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| 1 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 2 | The PCA3 test for guiding repeat biopsy of prostate cancer and its cut-off score: a systematic review and meta-analysis显示文摘为在重复活体检视的早干预的前列腺特定的抗原(PSA ) 的特性是不能令人满意的。(PCA3 ) 前列腺癌症抗原 3 可能比为前列腺癌症(PCa ) 的早察觉的另外的方法在结果预言是更精确的。然而,结果在重复活体检视是不一致的。因此,我们执行了系统的评论和元分析在结果预言评估 PCA3 的角色。系统的文献的搜索为在 2013 年 4 月前出版的文章被进行,用从健康技术评价机构的 PubMed, Medline,科学的网, Embase 和另外的数据库。研究的质量根据 QUADAS 标准被估计。诊断测试与的十一研究对高质量中等被选择。元分析被执行综合结果。元分析的结果在研究之中是异构的。我们执行了亚群分析(与或没有高级 prostatic intraepithelial 瘤形成(HGPIN ) 和不正常的小 acinar 增长的包括(尽快)) 。用 20 或 35 的 PCA3 截止,在二亚群,全球敏感价值是 0.93 或 0.80 和 0.79 或 0.75 ,特性是 0.65 或 0.44 和 0.78 或 0.70 ,积极可能性的比率是 1.86 或 1.58 和 2.49 或 1.78 ,否定可能性的比率是 0.81 或 0.43 和 0.91 或 0.82 ,诊断奇怪的比率( ORs )分别地是 5.73 或 3.45 和 7.13 或 4.11 。在操作典型曲线的概括接收装置的曲线(AUC ) 下面的区域分别地是 0.85 或 0.72 和 0.81 或 0.69。PCA3 能被用于前列腺的重复活体检视改进 PCa 察觉的精确性。不必要的活体检视能被使用 20 的一个 PCa 截止分数避免。 | Yong Luo Xin Gou Peng Huang Chan Mou | 2014 | Asian Journal of Andrology2014，16，3： | 13 |
| 3 | Dapper1 promotes autophagy by enhancing the Beclinl -Vps34-Atg14L complex formation显示文摘 | Benvu Ma Weipeng Cao Wenxia Li Chan Gao Zhen Qi Yan Zhao Jun Du Hua Xue Junya Peng Jun Wen Hua Chen Yuanheng Ning Lei Huang Hong Zhang Xiang Gao Li Yu Ye-Guang Chen | 2014 | Cell Research2014，24，8： | 12 |
| 4 | Estimation and Projection of the HIV Epidemic Trend among the Migrant Population in China显示文摘Objective The migrant population is a vulnerable group for HIV infection in China.Understanding potential epidemic trends among migrants is critical for developing HIV preventative measures in this population.Methods The Estimation and Projection Package (EPP) model was used to process prefecture and county-level surveillance data to generate HIV prevalence and epidemic trends for migrant populations in China.Results The prevalence of HIV among migrants in 2009 was estimated at 0.075% (95% CI:0.042%,0.108%) in China.The HIV epidemic among migrants is likely to increase over the next 5 years,with the prevalence expected to reach 0.110% (95% CI:0.070%,0.150%) by 2015.Conclusion Although the 2009 estimates for the HIV/AIDS epidemic in China indicate a slower rate of increase compared with the national HIV/AIDS epidemic,it is estimated to persistently increase among migrants over the next 5 years.Migrants will have a strong impact on the overall future of the HIV epidemic trend in China and evidence-based prevention and monitoring efforts should be expanded for this vulnerable population. | MENGXiaoJun WANG Lu Susan CHAN Kathleen Heather REILLY PENG ZhiHang GUO Wei DING GuoWei DING ZhengWei QIN QianQian | 2011 | Biomedical and Environmental Sciences2011，24，4： | 8 |
| 5 | Adsorptive hemofiltration for sepsis management: expert recommendations based on the Asia Pacific experience显示文摘To the Editor:In sepsis,bacterial endotoxins play a central role by inducing a dysregulated and exaggerated release of inflammatory mediators and cytokines,often described as the“cytokine storm”or“cytokinemia.”[1]Both endotoxins and cytokines have been implicated in the development of organ dysfunction,including acute kidney injury(AKI).[2]Removing circulating endotoxins and excess cytokines from the circulation restores chemotactic gradients,localizing the immune response to the principal site of infection and re-establishing a regulated immune response.[1,3]Therefore,using hemofilters with enhanced endotoxin and cytokine adsorptive properties may bring about additional therapeutic benefits compared with conventional continuous renal replacement therapy(CRRT)filters. | Ling Zhang Matthew Cove Binh G.Nguyen Nuttha Lumlertgul Kartik Ganesh Alfred Chan Giang T.H.Bui Chunwen Guo Junhua Li Songqiao Liu Mian Peng Kit W.Foong Jian Zhang Minmin Wang Jacques Goldstein Kai Harenski | 2021 | Chinese Medical Journal2021，，18： | 6 |
