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| 1 | 以便秘和腹泻为主的肠易激综合征与5-羟色胺信号改变显示文摘Background &Aims: Evidence suggests that postprandial platelet-depleted plasma 5-hydroxytryptamine (5-HT) concentrations may be abnormal in irritable bowel syndrome (IBS). However, interpretation of the data has been hampered by the variable methodology and rather small numbers used in previous studies. Therefore, the aim of this study was to measure concentrations of platelet-depleted plasma 5-HT and its metabolite 5-HIAA under fasting and fed conditions in a large group of patients with diarrhea-predominant (d-) and constipation-predominant (c-) IBS, compared with controls. The ratio of plasma 5-HIAA:5-HT and platelet stores was also assessed. Methods: Twenty-nine c-IBS patients (aged, 19-53 years), 55 d-IBS patients (aged, 19-52 years), and 35 healthy volunteers (aged, 18-46 years) had platelet-depleted plasma 5-HT/5-HIAA concentrations measured using reverse-phase, high-performance liquid chromatography with fluorimetric detection before and after a standard meal. Results: d-IBS patients had raised platelet-depleted plasma 5-HT concentrations under fasting and fed conditions (P < .05). However, the postprandial relative to fasting concentration was similar to controls. In contrast, c-IBS patients failed to show an increase in platelet-depleted plasma 5-HT concentration with meal ingestion compared with controls (P < .01). c-IBS was associated with decreased 5-HIAA (P < .01) but normal 5-HIAA:5-HT ratio and d-IBS with normal 5-HIAA concentrations but reduced 5-HIAA:5-HT ratio (P < .005). c-IBS but not d-IBS patients had increased platelet 5-HT. Conclusions: These results support the concept that d-IBS is characterized by reduced 5-HT reuptake, whereas impaired release may be a feature of c-IBS. These results also provide a rational basis for current pharmacologic approaches involving modulation of different 5-HT receptors in c-and d-IBS. | Atkinson W. Lockhart S. Whorwell P. J. L.A. Houghton. 李宏宇(译) 郑世成(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，6： | 8 |
| 2 | Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice – an evidence‐based international guide显示文摘 | A. P. S. Hungin C. Mulligan B. Pot P. Whorwell L. Agréus P. Fracasso C. Lionis J. Mendive J.‐M. Philippart de Foy G. Rubin C. Winchester N. Wit | 2013 | Aliment Pharmacol Ther2013，，8： | 4 |
| 3 | Calprotectin Is a Useful Tool in Distinguishing Coexisting Irritable Bowel-Like Symptoms from That of Occult Inflammation among Inflammatory Bowel Disease Patients in Remission显示文摘 | Lars-Petter Jelsness-J?rgensen Tomm Bernklev Bj?rn Moum Peter James Whorwell | 2013 | Gastroenterology Research and Practice2013，，： | 2 |
| 4 | Psychological or organic vomiting显示文摘 | Mohammed F Whorwell PJ | 2006 | Eur J Gastroenterol Hepatol2006，18，7： | 1 |
| 5 | IgG-mediated food intolerance in irritable bowel syndrome:a real phenomenon or an epiphenomenom显示文摘 | Shanahan F Whorwell PJ | | 0，，07： | 1 |
| 6 | New insights into the psychosocial aspects of irritable bowel syndrome显示文摘 | Lea R Whorwell PJ | 2003 | Curr Gastroenterol Rep2003，5，4： | 1 |
| 7 | The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress 显示文摘 | Francis CY Morris J Whorwell PJ | 1997 | Aliment Pharmacol Ther1997，11，2： | 1 |
| 8 | The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40,000 subjects显示文摘 | Hungin AP Whorwell P J Tack J | 2003 | Aliment Pharmacol Ther2003，17，5： | 1 |
| 9 | Psychological or organic vomiting 显示文摘 | Mohammed F Whorwell PJ | 2006 | Eur J Gastroenterol Hepatol2006，18，7： | 1 |
| 10 | Opioid-Induced Constipation: Pathophysiology, Clinical Consequences, and Management显示文摘 | Lalit Kumar Chris Barker Anton Emmanuel Peter James Whorwell | 2014 | Gastroenterology Research and Practice2014，，： | 1 |
| 11 | Food elimination based on IgG antibodies in irritable bowel syndrome: a randomisedcontrolled trial显示文摘 | Atkinson W Shaath N Whorwell PJ | 2004 | Gut2004，53，10： | 1 |
| 12 | Hypnotherapy in irritable bowel syndrome: a large-scale audit of a clinical service with examination of factors influencing responsiveness显示文摘 | Gonsalkorale WM Houghton LA Whorwell PJ | 2002 | Am J Gastroenterol2002，97，4： | 1 |
| 13 | Efficacy of an encap- sulated probiotic bifidobacterium infantis 35624 in women with irritable bowel syndrome 显示文摘 | Whorwell PJ Altinger L Morel J | 2006 | Am J Gastroenterol2006，101，： | 1 |
| 14 | Dietary treatment of the irritable bowel syndrome 显示文摘 | Whorwell P Lea R | 2004 | Curt Treat 0ptions Gastroenterol2004，7，4： | 1 |
| 15 | Abdominal bloating and distension in functional gastrointestinal disorders epidemiology and possible mechanisms 显示文摘 | Agrawala Whorwell Pj | 2008 | Aliment Pharmacol Ther2008，27，1： | 1 |
| 16 | The irritable bowel Beverity scoring system:a simple method of monitoring irritabie bowel syndrome and its progress显示文摘 | Francis CY Moris J Whorwell PJ | 1997 | Alim Pharmacol Ther1997，11，2： | 1 |
| 17 | The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40000 subjects 显示文摘 | Hungin AP Whorwell PJ Tack J Mearin F | 2003 | Aliment Pharmacol Ther2003，17，5： | 1 |
| 18 | New insights into the psychosocial aspects of irritable bowel syndrome 显示文摘 | Lea R Whorwell PJ | 2003 | Curr Gastroenterol Rep2003，5，4： | 1 |
| 19 | Non-colonic featuresof irritable bowel syndrome显示文摘 | Whorwell PJ McCallum M Creed FH | 1986 | Gut1986，27，1： | 1 |
| 20 | Unraveling functional abdominal bloating and- distension :the role of thoraco-abdominal accommodation and a physical sign to aid its detection 显示文摘 | Whorwell PJ | 2012 | Neurogastroen- terol Motil2012，24，4： | 1 |
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