|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Function-preserving gastrectomy for gastric cancer in Japan显示文摘Surgery used to be the only therapy for gastric cancer, and since its ability to cure gastric cancer was the focus of attention, less attention was paid to functionpreserving surgery in gastric cancer, though it was studied for gastroduodenal ulcer. Maki et al developed pylorus-preserving gastrectomy for gastric ulcer in 1967. At the same time, the definition of early gastric cancer(EGC) was being considered, histopathological investigations of EGC were carried out, and the validity of modified surgery was sustained. After the development of H2-blockers, the number of operations for gastroduodenal ulcers decreased, and the number of EGC patients increased simultaneously. As a result, the indications for pylorus-preserving gastrectomy for EGC in the middle third of the stomach extended, and various alterations were added. Since then, many kinds of function-preserving gastrectomies have been performed and studied in other fields of gastric cancer, and proximal gastrectomy, jejunal pouch interposition, segmental gastrectomy, and local resection have been performed. On the other hand, from the overall perspective, it can be said that endoscopic resection, which was launched at almost the same time, is the ultimate function-preserving surgery under the current circumstances. The current function-preserving gastrectomies that are often performed and studied are pylorus-preserving gastrectomy and proximal gastrectomy. The reasons for this are that these procedures that can be performed with systemic lymph node dissection, and they include three important elements:(1) reduction of the extent of gastrectomy;(2) preservation of the pylorus; and(3) preservation of the vagal nerve. In addition, these operations are more likely to be performed with a laparoscopic approach as minimally invasive surgery. Of the above-mentioned three elements, reduction of the extent of gastrectomy is the most important in our view. Therefore, we should try to reduce the extent of gastrectomy if curability of the gastric cancer can still be achieved. However, if we preserve a wider residual stomach in functionpreserving gastrectomy, we should pay attention to the development of metachronous gastric cancer. | Eiji Nomura Kunio Okajima | 2016 | World Journal of Gastroenterology2016，22，26： | 23 |
| 2 | Liquid biopsy in patients with hepatocellular carcinoma: Circulating tumor cells and cell-free nucleic acids显示文摘Hepatocellular carcinoma(HCC), with its high incidence and mortality rate, is one of the most common malignant tumors. Despite recent development of a diagnostic and treatment method, the prognosis of HCC remains poor. Therefore, to provide optimal treatment for each patient with HCC, more precise and effective biomarkers are urgently needed which could facilitate a more detailed individualized decision-making during HCC treatment, including the following; risk assessment, early cancer detection, prediction of treatment or prognostic outcome. In the blood of cancer patients, accumulating evidence about circulating tumor cells and cell-free nucleic acids has suggested their potent clinical utilities as novel biomarker. This concept, so-called 'liquid biopsy' is widely known as an alternative approach to cancer tissue biopsy. This method might facilitate a more sensitive diagnosis and better decision-making by obtaining genetic and epigenetic aberrations that are closely associated with cancer initiation and progression. In this article, we review recent developments based on the available literature on both circulating tumor cells and cell-free nucleic acids in cancer patients, especially focusing on Hepatocellular carcinoma. | wataru okajima shuhei komatsu daisuke ichikawa mahito miyamae takuma ohashi taisuke imamura jun kiuchi keiji nishibeppu tomohiro arita hirotaka konishi atsushi shiozaki ryo morimura hisashi ikoma kazuma okamoto eigo otsuji | 2017 | World Journal of Gastroenterology2017，23，31： | 22 |
