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| 1 | Frequency-dependent rupture process,stress change,and seismogenic mechanism of the 25 April 2015 Nepal Gorkha M_w 7.8 earthquake显示文摘On 25 April 2015,an M_w 7.8 earthquake occurred on the Main Himalaya Thrust fault with a dip angle of^7° about77 km northwest of Kathmandu,Nepal.This Nepal Gorkha event is the largest one on the Himalayan thrust belt since 1950.Here we use the compressive sensing method in the frequency domain to track the seismic radiation and rupture process of this event using teleseismic P waves recorded by array stations in North America.We also compute the distribution of static shear stress changes on the fault plane from a coseismic slip model.Our results indicate a dominant east-southeastward unilateral rupture process from the epicenter with an average rupture speed of ~3 km s^(-1).Coseismic radiation of this earthquake shows clear frequency-dependent features.The lower frequency(0.05-0.3 Hz) radiation mainly originates from large coseismic slip regions with negative coseismic shear stress changes.In comparison,higher frequency(0.3-0.6 Hz) radiation appears to be from the down-dip part around the margin of large slip areas,which has been loaded and presents positive coseismic shear stress changes.We propose an asperity model to interpret this Nepal earthquake sequence and compare the frequency-dependent coseismic radiation with that in subduction zones.Such frequency-dependent radiation indicates the depth-varying frictional properties on the plate interface of the Nepal section in the main Himalaya thrust system,similar to previous findings in oceanic subduction zones.Our findings provide further evidence of the spatial correlation between changes of static stress status on the fault plane and the observed frequency-dependent coseismic radiation during large earthquakes.Our results show that the frequency-dependent coseismic radiation is not only found for megathrust earthquakes in the oceanic subduction environment,but also holds true for thrust events in the continental collision zone. | YIN JiuXun YAO HuaJian YANG HongFeng LIU Jing QIN WeiZe ZHANG HaiJiang | 2017 | Science China Earth Sciences2017，60，4： | 7 |
| 2 | Measurement-Based Channel Characterization for 5G Wireless Communications on Campus Scenario显示文摘The fifth generation(5G)communication has been a hotspot of research in recent years,and both research institutions and industrial enterprises put a lot of interests in 5G communications at some new frequency bands.In this paper,we investigate the radio channels of 5G systems below 6 GHz according to the 5G communication requirements and scenarios.Channel measurements were conducted on the campus of Beijing Jiaotong University,China at two key optional frequency bands below 6 GHz.By using the measured data,we analyzed key channel parameters at 460 MHz and 3.5 GHz,such as power delay profile,path loss exponent,shadow fading,and delay spread.The results are helpful for the 5G communication system design. | YANG Mi HE Ruisi AI Bo XIONG Lei DONG Honghui LI Jianzhi WANG Wei FAN Wei QIN Hongfeng | 2017 | ZTE Communications2017，15，1： | 2 |
| 3 | A commu-nity detecting algorithm in directed weighted networks显示文摘 | LIU Hongtao QIN Xiao YUN Hongfeng | | 0，，： | 1 |
| 4 | Structure and chain conformation of a (1→6)-α- d -glucan from the root of Pueraria lobata (Willd.) Ohwi and the antioxidant activity of its sulfated derivative显示文摘 | Hengxiang Cui Qin Liu Yongzhen Tao Hongfeng Zhang Lina Zhang Kan Ding | 2008 | Carbohydrate Polymers2008，，4： | 1 |
| 5 | The morphology of hydroxyapatite nanoparticles regulates clathrinmediated endocytosis in melanoma cells and resultant anti-tumor efficiency显示文摘Clathrin-mediated endocytosis plays a critical role for hydroxyapatite nanoparticles(HANPs)to enter tumor cells,induce mitochondrial apoptosis,and inhibit tumor growth.This study was aimed to investigate how the morphology of HANPs impacts the endocytosis of the particles in melanoma cells,and their anti-tumor effect by using in vitro cell experiments and in vivo tumor animal model.Three shapes of HANPs,including granular HANPs(G-HANPs),rod-like HANPs(R-HANPs),and needle-like HANPs(N-HANPs),were successfully prepared by wet chemical method.All the three HANPs could be internalized into A375 melanoma cells as indicated by cellular transmission electron microscopy images.Among these HANPs,only G-HANPs induced morphological change of mitochondria and loss of mitochondrial membrane potential(Δψm),and exhibited the greatest intracellular internalization efficiency in the tumor cells.Furthermore,the results of immunofluorescence staining and western blotting indicated that the level of adaptin-2(AP2)protein was up-regulated by all the HANPs,and highest in G-HANPs treated A375 cells.Moreover,in the tumor-bearing mouse model,we found that tumor growth was delayed by all the three HANPs,of which,G-HANPs delayed tumor growth most efficiently and presented a highest expression level of AP2 protein in tumor tissues.Therefore,this study suggested that the morphology of HANPs regulated their endocytosis efficiency and their effect to inhibit tumor growth.This work facilitates to direct the rational design of nano-materials for tumor therapy. | Hongfeng Wu Yuchen Hua Jinjie Wu Qin Zeng Xiao Yang Xiangdong Zhu Xingdong Zhang | 2022 | Nano Research2022，15，7： | 0 |