| 6 | Analytical and experimental bearing capacities of system scaffolds显示文摘We investigated the structural behavior and bearing capacity of system scaffolds.The research showed that the critical load of a system scaffold structure without diagonal braces is similar to that of a door-shaped steel scaffold structure.Joint stiffness between vertical props in system scaffolds can be defined based on a comparison between analytical and experimental results.When the number of scaffold stories increases,the critical loads of system scaffolds decrease.Diagonal braces markedly enhance the critical load of system scaffolds.The coupling joint position between vertical props should be kept away from story-to-story joints to prevent a reduction in critical loads.The critical load of a system scaffold decreases as the quantity of extended vertical props at the bottom of the structure increases.A large Christmas tree set up by system scaffolds under various loads was used as an example for analysis and to check the design of system scaffolds. | Jui-lin PENG Tsong YEN Ching-chi KUO Siu-lai CHAN | 2009 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2009，10，1： | 6 |
| 7 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 8 | Moisture Origins and Transport Processes for the 2020 Yangtze River Valley Record-Breaking Mei-yu Rainfall显示文摘The summer of 2020 recorded a record-breaking flood due to excessive mei-yu rain falling over the Yangtze River Valley(YRV).Using the Lagrangian model FLEXPART,this paper investigates moisture sources and transport processes behind this extreme event.Based on climate data from 1979 to 2019,the air-particle(an infinitesimally small air parcel)trajectories reaching the YRV show sectors that correspond to five main moisture sources:the Indian monsoon region(IND,27.5%of the total rainfall),the local evaporation(27.4%),the Western Pacific Ocean(WPO,21.3%),the Eurasian continent(8.5%)and Northeast Asia(4.4%).In the 2020 mei-yu season,moisture from all source regions was above normal except that from Northeast Asia.A record-breaking moisture source from the IND and WPO dominated this extreme mei-yu flood in 2020,which was 1.5 and 1.6 times greater than the climate mean,respectively.This study reveals a significant relationship between the moisture source with three moisture transport processes,i.e.,trajectory density,moisture content,and moisture uptake of air-particles.A broad anomalous anticyclonic circulation over the Indo-Northwestern Pacific(Indo-NWP)provides a favorable environment to enhance the moisture transport from the IND and WPO into the YRV.In the 2020 mei-yu season,a record-breaking Indo-NWP anomalous anticyclonic circulation contributed to a higher trajectory density as well as higher moisture content and moisture uptake of air-particles from the IND and WPO regions.This collectively resulted in unprecedented moisture transport from source origins,thus contributing to the mei-yu flood over the YRV in 2020. | Lixia ZHANG Dan ZHAO Tianjun ZHOU Dongdong PENG Chan XIAO | 2021 | Advances in Atmospheric Sciences2021，38，12： | 4 |
| 9 | Trending IC design directions in 2022显示文摘For the non-stop demands for a better and smarter society, the number of electronic devices keeps increasing exponentially;and the computation power, communication data rate, smart sensing capability and intelligence are always not enough. Hardware supports software, while the integrated circuit(IC) is the core of hardware. In this long review paper, we summarize and discuss recent trending IC design directions and challenges, and try to give the readers big/cool pictures on each selected small/hot topics. We divide the trends into the following six categories, namely, 1) machine learning and artificial intelligence(AI) chips, 2) communication ICs, 3) data converters, 4) power converters, 5) imagers and range sensors, 6) emerging directions. Hope you find this paper useful for your future research and works. | Chi-Hang Chan Lin Cheng Wei Deng Peng Feng Li Geng Mo Huang Haikun Jia Lu Jie Ka-Meng Lei Xihao Liu Xun Liu Yongpan Liu Yan Lu Kaiming Nie Dongfang Pan Nan Qi Sai-Weng Sin Nan Sun Wenyu Sun Jiangtao Xu Jinshan Yue Milin Zhang Zhao Zhang | 2022 | Journal of Semiconductors2022，43，7： | 3 |