| 3 | Liquid biopsy in patients with pancreatic cancer: Circulating tumor cells and cell-free nucleic acids显示文摘Despite recent advances in surgical techniques and perioperative management, the prognosis of pancreatic cancer(PCa) remains extremely poor. To provide optimal treatment for each patient with Pca, superior biomarkers are urgently needed in all phases of management from early detection to staging, treatment monitoring, and prognosis. In the blood of patients with cancer, circulating tumor cells(CTCs) and cell-free nucleic acids(cf NAs), such as DNA, m RNA, and noncoding RNA have been recognized. In the recent years, their presence in the blood has encouraged researchers to investigate their potential use as novel blood biomarkers, and numerous studies have demonstrated their potential clinical utility as a biomarker for certain types of cancer. This concept, called 'liquid biopsy' has been focused on as a less invasive, alternative approach to cancer tissue biopsy for obtaining genetic and epigenetic aberrations that contribute to oncogenesis and cancer progression. In this article, we review the available literature on CTCs and cfN As in patients with cancer, particularly focusing on PCa, and discuss future perspectives in this field. | Taisuke Imamura Shuhei Komatsu Daisuke Ichikawa Tsutomu Kawaguchi Mahito Miyamae Wataru Okajima Takuma Ohashi Tomohiro Arita Hirotaka Konishi Atsushi Shiozaki Ryo Morimura Hisashi Ikoma Kazuma Okamoto Eigo Otsuji | 2016 | World Journal of Gastroenterology2016，22，25： | 10 |
| 4 | Antithrombin reduces reperfusion-induced hepatic metastasis of colon cancer cells显示文摘瞄准:检验是否反凝血酵素(在) 能阻止导致的肝的 ischemia/reperfusion (I/R ) 由禁止肿瘤的肝的转移在老鼠的 E-selectin 的坏死因素(TNF )-alpha-induced 表示。方法:肝的 I/R 被夹钳门静脉和肝的动脉的左分支在老鼠和老鼠导致。癌症房间 intrasplenically 被注射。变形小瘤的数字被依靠在 I/R 以后的白天 7。在肝的织物,浆液纤维蛋白原降级产品和肝的织物的 TNF-alpha 和 E-selectin mRNA 6-keto-PGF (1alpha ) 铺平, PGI2 的稳定的代谢物,被测量。结果:在肿瘤房间的肝的转移和在受到肝的 I/R 的动物的 TNF-alpha 和 E-selectin 的肝的织物 mRNA 层次的禁止的增加。Argatroban,一个凝血酵素禁止者,没压制任何这些变化。在并且 argatroban 禁止了 I/R-induced 凝结畸形。6-keto-PGF (1alpha ) 的肝的织物层次的 I/R-induced 增加显著地被提高由在。有消炎痛的预告的处理完全颠倒了效果在。OP-2507 的管理,稳定的 PGI2 类似于那些的模拟、显示出的效果在在这个模型。在受到肝的 I/R 的先天的在缺乏的老鼠的肝的转移显著地与在野类型的老鼠观察了那相比被增加。管理在显著地在先天的在缺乏的老鼠减少了肝的转移的数字。结论:在由通过 PGI2 的内皮生产的增加禁止 E-selectin 的 TNF-alpha-induced 表示的结肠癌房间的力量还原剂 I/R-induced 肝的转移。这些调查结果也提起可能性如果在肝肿瘤的切除术期间管理了,在力量阻止肿瘤房间的肝的转移。 | Masanao Kurata Kenji Okajima Toru Kawamoto Mitsuhiro Uchiba Nobuhiro Ohkohchi | 2006 | World Journal of Gastroenterology2006，12，1： | 8 |
| 5 | Photothermal therapy of tumors in lymph nodes using gold nanorods and near-infrared laser light with controlled surface cooling显示文摘Photothermal 治疗(PTT ) 用在红外线附近(NIR ) 激光光和金 nanorods (GNR ) 作为一种新奇癌症治疗形式显示出诺言。然而,要求破坏肿瘤房间的激光紧张在皮肤下面定位了比阀值紧张大那原因皮肤损坏;因此,有激光光的照耀损坏皮肤以及肿瘤。这里,我们证明一个温度控制系统允许变形淋巴节点(行) 被 PTT 用 NIR 激光光和 GNR 对待,没有皮肤损坏。行转移的一个老鼠模型被肿瘤房间的注射开发,并且忍受肿瘤的合适的腋的行在 GNR 的注射以后与 NIR 激光光被对待。皮肤温度在 45 点被维持。潮湿转移能力索引(h D A/P ) 最大因为 30essure (BP ) ,心率(HR ) 和官方补给的症状在 270min 上被估计。 | Tessai Sugiura Daisuke Matsuki Junnosuke Okajima Atsuki Komiya Shiro Mori Shigenao Maruyama Tetsuya Kodama | 2015 | Nano Research2015，8，12： | 5 |
| 6 | Role of sphingosine 1-phosphate in anti-atherogenic actions of high-density lipoprotein显示文摘The reverse cholesterol transport mediated by highdensity lipoprotein(HDL)is an important mechanism for maintaining body cholesterol,and hence,the crucial anti-atherogenic action of the lipoprotein.Recent studies,however,have shown that HDL exerts a variety of anti-inflammatory and anti-atherogenic actions independently of cholesterol metabolism.The present review provides an overview of the roles of sphingosine 1-phosphate(S1P)/S1P receptor and apolipoprotein A-I/ scavenger receptor class B typeⅠsystems in the antiatherogenic HDL actions.In addition,the physiological significance of the existence of S1P in the HDL particles is discussed. | Koichi Sato Fumikazu Okajima | 2010 | World Journal of Biological Chemistry2010，1，11： | 4 |
