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| 1 | Sirtuins and nonalcoholic fatty liver disease显示文摘Mammalian sirtuins are seven members belonging to the silent information regulator 2 family, a group of Class Ⅲ histone/protein deacetylases. Sirtuins(SIRT 1-7) have different subcellular localization and function and they regulate cellular protein function through various posttranslational modifications. SIRT1 and 3, the most studied sirtuins, use the product of cellular metabolism nicotinamide adenine dinucleotide as a cofactor to post-translationally deacetylate cellular proteins and consequently link the metabolic status of the cell to protein function. Sirtuins have been shown to play a key role in the development and rescue of various metabolic diseases including non-alcoholic fatty liver disease(NAFLD). NAFLD is currently the most chronic liver disease due mainly to high-calorie consumption and lower physical activity. No pharmacological approach is available to treat NAFLD, the current recommended treatment are lifestyle modification such as weight loss through calorie restriction and exercise. Recent studies have shown downregulation of sirtuins in human as well as animal models of NAFLD indicating an important role of sirtuins in the dynamic pathophysiology of NAFLD. In this review, we highlight the recent knowledge on sirtuins, their role in NAFLD and their unique potential role as novel therapeutic target for NAFLD treatment. | Fatiha Nassir Jamal A Ibdah | 2016 | World Journal of Gastroenterology2016，22，46： | 19 |
| 2 | Role of mitochondria in alcoholic liver disease显示文摘Alcohol abuse is the leading cause of liver related morbidity and mortality.Chronic or binge alcohol drinking causes hepatic steatosis which can develop to steatohepatitis,cirrhosis and ultimately hepatocellular carcinoma.The pathogenesis of alcoholic liver disease(ALD)is poorly characterized,however several recent studies point to a major role of mitochondria in this process.Mitochondria play a crucial role in cellular energy metabolism and in reactive species formation.Alcohol treatment causes mitochondrial DNA damage,lipid accumulation and oxidative stress.Studies in both animal models and in humans showed that alcohol administration causes changes in the mitochondrial morphology and function suggesting a role of these changes in the pathogenesis of ALD.We review recent findings on mechanisms by which alcohol negatively impacts mitochondrial biogenesis and function and we will discuss the specific intracellular pathways affected by alcohol consumption.Interestingly,recent findings indicate that a large number of mitochondrial proteins are acetylated and that mitochondrial proteins acetylation and sirtuins are modulated by alcohol.Un-derstanding the mechanisms behind alcohol mediated impaired mitochondrial biogenesis and function may help identify potential therapeutic targets for treating ALD in humans. | Fatiha Nassir Jamal A Ibdah | 2014 | World Journal of Gastroenterology2014，20，9： | 18 |
| 3 | 水稻外观品质性状和千粒重的QTLs分析显示文摘通过以明恢63和优质泰国香米KDML105两个籼稻品种为亲本杂交的重组自交系(Recombinantinbred line,RIL)群体,构建包含134个简单重复序列标记(SSR)的遗传连锁图谱。2009、2010年对水稻(Oryza sativa L.)的粒长、粒宽、粒形、粒厚、腹白率、心白率和千粒重进行数量性状位点(QTL)定位。2009年检测到16个QTLs,其中粒长、粒宽、粒形、粒厚、腹白率、心白率和千粒重分别检测到2、2、1、1、1、1和8个QTLs,单个QTL可解释表型变异的4.43%~13.06%。2010年检测到19个QTLs,其中粒长、粒宽、粒形、粒厚、腹白率、心白率和千粒重分别检测到2、3、3、2、3、3和3个QTLs,单个QTL可解释表型变异的6.04%~24.31%。千粒重qTGW-3和qTGW-6-2在2009、2010年两年中均被重复检测到,qTGW-3在两年中分别可解释表型变异的13.06%和7.12%,qTGW-6-2在两年中分别可解释表型变异的7.66%和14.56%。 | 于波 NASSIROU Tondi-yacouba 高冠军 张庆路 | 2012 | 湖北农业科学2012，51，19： | 7 |
