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| 1 | Anti-HBc screening in Indian blood donors:Still an unresolved issue显示文摘AIM:To study the seroprevalence of antibody to hepatitis B core antigen (anti-HBc) in healthy blood donors negative for HBsAg and to evaluate whether anti-HBc detection could be adopted in India as a screening assay for HBV in addition to HBsAg. METHODS: A total of 1700 serum samples collected from HBsAg-negative healthy blood donors were tested for the presence of anti-HBc antibody (IgM + IgG). All samples reactive for anti-HBc antibody were then investigated for presence of anti-HBs and for liver function tests (LFTs). One hundred serum samples reactive for anti-HBc were tested for HBV DNA by PCR method. RESULTS: Out of 1700 samples tested, 142 (8.4%) blood samples were found to be reactive for anti-HBc. It was signif icantly lower in voluntary (6.9%) as compared to replacement donors (10.4%, P = 0.011). Seventy- two (50.7%) anti-HBc reactive samples were also reactive for anti-HBs with levels > 10 mIU/mL and 70 (49.3%) samples were non-reactive for anti-HBs, these units were labeled as anti-HBc-only. These 142 anti-HBc reactive units were also tested for liver function test. HBV DNA was detected in only 1 of 100 samples tested. CONCLUSION: Keeping in view that 8%-18% of donor population in India is anti-HBc reactive, inclusion of anti- HBc testing will lead to high discard rate. Anti-HBs as proposed previously does not seem to predict clearance of the virus. Cost effectiveness of introducing universalanti-HBc screening and discarding large number of blood units versus considering ID NAT (Individual donor nuclic acid testing) needs to be assessed. | Hari Krishan Dhawan Neelam Marwaha Ratti Ram Sharma Yogesh Chawla Beenu Thakral Karan Saluja Sanjeev Kumar Sharma Manish K Thakur Ashish Jain | 2008 | World Journal of Gastroenterology2008，14，34： | 8 |
| 2 | Extraocular retinoblastoma in Indian children:clinical,imaging and histopathological features显示文摘AIM:To study eyes with extraocular dissemination(EORB),with the following aims:first to establish the mean lag period and to understand various reasons for delayed presentation,second to study their imaging profiles and third to analyze histopathological features of eyes enucleated after neoadjuvant chemotherapy.·METHODS:Prospective study of clinical and imaging features of EORBs(stage Ⅲ and Ⅳ International Retinoblastoma Staging System) presenting to a tertiary eye care centre.Histopathological features of eyes enucleated after receiving neoadjuvant chemotherapy were analyzed.A pictorial illustration of the varied imaging profile of EORB was also presented.·RESULTS:Over a period of one year,97 eyes were diagnosed with retinoblastoma;32 children(36 eyes)(37.1%) had EORB.Mean age 3.6±1.9 years,71.9% males,71.9% unilateral,3.1% with positive family history and40.6% with metastasis.On imaging,there was extrascleral involvement in 22.2%,involvement of orbital part of optic nerve in 33.3%,involvement of central nervous system in 27.8% and orbital wall involvement in2.9% eyes.On histopathological analysis of eyesenucleated after neoadjuvant chemotherapy,25.0% had no residual viable tumour tissue and rest all tumours were poorly differentiated.·CONCLUSION:There are very few human malignancies where definitive treatment is started without any confirmed histopathological diagnosis and imaging plays an important role in diagnosis and appropriate staging of the disease.Chemotherapy has a variable effect on EORB,75.0% of eyes with EORB had residual viable tumour tissue when enucleated after receiving neoadjuvant chemotherapy. | Sumita Sethi Neelam Pushker Seema Kashyap Sanjay Sharma Mridula Mehta Sameer Bakhshi Saurbhi Khurana Supriyo Ghose | 2013 | International Journal of Ophthalmology(English edition)2013，6，4： | 5 |
