter Gordon F. Mulligan Sandy Dall’erba | 2007 | Journal of Geographical Systems2007，，1： | 3 |
| 5 | Endoscopic treatment of anastomotic biliary strictures after living donor liver transplantation: outcomes after maximal stent therapy显示文摘 | Ting-Hui Hsieh Kristin L. Mekeel Michael D. Crowell Cuong C. Nguyen Ananya Das Bashar A. Aqel Elizabeth J. Carey Thomas J. Byrne Hugo E. Vargas David D. Douglas David C. Mulligan M. Edwyn Harrison | 2013 | Gastrointestinal Endoscopy2013，，1： | 3 |
| 6 | Heavy metal removal from sediments by biosurfactants显示文摘 | Catherine N Mulligan Raymond N Yong Bernard F Gibbs | 2001 | Journal of Hazardous Materials2001，，1： | 2 |
| 7 | Recommendations for Comprehensive Stroke Centers: A Consensus Statement From the Brain Attack Coalition显示文摘 | Mark J. Alberts Richard E. Latchaw Warren R. Selman Timothy Shephard Mark N. Hadley Lawrence M. Brass Walter Koroshetz John R. Marler John Booss Richard D. Zorowitz Janet B. Croft Ellen Magnis Diane Mulligan Andrew Jagoda Robert O’Connor C Michael Cawley | 2005 | Stroke2005，，7： | 2 |
| 8 | Endoscopic treatment of anastomotic biliary strictures after deceased donor liver transplantation: outcomes after maximal stent therapy显示文摘 | Shabana F. Pasha M. Edwyn Harrison Ananya Das Cuong C. Nguyen Hugo E. Vargas Vijayan Balan Thomas J. Byrne David D. Douglas David C. Mulligan | 2007 | Gastrointestinal Endoscopy2007，，1： | 2 |
| 9 | Surfactant-enhanced remediation of contaminated soil: a review显示文摘 | C.N Mulligan R.N Yong B.F Gibbs | 2001 | Engineering Geology2001，，1： | 2 |
| 10 | Recent developments in RF sputtered cadmium stannate films 显示文摘 | Wu X Mulligan W P | 1996 | Thin Solid Films1996，289，： | 2 |
| 11 | Production diseases of the transition cow显示文摘 | F.J. Mulligan M.L. Doherty | 2008 | The Veterinary Journal2008，，1： | 2 |
| 12 | Agreement and conversion formula between mini-mental state examination and montreal cognitive assessment in an outpatient sample显示文摘AIM To explore the agreement between the mini-mental state examination(MMSE) and montreal cognitive assessment(Mo CA) within community dwelling older patients attending an old age psychiatry service and to derive and test a conversion formula between the two scales.METHODS Prospective study of consecutive patients attending outpatient services.Both tests were administered by the same researcher on the same day in random order.RESULTS The total sample(n = 135) was randomly divided into two groups.One to derive a conversion rule(n = 70),and a second(n = 65) in which this rule was tested.The agreement(Pearson's r) of MMSE and Mo CA was 0.86(P < 0.001),and Lin's concordance correlation coefficient(CCC) was 0.57(95%CI:0.45-0.66).In the second sample Mo CA scores were converted to MMSE scores according to a conversion rule from the first sample which achieved agreement with the original MMSE scoresof 0.89(Pearson's r,P < 0.001) and CCC of 0.88(95%CI:0.82-0.92).CONCLUSION Although the two scales overlap considerably,the agreement is modest.The conversion rule derived herein demonstrated promising accuracy and warrants further testing in other populations. | Luqman Helmi David Meagher Edmond O'Mahony Donagh O'Neill Owen Mulligan Sutha Murthy Geraldine McCarthy Dimitrios Adamis | 2016 | World Journal of Psychiatry2016，6，3： | 2 |
| 13 | Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1显示文摘 | Yujiang Shi Fei Lan Caitlin Matson Peter Mulligan Johnathan R. Whetstine Philip A. Cole Robert A. Casero Yang Shi | 2004 | Cell2004，，7： | 2 |
| 14 | Breast, colorectal, and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition - Norfolk in relation to phytoestrogen intake derived from an improved database显示文摘 | Wardh A Kulhne GG Mulligan AA | 2010 | Am J Clin Nutr2010，91，2： | 1 |
| 15 | Requirments for neutrophil products and L-arginine in ischemia-reperfusion injury显示文摘 | Seekamp A Mulligan MS Till GO | 1993 | Am J Pathol1993，142，4： | 1 |
| 16 | CrN-Ag self-lubricating hard coatings显示文摘 | Mulligan C P Gall D | 2005 | Surface & Coatings Technology2005，200，： | 1 |
| 17 | Metastatic potential of encapsulated (intracystic) papillary carcinoma of the breast: a report of 2 cases with axillary lymph node micrometastases 显示文摘 | Mulligan AM O' Malley FP | 2007 | Int J Surg Pathol2007，15，2： | 1 |
| 18 | Review of thermo-mechanical cracking and wear mechanisms in largecaliber guns 显示文摘 | Underwood J H Vigilante G N Mulligan C P | 2007 | Wear2007，263，712： | 1 |
| 19 | The Endogenous Determi- nation of Time Preference 显示文摘 | BARKER G S MULLIGAN C B | 1997 | The Quarterly Journal of E-eonomics1997，112，3： | 1 |
| 20 | Biosorption of lead (Ⅱ),cadmium (Ⅱ),copper (Ⅱ) and nickel (Ⅱ) by anaerobic granular biomass显示文摘 | HAWARI A H MULLIGAN C N | | 0，，： | 1 |
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