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| 1 | Anisotropic coding metamaterials and their powerful manipulation of differently polarized terahertz waves显示文摘Metamaterials based on effective media can be used to produce a number of unusual physical properties(for example,negative refraction and invisibility cloaking)because they can be tailored with effective medium parameters that do not occur in nature.Recently,the use of coding metamaterials has been suggested for the control of electromagnetic waves through the design of coding sequences using digital elements‘0’and‘1,'which possess opposite phase responses.Here we propose the concept of an anisotropic coding metamaterial in which the coding behaviors in different directions are dependent on the polarization status of the electromagnetic waves.We experimentally demonstrate an ultrathin and flexible polarization-controlled anisotropic coding metasurface that functions in the terahertz regime using specially designed coding elements.By encoding the elements with elaborately designed coding sequences(both 1-bit and 2-bit sequences),the x-and y-polarized waves can be anomalously reflected or independently diffused in three dimensions.The simulated far-field scattering patterns and near-field distributions are presented to illustrate the dual-functional performance of the encoded metasurface,and the results are consistent with the measured results.We further demonstrate the ability of the anisotropic coding metasurfaces to generate a beam splitter and realize simultaneous anomalous reflections and polarization conversions,thus providing powerful control of differently polarized electromagnetic waves.The proposed method enables versatile beam behaviors under orthogonal polarizations using a single metasurface and has the potential for use in the development of interesting terahertz devices. | Shuo Liu Tie Jun Cui Quan Xu Di Bao Liangliang Du Xiang Wan Wen Xuan Tang Chunmei Ouyang Xiao Yang Zhou Hao Yuan Hui Feng Ma Wei Xiang Jiang Jiaguang Han Weili Zhang Qiang Cheng | 2016 | Light(Science & Applications)2016，5，1： | 36 |
| 2 | Effect of Helicobacter pylori infection on gastric epithelial proliferation in progression from normal mucosa to gastric carcinoma显示文摘EfectofHelicobacterpyloriinfectionongastricepithelialproliferationinprogressionfromnormalmucosatogastriccarcinomaLIUWenZhon... | LIU Wen Zhong, ZHENG Xiong, SHI Yao, DONG Quan Jiang and XIAO Shu Dong | 1998 | World Journal of Gastroenterology1998，4，3： | 30 |
| 3 | MicroRNA-125b Induces Cancer Cell Apoptosis Through Suppression of Bcl-2 Expression显示文摘MicroRNAs(miRNAs) are small,noncoding RNAs which can often act as an oncogene or a tumor suppressor.Several miRNAs are associated with the development of hepatocellular carcinoma(HCC).We demonstrated that miR-125b significantly suppresses HCC cell proliferation and promotes apoptosis by inhibiting the gene expression of the anti-apoptotic protein,Bcl-2.Bioinformatic analysis indicated that the 3'UTR of Bcl-2 has binding sites for miR-125b.Luciferase reporter assay confirmed the ability of miR-125b to dramatically suppress Bcl-2 transcription,suggesting that Bcl-2 is a target gene for miR-125b.We concluded that miR-125b acts as a tumor suppressor in hepatic tumor development by targeting Bcl-2 and inducing cancer cell apoptosis. | Aihua Zhao Quan Zeng Xiaoyan Xie Junnian Zhou Wen Yue Yali Li Xuetao Pei | 2012 | Journal of Genetics and Genomics2012，39，1： | 30 |
