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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | 2013 ESH/ESC Guidelines for the management of arterial hypertension显示文摘 | Giuseppe Mancia Robert Fagard Krzysztof Narkiewicz Josep Redon Alberto Zanchetti Michael B?hm Thierry Christiaens Renata Cifkova Guy De Backer Anna Dominiczak Maurizio Galderisi Diederick E. Grobbee Tiny Jaarsma Paulus Kirchhof Sverre E. Kjeldsen Stéphane | 2013 | European Heart Journal2013，，28： | 5 |
| 3 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 4 | Melanoma of the gallbladder misdiagnosed as gallbladder cancer显示文摘To the Editor:Metastatic melanoma of the gallbladder is extremely rare,and despite appropriate therapy its prognosis is poor withfew patients surviving more than 2 years. We present acase of gallbladder involvement by malignant melanomain | Renata Potonyacz Colaneri Bárbara dos Santos Nunes Paulo Herman | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 3 |
| 5 | Use of siRNA molecular beacons to detect and attenuate mycobacterial infection in macrophages显示文摘Tuberculosis is one of the leading infectious diseases plaguing mankind and is mediated by the facultative pathogen, Mycobacterium tuberculosis(MTB). Once the pathogen enters the body, it subverts the host immune defenses and thrives for extended periods of time within the host macrophages in the lung granulomas, a condition called latent tuberculosis(LTB). Persons with LTB are prone to reactivation of the disease when the body's immunity is compromised. Currently there are no reliable and effective diagnosis and treatment options for LTB, which necessitates new research in this area. The mycobacterial proteins and genes mediating the adaptive responses inside the macrophage is largely yet to be determined. Recently, it has been shown that the mce operon genes are critical for host cell invasion by the mycobacterium and for establishing a persistent infection in both in vitro and in mouse models of tuberculosis. The Yrb E and Mce proteins which are encoded by the MTB mce operons display high degrees of homology to the permeases and the surface binding protein of the ABC transports, respectively. Similarities in structure and cell surface location impute a role in cell invasion at cholesterol rich regions and immunomodulation. The mce4 operon is also thought to encode a cholesterol transport system that enables the mycobacterium to derive both energy and carbon from the host membrane lipids and possibly generating virulence mediating metabolites, thus enabling the bacteria in its long term survival within the granuloma. Various deletion mutation studies involving individual or whole mce operon genes have shown to be conferring varying degrees of attenuation of infectivity or at times hypervirulence to the host MTB, with the deletion of mce4 A operon gene conferring the greatest degree of attenuation of virulence. Antisense technology using synthetic si RNAs has been used in knocking down genes in bacteria and over the years this has evolvedinto a powerful tool for elucidating the roles of various genes mediating infectivity and survival in mycobacteria. Molecular beacons are a newer class of antisense RNA tagged with a fluorophore/quencher pair and their use for in vivo detection and knockdown of mR NA is rapidly gaining popularity. | Remo George Renata Cavalcante Celso Carvalho Jr Elyana Marques Jonathan B Waugh M Tino Unlap | 2015 | World Journal of Experimental Medicine2015，5，3： | 2 |
| 6 | Sequences of cDNAs and expression of genes encoding chitin synthase and chitinase in the midgut of Spodoptera frugiperda 显示文摘 | RENATA B YASUYUKI A SUBBARATNAM M | 2005 | Insect Biochemistry and Molecular Biology2005，35，11： | 1 |
| 7 | Degradation of chitosan and starch by 360kHz ultrasound显示文摘 | Renata C B Bozena R Salah L | 2005 | Carbohydrate Polymers2005，60，2： | 1 |
| 8 | Glial cell line - derived neurotrophic factor $ stimulated phosphatidylinositol 3 - kinase and Akt activities exert opposing effects on the ERK pathway显示文摘 | Baharia M Renata B lsabelle B | 2001 | Biological Chem2001，276，45： | 1 |
| 9 | Adsorption and uptake of copper by green alga scenedesmus subspicatus (Chloro- phyta) 显示文摘 | Katja K Renata B Laura S | 1997 | Journal of Phycology1997，33，4： | 1 |
| 10 | An efficient tension-stiffening model for nonlinear analysis of reinforced concrete members显示文摘 | Stramandinoli Renata S B Rovere Henriette L La | 2008 | Engineering Structures2008，30，7： | 1 |
| 11 | 2013 ESH/ESC Guidelines for the management of arterial hypertension显示文摘 | Giuseppe Mancia Robert Fagard Krzysztof Narkiewicz Josep Redon Alberto Zanchetti Michael B?hm Thierry Christiaens Renata Cifkova Guy De Backer Anna Dominiczak Maurizio Galderisi Diederick E. Grobbee Tiny Jaarsma Paulus Kirchhof Sverre E. Kjeldsen Stéphane | 2013 | European Heart Journal2013，，28： | 1 |
| 12 | 2013 ESH/ESC Guidelines for the management of arterial hypertension显示文摘 | Giuseppe Mancia Robert Fagard Krzysztof Narkiewicz Josep Redon Alberto Zanchetti Michael B? hm Thierry Christiaens Renata Cifkova Guy De Backer Anna Dominiczak Maurizio Galderisi Diederick E. Grobbee Tiny Jaarsma Paulus Kirchhof Sverre E. Kjeldsen Sté pha | 2013 | Blood Pressure2013，，4： | 1 |
| 13 | Degradation of chitosan and starch by 360 kHz ultrasound显示文摘 | Renata C B Bozena R Salah L | 2005 | Carbohydrate Polymers2005，60，2： | 1 |
| 14 | Effects of free Cu2+and Zn2+ions ongrowth and metal accumulation in freshwater algae显示文摘 | KATJA K RENATA B LAURA S | 1997 | EnvironmentalToxicology and Chemistry1997，16，2： | 1 |
| 15 | Detection of Schistosoma mansoni eggs in feces through their interaction with paramagnetic beads in a magnetic field显示文摘 | Candida FT Erli N Renata B | 2007 | PLoS Negl Trop Dis2007，1，2： | 1 |
| 16 | Differential gene expression profiles between tumor biopsies and short-term primary cultures of ovarian serous carcinomas, Identification of novel molecular biomarkers for early diagnosis and therapy显示文摘 | Eliana B Renata AT Stefano C | 2006 | Gynecol Oncol2006，103，： | 1 |
| 17 | A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis 显示文摘 | Renata B Stephen A Kenneth B | 2006 | N Engl J Med2006，355，2： | 1 |
| 18 | Hydrogen sulfide is an endogenous modulator of leukocyte-mediated in flammation显示文摘 | Renata COZ Vinceazo B Eleanora D | 2006 | FASEB 12006，20，12： | 1 |
| 19 | Osmotic dehydra-tion of tomato in ternary solutions:Influence of process vari-ables on mass transfer kinetics and an evaluation of the re-tention of carotenoids显示文摘 | Renata V T Alessandra F B Miriam D H | 2007 | Journal of Food Engineering2007，，82： | 1 |
| 20 | Effects of botulinum toxintype a in the bladder wall of children with neumgenic bladder dys-function: A comparison of histological features before and af- ter injec-tions显示文摘 | Maria P P Giovanni M Renata B | 2011 | The Journal of Urology2011，185，6： | 1 |
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