| 4 | Assessment of the Acute Effects of DEE (Diesel Exhaust Emitted) on Blood Parameters in Guinea Pigs Cavia porcellus显示文摘 | Ayoub Bazzaz Nahid Nassir A1-Manea | 2012 | Journal of Environmental Science and Engineering(A)2012，1，5： | 5 |
| 5 | 水稻糙米蛋白质和粗脂肪含量的QTLs分析显示文摘蛋白质和粗脂肪含量是评价稻米营养品质的重要指标,控制水稻(Oryza sativa L.)糙米蛋白质及脂肪含量的基因位点是数量性状,检测水稻糙米蛋白质及脂肪含量的数量性状位点(QTL)对于水稻品质遗传育种具有重要的意义。通过明恢63和优质泰国香米KDML105两个籼稻品种为亲本杂交的重组自交系(Recombinant inbred line,RIL)群体构建了包含113个简单重复序列标记(SSR)的遗传连锁图谱,对2009、2010年群体的蛋白质和粗脂肪含量进行了QTL定位。2009年检测到5个QTLs,其中蛋白质含量检测到2个QTLs,单个QTL贡献率分为别为5.44%和5.52%;粗脂肪含量检测到3个QTLs,单个QTL贡献率为5.42%~7.30%。2010年蛋白质含量检测到3个QTLs,单个QTL可解释表型变异为6.24%~20.75%;未检测到粗脂肪含量QTL。此外,还检测到14对粗脂肪含量和8对蛋白质含量的上位性QTLs。 | 黄覃 于波 NASSIROU Tondi-yacouba 高冠军 张庆路 何予卿 | 2012 | 湖北农业科学2012，51，21： | 5 |
| 6 | 肠道子宫内膜异位症诊断和治疗的新观点显示文摘子宫内膜异位症是一种主要影响育龄妇女的慢性疾病。部分肠道子宫内膜异位症患者可能是无症状的,除了不孕之外,有部分患者表现为各种各样的症状,如排便习惯改变(便秘或腹泻)、排便困难、痛经和性交痛等。迄今为止,对于疑似有肠道受累的子宫内膜异位症患者,尚无明确的评估指南。目前的检查手段包括经阴道或经直肠超声检查、核磁共振成像和气钡双重对比造影。不同的检查方法可提供更多的信息,包括是否存在病灶、病灶的位置和累及的范围等,确保患者充分了解病情,同时也可对术前计划进行优化。如需手术治疗,应由经验丰富的医生在有多学科护理条件的中心进行手术。治疗应根据患者的症状和意愿进行调整,目的是尽可能切除所有病灶的同时保留器官的功能。本综述将讨论肠道子宫内膜异位症诊断和处理的最新观点。 | 梁炎春 韦雅婧 杨如玉 姚书忠(译/审校) Nassir Habib Gabriele Centini Lucia Lazzeri Nicola Amoruso Lionel El Khoury Errico Zupi Karolina Afors | 2020 | 国际妇产科学杂志2020，47，6： | 3 |
| 7 | Hypoglycemic and antioxidant activities of Caesalpinia ferrea Martius leaf extract in streptozotocininduced diabetic rats显示文摘Objective: To evaluate the antidiabetic and antioxidant ef ects of aqueous ethanolic extract of Caesalpinia ferrea(C. ferrea) leaf in normal and streptozotocin(STZ) induced diabetic rats.Methods: Male Sprague-Dawley rats divided into 6 groups of 6 rats each were assigned into diabetic and non-diabetic groups. Diabetes was induced in rats by single intraperitoneal administration of STZ(65 mg/kg body weight). C. ferrea extract at the doses of 250 and 500 mg/kg body weight was orally administered to both diabetic and non-diabetic animals for a period of 30 days. After completion of experimental duration serum, liver and pancreas were used for evaluating biochemical and histopathological changes.Results: Oral administration of C. ferrea leaf extract significantly reduced elevated serum glucose, α-amylase, liver function levels and signii cantly increased serum insulin, total protein and body weight as well as improved lipid proi le due to diabetes. Furthermore, the treatment resulted in a marked increase in glutathione peroxidase, superoxide dismutase, catalase and reduced glutathione, and diminished levels of lipid peroxidation in liver and pancreas of diabetic rats. Histopathological studies demonstrated the reduction in the pancreas and liver damage and coni rmed the biochemical i ndings.Conclusions: From the present study, it can be concluded that the C. ferrea leaf extract ef ectively improved hyperglycaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats. Hence, it can be used in the management of diabetes mellitus. | Sherien Kamal Hassan Nermin Mohammed El-Sammad Amria Mamdouh Mousa Maha Hashim Mohammed Abd el Razik Hussein Farrag Amani Nassir Eldin Hashim Victoria Werner Ulrike Lindequist Mahmoud Abd El-Moein Nawwar | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，6： | 3 |
