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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Computed tomography of urinary calculi显示文摘 | Daniel CA Peter KV Raymond DB | 2005 | Contemp Diagn Radiol2005，28，6： | 1 |
| 3 | Pediatric robot-assisted pyeloplasty显示文摘 | Peters CA | | 0，，02： | 1 |
| 4 | Apolipoprotein E structure insights into function 显示文摘 | Hatters DM Peters - Libeu CA Weisgraber KH | 2006 | Trend Biochem Sci2006，31，8： | 1 |
| 5 | Percutaneous nephro- lithotomy in infants and preschool age children: experience with a new technique显示文摘 | Jackman SV Hedican SP Peters CA | 1998 | Urology1998，52，4： | 1 |
| 6 | Pediatric laparo- seopic dismembered pyeloplasty显示文摘 | PETERS CA SCHLUSSEL RN RETIK AB | 1995 | J Urol1995，153，6： | 1 |
| 7 | Percuaneuos nephro-lithotomy in infants and preschool age children:experience with anew technique显示文摘 | Jackman SV Hedican SP Peters CA | 1998 | Urology1998，52，4： | 1 |
| 8 | lumbar fusion with and without pedicle screw显示文摘 | Peter D Angevine CA Dickman PC | 2007 | Spine2007，32，13： | 1 |
| 9 | Dynamic visual acuity during walking after long-duration spaceflight显示文摘 | Peters BT Miller CA Brady RA | 2011 | Aviat Space Environ Med2011，82，4： | 1 |
| 10 | Tubularized incised plate urethroplasty: expanded use in primary and repeat surgery for hypospadias 显示文摘 | Borer JG Bauer SB Peters CA | 2001 | J Urol2001，165，2： | 1 |
| 11 | Lumbar fusion with and without pedicle screw fixation显示文摘 | Peter D Angevine CA Dickman PC | 2007 | Spine2007，13，： | 1 |
| 12 | Percutaneous nephrolithotomy in infants and preschool age children:experience with a new technique显示文摘 | Jackman SV Hedican SP Peters CA | 1998 | Urology1998，52，4： | 1 |
| 13 | Percutaneuos nephrolithotomy in infants and preschool age children:experience with a new technique显示文摘 | Hedican SP Peters CA | 1998 | Urology1998，52，4： | 1 |
| 14 | Pneumoperitoneum produces reversible renal dysfuction in animals with normal and chronically reduced renal function显示文摘 | Cisek LJ Gobet RM Peter CA | 1998 | J Endourol1998，12，： | 1 |
| 15 | Evaluation of two methods for monitoring surface cleanliness-ATP bioluminescence and traditional hygiene swabbing显示文摘 | Davidson CA Griffith CJ Peters AC | 1999 | Luminescence1999，14，1： | 1 |
| 16 | Amiodarone induced epidid- ymitis in children显示文摘 | Hutcheson J Peters CA Diamond DA | 1998 | J Urol1998，160，： | 1 |
| 17 | Lumbar fu- sion with and without pedicle screw fixation显示文摘 | PETER D ANGEVINE CA DICKMAN PC | 2007 | Spine2007，32，13： | 1 |
| 18 | Lumbar fusion with and without pedicle screw fixation 显示文摘 | Peter D Angevine CA Dickman PC | 2007 | Spine2007，13，： | 1 |
| 19 | Pneumoperitoneum produces reversible renal dysfunction in animals with normal and chronically reduced renal function显示文摘 | Cisek LJ Gobet RM Peters CA | 1999 | J Endourol1999，13，5： | 1 |
| 20 | Ureteropelvic junction obstruction: morphological and clinical studies显示文摘 | Zhang P Peters CA Rosen S | 2000 | Ped- iatric Nephrology2000，14，8： | 1 |
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