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| 1 | Chemotherapy initiation with single-course methotrexate alone or combined with dactinomycin versus multi-course methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric randomized clinical trial显示文摘We aimed to evaluate the effectiveness and safety of single-course initial regimens in patients with low-risk gestational trophoblastic neoplasia(GTN).In this trial (NCT01823315),276 patients were analyzed.Patients were allocated to three initiated regimens:single-course methotrexate(MTX),single-course MTX+dactinomycin(ACTD),and multi-course MTX(control arm).The primary endpoint was the complete remission(CR)rate by initial drug(s).The primary CR rate was 64.4%with multi-course MTX in the control arm.For the single-course MTX arm,the CR rate was 35.8%by one course;it increased to 59.3%after subsequent multi-course MTX,with non-inferiority to the control(difference-5.1%,95%confidence interval(CI)-19.4%to 9.2%,P=0.014).After further treatment with multi-course ACTD,the CR rate(93.3%)was similar to that of the control(95.2%,P=0.577).For the single-course MTX+ACTD arm,the CR rate was 46.7%by one course,which increased to 89.1%after subsequent multi-course,with non-inferiority(difference 24.7%,95%CI 12.8%-36.6%,P<0.001)to the control.It was similar to the CR rate by MTX and further ACTD in the control arm(89.1%vs.95.2%,P=0.135).Four patients experienced recurrence,with no death,during the 2-year follow-up.We demonstrated that chemotherapy initiation with single-course MTX may be an alternative regimen for patients with low-risk GTN. | Lili Chen Ling Xi Jie Jiang Rutie Yin Pengpeng Qu Xiuqin Li Xiaoyun Wan Yaxia Chen Dongxiao Hu Yuyan Mao Zimin Pan Xiaodong Cheng Xinyu Wang Qingli Li Danhui Weng Xi Zhang Hong Zhang Quanhong Ping Xiaomei Liu Xing Xie Beihua Kong Ding Ma Weiguo Lu | 2022 | Frontiers of Medicine2022，16，2： | 2 |
| 2 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 3 | Inhibitory effect of fruit extracts on the formation of heterocyclic amines显示文摘 | CHENG K W WU Qingli ZHENG Zongping | 2007 | Journal of Azricultural and Food Chemistry2007，55，10： | 1 |
| 4 | Superior performance of a 2 kHz pulse Nd:YAG laser based on a gradient-doped crystal显示文摘Herein,we report a homemade new Nd:YAG crystal rod that contains a gradient dopant of 0.39–0.80 at.%Nd3+ from end to end,achieving superior performance of a 2 kHz Nd:YAG pulse laser at 1064 nm. The optical-tooptical conversion efficiency reached 53.8%,and the maximum output power of the laser was 24.2 W,enhanced by 35.9% compared with a uniform crystal rod with the same total concentration of Nd3+. Significantly,our experiments revealed that the gradient concentration crystal produced a relatively even pumping distribution along the rod axis,greatly reducing the temperature gradient as well as having a smaller thermal effect. The pump and thermal distribution smoothing obviously improved the features of laser oscillation and output. | MENG’EN WEI TINGQING CHENG RENQIN DOU QINGLI ZHANG HAIHE JIANG | 2021 | Photonics Research2021，9，7： | 1 |
| 5 | Confocal laser endomicroscopy for diagnosis of Helicobacter pylori infection: A prospective study显示文摘 | RuiJi Yan‐QingLi Xiao‐mengGu TaoYu Xiu‐LiZuo Cheng‐junZhou | 2010 | Journal of Gastroenterology and Hepatology2010，，4： | 1 |
| 6 | Confocal laser endomicroscopy for diagnosis of Helicobacter pylori infection: A prospective study显示文摘 | RuiJi Yan‐QingLi Xiao‐mengGu TaoYu Xiu‐LiZuo Cheng‐junZhou | 2010 | Journal of Gastroenterology and Hepatology2010，，4： | 1 |
| 7 | Fluoride-induced oxidative stress in rat myocardium through the Bax/Bcl-2 signally pathway显示文摘 | Ruiying Cheng Qingli Nie Hongfei Sun et a1 | 2013 | Fluoride2013，46，4： | 1 |
| 8 | Inhibitory effect of fruit extracts on the formation of heterocyclic amines显示文摘 | CHENG Kawing WU Qingli ZHENG Zongping | 2007 | Journal of Agricultural and Food Chemistry2007，55，10： | 1 |
| 9 | Influence of meteorological factors on open biomass burning at a background site in Northeast China显示文摘Biomass burning(BB)is a very important emission source that significantly adversely impacts regional air quality.BB produces a large number of primary organic aerosol(POA)and black carbon(BC).Besides,BB also provides many precursors for secondary organic aerosol(SOA)generation.In this work,the ratio of levoglucosan(LG)to organic carbon(OC)and the fire hotspots map was used to identify the open biomass burning(OBB)events,which occurred in two representative episodes,October 13 to November 30,2020,and April1 to April 30,2021.The ratio of organic aerosol(OA)to reconstructed PM_(2.5)concentration(PM_(2.5)^(*))increased with the increase of LG/OC.When LG/OC ratio is higher than 0.03,the highest OA/PM_(2.5)^(*)ratio can reach 80%,which means the contribution of OBB to OA is crucial.According to the ratio of LG to K^(+),LG to mannosan(MN)and the regional characteristics of Longfengshan,it can be determined that the crop residuals are the main fuel.The occurrence of OBB coincides with farmers’preferred choices,i.e.,burning biomass in“bright weather”.The“bright weather”refers to the meteorological conditions with high temperature,low humidity,and without rain.Meteorological factors indirectly affect regional biomass combustion pollution by influencing farmers’active choices. | Yulong Wang Linlin Liang Wanyun Xu Chang Liu Hongbing Cheng Yusi Liu Gen Zhang Xiaobin Xu Dajiang Yu Peng Wang Qingli Song Jiumeng Liu Yuan Cheng | 2024 | Journal of Environmental Sciences2024，，4： | 0 |