| 3 | Exploiting DNA repair pathways for tumor sensitization,mitigation of resistance,and normal tissue protection in radiotherapy显示文摘More than half of cancer patients are treated with radiotherapy,which kills tumor cells by directly and indirectly inducing DNA damage,including cytotoxic DNA double-strand breaks(DSBs).Tumor cells respond to these threats by activating a complex signaling network termed the DNA damage response(DDR).The DDR arrests the cell cycle,upregulates DNA repair,and triggers apoptosis when damage is excessive.The DDR signaling and DNA repair pathways are fertile terrain for therapeutic intervention.This review highlights strategies to improve therapeutic gain by targeting DDR and DNA repair pathways to radiosensitize tumor cells,overcome intrinsic and acquired tumor radioresistance,and protect normal tissue.Many biological and environmental factors determine tumor and normal cell responses to ionizing radiation and genotoxic chemotherapeutics.These include cell type and cell cycle phase distribution;tissue/tumor microenvironment and oxygen levels;DNA damage load and quality;DNA repair capacity;and susceptibility to apoptosis or other active or passive cell death pathways.We provide an overview of radiobiological parameters associated with X-ray,proton,and carbon ion radiotherapy;DNA repair and DNA damage signaling pathways;and other factors that regulate tumor and normal cell responses to radiation.We then focus on recent studies exploiting DSB repair pathways to enhance radiotherapy therapeutic gain. | Jac A.Nickoloff Lynn Taylor Neelam Sharma Takamitsu A.Kato | 2021 | Cancer Drug Resistance2021，4，2： | 4 |
| 4 | Recent Developments in Integrated Solar Combined Cycle Power Plants显示文摘Global concern for depleting fossil fuel reserves have been compelling for evolving power generation options using renewable energy sources. The solar energy happens to be a potential source for running the power plants among renewable energy sources. Integrated Solar Combined Cycle(ISCC) power plants have gained popularity among the thermal power plants. Traditional ISCC power plants use Direct Steam Generation(DSG) approach. However, with the DSG method, the ISCC plant’s overall thermal efficiency does not increase significantly due to variations in the availability of solar energy. Thermal Energy Storage(TES) systems when integrated into the solar cycle can address such issues related to energy efficiency, process flexibility, reducing intermittency during non-solar hours. This review work focuses and discusses the developments in various components of the ISCC system including its major cycles and related parameters. The main focus is on CSP technologies, Heat Transfer Fluid(HTF), and Phase Change Material(PCM) used for thermal energy storage. Further, study includes heat enhancement methods with HTF and latent heat storage system. This study will be beneficial to the power plant professionals intending to modify the solar-based Combined Cycle Power Plant(CCPP) and to retrofit the existing Natural Gas Combined Cycle(NGCC) plant with the advanced solar cycle. | KHANDELWAL Neelam SHARMA Meeta SINGH Onkar SHUKLA Anoop Kumar | 2020 | Journal of Thermal Science2020，29，2： | 4 |
| 5 | Aerobic bacterial flora of the normal conjunctiva at high altitude area of Shimla Hills in India:a hospital based study显示文摘AIM:To study the normal aerobic conjunctival flora in lower to mid Himalayan region of Shimla Hills.METHODS:Samples from normal conjunctiva of 200 individuals above the age of 13 years who visited Indira Gandhi Medical College Hospital Shimla for refraction or cataract surgery were taken by anaesthetising the conjunctival sac with sterile 4% Xylocaine solution.Samples were obtained by gently rubbing lower fornix with a sterile cotton wool swab moistened with normal saline and keeping the eye lids wide apart to avoid contamination from lid margins.It was immediately inoculated in Brain Heart infusion and subjected to standard aerobic culture and identification techniques.RESULTS:Totally,72 eyes(36%) conjunctival sacs were sterile.Predominant aerobes isolated were Staphylococcus spp.in 120(60%) followed by Haemophilus in 16(8%),diphtheroids in 10(5%),and Escherichia coli(E.coli) in 4(2%).A single aerobe was isolated from 98 eyes(49%) while 30 eyes(15%) yielded more than 1 aerobe.Staphylococcus epidermidis(S.epidermidis) was the most common bacterium,found alone in 58 eyes(29%) and in combination with another aerobe in 30 eyes(15%),followed by Staphylococcus aureus(S.aureus) in 