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| 1 | Bone marrow cells produce nerve growth factor and promote angiogenesis around transplanted islets显示文摘AIM:To clarify the mechanism by which bone marrow cells promote angiogenesis around transplanted islets.METHODS: Streptozotocin induced diabetic BALB/ c mice were transplanted syngeneically under the kidney capsule with the following: (1) 200 islets (islet group: n=12), (2) 1-5×106 bone marrow cells (bone marrow group: n=11), (3) 200 islets and 1-5×106 bone marrow cells (islet + bone marrow group: n= 13), or (4) no cells (sham group:n=5). All mice were evaluated for blood glucose, serum insulin, serum nervegrowth factor (NGF) and glucose tolerance (GTT) up to postoperative day (POD) 14. Histological assessment for insulin, von Willebrand factor (vWF) and NGF was performed at POD 3, 7 and 14.RESULTS: Blood glucose level was lowest and serum insulin was highest in the islet + bone marrow group. Serum NGF increased in islet, bone marrow, and islet + bone marrow groups after transplantation, and there was a significant difference (P=0.0496, ANOVA) between the bone marrow and sham groups. The number of vessels within the graft area was signif icantly increased in both the bone marrow and islet + bone marrow groups at POD 14 as compared to the islet alone group (21.2 ± 3.6 in bone marrow, P=0.01, vs islet group, 22.6 ± 1.9 in islet + bone marrow, P = 0.0003, vs islet group, 5.3 ± 1.6 in islet-alone transplants). NGF was more strongly expressed in bone marrow cells compared with islets. CONCLUSION: Bone marrow cells produce NGF and promote angiogenesis. Islet co-transplantation with bone marrow is associated with improvement of islet graft function. | Naoaki Sakata Nathaniel K Chan John Chrisler Andre Obenaus Eba Hathout | 2010 | World Journal of Gastroenterology2010，16，10： | 2 |
| 2 | Asymmetric Synthesis of Novel Quaternary ot-Hydroxy-8-Lactam Dipeptide Surrogates 显示文摘 | NATHANIEL K M JOHN E R | 1999 | Med Chem Lett1999，，9： | 1 |
| 3 | Defects in cardiac function precede morphological abnormalities in fish embryos exposed to polycyclic aromatic hydrocarbons 显示文摘 | John P I Tracy K C Nathaniel L S | 2004 | Toxicology and Appliocl Pharmacology2004，196，： | 1 |
| 4 | Is sleep apnea an independent risk factor for prevalent and incident diabete] in the Busseh on Health Study? 显示文摘 | Nathaniel S Marshal I Keith K | 2009 | J Clin Sleep Med2009，15，5： | 1 |
| 5 | Yield trends are insufficient to doubleglobal crop production by 2050显示文摘 | Ray Deepak K Mueller Nathaniel D West Paul C Foley Jonathan A | 2013 | Plos One2013，8，66： | 1 |
| 6 | Fabrication and me- chanical characterizat ion of carbon/SiC-epoxy anocomposites 显示文摘 | Nathaniel C Hassan M Vijaya K | 2005 | Composites Structures2005，67，1： | 1 |
| 7 | Systematic Design ofPore Size and Functionality in Iso-Reticular MOFs and Their Appli-cation in Methane Storage 显示文摘 | Mohamed E Jaheon K Nathaniel R | 2002 | Science2002，295，： | 1 |
| 8 | The ecology of terror defense显示文摘 | Nathaniel O K Richard J Z | 2003 | Journal of Risk and Uncertainty2003，26，： | 1 |
| 9 | lnterferometric measurements of femtosecond group delay in optical components 显示文摘 | WAYNE H K NATHANIEL M P KATHRYN D L | 1988 | Opt Lett1988，13，7： | 1 |
| 10 | Fabrication and Mechanical Characterization of Carbon/SiC-epoxy Nanocomposites 显示文摘 | Nathaniel C Hassan M Vijaya K | 2005 | Composites Structures2005，67，1： | 1 |
| 11 | Tera-hertz Metamaterials for Linear Polarization Conversion and Anomalous Refraction显示文摘 | Nathaniel K Grady Jane E Heyes Dibakar Roy Chowdhu-ry Yong Zeng Matthew T Reiten AbulK Azad Antoi-nette J Taylor DiegoA R Dalvit Hou-Tong Chen | | 0，，： | 1 |
| 12 | Treatment of Postherpetic Neuralgia:A Review of Therapeutic Options 显示文摘 | Charles EA Nathaniel K Miroslav B | 2004 | J Pain Symptom Manage2004，28，4： | 1 |
| 13 | Terahertz metamaterials for linear polarization conver- sion and anomalous refraction 显示文摘 | Nathaniel K Grady Jane E Heyes Dibakar Roy Chowdhury | 2013 | Science2013，340，： | 1 |
| 14 | Infusion of SiC nanoparticles into SC -15 epoxy: an investigation of ther- mal and mechanical response 显示文摘 | NATHANIEL C HASSAN M VIJAYA K | 2005 | Macromol Mater Eng2005，290，： | 1 |
| 15 | Asymmetric synthesis of novel quaternary α-hydroxy-δ-lactam dipeptide surrogates显示文摘 | NATHANIEL K M JOHN E R | 1999 | Med Chem Lett1999，，9： | 1 |
| 16 | An improved QC process for temperature in the daily cooperative weather obser- vations 显示文摘 | Hubbard K G Nathaniel B G You J S | 2007 | Atmos Oceanic Technical2007，24，： | 1 |
| 17 | Fabrication and Mechanical Characterization of Cabon/SiC Epoxy Nanocomposites显示文摘 | Nathaniel C Hassan M Vijaya K | 2004 | Composites Structures2004，，1： | 1 |
| 18 | Single-longtidinal-mode tunable WDM-channel-select able fiber laser显示文摘 | Nathaniel J C Libatique Li Wang Ravi K Jain | 2002 | Optics Express2002，10，25： | 1 |
| 19 | Fabrication and mechanical characterization of cabon/SiC epoxy nano- composites显示文摘 | NATHANIEL C HASSAN M VIJAYA K | 2004 | Composites Structures2004，，1： | 1 |
| 20 | Fabrication and mechanical characterization of carbon/SiC-epoxy nanocomposites 显示文摘 | Nathaniel C Hassan M Vijaya K | 2005 | Composites Structures2005，67，1： | 1 |
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