|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Expression of IGF-Ⅱ,p53,p21 and HBxAg in precancerous events of hepatocarcinogenesis induced by AFBI and/or HBV in tree shrews显示文摘INTRODUCTIONIn order to study the relationship between oncogeneexpression and HCC generation,we observed theprecancerous hepatic GGT loci,IGF-Ⅱ,p53 andp21 expression during hepatocarcinogenesis of treeshrew induced by hepatitis B virus (HBV) and/oraflatoxin B1 (AFB1). | Qin LL Su JJ Li Y Yang C Ban KC Yian RQ | 2000 | World Journal of Gastroenterology2000，6，1： | 37 |
| 2 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
| 3 | Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease显示文摘 | Feng Z Qin C Chang Y Zhang JT | 2006 | 中国生物学文摘2006，20，10： | 13 |
| 4 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 5 | 代谢健康的肥胖和腹型肥胖与高血压风险增加相关显示文摘代谢健康型肥胖是指具有正常代谢特征的肥胖人群。研究者在中国农村地区队列研究(the rural Chinese cohort study)的成年人中,探究了代谢健康型肥胖与高血压风险的关系。这项前瞻性队列研究纳入中国成人9137名,在基线时(2007-2008年)无高血压、2型糖尿病或血脂异常,在2013-2014年进行随访。 | 周卫(译) 袁源(审校) Zhao Y Qin P Sun HH Liu Y Liu D Zhou Q Guo C Li Q Tian G Wu X Hu D Sun X Zhang M | 2020 | 中华高血压杂志2020，28，9： | 7 |
| 6 | Two limit theorems for NA random variables显示文摘THE NA (negatively associated) random variables are of considerable uses in system reliability and multivariate statistical analysis. Many authors have studied the limit properties for them. Definition 1. Random variables X1,…,Xn(n≥2) are called NA if for every two distinct nonempty subsets T1 and T2 of {1,…,n} and every pair of coordinatewise nondecreasing (or nonincreasing) functions f1 and f2, there | Su, C Qin, YS | 1997 | Chinese Science Bulletin1997，42，5： | 6 |
| 7 | Cervical inlet patch-optical coherence tomography imaging and clinical significance显示文摘AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP. | Chao Zhou Tejas Kirtane Tsung-Han Tsai Hsiang-Chieh Lee Desmond C Adler Joseph M Schmitt Qin Huang James G Fujimoto Hiroshi Mashimo | 2012 | World Journal of Gastroenterology2012，18，20： | 3 |
| 8 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 9 | 含高钙和维生素D的强化奶能有效提高健康的绝经后的中国女性体内的维生素D水平并减少骨吸收显示文摘目的钙摄入水平低以及体内维生素D不足是导致亚洲女性罹患骨质疏松的危险因素。此项研究的目的是评估高钙维生素D强化牛奶(HCM)对健康的中国绝经后妇女的体内维生素D状态和骨吸收标志物进行干预的影响。方法本试验对象为55岁以上,绝经至少5年的女性。共有124名女性进行了总体健康状况和骨密度检查筛选。63名女性被随机分为对照组和试验组,试验组在12w内每日饮用两次高钙/维生素D强化奶(含900 mg钙、96 mg镁、2.4 mg锌和6.4μg维生素D)。2组分别在试验开始、试验2 w、8 w和12 w时测量血矿物质、25(OH)维生素D3和Ⅰ型胶原C端肽(CTX)水平。结果对照组女性平均年龄为63±4.6岁,高钙强化奶(HCM)组女性平均年龄为62±3.8岁。所测得的每日钙摄入量的基线值为HCM组260~482 mg,对照组为252~692 mg。12 w后HCM组的平均身体质量指数(BMI)显著降低(P<0.05)。HCM组的血25(OH)维生素D3水平显著提高(33.13~39.49 nmol/L),而对照组则维持不变(29.27~28.21 nmol/L)。HCM组的血CTX水平在0 w和2 w之间下降了25%,并保持不变直至第12w。从第2w开始HCM组和对照组相比血CTX水平就出现了显著差异(P<0.001)。结论通过饮用含高钙和维生素D的强化奶(HCM),在2至4w内能显著提高中国绝经妇女体内维生素D水平,并减少骨吸收破坏。如果长期持续地饮用含高钙和维生素D的强化奶(HCM),能减少骨吸收和骨量丢失的风险,从而减少患骨质疏松和由此引起骨折的风险。 | Marlena C Kruger PengCheng Ha Joanne M Todd Barbara Kuhn-Sherlock Linda M Schollum Jiliang Ma George Qin Edith Lau | 2013 | 中国骨质疏松杂志2013，19，2： | 2 |