| 7 | Monomorphic epitheliotropic intestinal T-cell lymphoma presenting as melena with long-term survival: A case report and review of literature显示文摘BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is a rare primary intestinal T-cell lymphoma,previously known as enteropathy-associated T-cell lymphoma type II.MEITL is an aggressive T-cell lymphoma with a poor prognosis and high mortality rate.The known major complications of MEITL are intestinal perforation and obstruction.Here,we present a case of MEITL that was diagnosed following upper gastrointestinal bleeding from an ulcerative duodenal lesion,with recurrence-free survival for 5 years.CASE SUMMARY A 68-year-old female was admitted to our hospital with melena and mild anemia.An urgent esophagogastroduodenoscopy(EGD)revealed bleeding from an ulcerative lesion in the transverse part of the duodenum,for which hemostatic treatment was performed.MEITL was diagnosed following repeated biopsies of the lesion,and cyclophosphamide,doxorubicin,vincristine,and prednisone(CHOP)chemotherapy was administered.She achieved complete remission after eight full cycles of CHOP therapy.At the last follow-up examination,EGD revealed a scarred ulcer and 18Fluorodeoxyglucose(18FDG)positron emission tomography/computed tomography showed no abnormal FDG accumulation.The patient has been in complete remission for 68 mo after initial diagnosis.CONCLUSION To rule out MEITL,it is important to carefully perform histological examination when bleeding from a duodenal ulcer is observed. | Sotaro Ozaka Kunimitsu Inoue Tomoya Okajima Takako Tasaki Shimpei Ariki Hideki Ono Takeaki Ando Tsutomu Daa Kazunari Murakami | 2021 | World Journal of Gastroenterology2021，27，38： | 3 |
| 8 | 三菱重工地面燃气轮机热障涂层研究进展显示文摘燃气轮机联合循环热效率的提高,要求涡轮进口温度不断增加。目前,三菱重工(MHI)已经积极参与日本国家项目,通过发展1700℃级燃气轮机,以使联合循环热效率实现达到62%指标。在此国家项目中开发的部分组件技术适用于1600℃级燃气轮机M501J,它具有世界上最高的涡轮进口温度。而热障涂层(TBC)是实现此目标的最关键技术之一。在发展先进的热障涂层中,在MHI工厂中建立名为T点的试验电厂是有必要的。在真实热部件中制备的先进TBC可以在工厂中进行验证,并且运行后的效果可以得到反馈。本文讨论了TBC的开发以及在三菱重工实际电厂中的验证。 | Yoshifumi Okajima Daisuke Kudo Naotoshi Okaya Taiji Torigoe Hideaki Kaneko Masahiko Mega Eisaku Ito Junichiro Masada Keizo Tsukagoshi 吴琼 | 2014 | 热喷涂技术2014，，3： | 2 |
| 9 | How transplant surgeons can overcome the inevitable insufficiency of allograft size during adult living‐donor liver transplantation: strategy for donor safety with a smaller‐size graft and excellent recipient results显示文摘 | Tomohide Hori Yasuhiro Ogura Kohei Ogawa Toshimi Kaido Hajime Segawa Hideaki Okajima Takayuki Kogure Shinji Uemoto | 2012 | Clin Transplant2012，，3： | 2 |
| 10 | Increase in sphingolipid catabolic enzyme activity during aging显示文摘 | Santosh J SACKET Hae-young CHUNG Fumikazu OKAJIMA Dong-soon IM | 2009 | Acta Pharmacologica Sinica2009，30，10： | 2 |
| 11 | Extracellular O-linked β-N-acetylglucosamine: Its biology and relationship to human disease显示文摘The O-linked β-N-acetylglucosamine(O-GlcNAc)ylation of cytoplasmic and nuclear proteins regulates basic cellular functions and is involved in the etiology of neurodegeneration and diabetes. Intracellular O-GlcNAcylation is catalyzed by a single O-GlcNAc transferase, O-GlcNAc transferase(OGT). Recently, an atypical O-GlcNAc transferase, extracellular O-linked β-N-acetylglucosamine(EOGT), which is responsible for the modification of extracellular O-GlcNAc, was identified. Although both OGT and EOGT are regulated through the common hexosamine biosynthesis pathway, EOGT localizes to the lumen of the endoplasmic reticulum and transfers GlcNAc to epidermal growth factor-like domains in an OGT-independent manner. In Drosophila, loss of Eogt gives phenotypes similar to those caused by defects in the apical extracellular matrix. Dumpy, a membrane-anchored apical extracellular matrix protein, was identified as a major O-GlcNAcylated protein, and EOGT mediates Dumpy-dependent cell adhesion. In mammals, extracellular O-GlcNAc was detected on extracellular proteins including heparan sulfate proteoglycan 2, Nell1, laminin subunit alpha-5, Pamr1, and transmembrane proteins, including Notch receptors. Although the physiological function of O-GlcNAc in mammals has not yet been elucidated, exome sequencing identified homozygous EOGT mutations in patients with Adams-Oliver syndrome, a rare congenital disorder characterized by aplasia cutis congenita and terminal transverse limb defects. This review summarizes the current knowledge of extracellular O-GlcNAc and its implications in the pathological processes in Adams-Oliver syndrome. | Mitsutaka Ogawa Koichi Furukawa Tetsuya Okajima | 2014 | World Journal of Biological Chemistry2014，5，2： | 2 |