| 4 | An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay显示文摘Objective To investigate oxidative DNA damage in pharmacy technicians preparing antineoplastic drugs at the PIVAS (Pharmacy Intravenous Admixture Service) in two Chinese hospitals.Methods Urinary 8-OHdG served as a biomarker.5-Fluorouracil (5-FU) concentrations in air,masks and gloves were determined.The spill exposure of each PIVAS technician to antineoplastic drugs was investigated.Eighty subjects were divided into exposed group I,II,and control group I,II.Results 5-FU concentration ratios for gloves and masks in exposed group I were significantly higher than those in exposed group II (P<0.05 or P<0.01).The average urinary 8-OHdG concentrations in exposed group I,control group I,exposed group II,and control group II were 14.69±0.93,10.68±1.07,10.57±0.55,and 11.96±0.73 ng/mg Cr,respectively.Urinary 8-OHdG concentration in exposed group I was significantly higher than that in control group I or that in exposed group II (P<0.01).There was a significant correlation between urinary 8-OHdG concentrations and spill frequencies per technician (P<0.01).Conclusion There was detectable oxidative DNA damage in PIVAS technicians exposed to antineoplastic drugs.This oxidative DNA damage may be associated with their spill exposure experience and contamination of their personal protective equipment. | HUANG Yu Wen JIAN Le ZHANG Mei Bian ZHOU Quan YAN Xiao Feng HUA Xu Dong ZHOU Ying HE Ji Liang | 2012 | Biomedical and Environmental Sciences2012，25，1： | 30 |
| 5 | Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro显示文摘 | Jia-lin DUAN Jing-wen WANG Yue GUAN Ying YIN Guo WEI Jia CUI Dan ZHOU Yan-rong ZHU Wei QUAN Miao-miao XI Ai-dong WEN | 2013 | Acta Pharmacologica Sinica2013，34，4： | 27 |
| 6 | Isolation and Identification of Cancer Stem-Like Cells from Murine Melanoma Cell Lines显示文摘In current study,cancer stem-like cells in the murine melanoma B16F10 cells were investigated.CD phenotypes of the B16F10 cells were analyzed by flow cytometry,and the specific CD phenotype cells from the B16F10 cells were isolated by MACS.Then we used colony formation assay in soft agar media,the cell growth assay in serum-free culture media as well as the tumorigenicity investigation of the specific CD phenotype cells in C57BL/6 mice, respectively,to identify cancer stem-like cells in the B16F10 cells.The results showed that the B16F10 cells could form spherical clones in serum-free culture media,and the rate of clonegenesis of CD133 + ,CD44 + and CD44 + CD133 + cells was higher than that of CD133 - ,CD44 - and CD44 + CD133 - cells in soft agar media,respectively. The tumorigenic potential of CD133 + ,CD44 + ,CD44 + CD133 + cells and CD44 + CD133 + CD24 + cells was stronger than that of CD133 - ,CD44 - ,CD44 + CD133 - cells and CD44 + CD133 + CD24 - cells in mice,respectively.In conclusion,the CD44 + CD133 + CD24 + cells have some biological properties of cancer stem-like cells or are highly similar to the characteristics of cancer stem cells(CSC).These results provide an important method for identifying cancer stem-like cells in B16F10 cells and for further cancer target therapy. | Jun Dou Meng Pan Ping Wen Yating Li Quan Tang Lili Chu Fengshu Zhao Chuilian Jiang Weihua Hu Kai Hu Ning Gu | 2007 | Cellular & Molecular Immunology2007，4，6： | 25 |
| 7 | Experimental and clinical study of influence of high-frequency electric surgical knives on healing of abdominal incision显示文摘瞄准:在腹壁切口愈合上学习高周波的电的外科的刀的影响。方法:240 只白鼠被划分成 10 (0 ) , 10 (2 ) , 10 (5 ) ,并且 10 (8 ) 组和腹部手术的老鼠模型被分别地使用电的外科的刀和普通口针劝诱。然后,他们分别地被给生理盐水和 0.2 mL 的皮下注射在 10 的集中(2 ) 的埃希氏杆菌属关口 i,葡萄球菌 aureus 和绿脓假单胞菌的量的混合, 10 (5 ) 并且 10 (8 ) 。根据动物实验,经历腹部手术(上面的类型 II ) 的 220 个病人随机被分配进跟随三个组之一:电热刀(EK, 93 个盒子) ,电凝法(EC, 55 个盒子) 并且控制(72 个盒子) 。高周波的电的外科的刀习惯于为在 EK 的血壅滞的腹的纸巾和电凝法组织的 dissect。普通口针和电凝法在 EC 组被使用。普通口针和系住的丝缝线在控制被使用。结果:在除了组 10 的所有组(0 ) ,电的外科的刀做的 incisional 创伤的感染率与普通口针比那显著地高。