| 10 | 高血压患者血清磷酸盐与新发高尿酸血症风险的关系显示文摘血清磷酸盐与新发高尿酸血症的关系仍不确定。该研究对中国脑卒中一级预防试验(China stroke primary prevention trial,CSPPT)的尿酸亚组研究进行事后分析,旨在评估血清磷酸盐与新发高血尿酸症的风险之间的关系。研究包括基线尿酸水平正常(<357μmol/L)的参与者共10612人。主要观察指标是新发高血尿酸症,其定义为男性血尿酸浓度≥417或女性≥357μmol/L。在中位数为4.4年的随访期间,1663名(15.7%)参与者发生了新发高尿酸血症。 | 刘莉(译) 叶鹏(摘、审校) Cao J Zhang J Li Q Jiang C Song Y Liu C Liu L Wang B Li J Zhang Y Cui Y Huo Y Wang X Tang G Xu X Qin X | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 11 | Research on Service Life Prediction Model of Concrete Structure of Sea-crossing Bridge显示文摘According to the chloride corrosion environment,service life prediction model of concrete structure of sea-crossing bridge was built using modified Fick's second law and the whole probability calculation method,which was suitable for China. Furthermore,a visual service life prediction program of concrete structure was developed by optimized Monte Carlo method. Meanwhile,Life 365 program was compared,indicating reliability of the prediction program. Finally,the validity of prediction model was verified in JinTang Bridge of Zhoushan Island Mainland Linkage Project. | WANG C J ZHANG G Z LIU K X TU L Q LI J H QIN M Q | 2010 | 武汉理工大学学报2010，32，17： | 2 |
| 12 | 显示文摘 | Zhang S Qin C D | 1993 | International Journal of Refractory Metals & Hard Materials1993，12，： | 1 |
| 13 | Tumor necrosis factor-alpha expression products increased blood-brain barrier peremeability following temporary focal cerebral ischemia in mice显示文摘 | Gong C Qin Z | 1999 | Brain Res Mol Brain Res1999，69，1： | 1 |
| 14 | Study of the adsorption behavior of heavy metal ions on nanometer-size titanium dioxide with ICP-AES显示文摘 | QIN Y C HU B | 2000 | FreseniusJ Anal Chem2000，368，： | 1 |
| 15 | System Xc-and apohpoprotein E expressed by micrnglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40显示文摘 | Qin S Colin C Hinners I | 2006 | J Ncurosci2006，26，12： | 1 |
| 16 | Efficacy and safety of sorafenib in patients in the Asia Pacific region with advanced hepatocellular carcinoma: a phase Ⅲ randomised,double-blind, placebo controlled trial显示文摘 | Cheng A L Kang Y K Chen Z Tsao C J Qin S Kim J S | 2009 | Lancet Oncol2009，10，： | 1 |
| 17 | Short telomeres and prognosis of hypertension in a Chinese popula- tion显示文摘 | Yang ZW Huang X Jiang H Zhang YR Liu HX Qin C | 2009 | Hypertension2009，53，4： | 1 |
| 18 | FritiUaria thumbergii - a new host of Potato leafroU virus in China显示文摘 | Tu S Qin C Chen C | 2006 | Australasian Plant Disease Notes2006，1，1： | 1 |
| 19 | Finite element analysis about effects of particle morphology on mechanical response of composites显示文摘 | Chen C R Qin S Y Li S X | 2000 | Materials Science and Engineering2000，278，： | 1 |
| 20 | Electroreduction of nitrate to ammonia inalkaline solution using hydrogen storage alloy cathodes显示文摘 | C Lu S A Lu W H Qin Q G Liu | 1999 | Electrochimica Acta1999，44，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员