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| 1 | Human NK cells: surface receptors, inhibitory checkpoints, and translational applications显示文摘NK cells play important roles in innate defenses against viruses and in the control of tumor growth and metastasis.The regulation/induction of NK cell function is mediated by an array of activating or inhibitory surface receptors.In humans,major activating receptors involved in target cell killing are the natural cytotoxicity receptors(NCRs)and NKG2D.Activating receptors recognize ligands that are overexpressed or expressed de novo upon cell stress,viral infection,or tumor transformation.The HLA-class I-specific inhibitory receptors,including KIRs recognizing HLA-class I allotypic determinants and CD94/NKG2A recognizing the class-Ib HLA-E,constitute a fail-safe mechanism to avoid unwanted NK-mediated damage to healthy cells.Other receptors such as PD-1,primarily expressed by activated T lymphocytes,are important inhibitory checkpoints of immune responses that ensure T-cell tolerance.PD-1 also may be expressed by NK cells in cancer patients.Since PD-1 ligand(PD-L1)may be expressed by different tumors,PD-1/PD-L1 interactions inactivate both T and NK cells.Thus,the reliable evaluation of PD-L1 expression in tumors has become a major issue to select patients who may benefit from therapy with mAbs disrupting PD-1/PD-L1 interactions.Recently,NKG2A was revealed to be an important checkpoint controlling both NK and T-cell activation.Since most tumors express HLA-E,mAbs targeting NKG2A has been used alone or in combination with other therapeutic mAbs targeting PD-1 or tumor antigens(e.g.,EGFR),with encouraging results.The translational value of NK cells and their receptors is evidenced by the extraordinary therapeutic success of haploidentical HSCT to cure otherwise fatal high-risk leukemias. | Simona Sivori Paola Vacca Genny Del Zotto Enrico Munari Maria Cristina Mingari Lorenzo Moretta | 2019 | Cellular & Molecular Immunology2019，16，5： | 33 |
| 2 | Helicobacter pylori secreted peptidyl prolyl cis , trans -isomerase drives Th17 inflammation in gastric adenocarcinoma显示文摘 | Amedeo Amedei Fabio Munari Chiara Della Bella Elena Niccolai Marisa Benagiano Lapo Bencini Fabio Cianchi Marco Farsi Giacomo Emmi Giuseppe Zanotti Marina Bernard Manikuntala Kundu Mario Milco D’Elios | 2014 | Internal and Emergency Medicine2014，，3： | 2 |
| 3 | HP-NAP inhibits the growth of bladder cancer in mice by activating a cytotoxic Th1 response显示文摘 | Gaia Codolo Matteo Fassan Fabio Munari Andrea Volpe Piefrancesco Bassi Massimo Rugge Francesco Pagano Mario Milco D’Elios Marina Bernard | 2012 | Cancer Immunology Immunotherapy2012，，1： | 2 |
| 4 | Middle cerebral artery thrombosis following blunt head trauma 显示文摘 | De Caro R Munari PF Parenti A | 1998 | Clin Neuropathol1998，17，： | 1 |
| 5 | Correlation between stereo-EEG, CT-scan and stereotactic biopsy data in epileptic patients with low-grade gliomas 显示文摘 | Munari C Musolino A Daumas-Duport C | 1985 | Appl Neurophysiol1985，48，16： | 1 |
| 6 | Influence of branching on melting behavior and isothermal crystallization of poly (butylene terephthalate) 显示文摘 | Righetti M C Munari A | 1997 | Macromolecular Chemistry and Physics1997，198，2： | 1 |
| 7 | Preparation of ultrafiltration membranes: State of the art显示文摘 | Munari S Bottino A Camera R G | 1990 | Desalination1990，77，： | 1 |
| 8 | Progress of the Maillard reaction and antioxidant action of Maillard reaction products in reheated model systems during storage显示文摘 | Mastrocola D Munari M | 2000 | Journal of Agricultural and Food Chemistry2000，48，： | 1 |
| 9 | Role of the hypothalamic hamartoma in the genesis of gelastic fits (a video-stereo-EEG study)显示文摘 | Munari C Kahane P Francione S | 1995 | Electroencephalogr Clin Neurophysiol1995，95，3： | 1 |
| 10 | High performance ultrafiltration membranes cast from LiCI doped solutions显示文摘 | Bottino A Capannelli G Munari S | 1988 | Desalination1988，68，： | 1 |
| 11 | Assessing theImpact of Public Ven-ture Capital Programs in the United Kingdom:do Re-gional Characteristics Matter?显示文摘 | Federico Munari | 2009 | Department ofManagement Universitàdegli Studi di Bologna2009，，7： | 1 |
| 12 | Auditory and somatosensory evoked potentials in coma following spontaneous cerebral hemorrhage: early prognosis and outcome显示文摘 | BEHR AU MUNARI M | 1998 | Electroencephalogr Clin Neurophysiol1998，107，5： | 1 |
| 13 | A novel efficient and versatile route to the synthesis of 5-O-feruloylquinic acids 显示文摘 | SMARRITO C MUNARI C ROBERT F | 2008 | Org Biomol Chem2008，6，6： | 1 |
| 14 | Auditory and somatogensory evoked potentials in coma following spontaneous cerebral hemorrhage: early prognosis and outcome 显示文摘 | Facco E Behr AU Munari M | 1998 | Electroencephalogr Clin Neurophysiol1998，107，5： | 1 |
| 15 | Interferons in relapsing remitting multiple sclerosis: a systematic review显示文摘 | Filippini G Munari L Incorvaia B | 2003 | Lancet2003，361，9357： | 1 |
| 16 | Human amnion mesen- chyme harbors ceils with ailogeneie T-cell suppression and stimulation capabilities显示文摘 | Magatti M De Munari S Vertaa E | 2008 | Stem Cells2008，26，1： | 1 |
| 17 | Dysregulation of mammalian target of rapamycin pathway in upper tract urothelial carcinoma显示文摘 | Munari E Fujita K Faraj S | 2013 | Hum Pathol2013，44，12： | 1 |
| 18 | Comprehensive profile of GATA binding protein 3 immunohistochemieal expression in primary and metastatic renal neoplasms 显示文摘 | Gonzalez-Roibon N Faraj SF Munari E | 2014 | Hum Pathol2014，45，2： | 1 |
| 19 | TERT promoter mutations oc- cur early in urothelial neoplasia and are biomarkers of early dis- ease and disease recurrence in urine显示文摘 | Kinde I Munari E Faraj SF | 2013 | Cancer Res2013，73，24： | 1 |
| 20 | Passive optical components:from degradation data to reliability assessment-preliminary results显示文摘 | Tomasi T De Munari I Lista V | 2002 | Microelectronics Reliability2002，，42： | 1 |
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