而且,在组有有效差量 10 (2 ) , 10 (5 ) ,并且 10 (8 )(P<0.05 ) ,然而并非(0 )(P>0.05 ) 在组, 10 在 EK 和 EC 之间组织。临床的研究显示出在控制组在 EK,在 EC 的 11 个盒子(16.36%) 和 2 个盒子(2.86%) 在 16 种情况(17.20%) 中愈合的一处推迟的创伤。在 EK 和控制之间的有效差量组织(chi2 = 8.57, P<0.01 ) ,并且在 EC 和控制组之间(chi2 = 5.66, P<0.05 ) 被观察,然而并非在 EK 和 EC 之间(chi2 = 0.017, P>0.05 ) 。结论:高周波的电的刀可以显著地推迟腹壁切口愈合。它的申请应该被最小化以便减少手术后的复杂并发症的可能性。 | Guang-Wei Ji Yuan-Zhi Wu Xu Wang Hua-Xiong Pan Ping Li Wan-Ying Du Zhi Qi An Huang Li-Wei Zhang Li Zhang Wen Chen Guang-Hua Liu Hui Xu Quan Li Ai-Hua Yuan Xiao-Ping He Guo-Hua Mei | 2006 | World Journal of Gastroenterology2006，12，25： | 23 |
| 8 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 9 | Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardial ischemia/reperfusion injury in vivo and in vitro显示文摘OBJECTIVE: To determine the cardioprotective effect of magnesium lithospermate B (MLB) on myocardial ischemia/reperfusion (MI/R) injury and to investigate the antioxidant potential in vivo and in vitro. METHODS: MI/R injury was induced by the occlusion of left anterior descending coronary artery for 30 min followed by reperfusion for 3 h in rats. After reperfusion, hearts were harvested to assess infarct size, histopathological damages, the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and malondialdehyde (MDA). Blood samples were col- lected to determine serum levels of creatine kinase-MB (CK-MB), cardiac troponin (cTnI) and lactate dehydrogenase (LDH). Furthermore, simulatedischemia/reperfusion (SI/R) injury in vitro was established by oxygen and glucose deprivation (OGD) for 2 h followed by 24-hour recovery period in cardiomyocytes. The activity of LDH in the cultured supernatant and the levels of intracellular reactive oxygen species (ROS), SOD and MDA in cardiomyocytes were also measured. Finally, cardiomyocytes apoptosis was determined with flow cytometry. RESULTS: MLB significantly limited infarct size, ameliorated histopathological damages and prevented leakage of CK-MB, cTnI and LDH. Additionally, SOD, CAT, GPx and GSH activities were notably increased by MLB, along with the MDA content decreased as compared with the model group in rats. In vitro study, MLB also decreased LDH activity in the cultured supernatant, increased SOD activity in cardiomyocytes, reduced intracellular ROS and MDA levels, and significantly suppressed cardiomyocytes apoptosis. CONCLUSION: MLB possessed remarkably cardioprotective effects on MI/R injury in vivo and in vitro. The protection of MLB may contribute to its antioxidant properties. | Wei Quan Ying Yin Miaomiao Xi Dan Zhou Yanrong Zhu Yue Guan Chao Guo Yanhua Wang Jialin Duan Aidong Wen | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 21 |
| 10 | BMI, WC, WHtR, VFI and BFI: Which Indictor is the Most Efficient Screening Index on Type 2 Diabetes in Chinese Community Population显示文摘Objective Obesity is a major risk factor for type 2 diabetes, many indexes can be used to describes obesity and predict diabetes. This research attempts to identify the best indicator of obesity to screening diabetes in Chinese population. Methods A cross-sectional data of 8121 subjects aged 35-60 years were included in this research belongs to the Diabetes Appropriate Technology Intervention Study. Anthropometric indicators including body weight, height, waist circumferences (WC), body fat index (BFI) and visceral fat index (VFI) and blood biochemical indicators after an overnight fast [fasting blood glucose, total cholesterol, high-density lipoprotein (HDL) cholesterol, and triacylglycerol] were measured. BMI (body mass index) and Weight to Height Ratio was calculated. Results Subjects with obesity had a higher risk of physician diagnosed diabetes (OR=2.50, 95% CI 