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| 1 | Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms显示文摘AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC. | Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 3 |
| 2 | Antiviral activity of ribosome-inactivating proteins in medicine显示文摘 | Parikh B A Tumer N E | 2004 | Mini Rev Med Chem2004，4，5： | 1 |
| 3 | Radiofre- quency ablation of hepatic metastases显示文摘 | Parikh A A Curley S A Fomage B D | 2002 | Semin Oncol2002，29，2： | 1 |
| 4 | Influence of intermittent pneumatic compression devices on non-invasive blood pressure measurement of the ankle 显示文摘 | Parikh B R Simon A M Kouvaras J N | 2007 | Journal of Clinical Monitoring and Momputing2007，21，6： | 1 |
| 5 | Hal ux valgus interphalangeus deformity:A case series in the pediatric population显示文摘 | Grawe B Parikh S Crawford A | | 0，，01： | 1 |
| 6 | Adaptive decision support systems显示文摘 | Fazlollahi B Parikh M A Verma S | 1997 | Decision Support Systems1997，20，4： | 1 |
| 7 | Pokeweed antivi- ral protein regulates the stability of its own mRNA by a mechanism that requires depurination but can be separa- ted from depurination of the alpha-sarcinp ricin loop of rRNA显示文摘 | Parikh B A Coetzer C Turner N E | 2002 | The Journal of Biological Chemistry2002，277，41： | 1 |
| 8 | PknB-mediated phosphorylation of a novel substrate,Nacetylglucosamine-1-phosphate uridyltransferase,modulates its acetyltransferase activity显示文摘 | Parikh A Verma SK Khan S Prakash B Nandicoori VK | 2009 | J Mol Biol2009，386，2： | 1 |
| 9 | Antiviral activity of ribosome inactivating proteins in medicine 显示文摘 | Parikh B A Tumer N E | 2004 | Mini Rev Med Chem2004，4，5： | 1 |
| 10 | Synthesis and biological evalution of pyridopyrimidine and isoxazoline derivatives显示文摘 | Merja B C Joshi A M Parikh K A | 2004 | Indian J Chem(Section B)2004，，4： | 1 |
| 11 | Generation of poke- weed antiviral protein mutations in Saccharomyces cerevi- siae: Evidence that ribosome depurination is not suffi- cient for cytotoxicity 显示文摘 | Hudak K A Parikh B A Di R | 2004 | Nucleic Acids Research2004，32，14： | 1 |
| 12 | Student feedback in problem based learning: a survey of 103 final year students across five Ontario medical schools显示文摘 | Parikh A McReelis K Hodges B | 2001 | Med Educ2001，35，7： | 1 |
| 13 | Rhodium nanoparticles intercalated into montmorillonitefor hydrogenation of aromatic compounds in the presenceof thiophene 显示文摘 | SIDHPURIA K B PATEL H A PARIKH P A | 2009 | Applied Clay Science2009，42，3： | 1 |
| 14 | Should all distal pancreatectomies be performed laparo- scopically?显示文摘 | MERCHANT N B PARIKH A A KOOBY D A | 2009 | Adv Surg2009，43，1： | 1 |
| 15 | An update on growth and development of telemedicine with pharmacological im- plications显示文摘 | PARIKH D P SATTIGERI B M KUMAR A | 2014 | Int J Med Sei Public Health2014，3，5： | 1 |
| 16 | Fatty acid methyl ester production from acid oil using silica sulfuric acid: Process optimization and reaction kinetics显示文摘 | SHAH K A PARIKH J K DHOLAKIYA B Z MAHERIA K C | 2014 | Chemical Papers2014，68，4： | 1 |
| 17 | Student feedback in problem based learning: a survey of 103 final year students across five Ontario medical schools 显示文摘 | PARIKH A MCREELIS K HODGES B | 2001 | Med Edue2001，35，7： | 1 |
| 18 | Detailed phenotypic and molecular analyses of genetically modified mice generated by CRISPR-Cas9-mediated editing显示文摘 | Parikh B A Beckman D L Patel S J | 2015 | PLoS One2015，10，01： | 1 |
| 19 | Rhodium supported Hβ zeolite for the hydrogenation of toluene显示文摘 | Sidhpuria K B Parikh P A Bahadur P | 2008 | Ind Eng Chem Res2008，47，： | 1 |
| 20 | An update on growth and development of telemedicine with pharmacological im- plications显示文摘 | PARIKH D P SATTIGERI B M KUMAR A | 2014 | Int J Med Sci Public Health2014，3，5： | 1 |
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