| 12 | Landiolol, an ultra-short-acting β1-blocker, is useful for managing supraventricular tachyarrhythmias in sepsis显示文摘AIM: To investigate whether landiolol, an ultra-shortacting β1-antagonist, can safely and effectively control heart rate in septic patients with supraventricular tachyarrhythmias.METHODS: We reviewed all patients with sepsis who admitted to our intensive care unit between January 2006 and December 2011. Sixty one septic patients suffered from supraventricular tachyarrhythmias(heart rate ≥ 120 bpm for > 1 h). Among 61 patients, 39 patients were treated with landiolol(landiolol group) and 22 patients were not treated with landiolol(control group). Arterial pressure, heart rate, cardiac rhythm, pulmonary arterial pressure and cardiac output(if a pulmonary arterial catheter was inserted) were compared between the 2 groups at 1, 8 and 24 h after the initiation of tachyarrhythmias. RESULTS: Mean age and Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores were similar between the 2 groups. Paroxysmal atrial fibrillation/flutter(87%), paroxysmal atrial tachycardia(10%), and paroxysmal supraventricular tachycardia(3%) were observed. The initial landiolol dose administered was 6.3 ± 5.8 g/kg per minute. Rapid and substantial reduction of heart rate was observed in the landiolol group without anydeterioration of hemodynamics. Landiolol significantly reduced heart rate(from 145 ± 14 bpm to 90 ± 20 bpm) compared to the control group(from 136 ± 21 bpm to 109 ± 18 bpm, P < 0.05). The conversion to sinus rhythm was observed more frequently in the landiolol group than in the control group at every point(P < 0.01 at 8 h; P < 0.05 at 1 and 24 h).CONCLUSION: Landiolol safely reduced heart rate and, in part, converted to sinus rhythm in septic patients with supraventricular tachyarrhythmias. | Masaki Okajima Masayuki Takamura Takumi Taniguchi | 2015 | World Journal of Critical Care Medicine2015，4，3： | 2 |
| 13 | Effect of Left Colonic Artery Preservation on Anastomotic Leakage in Laparoscopic Anterior Resection for Middle and Low Rectal Cancer显示文摘 | Takao Hinoi Masazumi Okajima Manabu Shimomura Hiroyuki Egi Hideki Ohdan Fumio Konishi Kenichi Sugihara Masahiko Watanabe | 2013 | World Journal of Surgery2013，，12： | 2 |
| 14 | Penetration of 6061-T651 Aluminum Targets with Rigid Long Rods显示文摘 | FORRESTAL M J OKAJIMA K LUK V K | 1988 | Trans ASME J Appl Mech1988，55，： | 1 |
| 15 | Gabexate mesilate,a synthetic protease inhibitor,inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappaB and activatorprotein-1 in humanmon-ocytes显示文摘 | Yuksel M Okajima K UchibaM | 2003 | J Pharmacol Exp Ther2003，305，1： | 1 |
| 16 | In- terphotoreceptor retinoid-binding protein promotes rhodopsin regeneration in toad photoreceptors 显示文摘 | Okajima TIL Pepperberg DR Ripps H Wiggert B Chader GJ | 1990 | Proc Natl Acad Sci USA1990，87，36： | 1 |
| 17 | Measurements of differential capacitance in room temperature ionic liquid at mercury, glassy carbon and gold electrode interfaces 显示文摘 | Alam M T Islam M M Okajima T | 2007 | Electrochem Commun2007，9，9： | 1 |
| 18 | Activated protein C inhibits lipopolysaccharide -induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor - kappa B and activator protein- 1 in human monocytes显示文摘 | Yuksel M Okajima K Uchiba M | 2002 | Thromb Haemost2002，88，2： | 1 |
| 19 | Immunization with anti-idiotype monoclonal antibodies bearing the internal image of the renal-cell carcinoma-associated antigen G250 induces specific cellular immune responses显示文摘 | Uemura H Okajima E Debruyne F | 1994 | Int J Cancer1994，59，6： | 1 |
| 20 | Clinical evaluation of lymph node metastasis in gastric cancer defined by the fifth edition of the TNM classification in comparison with the Japanese system 显示文摘 | Fujii K Isozaki H Okajima E | 1999 | Br J Surg1999，86，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员