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| 1 | Radioembolisation and portal vein embolization before resection of large hepatocellular carcinoma显示文摘Resectability of hepatocellular carcinoma in patients with chronic liver disease is dramatically limited by the need to preserve sufficient remnant liver in order to avoid postoperative liver insufficiency. Preoperative treatments aimed at downsizing the tumor and promoting hypertrophy of the future remnant liver may improve resectability and reduce operative morbidity. Here we report the case of a patient with a large hepatocellular carcinoma arising from chronic liver disease. Preoperative treatment, including tumor downsizing with transarterial radioembolization and induction of future remnant liver hypertrophy with right portal vein embolization, resulted in a 53% reduction in tumor volume and compensatory hypertrophy in the contralateral liver. The patient subsequently underwent extended right hepatectomy with no postoperativesigns of liver decompensation. Pathological examination demonstrated a margin-free resection and major tumor response. This new therapeutic sequence, combining efficient tumor targeting and subsequent portal vein embolization, could improve the feasibility and safety of major liver resection for hepatocellular carcinoma in patients with liver injury. | Fikri Bouazza Arthur Poncelet Camilo Alejandro Garcia Philippe Delatte Jean Luc Engelhom Maria Gomez Galdon Amélie Deleporte Alain Hendlisz Bruno Vanderlinden Patrick Flamen Vincent Donckier | 2015 | World Journal of Gastroenterology2015，21，32： | 2 |
| 2 | Dose–response relationships within the parotid gland after radiotherapy for head and neck cancer显示文摘 | Barbara Bussels Annelies Maes Patrick Flamen Philippe Lambin Katrien Erven Robert Hermans Sandra Nuyts Caroline Weltens Silvia Cecere Emmanuel Lesaffre Walter Van den Bogaert | 2004 | Radiotherapy and Oncology2004，，： | 1 |
| 3 | 18FDG PET in oncology: The best and the worst (Review)显示文摘 | Tarik Belhocine Karoline Spaepen Michelle Dusart Catherine Castaigne Kristof Muylle Pierre Bourgeois Daniel Bourgeois Lawrence Dierickx Patrick Flamen | 2006 | International Journal of Oncology2006，，5： | 1 |
| 4 | Is there a role for FGD-PET in radiotherapy planning in esophageal carcinoma?显示文摘 | Olga Vrieze Karin Haustermans Walter De Wever Toni Lerut Eric Van Cutsem Nadine Ectors Martin Hiele Patrick Flamen | 2004 | Radiotherapy and Oncology2004，，3： | 1 |
| 5 | Preservation of parotid function with uncomplicated conformal radiotherapy显示文摘 | Annelies Mases Carline Weltens Patrick Flamen | 2002 | Radiother Oncol2002，63，： | 1 |
| 6 | High-volume versus standard-volume haemofiltration for septic shock patients with acute kidney injury (IVOIRE study): a multicentre randomized controlled trial显示文摘 | Olivier Joannes-Boyau Patrick M. Honoré Paul Perez Sean M. Bagshaw Hubert Grand Jean-Luc Canivet Antoine Dewitte Claire Flamens Wilfried Pujol Anne-Sophie Grandoulier Catherine Fleureau Rita Jacobs Christophe Broux Hervé Floch Olivier Branchard Stephane F | 2013 | Intensive Care Medicine2013，，9： | 1 |
| 7 | Preservation of parotid function with uncomplicated conformal radiotherapy显示文摘 | Annelies Mases Caroline Weltens Patrick Flamen et cd | 2002 | adiother Oncol2002，63，： | 1 |
| 8 | Inducing Resectability of Chemotherapy Refractory Colorectal Liver Metastasis by Radioembolization With Yttrium-90 Microspheres显示文摘 | Marc Van den Eynde Patrick Flamen Issam El Nakadi Gabriel Liberale Philippe Delatte Denis Larsimont Alain Hendlisz | 2008 | Clinical Nuclear Medicine2008，，： | 1 |
| 9 | Sequential tumor-directed and lobar radioembolization before major hepatectomy for hepatocellular carcinoma显示文摘Preoperative radioembolization may improve the resectability of liver tumor by inducing tumor shrinkage, atrophy of the embolized liver and compensatory hypertrophy of non-embolized liver. We describe the case of a cirrhotic Child-Pugh A patient with a segment Ⅳ hepatocellular carcinoma requiring a left hepatectomy. Preoperative angiography demonstrated 2 separated left hepatic arteries, for segment Ⅳ and segments Ⅱ-Ⅲ. This anatomic variant allowed sequential radioembolizations, delivering high-dose ^(90)Yttrium(160 Gy) to the tumor, followed 28 d later by lower dose(120 Gy) to segments Ⅱ-Ⅲ. After 3 mo, significant tumor response and atrophy of the future resected liver were obtained, allowing uneventful left hepatectomy. This case illustrates that, when anatomic disposition permits it, sequential radioembolizations, delivering different ^(90)Yttrium doses to the tumor and the future resected liver, could represent a new strategy to prepare major hepatectomy in cirrhotic patients, allowing optimal tumoricidal effect while reducing the toxicity of the global procedure. | Michael Vouche Thierry Degrez Fikri Bouazza Philippe Delatte Maria Gomez Galdon Alain Hendlisz Patrick Flamen Vincent Donckier | 2017 | World Journal of Hepatology2017，9，36： | 0 |
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