18(9%) and 10 eyes(5%) respectively.CONCLUSION:S.epidermidis is the most common commensal organism followed by Haemophilus species.diphtheroids occupied the third position which otherwise are found more abundantly in literature.Pathogens like S.aureus,Staphylococcus citreus and E.coli were also found.Therefore,preoperative administration of topical broad spectrum antibiotics is extremely important in prophylaxis against ocular infection.The variation in microflora of normal conjunctiva in this part of world can be attributed to geographical,climatic and ethnic characteristics of the population under study. | Sharma Parmeshri Dass Sharma Neelam Gupta Ravinder Kumar Singh Parul | 2013 | International Journal of Ophthalmology(English edition)2013，6，5： | 4 |
| 6 | 2,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents显示文摘In this study we examined the suitability of the 3H-imidazo[4,5-b]pyridine ring system in developing novel anticancer and anti-inflammatory agents incorporating a diaryl pharmacophore. Eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives retrieved from our in-house database were evaluated for their cytotoxic activity against nine cancer cell lines. The results indicated that the compounds showed moderate cytotoxic activity against MCF-7, MDA-MB-468, K562 and SaOS2 cells, with K562 being the most sensitive among the four cancer cell lines. The eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives were also evaluated for their COX-1 and COX-2 inhibitory activity in vitro. The results showed that compound 3f exhibited 2-fold selectivity with IC_(50) values of 9.2 and 21.8 mmol/L against COX-2 and COX-1, respectively. Molecular docking studies on the most active compound 3f revealed a binding mode similar to that of celecoxib in the active site of the COX-2 enzyme. | Erin Marie Kirwen Tarun Batra Chandrabose Karthikeyan Girdhar Singh Deora Vandana Rathore Chaitanya Mulakayala Naveen Mulakayala Amy Catherine Nusbaum Joel Chen Haneen Amawi Kyle Mc Intosh Sahabjada Neelam Shivnath Deepak Chowarsia Nisha Sharma Md Arshad Piyush Trivedi Amit KTiwari | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 3 |
| 7 | Consensus and controversies in platelet transfusion显示文摘 | Neelam Marwaha R.R. Sharma | 2009 | Transfusion and Apheresis Science2009，，2： | 1 |
| 8 | Consensus and controversies in platelet transfusion显示文摘 | Neelam M Sharma RR | 2009 | Transfus Apher Sci2009，41，2： | 1 |
| 9 | MYB transcription factor genes as regulators for plant responses:an overview显示文摘 | Ambawat S Sharma P Neelam R | 2013 | Physiol Mol Biol Plants2013，19，3： | 1 |
| 10 | Drug resistant urinary i-solates of Pseudomonas aeruginosa and Acinetobacter显示文摘 | Sharma J Neelam G Chander J | | 0，，03： | 1 |
| 11 | Outcome, Pathologic Findings, and Compliance in Orbital Retinoblastoma (International Retinoblastoma Staging System Stage III) Treated with Neoadjuvant Chemotherapy显示文摘 | Venkatraman Radhakrishnan Seema Kashyap Neelam Pushker Sanjay Sharma Sushmita Pathy Bidhu K. Mohanti Sreenivas Vishnubhatla Supriyo Ghose Sameer Bakhshi | 2012 | Ophthalmology2012，，7： | 1 |
| 12 | Value of neutrophil-lymphocyte ratio in evaluating response to percutaneous catheter drainage in patients with acute pancreatitis显示文摘BACKGROUND Early prediction of response to percutaneous catheter drainage(PCD)of necrotic collections in acute pancreatitis(AP)using simple and objective tests is critical as it may determine patient prognosis.The role of white blood cell(WBC)count and neutrophil-lymphocyte ratio(NLR)has not been assessed as a tool of early prediction of PCD success and is the focus of this study.AIM To assess the value of WBC and NLR in predicting response to PCD in AP.METHODS This retrospective study comprised consecutive patients with AP who underwent PCD between June 2018 and December 2019.Severity and fluid collections were classified according to the revised Atlanta classification and organ failure was defined according to the modified Marshall Score.WBC and NLR were monitored 24 h prior PCD(WBC-0/NLR-0)and 24 h(WBC-1/NLR-1),48 h(WBC-2/NLR-2)and 72 h(WBC-3/NLR-3)after PCD.NLR was calculated by dividing the number of neutrophils by the number of