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| 1 | Biomarkers in sepsis at time zero:intensive care unit scores,plasma measurements and polymorphisms in Argentina显示文摘 | Perés Wingeyer SD Cunto ER Nogueras CM | | 0，，： | 1 |
| 2 | Inability of HDL from abdominally obese subjects to counteract the inhibitory effect of oxidized LDL on vasorelaxation显示文摘 | Perségol L Vergès B Gambert P | | 0，，： | 1 |
| 3 | A note on thereasonableness of PERT hypotheses显示文摘 | Pleguezuelo R H Peréz J G Rambaud S C | 2003 | Operations ResearchLetters2003，31，1： | 1 |
| 4 | Pit-and trench-forming osteoclasts:a distinction that matters显示文摘Osteoclasts(OCs)seeded on bone slices either drill round pits or dig long trenches.Whereas pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption apparatus.It is unknown whether the distinction between pits and trenches has any biological relevance.Using OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench formation.Trench formation went along with high collagenolytic activity and high cathepsin K(CatK)expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of pits.OCs obtained from bone marrow were more prone to generate trenches than those obtained from blood.Scanning electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in culture.We conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic power.This indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption. | Ditte MH Merrild Dinisha C Pirapaharan Christina M Andreasen Per Kjxrsgaard-Andersen Anas MJ Mùller Ming Ding Jean-Marie Delaissé Kent Sùe | 2015 | Bone Research2015，3，4： | 2 |
| 5 | Decreasing Time-Trends of Colorectal Cancer in a Large Cohort of Patients With Inflammatory Bowel Disease显示文摘 | Sverre S?derlund Lena Brandt Annika Lapidus Per Karlén Olle Brostr?m Robert L?fberg Anders Ekbom Johan Askling | 2009 | Gastroenterology2009，，5： | 1 |
| 6 | Human cardiac tissue induces transdifferentiation of adult stem cells towards cardiomyocytes显示文摘 | Macarena Perán Juan A. Marchal Elena López Manuel Jiménez-Navarro Houria Boulaiz Fernando Rodríguez-Serrano Esmeralda Carrillo Gema Sánchez-Espin Eduardo de Teresa David Tosh Antonia Aranega | 2010 | Cytotherapy2010，，3： | 1 |
| 7 | Major Depressive Disorder in recovery and neuropsychological functioning: Effects of selective serotonin reuptake inhibitor and dual inhibitor depression treatments on residual cognitive deficits in patients with Major Depressive Disorder in recovery显示文摘 | Ixchel Herrera-Guzmán Esteve Gudayol-Ferré Jorge E. Herrera-Abarca Daniel Herrera-Guzmán Pedro Montelongo-Pedraza Ferran Padrós Blázquez Maribel Peró-Cebollero Joan Guàrdia-Olmos | 2009 | Journal of Affective Disorders2009，，： | 1 |
| 8 | Decreasing Time-Trends of Colorectal Cancer in a Large Cohort of Patients With Inflammatory Bowel Disease显示文摘 | Sverre S?derlund Lena Brandt Annika Lapidus Per Karlén Olle Brostr?m Robert L?fberg Anders Ekbom Johan Askling | 2009 | Gastroenterology2009，，5： | 1 |
| 9 | Structural parameters effect on the electrical and electroluminescence properties of silicon nanocrystals/SiO2 superlattices显示文摘 | J López-Vidrier Y Berencén S Hernández B Mundet S Gutsch J Laube D Hiller P L?per M Schnabel S Janz M Zacharias B Garrido | 2015 | Nanotechnology2015，，： | 1 |
| 10 | Decreasing Time-Trends of Colorectal Cancer in a Large Cohort of Patients With Inflammatory Bowel Disease显示文摘 | Sverre S?derlund Lena Brandt Annika Lapidus Per Karlén Olle Brostr?m Robert L?fberg Anders Ekbom Johan Askling | 2009 | Gastroenterology2009，，5： | 1 |
| 11 | MULTIPLE SCLEROSIS AFTER HEPATITIS B VACCINATION IN A 16-YEAR-OLD PATIENT显示文摘 | DANIELLA TERNEY SáNDOR BENICZKY PéTER BARSI ISTVáN KONDáKOR JóZSEF PERéNYI BéLA FALUDI MAGDOLNA SZAPPER LáSZLó VéCSEI | 2006 | Chinese Medical Journal2006，，1： | 0 |
| 12 | The animal cachexia score(ACASCO)显示文摘Background:None of the published studies involving cancer cachexia experimental models have included a measure of the severity of the syndrome like the scoring system previously developed for human subjects.The aim of the present investigation was to define and validate a cachexia score usable in both rat and mouse tumor models.Methods:In order to achieve this goal,we included in the study one rat model(Yoshida AH‐130ascites hepatoma)and two mouse models(Lewis lung carcinoma and Colon26 carcinoma).The Animal cachexia score(ACASCO)includes five components:(a)body and muscle weight loss,(b)inflammation and metabolic disturbances,(c)physical performance,(d)anorexia,and(e)quality of life measured using discomfort symptoms and behavioral tests.Results:Using the ACASCO values,three cut‐off values were estimated by applying hierarchical cluster analysis.Four groups were originally described,one exactly below the observed mean,a second exactly over the mean,and two other groups adjusted to every cue(inferior and superior).The three cut‐off values were estimated through maximization of the classification function.This was accomplished by using a similarity matrix based on the metric properties of the variables and assuming multinormal distribution.The results show that the four groups were:no cachexia,mild cachexia,moderate cachexia and advanced cachexia.Conclusions:The results obtained allow us to conclude that the score could be very useful as an endpoint in pre‐clinical studies involving therapeutic strategies for cancer cachexia.The potential usefulness of ACASCO relates to the primary endpoint in pre‐clinical cancer cachexia drug evaluations. | Angelica Betancourt Sílvia Busquets Marta Ponce Míriam Toledo Joan Guàrdia‐Olmos Maribel Peró‐Cebollero Francisco J.López‐Soriano Josep M.Argilés | 2019 | Animal Models and Experimental Medicine2019，2，3： | 0 |
| 13 | Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF‐A and TGFβ2 in vascular abnormalization显示文摘 | Lothar C Dieterich Sofie Mellberg Elise Langenkamp Lei Zhang Agata Zieba Henriikka Salom?ki Martin Teichert Hua Huang Per‐Henrik Edqvist Theo Kraus Hellmut G Augustin Tommie Olofsson Erik Larsson Ola S?derberg Grietje Molema Fredrik Pontén Patrik Georgii‐ | 2012 | J. Pathol2012，，3： | 1 |
| 14 | Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target显示文摘 | Baryawno Ninib Rahbar Afsar Wolmer-Solberg Nina Taher Chato Odeberg Jenny Darabi Anna Khan Zahidul Sveinbj?rnsson Baldur Fuskev?g O-M Segerstr?m Lova Nordenskj?ld Magnus Siesj? Peter Kogner Per Johnsen John Inge S?derberg-Nauclér Cecilia | 2011 | Journal of Clinical Investigation2011，，10： | 1 |
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