| 6 | Hydroxyapatite nanoparticles drive the potency of Toll-like receptor 9 agonist for amplified innate and adaptive immune response显示文摘The potency of Toll-like receptor 9(TLR9)agonist to drive innate immune response was limited due to immune suppression or tolerance during TLR9 signaling activation in immune cells.Herein we addressed this problem by introducing hydroxyapatite nanoparticles(HANPs)to CpG ODN(CpG),a TLR9 agonist.The study revealed that HANPs concentration and durationdependently reprogramed the immune response by enhancing the secretion of immunostimulatory cytokines(tumor necrosis factorα(TNFα)or IL-6)while reducing the production of immunosuppressive cytokine(IL-10)in macrophages in response to CpG.Next,the enhanced immune response benefited from increased intracellular Ca2+in macrophage by the addition of HANPs.Further,we found exposure to HANPs impacted the mitochondrial function of macrophages in support of the synthesis of adenosine triphosphate(ATP),the production of nicotinamide adenine dinucleotide(NAD),and reactive oxygen species(ROS)in the presence or absence of CpG.In vaccinated mice model,only one vaccination with a mixture of CpG,HANPs,and OVA,a model antigen,allowed the development of a long-lasting balanced humoral immunity in mice without any histopathological change in the local injection site.Therefore,this study revealed that HANPs could modulate the intracellular calcium level,mitochondrial function,and immune response in immune cells,and suggested a potential combination adjuvant of HANPs and TLR9 agonist for vaccine development. | Qin Zeng Ruiqi Wang Yuchen Hua Hongfeng Wu Xuening Chen You-cai Xiao Qiang Ao Xiangdong Zhu Xingdong Zhang | 2022 | Nano Research2022，15，10： | 0 |
| 7 | Isolation and analysis of SSEA-4 positive cells derived from fetal marrow mesenchymal stem cells显示文摘A big issue in stem cell research is to derive prospective totipotential stem cells. In this study, fMSC-SSEA-4 cells expressing SSEA-4 anti- gen were isolated from fetal marrow masenchymal stem cells (fMSCs) using immunomagnetic bead sorting technique. The totipotent cells were identified and their biological characteristics were further stud- ied. The expression of Oct-4 and SSEA-4, carcino- genicity, and the ability to differentiation of fMSC- SSEA-4 cells were evaluated to verify the totipotent potential. fMSC-SSEA-4 cells were isolated suc- cessfully from fMSCs (2.5% among fMSCs), while no obvious differences were seen in morphology, growth curve, cell cycle and immunophenotype, Oct-4 and SSEA-4 expression between fMSC-SSEA-4 cells and fMSCs. fMSC-SSEA-4 cells showed normal diploid chromosome karyotype and no carcinoma was in- duced after inoculation into nude mice. fMSC- SSEA-4 cells could be induced to fat cells, osteo- genic cells and neuron-like cells in vitro with different induced factors. The results indicated that there may be a few totipotent cells among the fMSCs and it may offer the experimental basis for the further study and application of fMSCs. | LIU Daqing YANG Yinxiang GAO Yanhong YUAN Hongfeng QIN Lipeng WANG Yunfang NAN Xue SHI Shuangshuang YUE Wen PEI Xuetao | 2006 | Chinese Science Bulletin2006，51，12： | 0 |
| 8 | 低分化型粘膜内早期胃癌淋巴结转移的危险因素和腹腔镜手术探讨(英文)显示文摘Objective:The aim of this study was to identify clinicopathological factors predictive of lymph node metastasis (LNM) in intramucosal poorly differentiated early gastric cancer (EGC), and further to expand the possibility of using laparoscopic surgery for the treatment of intramucosal poorly differentiated EGC. Methods:Data from 65 patients with intramucosal poorly differentiated EGC and surgically treated were collected, and the association between the clinicopathological factors and the presence of LNM was retrospectively analyzed by univariate and multivariate logistic regression analyses. Results:Univariate analysis showed that number of tumors, tumor size and lymphatic vessel involvement (LVI) were the significant and independent risk factors for LNM (all P < 0.05). The LNM rates were 5.0%, 18.2% and 66.7%, respectively. There was no LNM in 31 patients without the three risk clinicopathological factors. Conclusion:The number of tumors, tumor size, and LVI are independently associated with the presence of LNM in intramucosal poorly differentiated EGC. Thus, these three risk factors may be used to set as a simple criterion to expand the possibility of using laparoscopic surgery for the treatment of intramucosal poorly differentiated EGC. | Zhibin Huo Shubo Chen Jing Zhang Hua Li Dianchao Wu Tongshan Zhai Shuxia Wang Qihai Xiao Bingge Mu Shangfeng Luan Hongfeng Nie Yan Qin | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，8： | 0 |
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