lymphocytes.The association of success of PCD(defined as survival without the need for surgery)with WBC and NLR was assessed.The trend of WBC and NLR was also assessed post PCD.RESULTS One hundred fifty-five patients[median age 40±13.6(SD),64.5%males,53.5%severe AP]were included in the final analysis.PCD was done for acute necrotic collection in 99(63.8%)patients and walled-off necrosis in 56(36.1%)patients.Median pain to PCD interval was 24±69.89 d.PCD was successful in 109 patients(group 1)and 46 patients(group 2)who failed to respond.There was no significant difference in the baseline characteristics between the two groups except the severity of AP and frequency of organ failure.Both WBC and NLR showed an overall decreasing trend.There was a significant difference between WBC-0 and WBC-1(P=0.0001).WBC-1 and NLR-1 were significantly different between the two groups(P=0.048 and 0.003,respectively).The area under the curve of WBC-1 and NLR-1 for predicting the success of PCD was 0.602 and 0.682,respectively.At a cut-off value of 9.87 for NLR-1,the sensitivity and specificity for predicting the success of PCD were calculated to be 75%and 65.4%respectively.CONCLUSION WBC and NLR can be used as simple tests for predicting response to PCD in patients with acute necrotizing pancreatitis. | Pankaj Gupta Gaurav Chayan Das Akash Bansal Jayanta Samanta Harshal S Mandavdhare Vishal Sharma Shano Naseem Vikas Gupta Thakur Deen Yadav Usha Dutta Neelam Varma Manavjit Singh Sandhu Rakesh Kochhar | 2022 | World Journal of Clinical Cases2022，10，1： | 1 |
| 13 | Drug resistant urinary isolates of Pseudomonas aeruginosa and Acinetobacter species显示文摘 | Sharma J Neelam G Chander J | 2010 | J Glob Infect Dis2010，2，3： | 1 |
| 14 | One Week of Nitrofurantoin Before Percutaneous Nephrolithotomy Significantly Reduces Upper Tract Infection and Urosepsis: A Prospective Controlled Study显示文摘 | Sanand Bag Santosh Kumar Neelam Taneja Varun Sharma Arup K. Mandal Shrawan K. Singh | 2011 | Urology2011，，1： | 1 |
| 15 | Purification of an isoform of patatin with antimicrobial activity against Phytophthora infestans 显示文摘 | Neelam Sharma Hope A Gruszewski | 2004 | Plant Physiology and Biochemistry2004，42，： | 1 |
| 16 | Corrosion resistant behaviour of DLC films显示文摘 | Rishi Sharma P.K. Barhai Neelam Kumari | 2007 | Thin Solid Films2007，，16： | 1 |
| 17 | Early Results of Core Decompression and Autologous Bone Marrow Mononuclear Cells Instillation in Femoral Head Osteonecrosis显示文摘 | Ramesh Kumar Sen Sujit Kumar Tripathy Sameer Aggarwal Neelam Marwaha Ratti Ram Sharma Niranjan Khandelwal | 2012 | The Journal of Arthroplasty2012，，5： | 1 |
| 18 | Performance Enhancement of Adaptive Neural Networks Based on Learning Rate显示文摘Deep learning is the process of determining parameters that reduce the cost function derived from the dataset.The optimization in neural networks at the time is known as the optimal parameters.To solve optimization,it initialize the parameters during the optimization process.There should be no variation in the cost function parameters at the global minimum.The momentum technique is a parameters optimization approach;however,it has difficulties stopping the parameter when the cost function value fulfills the global minimum(non-stop problem).Moreover,existing approaches use techniques;the learning rate is reduced during the iteration period.These techniques are monotonically reducing at a steady rate over time;our goal is to make the learning rate parameters.We present a method for determining the best parameters that adjust the learning rate in response to the cost function value.As a result,after the cost function has been optimized,the process of the rate Schedule is complete.This approach is shown to ensure convergence to the optimal parameters.This indicates that our strategy minimizes the cost function(or effective learning).The momentum approach is used in the proposed method.To solve the Momentum approach non-stop problem,we use the cost function of the parameter in our proposed method.As a result,this learning technique reduces the quantity of the parameter due to the impact of the cost function parameter.To verify that the learning works to test the strategy,we employed proof of convergence and empirical tests using current methods and the results are obtained using Python. | Swaleha Zubair Anjani Kumar Singha Nitish Pathak Neelam Sharma Shabana Urooj Samia Rabeh Larguech | 2023 | Computers, Materials & Continua2023，，1： | 0 |
