2篇
您的检索式：作者名="Peter M.Andrews"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intravital imaging of adriamycin-induced renal pathology using two-photon microscopy and optical coherence tomography显示文摘Adriamycin(doxorubicin),a common cancer chemotherapeutic drug,can be used to induce a model of chronic progressive glomerular disease in rodents.In our studies,we evahuated renal changes in a rat model after Adriamydin injection using two photon microscopy(TPM),optical coherence tomography(OCT)and Doppler OCT(DOCT).Taking advantage of deep penetra-tion and fast scanning speed for three dimensional(3D)label-free imaging,OCT/DOCT system was able to reveal glomerular and tubular pathology noninvasively and in real time.By imaging renal pathology following the infusion of fAuorophore-labeled dextrans of different molecular weights,TPM can provide direct views of glomerular and tubular flow dynamics with the onset and progression of renal disease.Specifically,glomerular permeability and filtration,proximal and distal tubular flow dynamics can be revealed.6-8 weeks after injection of Adriamycin,TPM and OCT/DOCT imaging revealed glomerular sclerosis,compromised flow across the glomerular wall,tubular atrophy,tubular dilation,and variable intra-tubular flow dynamics.Our results indicate that TPM and OCT/DOCT provide real-time imaging of renal pathology in vivo that has not been previously available using conventional microscopic procedures. | Hengchang Guo Hsing-Wen Wang Qinggong Tang Erik Anderson Reuben Falola Tikina Smith Yi Liu Moshe Levi Peter M.Andrews Yu Chen | 2018 | Journal of Innovative Optical Health Sciences2018，，5： | 0 |
| 2 | Optical coherence tomography of the living human kidney显示文摘Acute tubular necrosis(ATN)induced by ischemia is the most common insult to donor kidneysdestined for trarsplantation.ATN results from sweling and subsequent damage to cells lining thelkidney tubules.In this study,we demonstrate the capability of optical coherence tomography(OcT)to image the renal microst ructures of living human donor kidneys and potentially providea measure to det ermine the extent of A TN.We also found that Doppler-based OCT(i.e.,DOCT)reveals renal blood flow dynamics that is another major factor which could relate to post-transplant renal finction.All OCT/DoCT oberva tions were performed in a noninvasive,sterileand timely manner on intact human kidneys both prior to(er vivo)and following(in vivo)theirtransplantation.Our results indicate that this imaging model provides transplant surgeons withan objective visualization of the transplant lidneys prior and immediately post transplantation. | Peter M.Andrews Hsing-Wen Wang Jeremiah Wierwlle Wei Gong Jennifer Verbesey Matthew Cooper Yu Chen | 2014 | Journal of Innovative Optical Health Sciences2014，7，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员