1.83-3.43), new diagnosed diabetes (OR=4.23, 95% CI 2.91-6.15) and pre-diabetes (OR=1.75, 95% CI 1.31-2.34) compared to those with normal Body mass index (BMI). There was a significant trend of increased risk of all diabetes status with increased waist circumference (WC). The waist-to-height ratio (WHtR) yielded the most significant association with new diagnosed diabetes and physician diagnosed diabetes than other indices. Conclusion Central obesity is significantly correlated with diabetes. VFI was most correlated with pre-diabetes while WHtR is an efficient screening index than BMI and WC in Chinese community diabetes screening. | MI Sheng Quan YIN Peng HU Nan LI Jian Hong CHEN Xiao Rong CHEN Bo YAN Liu Xia ZHAO Wen Hua | 2013 | Biomedical and Environmental Sciences2013，26，6： | 20 |
| 11 | A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30显示文摘Mitochondrial 熔化是为正常 mitochondrial 功能和 mitochondrial DNA 继承混合并且统一 mitochondrial 分隔空间的一个高度协调的过程。Dysregulated mitochondrial 熔化原因 mitochondrial 破碎,反常 mitochondrial 生理学和继承,并且有原因地与很多 neuronal 疾病被连接了。这里,我们识别了 potently 导致了 mitochondrial 熔化在在 Mfn1 或 Mfn2 是缺乏的房间恢复 mitochondrial 网络和氧化呼吸的 diterpenoid 衍生物 15-oxospiramilactone (S3 ) 。线粒体局部性的 deubiquitinase USP30 是 S3 的一个目标。由 S3 的 USP30 的抑制导致 Mfn1/2 的 non-degradative ubiquitination 的增加,它提高 Mfn1 和 Mfn2 活动并且支持 mitochondrial 熔化。通过 USP30 的一个禁止者的使用,因此,我们的学习揭开在支持 mitochondrial 的 Mfns 的 non-degradative ubiquitination 的异乎寻常的功能熔化。 | Wen Yue Ziheng Chen HaiYang Li Chen Yan Ming Chen Du Feng Chaojun Yan Hao Wu Lei Du Yueying Wang Jinhua Liu Xiaohu Huang Laixin Xia Lei Liu Xiaohui Wang Haijing Jin Jun Wang Zhiyin Song Xiaojiang Hao Quan Chen | 2014 | Cell Research2014，24，4： | 18 |
| 12 | Gene expression of hepatocyte growth factor and its receptor in HCC and nontumorous liver tissues显示文摘METHODSGeneexpressionofHGFandHGFrin26casesofHCCtissueandtheiradjacentnontumorouslivertissueswasdeterminedwithdigoxigeninla... | LUO Yun Quan, WU Meng Chao and CONG Wen Ming | 1999 | World Journal of Gastroenterology1999，5，2： | 17 |
| 13 | Construction and Functional Analysis of a Lentiviral Expression Vector Containing a Scavenger Receptor (SR-PSOX) that Binds Uniquely Phosphatidylserine and Oxidized Lipoprotein显示文摘这研究的目的是构造包含特别地绑与的 scavenger 受体(SR-PSOX ) 的 lentiviral 表达式向量有六个 histidine 标签并且到的 phosphatidylserine 和氧化脂蛋白在动脉粥样硬化调查 SR-PSOX 的函数。我们利用有效在 vitro 或 invivo 交付目标基因进用提高的 biosafetyreplication 无能的 lentivirus 划分和非划分的哺乳动物的房间的 ViraPower lentiviral 表达式系统。钝结束的顺序用克隆反应的 reversetranscription 聚合酶链反应和方向性的 TOPO 被放大。通过一双 thecytomegalovirus 提交教材和 SR-PSOX 的反向的教材,正确克隆被聚合酶链反应识别并且定序。包装混合 andSR-PSOX-pLenti6/V5 TOPO 表示原生质标志的 ViraPower 是进 293FT 房间线 usingLipofectamine 的 co-transfected 2000。内长、外长的 SR-PSOX 以及在在不同时间的各种各样的泡沫房间模型的 - α蛋白质削尖的肿瘤坏死因素(TNF ) 的表示被 sodiumdodecyl sulfate-polyacrylamide 凝胶电泳,蛋白质印迹和间接 immunofluorescenceassay 检测。蛋白质印迹和免疫荧光分析证实α蛋白质是起来的 SR-PSOX andTNF- 的表情在泡沫房间模型调整了。我们的数据建议过去表示 ofrecom-binant 人 SR-PSOX 蛋白质能支持泡沫房间形成并且起来调整煽动性的因素 TNF- α的表示。 | Zhihua QUAN Huiling YANG Yongzong YANG Bin YAN Renxian CAO Gebo WEN Changhui LIU Yangyan XU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，3： | 16 |
| 14 | Sequencing of PCR amplified HBV DNA pre-c and c regions in 2.2.15 cells and antiviral action by targeted antisense oligonucleotide directed against sequence显示文摘INTRODUCTIONManystudieshaveshownthatantisenseoligonucleotides(ASONs)canefficientlyinhibitHBVDNAreplicationandexpresioninvitro... | ZHOUG Sen 1, WEN Shou Ming 2, ZHANG Ding Feng 3, WANG Quan Li 4, WANG Seng Qi 4 and REN Hong 3 | 1998 | World Journal of Gastroenterology1998，4，5： | 16 |
