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| 1 | An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure显示文摘Acute hepatic failure (AHF) is a severe liver injury accompanied by hepatic encephalopathy which causes multiorgan failure with an extremely high mortality rate, even if intensive care is provided. Management of severe AHF continues to be one of the most challenging problems in clinical medicine. Liver transplantation has been shown to be the most effective therapy, but the procedure is limited by shortage of donor organs. Although a number of clinical trials testing different liver assist devices are under way, these systems alone have no significant effect on patient survival and are only regarded as a useful approach to bridge patients with AHF to liver transplantation. As a result, reproducible experimental animal models resembling the clinical conditions are still needed. The three main approaches used to create an animal model for AHF are: surgical procedures, toxic liver injury and infective procedures. Most common models are based on surgical techniques (total/partial hepatectomy, complete/transient devascularization) or the use of hepatotoxic drugs (acetaminophen, galactosamine, thioacetamide, and others), and very few satisfactory viral models are available. We have recently developed a viral model of AHF by means of the inoculation of rabbits with the virus of rabbit hemorrhagic disease. This model displays biochemical and histological characteristics, and clinical features that resemble those in human AHF. In the present article an overview is given of the most widely used animal models of AHF, and their main advantages and disadvantages are reviewed. | María Jesús Tuón Marcelino Alvarez Jesús M Culebras Javier González-Gallego | 2009 | World Journal of Gastroenterology2009，15，25： | 29 |
| 2 | Bt水稻对飞虱和叶蝉及其卵寄生蜂扩散规律的影响显示文摘研究了Bt水稻两个纯合品系TT9-3和TT9-4在田间对飞虱、叶蝉及其卵寄生蜂扩散规律的影响。结果表明:在Bt稻区与对照(IR72)区间相互扩散的飞虱有白背飞虱(Sogatellafurcifea)、褐飞虱(Nilaparvatalugens);叶蝉有黑尾叶蝉(Nephotetixcincticeps)、白翅叶蝉(Erythroneurasubrufa)和电光叶蝉(Deltpcephalusdorsalis);其中以白背飞虱和黑尾叶蝉为主。扩散数量叶蝉多于飞虱;扩散方向以Bt稻区向对照区扩散为主,其中TT9-3与IR72、TT9-4与IR72间白背飞虱与黑尾叶蝉的扩散量差异均达显著水平(P<0.05)。在Bt稻区与对照区间相互扩散的飞虱和叶蝉的卵寄生蜂有稻虱缨小蜂(Anagrusspp.)和叶蝉柄翅小蜂(Lynaenonlongicrus),数量上后者多于前者,扩散方向也以Bt稻区向对照区扩散为主。 | 陈茂 叶恭银 胡萃 Tu J Datta S K | 2003 | 浙江大学学报(农业与生命科学版)2003，29，1： | 30 |
| 3 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 4 | A novel experience of deferential vessel-sparing microsurgical vasoepididymostomy显示文摘Microsurgical 纵的摄取 vasoepididymostomy (实时) 广泛地被用来对待 epididymal 妨碍的精子缺乏自从 2004。尽管恭敬 vasculature 在供应血到睾丸和 epididymis 起一个重要作用,注意对潜力被给予了的很少在吻合期间 sparing 有益于恭敬容器在实时。这研究试图在人现场评估恭敬容器圆材的功效和安全。从 2013 年 12 月到 2015 年 12 月,有 epididymal 阻塞的 69 个 azoospermic 人在孙中山大学的首先隶属于的医院里现场由于生殖器的感染,损伤,或自发的因素经历了恭敬容器圆材,广州,中国。这些病人的结果回顾地被分析。吝啬的年龄为他们的搭挡是为人和 28.3 年的 31.1 年。59 (85.5% , 59/69 ) 人们被跟随在上面在为约 16 个月的外科以后。明显被精液分析注意并且证实(> 10 000 sperm/ml ) 在 83.1%(49/59 ) 人。自然怀孕率是 40.7%(24/59 ) 在学习底,(21/24 ) 与 87.5% ,这些,自然怀孕在外科以后在 12 以内完成了月。没有严重不利事件或复杂并发症被观察。在这研究,我们在场为 sparing 的一种新奇技术恭敬容器在期间生活。初步的结果显示这种技术与有利明显和怀孕率安全。 | Kun-Long Lyu Jin-Tao Zhuang Philip S Li Yong Gao Liang Zhao Ya-Dong Zhang Ming-Kuan Zhou Jing-Wei Yu Xin Feng Xiang-Zhou Sun Chun-Hua Deng Xiang-An Tu | 2018 | Asian Journal of Andrology2018，20，6： | 6 |