| 10 | Chinese herbal medicine for chronic heart failure:a multicenter,randomized,double-blind,placebo-controlled trial显示文摘Objective:The purpose of this study was to assess the efficacy and safety of Chinese herbal medicine(CHM)in the treatment of chronic heart failure(CHF)patients according to syndrome differentiation.Methods:In this multicenter,randomized,double-blind,placebo-controlled clinical trial,a total of 220 CHF patients were assigned to receive CHM or placebo granules without decoction according to syndrome differentiation in addition to their standard western treatment for 4 weeks.The change in the left ventricular ejection fraction(LVEF)was the primary outcome,and the changes in the TCM syndrome scores(TCM-SS)and New York Heart Association functional classification(NYHA-FC)were the secondary outcomes. | Liangtao Luo Juan Wang Aiqing Han Peng Zhang Shuzhen Guo Chan Chen Xuegong Xu Qian Lin Huihui Zhao Wei Wang | 2014 | Journal of Traditional Chinese Medical Sciences2014，1，2： | 3 |
| 11 | A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration显示文摘The osteogenic microenvironment of bone-repairing materials plays a key role in accelerating bone regeneration but remains incompletely defined,which significantly limits the application of such bioactive materials.Here,the transcriptional landscapes of different osteogenic microenvironments,including three-dimensional(3D)hydroxyapatite(HA)scaffolds and osteogenic medium(OM),for mesenchymal stromal cells(MSCs)in vitro were mapped at single-cell resolution.Our findings suggested that an osteogenic process reminiscent of endochondral ossification occurred in HA scaffolds through sequential activation of osteogenic-related signaling pathways,along with inflammation and angiogenesis,but inhibition of adipogenesis and fibrosis.Moreover,we revealed the mechanism during OM-mediated osteogenesis involves the ZBTB16 and WNT signaling pathways.Heterogeneity of MSCs was also demonstrated.In vitro ossification of LRRC75A+MSCs was shown to have better utilization of WNT-related ossification process,and PCDH10+MSCs with superiority in hydroxyapatite-related osteogenic process.These findings provided further understanding of the cellular activity modulated by OM conditions and HA scaffolds,providing new insights for the improvement of osteogenic biomaterials.This atlas provides a blueprint for research on MSC heterogeneity and the osteogenic microenvironment of HA scaffolds and a database reference for the application of bioactive materials for bone regeneration. | Peng Guo Xizhe Liu Penghui Zhang Zhongyuan He Zhen Li Mauro Alini RGeoff Richards Sibylle Grad Martin J.Stoddart Guangqian Zhou Xuenong Zou Danny Chan Wei Tian Dafu Chen Manman Gao Zhiyu Zhou Shaoyu Liu | 2022 | Bioactive Materials2022，7，3： | 3 |