| 19 | Clinical pregnancy rate of women with unexplained infertility with or without cervical mucus aspiration before intrauterine insemination: A randomized controlled trial显示文摘Objective:To detect effect of removing cervical mucus before performing intrauterine insemination(IUI)on pregnancy rate in patients with unexplained infertility.Methods:The randomized controlled trial was conducted in Infertility Division of Department of Obstetrics and Gynaecology of a tertiary care hospital.Totally 80 patients of unexplained infertility were recruited.By computer generated block randomization in block size of 4 and 6,patients were randomly allocated at time of starting ovarian stimulation into the cervical mucus removal group or the non-removal of cervical mucus group before IUI,40 in each group.Ovarian stimulation with clomiphene 100 mg from day 2-6 of menstrual cycle along with human menopausal gonadotropin 150 IU was given alternate day starting from day 7.Follicular monitoring was done and further doses given as per response;trigger was planned when 1-3 follicle reach a diameter of>18 mm.IUI was planned after trigger.IUI was done as per the group allocated.Mucus cleaning was done in the cervical mucus removal group by aspirating mucus with IUI syringe and sterile cotton swab before IUI.The primary outcome was clinical pregnancy rate.Number of difficult IUIs and cycle cancellation due to ovarian hyperstimulation were also noted.Results:IUI was not done in 4 patients due to hyperstimulation.Pregnancies per IUI cycle occurred in 7.9%(3/38)in the cervical mucus removal group and 21.1%(8/38)in the non-removal of cervical mucus group.There was no statistically significant difference in clinical pregnancy rate between two groups(P=0.19).Conclusions:There is a trend towards a lower clinical pregnancy rate with removal of cervical mucus before IUI in women of unexplained infertility though the difference is not statistically significant.Further studies with large sample size need to be done on this intervention. | Richa Vatsa Vanita Suri Shalini Gainder Aashima Arora Japleen Kaur Neelam Choudhary Shruti Sharma | 2022 | Asian pacific Journal of Reproduction2022，11，6： | 0 |
| 20 | Design of ANN Based Non-Linear Network Using Interconnection of Parallel Processor显示文摘Suspicious mass traffic constantly evolves,making network behaviour tracing and structure more complex.Neural networks yield promising results by considering a sufficient number of processing elements with strong interconnections between them.They offer efficient computational Hopfield neural networks models and optimization constraints used by undergoing a good amount of parallelism to yield optimal results.Artificial neural network(ANN)offers optimal solutions in classifying and clustering the various reels of data,and the results obtained purely depend on identifying a problem.In this research work,the design of optimized applications is presented in an organized manner.In addition,this research work examines theoretical approaches to achieving optimized results using ANN.It mainly focuses on designing rules.The optimizing design approach of neural networks analyzes the internal process of the neural networks.Practices in developing the network are based on the interconnections among the hidden nodes and their learning parameters.The methodology is proven best for nonlinear resource allocation problems with a suitable design and complex issues.The ANN proposed here considers more or less 46k nodes hidden inside 49 million connections employed on full-fledged parallel processors.The proposed ANN offered optimal results in real-world application problems,and the results were obtained using MATLAB. | Anjani Kumar Singha Swaleha Zubair Areej Malibari Nitish Pathak Shabana Urooj Neelam Sharma | 2023 | Computer Systems Science & Engineering2023，46，9： | 0 |
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