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| 1 | Characteristic pathological findings and effects of ecabet sodium in rat reflux esophagitis显示文摘AIM:To explore the pathological flndings in the entire esophagus in rats with reflux esophagitis, and the effects of ecabet sodium(ES).METHODS:A rat model of chronic acid reflux esophagitis was used.In the treatment group, ES was administered after surgery(n = 16).No drug was administered postoperatively to the esophagitis group(n = 9).Shamoperated rats were used as a control group(n = 5).Rats were sacriflced on day 7 after the operation.The epithelial thickness and leukocyte inflltration were examined in the upper, middle and lower areas of the esophagus.The survival rate, incidence of esophageal ulcer, and mean surface area and number of esophageal ulcers were determined in the esophagitis and ES groups.Esophageal histology was assessed in all three groups.RESULTS:Leukocyte infiltration in the esophagitis group was 26.3 ± 22.0 in the middle esophagus and 8.2 ± 4.9 in the upper esophagus, which was signiflcantly greater than that in the controls(1.3 ± 1.1 and 1.4 ± 1.0, respectively)(P < 0.05).The thickness of the epithelium in the esophagitis group was 210.8 ± 47.7 μm in the lower esophagus and 204.2 ± 60.1 μm in the middle esophagus, which was significantlygreater than that in the controls(26.0 ± 5.5 and 21.0 ± 6.5 μm, respectively)(P < 0.05).The mean number of ulcers per animal in the ES group in the entire esophagus was 5.4 ± 2.5, which was signiflcantly less than that in the esophagitis group(9.0 ± 3.5)(P < 0.05).The epithelial thickness in the ES group was 97.5 ± 32.2 μm in the lower esophagus, which was decreased compared with that in the esophagitis group(210.8 ± 47.7 μm)(P < 0.05).CONCLUSION:Mucosal inflammation extended to the upper esophagus close to the hypopharynx.Our study suggested that ES may have a useful defensive role in reflux esophagitis. | Daisuke Asaoka Akihito Nagahara Masako Oguro Yuko Izumi Akihiko Kurosawa Taro Osada Masato Kawabe Mariko Hojo Michiro Otaka Sumio Watanabe | 2009 | World Journal of Gastroenterology2009，15，28： | 2 |
| 2 | Overexpression of a 60-kDa heat shock protein enhances cytoprotective function of small intestinal epithelial cells显示文摘 | Makiko Takada Michiro Otaka Taiji Takahashi Yuko Izumi Kumiko Tamaki Tomoyoshi Shibuya Naoto Sakamoto Taro Osada Sou Yamamoto Ryuichi Ishida Masaru Odashima Hideaki Itoh Sumio Watanabe | 2010 | Life Sciences2010，，13： | 2 |
| 3 | Study on option pricing in an incomplete market with stochastic volatility based on risk premium analysis 显示文摘 | Masaaki Otaka | 2003 | Mathematical and Computer Modelling2003，38，： | 1 |
| 4 | Selective isolation ofnanog-positive human amniotic mesenchymal cells and dif-ferentiation into cardiomyocytes 显示文摘 | Otaka S Nagura S Koike C | 2013 | Cell Reprogram2013，15，： | 1 |
| 5 | Effect of additive on phase transition of N-isopropylacrylamide gels 显示文摘 | Inomata H Goto S Otaka K | 1992 | Langmuir1992，8，： | 1 |
| 6 | Soy protein reduces paraquat-induced oxidative stress in rats 显示文摘 | Aoki H Otaka Y lgarashi K | 2002 | J Nutr2002，132，8： | 1 |
| 7 | Determination of bisphenol A and 4-nonylphenol in human milk using alkaline digestion and clean up by solid phase extraction 显示文摘 | Otaka H Yasuhara A Morita M | 2003 | Ana Science2003，19，35： | 1 |
| 8 | Numerical simulation of coal gasification in entrained flow coal gasifier显示文摘 | H. Watanabe M. Otaka | 2006 | Fuel2006，，12： | 1 |
| 9 | A low-power low-noise accurate linear-in-dB variable- gain amplifier with 500 MHz bandwidth显示文摘 | Shoji Otaka Gaku Takemura Hiroshi Tanimoto | 2000 | IEEE J Solid-state Circuit2000，35，12： | 1 |
| 10 | Effects of bipolar electro- eoa'uation ,ersus suture after lparoscopic excision of o,arian endom- etrioma on the ovarian reserve and outcome of in vitro fertilization 显示文摘 | Takashima A Takeshita N Otaka K | 2013 | J Obstet Gynaecol Res2013，39，7： | 1 |
| 11 | Expression of a 72-kDa heat shock protein,and its cytoprotective function,in gastric mucosa in cirrhotic rats显示文摘 | Watanabe D Otaka M Mikami K | 2004 | J Gastroenterol2004，39，8： | 1 |
| 12 | Single session of transcranial direct current stimulation transiently in- creases knee extensor force in patients with hemiparetic stroke显示文摘 | Tanaka S Takeda K Otaka Y | 2011 | Neurorehabil Neural Repair2011，25，6： | 1 |
| 13 | Remodeling of gp41 C34 pepfide leads to highly effective inhibitors of the fusion of HIV-1 with targe cells显示文摘 | OTAKA A NALAMUR M NAMEKI D | 2002 | Angew Chem Int Ed Engl2002，41，16： | 1 |
| 14 | Gastric small cell carcinoma with marked response to neoadjuvant chemotherapy显示文摘 | Yasuhiro Nakamura Setsuya Otani Michiro Otaka Tomoyuki Shimada Satsuki Takahashi Masahiro Saito Tohru Takahashi Masahumi Komatsu Toshie Suzuki Shunji Okubo Masato Hayashi Hironobu Sasano | 2005 | International Journal of Clinical Oncology2005，，5： | 1 |
| 15 | MEK activation suppresses CPT11 -induced apoptosis in rat intestinal epithelial cells through a COX - 2 - dependent mechanism 显示文摘 | Horikawa Y Otaka M Komatsu K | 2007 | Dig Dis Sci2007，52，10： | 1 |
| 16 | Effect of alcohol consumption on leptin level in serum, adipose tissue, and gastric mueosa 显示文摘 | Otaka M Konishi N Odashima M | 2007 | Dig Dis Sci2007，52，11： | 1 |
| 17 | Fire resistance characteristics of materials with polymer gels which absorb aqueous solution of calcium chloride显示文摘 | Asako Y Otaka T Yamaguehi Y | 2004 | Numerical Heat Trans fer: Part A2004，45，： | 1 |
| 18 | Surgically induced necrotizing seleritis after primary pterygium surgery with eonjuncti- val autograft显示文摘 | Yamazoe K Shimazaki-Den S Otaka I | 2011 | Clin Ophthalmol2011，5，： | 1 |
| 19 | Synthesis of potent beta-secretase inhibitors containing a hydroxyethylamine dipeptide isostere and their structure-activity relationship studies显示文摘 | Tamamura H Kato T Otaka A | 2003 | Org Biomol Chem2003，1，14： | 1 |
| 20 | Effects of bipolar electrocoagulation versus suture after laparoscopic excision of ovarian endometrioma on the ovarian reserve and outcome of in vitro fertilization显示文摘 | Takashima A Takeshita N Otaka K | 2013 | Obstet Gynaecol Res2013，39，： | 1 |
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