| 15 | Surgical approaches for stage Ⅰ and Ⅱ thymoma-associated myasthenia gravis:feasibility of complete video-assisted thoracoscopic surgery (VATS) thymectomy in comparison with trans-sternal resection显示文摘Complete resection could be achieved in virtually all myasthenic patients with Masaoka stage Ⅰ and Ⅱ thymoma using the trans-sternal technique.Whether this is appropriate for minimally invasive approach is not yet clear.We evaluated the feasibility of complete video-assisted thoracoscopic surgery (VATS) thymectomy for the treatment of Masaoka stage Ⅰ and Ⅱ thymoma-associated myasthenia gravis,compared to conventional trans-sternal thymectomy.We summarized 33 patients with Masaoka stage Ⅰ and Ⅱ thymoma-associated myasthenia gravis between April 2006 and September 2011.Of these,15 patients underwent right-sided complete VATS (the VATS group) by using adjuvant pneuomomediastinum,comparing with 18 patients using the trans-sternal approach (the T3b group).No intraoperative death was found and no VATS case required conversion to median sternotomy.Significant differences between the two groups regarding duration of surgery and volume of intraoperative blood loss (P=0.001 and P < 0.001,respectively) were observed.Postoperative morbidities were 26.7% and 33.3% for the VATS and T3b groups,respectively.All 33 patients were followed up for 12 to 61 months in the study.The cumulative probabilities of reaching complete stable remission and effective rate were 26.7% (4/15) and 93.3% (14/15) in the VATS group,which had a significantly higher complete stable remission and effective rate than those in the T3b group (P=0.026 and P=0.000,respectively).We conclude that VATS thymectomy utilizing adjuvant pneuomomediastinum for the treatment of stage Ⅰ and Ⅱ thymoma-associated myasthenia gravis is technically feasible but deserves further investigation in a large series with long-term follow-up. | Zhicheng He Quan Zhu Wei Wen Liang Chen Hai Xu Hai Li | 2013 | The Journal of Biomedical Research2013，27，1： | 15 |
| 16 | Work Hardening Behavior and Stability of Retained Austenite for Quenched and Partitioned Steels显示文摘Both microstructure and mechanical properties of low alloy steels treated by quenching and partitioning(Q&P)process were examined.The mixed microstructure of martensite and large-fractioned retained austenite(about27.3%)was characterized and analyzed,excellent combinations of total elongation of 19% and tensile strength of1 835 MPa were obtained,and three-stage work hardening behavior was demonstrated during tensile test.The enhanced mechanical properties and work hardening behavior were explained based on the transformation-induced plasticity effect of large-fractioned austenite. | Cun-yu WANG Ying CHANG Jie YANG Wen quan CAO Han DONG Yi-de WANG | 2016 | Journal of Iron and Steel Research(International)2016，23，2： | 13 |
| 17 | Effects of total dissolved gas supersaturated water on lethality and catalase activity of Chinese sucker(Myxocyprinus asiaticus Bleeker)显示文摘Total dissolved gas(TDG) supersaturation caused by dam sluicing can result in gas bubble trauma(GBT) in fish and threaten their survival.In the present study,Chinese suckers(Myxocyprinus asiaticus Bleeker) were exposed to TDG supersaturated water at levels ranging from 120% to 145% for 48 h.The median lethal concentration(LC 50) and the median lethal time(LT 50) were determined to evaluate acute lethal effects on Chinese suckers.The results showed that the LC 50 values of 4,6,8,and 10 h were 142%,137%,135%,and 130%,respectively.The LT 50 values were 3.2,4.7,7.8,9.2,and 43.4 h,respectively,when TDG supersaturated levels were 145%,140%,135%,130%,and 125%.Furthermore,the biological responses in Chinese suckers were studied by assaying the catalase(CAT) activities in gills and muscles at the supersaturation level of 140% within LT 50.The