| 12 | Self-assembly of Au/MoS_(2) quantum dots core-satellite hybrid as efficient electrocatalyst for hydrogen production显示文摘Ultra-small MoS_(2) quantum dots(QDs)with an average size of 2.48 nm coated on Au nanoparticles with a core-satellite structure(Au/MoS_(2) QDs)are successfully prepared by a self-assembly strategy through the strong bonding between Au and S.Benefited from the unique structure,the Au/MoS_(2) QDs hybrid exhibits outstanding electrocatalytic performance toward hydrogen evolution reaction(HER).The Au/MoS_(2) QDs hybrid needs overpotentials of 112,146,and 206 mV to approach current densities of 10,20,and 50 mA·cm^(−2) in 0.5 mol·L^(−1) H_(2)SO_(4)(pH=0.3),respectively.And a low Tafel slope(83 mV·dec^(−1))is obtained.The catalyst also displays satisfactory stability and durability,indicating a negligible current density loss after 20 h of electrolysis.The high hydrogen generation activities and stability are attributed to the great number of active sites,high conductivity and synergistic effects between gold nanoparticles(Au NPs)and MoS_(2) QDs.Last but not least,this strategy opens up a favorable way to combine MoS_(2) QDs with other metals. | Xue‑Ping Yu Chan Yang Pin Song Juan Peng | 2020 | Tungsten2020，2，2： | 3 |
| 13 | Hydrogel-based flexible materials for diabetes diagnosis,treatment,and management显示文摘Diabetes is a chronic metabolic disease characterized by high glucose concentration in blood.Conventional management of diabetes requires skin pricking and subcutaneous injection,causing physical pain and physiological issues to diabetic individuals.Hydrogels possess unique advantages such as lightweight,stretchability,biocompatibility,and biodegradability,offering the opportunities to be integrated as flexible devices for diabetes management.This review highlights the development of hydrogels as flexible materials for diabetes applications in glucose monitoring,insulin delivery,wound care,and cell transplantation in recent years.Challenges and prospects in the development of hydrogel-based flexible devices for personalized management of diabetes are discussed as well. | Jiang Song Yanni Zhang Siew Yin Chan Zhaoyi Du Yinjia Yan Tengjiao Wang Peng Li Wei Huang | 2021 | npj Flexible Electronics2021，5，1： | 2 |
| 14 | A spatialized digital database for all bird species in China显示文摘The lack of refined spatial detail on bird distribution in China has hindered further research due to the large geographic unit(provincial level) in existing national bird distribution data. Based on multi-source bird distribution data, we built a more spatially detailed distribution database for every bird species(1,371 species) in China, covering 2,908 counties. The sources on bird distribution are grouped into six categories: Handbooks, Literature; Fauna, Avifauna; Paper; Citizen Science data by ornithologists or birders; GPS tracing; and Website data. The database contains the following records: taxonomy, distribution data, suspicious species information, and data sources. Our database recorded 835 species(61%) appearing outside the distribution range previously known. The use of provincial boundaries as the smallest geographical unit has created misleading distribution results due to geographic aggregation for most species. The new database was built based on increased observational frequency and individuals observed in previously undetected areas particularly in Western China and towards higher altitudes and latitudes. They coincided with the discovery of the range expansion of some waterfowls into Xinjiang. The dataset provides a new base for Chinese and international ornithology studies, especially for those requiring more detailed distribution information for many taxa and large-scale regional research. | Shuang Dai Duole Feng Karen Kie Yan Chan Peng Gong Bing Xu | 2019 | Science China(Life Sciences)2019，62，5： | 2 |