| 8 | Diffusion tensor imaging pipeline measures of cerebral white matter integrity: An overview of recent advances and prospects显示文摘Cerebral small vessel disease(CSVD)is a leading cause of age-related microvascular cognitive decline,resulting in significant morbidity and decreased quality of life.Despite a progress on its key pathophysiological bases and general acceptance of key terms from neuroimaging findings as observed on the magnetic resonance imaging(MRI),key questions on CSVD remain elusive.Enhanced relationships and reliable lesion studies,such as white matter tractography using diffusion-based MRI(dMRI)are necessary in order to improve the assessment of white matter architecture and connectivity in CSVD.Diffusion tensor imaging(DTI)and tractography is an application of dMRI that provides data that can be used to non-invasively appraise the brain white matter connections via fiber tracking and enable visualization of individual patient-specific white matter fiber tracts to reflect the extent of CSVD-associated white matter damage.However,due to a lack of standardization on various sets of software or image pipeline processing utilized in this technique that driven mostly from research setting,interpreting the findings remain contentious,especially to inform an improved diagnosis and/or prognosis of CSVD for routine clinical use.In this minireview,we highlight the advances in DTI pipeline processing and the prospect of this DTI metrics as potential imaging biomarker for CSVD,even for subclinical CSVD in at-risk individuals. | Amanina Ahmad Safri Che Mohd Nasril Che Mohd Nassir Ismail Nurul Iman Nur Hartini Mohd Taib Anusha Achuthan Muzaimi Mustapha | 2022 | World Journal of Clinical Cases2022，10，24： | 2 |
| 9 | Stent placement versus angioplasty for hepatic artery stenosis after liver transplant: a meta-analysis of case series显示文摘 | Nassir Rostambeigi David Hunter Sue Duval Srinath Chinnakotla Jafar Golzarian | 2013 | European Radiology2013，，5： | 2 |
| 10 | Phased-array intracardiac echocardiography monitoring during pulmonary vein isolation in patients with atrial fibrillation impact on outcome and complications显示文摘 | Nassir F Marrouche MD Martin DO | 2003 | Circulation2003，12，6： | 1 |
| 11 | Multilocular cystic renal cell carcinoma:a series of 12 cases and review of the literature显示文摘 | Nassir A Jollimore J Gupta R | 2002 | Urology2002，60，3： | 1 |
| 12 | Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: A double-blind,pacebo-controlled comparison of efficacy and dafety显示文摘 | Gary SS Fred G Nassir G | 2002 | Am J Psychiatry2002，159，： | 1 |
| 13 | BLastocystis hominis as acause of hypoalbuminemia and anasarca显示文摘 | Nassir E A wad J Abel AB | 2004 | Eur J Clin MicrobiolInefect Dis2004，23，5： | 1 |
| 14 | The bipolar spectrum:a clinical perspective显示文摘 | Katzow JJ Hsu DJ Nassir Ghaami S | 2003 | Bipolar Disord2003，5，6： | 1 |
| 15 | Multilocular cystic renal cell carcinoma:a series of 12cases and review of the literature显示文摘 | Nassir A Jollimore J Gupta R | 2002 | Urology2002，60，3： | 1 |
| 16 | Re-al-Time Simulation of Medical Uitrasoundfrom CTImages显示文摘 | Ramtin Shams Richard Hartley Nassir Navab | 2008 | MICCAI2008，5242，： | 1 |
| 17 | CD36 deficiency impairs intestinal lipid secretion and clear- ance of chylomicrons from the blood 显示文摘 | DROVER V A AJMAL M NASSIR F | 2005 | The Journal of Clinical Investigation2005，115，5： | 1 |
| 18 | Recognizing multiple human activities and tracking full-body pose in unconstrained environments显示文摘 | Loren Arthur Schwarz Diana Mateus Nassir Navab | 2011 | Pattern Recognition2011，，1： | 1 |
| 19 | Muhilocular cystic renal cell carcinoma :a series of 12 cases and review of the literature显示文摘 | Nassir A Jollimore J Gupta R | 2002 | Urology2002，60，3： | 1 |
| 20 | Multiloctdar cystie renal cell earcinoma:A series of 12 cases and review of the literature 显示文摘 | Anmar Nassir Jason Jollimore Rekha Gupta | 2002 | Urology2002，60，3： | 1 |
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