| 10 | Research and Development on Control System of Novel Winding Machine for High-pressure FRP Pipeline显示文摘The novel winding machine adopted steam inside solidification technics,can wind,solidify and extract high- pressure fiber reinforced plastic (FRP) pipelines in one single machine.Its control system consisted of the winding and extraction subsystem and the steam inside solidification subsystem.In order to improve the control precision and stability,a real-time control method was adopted in the winding and extraction subsystem.In this method,high-precision TRIO motion controller combined with industrial personal computer (IPC) forms an open-type CNC system which supports multitask.The Modbus protocol was adopted for the communication between the IPC and TRIO motion controller.The human-machine interface (HMI) was developed with VC++6.0 and the control software of the motion controller was developed with TRIO BASIC language.In the steam in- side solidification subsystem,embedded IPC and PLC were used to realize the closed-loop control of the steam temperature and the HMI was developed with MCGS 5.1 under WinCE.Practices show that this system has the good performances of high precision, good stability and high efficiency. | YOU Bo XU Jiazhong HU Haiyan CHENG Ningbo ZHANG Qingli College of Automation,Harbin University of Science and Technology,Harbin 150080,China | 2006 | 武汉理工大学学报2006，28，S2： | 0 |
| 11 | Rapid and sensitive detection of urinary KIM-1 using fully printed photonic crystal microarrays显示文摘Urinary kidney injury molecule 1(uKIM-1)serves as a reliable marker for the early diagnosis of acute kidney injury(AKI).The rapid and facile detection of changes in uKIM-1 is essential for early AKI diagnosis,ultimately improving the prognosis of patients.In this study,we developed a fully printed photonic crystal-integrated microarray with photonic crystal-enhanced fluorescence properties,which can detect uKIM-1 levels at the point-of-care.We confirmed its efficacy in the early diagnosis of AKI using clinical urine specimens.Direct quantitative detection of uKIM-1 was achieved within 10 min.The lowest limit of detection is 8.75 pg·mL^(-1) with an accuracy of 94.2%.The diagnostic efficacy was validated using 86 clinical urine samples,highlighting the high sensitivity and stability of the photonic crystal microarray.Consequently,a facile and reliable immunoassay was designed and prepared for the rapid quantitative detection of uKIM-1,which is crucial for the early identification and convenient detection of AKI in hospital or community settings.Rapid,convenient,cost-effective,and long-term monitoring of changes in uKIM-1 levels can assist clinicians in making timely adjustments to treatment regimens,preventing the transition from AKI to chronic kidney disease(CKD),improving the quality of life of patients with AKI,and reducing healthcare costs.It highlights the advantages of utilizing urine samples as a noninvasive and easily accessible medium for early detection and monitoring of kidney-related conditions. | Yang Liu Xuwei He Zewei Lian Qian Guo Jimei Chi Xiaoxue Lin Liyue Zhang Zheng Liu Yingyuan Liu Meng Su Keyu Wang Qiangguo Ao Qingli Cheng | 2024 | Nano Research2024，17，5： | 0 |
| 12 | DNA methylation markers in the diagnosis and prognosis of common leukemias显示文摘The ability to identify a specific type of leukemia using minimally invasive biopsies holds great promise to improve the diagnosis,treatment selection,and prognosis prediction of patients.Using genome-wide methylation profiling and machine learning methods,we investigated the utility of CpG methylation status to differentiate blood from patients with acute lymphocytic leukemia(ALL)or acute myelogenous leukemia(AML)from normal blood.We established a CpG methylation panel that can distinguish ALL and AML blood from normal blood as well as ALL blood from AML blood with high sensitivity and specificity.We then developed a methylation-based survival classifier with 23 CpGs for ALL and 20 CpGs for AML that could successfully divide patients into high-risk and low-risk groups,with significant differences in clinical outcome in each leukemia type.Together,these findings demonstrate that methylation profiles can be highly sensitive and specific in the accurate diagnosis of ALL and AML,with implications for the prediction of prognosis and treatment selection. | Hua Jiang Zhiying Ou Yingyi He Meixing Yu Shaoqing Wu Gen Li Jie Zhu Ru Zhang Jiayi Wang Lianghong Zheng Xiaohong Zhang Wenge Hao Liya He Xiaoqiong Gu Qingli Quan Edward Zhang Huiyan Luo Wei Wei Zhihuan Li Guangxi Zang Charlotte Zhang Tina Poon Daniel Zhang Ian Ziyar Run-ze Zhang Oulan Li Linhai Cheng Taylor Shimizu Xinping Cui Jian-kang Zhu Xin Sun Kang Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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