| 15 | Serum from Acute-on-chronic Liver Failure Patients May Affect Mesenchymal Stem Cells Transplantation by Impairing the Immunosuppressive Function of Cells显示文摘Background and Aims:The safety and efficacy of mesenchymal stem cells(MSCs)in the treatment of acute-onchronic liver failure(ACLF)have been validated.However,the impact of the pathological ACLF microenvironment on MSCs is less well understood.This study was designed to explore the changes in the functional properties of MSCs exposed to ACLF serum.Methods:MSCs were cultured in the presence of 10%,30%and 50%serum concentrations from ACLF patients and healthy volunteers.Then,the cell morphology,phenotype,apoptosis and proliferation of MSCs were evaluated,including the immunosuppressive effects.Subsequently,mRNA sequencing analysis was used to identify the molecules and pathways involved in MSC functional changes in the context of ACLF.Results:In the presence of ACLF serum,MSC morphology significantly changed but phenotype did not.Besides,MSC proliferation activity was weakened,while the apoptosis rate was lightly increased.Most importantly,the immunosuppressive function of MSCs was enhanced in a lowconcentration serum environment but transformed into a proinflammatory response in a high-concentration serum environment.RNA sequencing indicated that 10%serum concentration from ACLF patients mediated the PI3K-Akt pathway to enhance the anti-inflammatory effect of MSCs,while the 50%serum concentration from ACLF patients promoted the conversion of MSCs into a proinflammatory function by affecting the cell cycle.Conclusions:The 50%ACLF serum concentration is more similar to the environment in the human body,which means that direct peripheral blood intravenous infusion of MSCs may reduce the effect of transplantation.Combining treatments of plasma exchange to reduce harmful substances in serum may promote MSCs to exert a stronger anti-inflammatory effect. | Yongyuan Zheng Shu Zhu Xingrong Zheng Wenxiong Xu Xuejun Li Jianguo Li Zhiliang Gao Chan Xie Liang Peng | 2021 | Journal of Clinical and Translational Hepatology2021，9，4： | 2 |
| 16 | Antifungal and antiviral products of marine organisms显示文摘 | Randy Chi Fai Cheung Jack Ho Wong Wen Liang Pan Yau Sang Chan Cui Ming Yin Xiu Li Dan He Xiang Wang Evandro Fei Fang Sze Kwan Lam Patrick Hung Kui Ngai Li Xin Xia Fang Liu Xiu Yun Ye Guo Qing Zhang Qing Hong Liu Ou Sha Peng Lin Chan Ki Adnan A Bekhit Alaa | 2014 | Applied Microbiology and Biotechnology2014，，8： | 2 |
| 17 | Implications of anti-parietal cell antibodies and anti-Helicobacter pylori antibodies in histological gastritis and patient outcome显示文摘AIM: To develop a serum or histological marker for early discovery of gastric atrophy or intestinal metaplasia. METHODS: This study enrolled 44 patients with gastric adenocarcinoma, 52 patients with duodenal ulcer, 14 patients with gastric ulcer and 42 consecutive healthy adults as controls. Each patient received an endoscopy and five biopsy samples were obtained. The degrees of histological parameters of gastritis were categorized following the Updated Sydney System. Anti-parietal cell antibodies (APCA) and anti-Helicobacter pylori (H pylori) antibodies (AHPA) were analyzed by immunoassays. H pylori infection was diagnosed by rapid urease test and histological examination. RESULTS: Patients with gastric cancer and gastric ulcer are significantly older than healthy subjects, while also displaying higher frequency of APCA than healthy controls. Patients with positive APCA showed higher scores in gastric atrophy and intestinal metaplasia of corpus than patients with negative APCA. Patients with positive AHPA had higher scores in gastric atrophy, intestinal metaplasia, and gastric inflammation of antrum than those patients with negative AHPA. Elderly patients had greater prevalence rates of APCA. Following multivariant logistic regression analysis, the only significant risk factor for antral atrophy is positive AHPA, while that for corpus atrophy is positive APCA. CONCLUSION: The existence of positive APCA correlates with glandular atrophy in corpus and the presence of positive AHPA correlates with glandular atrophy in antrum. The existence of serum APCA and AHPA betokens glandular atrophy and requires further examination for gastric cancer. | Ching-Chu Lo Ping-I Hsu Gin-Ho Lo Kwok-Hung Lai Hui-Hwa Tseng Chiun-Ku Lin Hoi-Hung Chan Wei-Lun Tsai Wen-Chi Chen Nan-Jing Peng | 2005 | World Journal of Gastroenterology2005，11，30： | 2 |
