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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Structural and functional aspects of the Helicobacter pylori secretome显示文摘Proteins secreted by Helicobacter pylori(H. pylori), an important human pathogen responsible for severe gastric diseases, are reviewed from the point of view of their biochemical characterization, both functional and structural. Despite the vast amount of experimental data available on the proteins secreted by this bacterium, the precise size of the secretome remains unknown. In this review, we consider as secreted both proteins that contain a secretion signal for the periplasm and proteins that have been detected in the external medium in in vitro experiments. In this way, H. pylori 's secretome appears to be composed of slightly more than 160 proteins, but this number must be considered very cautiously, not only because the definition of secretome itself is ambiguous but also because the included proteins were observed as secreted in in vitro experiments that were not representative of the environmental situation in vivo. The proteins that appear to be secreted can be grouped into different classes: enzymes(48 proteins), outer membrane proteins(43),components of flagella(11), members of the cytotoxicassociated genes pathogenicity island or other toxins(8 and 5, respectively), binding and transport proteins(9), and others(11). A final group, which includes 28 members, is represented by hypothetical uncharacterized proteins. Despite the large amount of data accumulated on the H. pylori secretome, a considerable amount of work remains to reach a full comprehension of the system at the molecular level. | Giuseppe Zanotti Laura Cendron | 2014 | World Journal of Gastroenterology2014，20，6： | 3 |
| 3 | Human epididymis protein 4 as a serum marker for diagnosis of endometrial carcinoma and prediction of clinical outcome显示文摘 | Laura Zanotti Eliana Bignotti Stefano Calza Elisabetta Bandiera Giuseppina Ruggeri Claudio Galli Germana Tognon Monica Ragnoli Chiara Romani Renata A. Tassi Luigi Caimi Franco E. Odicino Enrico Sartori Sergio Pecorelli Antonella Ravaggi | 2012 | Clinical Chemistry and Laboratory Medicine2012，，12： | 2 |
| 4 | Helicobacter pylori secreted peptidyl prolyl cis , trans -isomerase drives Th17 inflammation in gastric adenocarcinoma显示文摘 | Amedeo Amedei Fabio Munari Chiara Della Bella Elena Niccolai Marisa Benagiano Lapo Bencini Fabio Cianchi Marco Farsi Giacomo Emmi Giuseppe Zanotti Marina Bernard Manikuntala Kundu Mario Milco D’Elios | 2014 | Internal and Emergency Medicine2014，，3： | 2 |
| 5 | Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock显示文摘 | Anand Kumar Daniel Roberts Kenneth E. Wood Bruce Light Joseph E. Parrillo Satendra Sharma Robert Suppes Daniel Feinstein Sergio Zanotti Leo Taiberg David Gurka Aseem Kumar Mary Cheang | 2006 | Critical Care Medicine2006，，6： | 2 |
| 6 | Can mutual funds characteristics explain fees?显示文摘 | Manuela Geranio Giovanna Zanotti | 2005 | Journal of Multinational Financial Management2005，，4： | 2 |
| 7 | Cytokine modulation in sepsis and septic shock显示文摘 | Zanotti S Kumar A Kumar A | 2002 | Expert Opin Investig Drugs2002，11，8： | 1 |
| 8 | Determination of cations in fruit juices and purees by ion chromatography显示文摘 | TRIFIRO A SACCANI G ZANOTTI A | 1996 | J Chromatogr A1996，739，12： | 1 |
| 9 | Seismic Enhancement of Existing Buildings by Means of Fiber Reinforced Concrete Diaphragms显示文摘 | Alessandra Marini Giovanni Plizzari Cristina Zanotti | 2010 | Journal of Civil Engineering and Architecture2010，4，3： | 1 |
| 10 | Neural stem cells and their use as therapeutic tool in neurological disorders 显示文摘 | Pluchino S Zanotti L Deleidi M | 2005 | Brain Res Brain Res Rev2005，48，： | 1 |
| 11 | Fl and F0 connections in the bovine mitochondrial ATP synthase:the role of the alpha subunit of N-terminus,Oligomycin sensitivity-conferring protein (OSCP) and subunit d 显示文摘 | XU T ZANOTTI F GABALLO A | 2000 | Eur J Biochem2000，267，14： | 1 |
| 12 | Interleukin- 10 blunts the human inflammatory response to lipopolysaccharide without affecting the cardiovascular response显示文摘 | Kumar A Zanotti S Bunnell G | 2005 | Crit Care Med2005，33，2： | 1 |
| 13 | Probucol inhibits ABCA1-Mediated cellular lipid efflux显示文摘 | Favari E Zanotti I Zimetti F | 2004 | Arterioscler Thromb Vasc Biol2004，24，12： | 1 |
| 14 | Premedication with intranasal midazolam in children of various ages 显示文摘 | Vivarelli R Zanotti F Battaglia D | 1998 | Minerva Anestesiol1998，64，11： | 1 |
| 15 | Probucol inhibits ABCAl-mediated cellular lipid efflux 显示文摘 | Favari E Zanotti I Zimetti F | 2004 | Arterioscler Thromb Vase Biol2004，24，12： | 1 |
| 16 | Notch regulation of bone devel- opment and remodeling and related skeletal disorders 显示文摘 | Zanotti S Canalis E | 2012 | Calcif Tissue Int2012，90，20： | 1 |
| 17 | Carboplatin skin testing:a skin-testing protocol for predicting hypersensitivity to carboplatin chemothertherapy显示文摘 | rybicki LA Kennedy AW | 2001 | J Clin Oncol2001，，19： | 1 |
| 18 | F1 and F0 connections in the bovine mitochondrial ATP synthase the role of the ofa Subunit N-terminus, oligomycin-sensitivity conferring protein (OSCP) and subunitd 显示文摘 | Xu T Zanotti F Gaballo A | 2000 | Eur J Biochem2000，267，14： | 1 |
| 19 | Notch and the skeleton 显示文摘 | Zanotti S E Canalis | 2010 | Molec Cellular Biol2010，30，4： | 1 |
| 20 | Initial experi- ence with a novel desensitization strategy for carboplatin-associat- ed hypersensitive-ty reactions: carboplatin-hypersensitivity reac- tions显示文摘 | MARKMAN M HSIEH F ZANOTTI K | 2004 | J Cancer Res Clin Oncol2004，130，1： | 1 |
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