CAT activities in the gills and muscle tissues exhibited a regularity of a decrease after an increase.CAT activities in the muscles were increased significantly at 3/5LT 50(P<0.05) and then came back to the normal level.However,there were no significant differences between the treatment group(TDG level of 140%) and the control group(TDG level of 100%) on CAT activities in the gills before 3/5LT 50(P>0.05),but the activities were significantly lower than the normal level at 4/5LT 50 and LT 50(P<0.05). | Shi-chao CHEN Xiao-qing LIU Wen JIANG Ke-feng LI Jun DU Dan-zhou SHEN Quan GONG | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，10： | 11 |
| 18 | Coastal blue carbon: Concept, study method, and the application to ecological restoration显示文摘Coastal blue carbon refers to the carbon taken from atmospheric CO2; fixed by advanced plants(including salt marsh,mangrove, and seagrass), phytoplankton, macroalgae, and marine calcifiers via the interaction of plants and microbes; and stored in nearshore sediments and soils; as well as the carbon transported from the coast to the ocean and ocean floor. The carbon sequestration capacity per unit area of coastal blue carbon is far greater than that of the terrestrial carbon pool. The mechanisms and controls of the carbon sink from salt marshes, mangroves, seagrasses, the aquaculture of shellfish and macroalgae, and the microbial carbon pump need to be further studied. The methods to quantify coastal blue carbon include carbon flux measurements, carbon pool measurements, manipulative experiments, and modeling. Restoring, conserving, and enhancing blue carbon will increase carbon sinks and produce carbon credits, which could be traded on the carbon market. The need to tackle climate change and implement China's commitment to cut carbon emissions requires us to improve studies on coastal blue carbon science and policy. The knowledge learned from coastal blue carbon improves the conservation and restoration of salt marshes,mangroves, and seagrasses; enhances the function of the microbial carbon pump; and promotes sustainable aquaculture, such as ocean ranching. | Jianwu TANG Shufeng YE Xuechu CHEN Hualei YANG Xiaohong SUN Faming WANG Quan WEN Shaobo CHEN | 2018 | Science China Earth Sciences2018，61，6： | 8 |
| 19 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 20 | Small Interfering RNA-mediated Caveolin-1 Knockout on Plasminogen Activator Inhibitor-1 Expression in Insulin-stimulated Human Vascular Endothelial Cells显示文摘把人的脉管的 endothelial 房间(ECV304 ) 用作目标,我们学习了 caveolin (CAV ) 的效果在 plasminogen 的刺激胰岛素的表示期间的 -1 禁止者(白族)-1。代表 RNAi CAV-1 基因的适当搁浅单人赛的 oligonucleotides 被 Ambion 软件分析。在退火产生双 stranded oligonucleotides (dsoligo ) 以后,它被克隆进由 T4 DNA 连接酶包含 RNA 聚合酶 III 表示元素的 pENTR/U6 入口向量。从 pENTR/U6 入口转移的短发卡(shRNA ) 序列与 LR 再结合反应被克隆进 pLenti6/BLOCK-iT-DEST 向量。由定序的 Afteridentification,我们成功地用网关技术构造了 CAV-1 RNAi lentiviral 表达式系统。Silencing 效率是由即时 reversetranscription 聚合酶链反应,免疫荧光染色并且西方的弄污的 assayed。ECV304cells 在包含胰岛素的不同集中的媒介是有教养的(1x10 ^( 有 CAV-1 基因 silenced 的 -9)to1x10^(-7) M ) 。表示水平和潜水艇 PAI-1 和 CAV-1 的细胞的本地化用反向的抄写聚合酶链反应,免疫荧光染色和蛋白质印迹试金被比较。结果证明有势力抑制 ofCAV-1 表示能到达 85% ,并且它对 CAV-1-derived shRNA,不是导出 theS100A13 的 shRNA 特定。在蛋白质确实在房间膜下面积累了的在与生理的胰岛素,而是 PAI-1 孵化的 RNAi^+andRNAi^- ECV304 房间之间的 PAI-1 表示没有戏剧的差别。当胰岛素的集中增加了, PAI-1 的表示是起来调整的,而 CAV-1 的表示稀释了。而且, PAI-1 清楚地在 CAV-1knockdown 以后扩充了。这些结果显示 hyperinsulinism 能由 inhibitingCAV-1 支持 PAI-1 表示,并且稳定或在 endothelial 房间的起来调整的 CAV-1 表示可能在糖尿病减少大容器和毛状的容器的复杂并发症。 | Huiling YANG Shuya HE Zhihua QUAN Weixia PENG Bin YAN Jianghua LIU Fang WEN Renxian CAO Yangyan XU Gebo WEN Weixin HU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，3： | 7 |
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