| 18 | FTIR Spectroscopy in Cultural Heritage Studies: Non-destructive Analysis of Chinese Handmade Papers显示文摘Chinese handmade papers have been the carriers of paper-based documents, paintings and calligraphies, which are of great importance for historical and cultural heritage studies. This research developed the attenuated total reflectance-Fourier transform infrared(ATR-FTIR) spectroscopic technique for the analysis of Chinese handmade papers. The test was applied to Chinese handmade papers taken from bark, hemp and bamboo groups, followed by papers from ancient books and arts collected in library and museum. Our study indicated tliat FTIR was an efficient analytical method to identify fiber types of library/museum papers of unknown origin. Moreover, information about degree of crystallinity and state of deterioration of cellulosic fibers was learned from FTIR spectra. This research provides a non-destnictive method to study the molecular structure of cellulosic fibers, and guides tlie selection of appropriate Chinese handmade papers for the restoration of cultural heritage objects. | YAN Yueer WEN Chenqing JIN Ming DUAN Lian ZHANG Ruohong LUO Chan XIAO Jianfang YE Zhaoqi GAO Boxu LIU Peng TANG Yi | 2019 | Chemical Research in Chinese Universities2019，35，4： | 2 |
| 19 | Imbalance of interleukin‐17‐producing CD 4 T cells/regulatory T cells axis occurs in remission stage of patients with hepatitis B virus‐related acute‐on‐chronic liver failure显示文摘 | Geng‐Lin Zhang Dong‐Ying Xie Bing‐Liang Lin Chan Xie Yi‐Nong Ye Liang Peng Shao‐Quan Zhang Yu‐Feng Zhang Qing Lai Jian‐Yun Zhu Ying Zhang Yang‐Su Huang Zhao‐Xia Hu Zhi‐Liang Gao | 2013 | J Gastroenterol Hepatol2013，，3： | 2 |
| 20 | Two hydroxypyruvate reductases encoded by OsHPR1 and OsHPR2 are involved in photorespiratory metabolism in rice显示文摘Mutations in the photorespiration pathway display a lethal phenotype in atmospheric air,which can be fully recovered by elevated CO2.An exception is that mutants of peroxisomal hydroxypyruvate reductase(HPR1)do not have this phenotype,indicating the presence of cytosolic bypass in the photorespiration pathway.In this study,we constructed overexpression of the OsHPR1 gene and RNA interference plants of OsHPR1 and OsHPR2 genes in rice(Oryza sativa L.cv.Zhonghua 11).Results from reverse transcription-polymerase chain reaction(RT-PCR),Western blot,and enzyme assays showed that HPR1 activity changed significantly in corresponding transgenic lines without any effect on HPR2 activity,which is the same for HPR2.However,metabolite analysis and the serine glyoxylate aminotransferase(SGAT)activity assay showed that the metabolitefiux of photorespiration was disturbed in RNAi lines of both HPR genes.Furthermore,HPR1 and HPR2proteins were located to the peroxisome and cytosol,respectively,by transient expression experiment.Double Research mutant hpr1 hpr2 was generated by crossing individual mutant of hpr1 and hpr2.The phenotypes of all transgenic lines were determined in ambient air and CO2-elevated air.The phenotype typical of photorespiration mutants was observed only where activity of both HPR1 and HPR2 were downregulated in the same line.Thesefindings demonstrate that two hydroxypyruvate reductases encoded by OsHPR1and OsHPR2 are involved in photorespiratory metabolism in rice. | Nenghui Ye Guozhen Yang Yan Chen Chan Zhang Jianhua Zhang Xinxiang Peng | 2014 | Journal of Integrative Plant Biology2014，56，2： | 2 |
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