| 5 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 6 | Video object tracking using adaptive Kalman filter显示文摘 | WENG S K KUO C M TU S K | 2006 | Journal of Visual Communication and Image Representation2006，17，6： | 1 |
| 7 | Enhanced low voltage cycling stability of LiMn204 cathode by ZnO coating for lithium ion batteries 显示文摘 | Tu J Zhao X B Xie J Cao G S Zhuang D G Zhu T J Tu J P | 2007 | Journal of Alloys and Compounds2007，432，12： | 1 |
| 8 | FritiUaria thumbergii - a new host of Potato leafroU virus in China显示文摘 | Tu S Qin C Chen C | 2006 | Australasian Plant Disease Notes2006，1，1： | 1 |
| 9 | Molecular mechanisms of the LPS-induced non-apoptotic ER Stress-CHOP pathway 显示文摘 | Blattner S M Tu Y Tisherman R | 2010 | J Biochem2010，147，4： | 1 |
| 10 | On key distribution management for conditional access system on Pay-TV system 显示文摘 | Tu F K Laih C S Tung H H | 1999 | IEEE Trans on Consumer Electronics1999，45，1： | 1 |
| 11 | Pathogenesis of diabetic macular oedema显示文摘 | Krohne TU Fauser S Kirchhof B | 2003 | Klin Monatsbl Augenheilkd2003，220，8： | 1 |
| 12 | Oxidative protein folding in eukaryotes:mechanisms and consequences显示文摘 | Tu B P Weissman J S | 2004 | J Cell Biol2004，164，： | 1 |
| 13 | Identification of gastric cancer stem cells using the cell surface marker CD44显示文摘 | Takaishi S Okumura T Tu S | 2009 | Stem Cells2009，27，5： | 1 |
| 14 | Association of anti-cyclic citrullinated peptide antibody levels with PADI4 haplotypes in early rheumatoid arthritis and with shared epitope alleles in very late rheumatoid arthritis 显示文摘 | Cha S Choi CB Han TU | 2007 | Arthritis Rheum2007，56，5： | 1 |
| 15 | Active carbon-ceramic sphere as sup- port of ruthenium catalysts for catalytic wet air oxidation (CWAO) of resin effluent 显示文摘 | Liu W M Hu Y Q Tu S T | 2010 | J Hazard Mater2010，179，： | 1 |
| 16 | Understanding detection performance in public health surveillance: modeling aberrancy-detection algorithms 显示文摘 | Buckeridge DL Okhmatovskaia A Tu S | 2008 | J Am Med Inform Assoc2008，15，6： | 1 |
| 17 | Nighttime transpiration in woody plants from contrasting ecosystems 显示文摘 | DAWSON T E BURGESS S S O TU K P | 2007 | Tree Physiology2007，27，： | 1 |
| 18 | Learning Gaussian mixture with automatic model selection:A comparative study on three Bayesian related approaches显示文摘 | Shi L Tu S K Xu L | | 0，，02： | 1 |
| 19 | Soil microbial biomass, crop yields, and bacterial community structure as affected by long-term fertilizer treatments under wheat-rice cropping显示文摘 | Gu Y F Zhang X P Tu S H | 2009 | European Journal of Soil Biology2009，45，： | 1 |
| 20 | Baicalin inhibits TLR2/4 signa- ling pathway in rat brain following permanent cerebral ischemia 显示文摘 | Tu X K Yang W Z Shi S S | 2011 | Inflammation2011，34，5： | 1 |
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