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| 1 | Risk factors for intraoperative perforation during endoscopic submucosal dissection of superficial esophageal squamous cell carcinoma显示文摘AIM To identify the risk factors and clarify the subsequent clinical courses.METHODS This study retrospectively analyzed consecutive patients with esophageal squamous cell carcinoma( ESCC) treated using endoscopic submucosal dissection(ESD) between April 2008 and October 2012. We divided the ESCC lesions into perforation cases and non-perforation cases, and compared characteristics and endoscopic findings between the two groups. 'Intraoperative perforation' was defined as the detection of a perforation site during ESD and the presence of mediastinal emphysema.RESULTS In total, 147 patients with 156 ESCC lesions were treated by ESD. Intraoperative perforation was recorded for nine lesions(5.8%) from nine patients. Multivariate analysis identified mucosal deficiency larger than 75% of the circumference of the esophagus as an independent risk factor for intraoperative perforation(OR = 7.37, 95%CI: 1.45-37.4, P = 0.016). The predominant site of perforation was the left wall [6/9(67%)]. Six of nine perforation sites were successfully closed by clips during the procedures. Two of nine cases required drainage for pleural effusions; however, all nine cases recovered with conservative treatment and without surgical intervention. At the median follow up of 42 mo after ESD, no cases of local recurrence or distant organ metastasis had been observed.CONCLUSION This study suggests that mucosal deficiency larger than 75% of the luminal circumference is a risk factor for intraoperative perforation during ESD for ESCC. | Masaaki Noguchi Tomonori Yano Tomoji Kato Tomohiro Kadota Maomi Imajoh Hiroyuki Morimoto Shozo Osera Atsushi Yagishita Tomoyuki Odagaki Yusuke Yoda Yasuhiro Oono Hiroaki Ikematsu Kazuhiro Kaneko | 2017 | World Journal of Gastroenterology2017，23，3： | 12 |
| 2 | Cytoprotective response induced by electromagnetic stimulation on SH-SY5Y human neuroblastoma cell line显示文摘 | Osera C Fassina L Amadio M Venturini L Buoso E Magenes G | 2011 | Tissue Eng Part A2011，17，： | 1 |
| 3 | Protein kinase C activation affects, via the mRNA-binding Hu-antigen R/ELAV protein, vas- cular endothelial growth factor expression in a pericytic/endothe- lial coculture model显示文摘 | Amadio M Osera C Lupo G | 2012 | Mol Vis2012，18，： | 1 |
| 4 | Pentraxins and Al-zheimer^s disease : at the interface between biomarkers andpharmacological targets显示文摘 | Osera C Pascale A Amadio M | 2012 | Ageing Res Rev2012，11，2： | 1 |
| 5 | Clinicopathological, endoscopic, and molecular characteristics of the 'skirt'-a new entity of lesions at the margin of laterally spreading tumors显示文摘 | Osera S Fujii S Ikematsu H | 2016 | Endoscopy2016，48，05： | 1 |
| 6 | Autophagy Is Modulated in Human Neuroblastoma Cells Through Direct Exposition to Low Frequency Electromagnetic Fields显示文摘 | Nicoletta Marchesi Cecilia Osera Lorenzo Fassina Marialaura Amadio Francesca Angeletti Martina Morini Giovanni Magenes Letizia Venturini Marco Biggiogera Giovanni Ricevuti Stefano Govoni Salvatore Caorsi Alessia Pascale Sergio Comincini | 2014 | J. Cell. Physiol2014，，11： | 1 |
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