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| 1 | 改善高血压患者的药物依从性:一项随机研究显示文摘治疗高血压和血脂异常能显著降低心血管事件和脑卒中风险,但服用降压药和降脂药的依从性差及没有持续性的现象仍很常见。数十年来已经对改善药物依从性的干预措施进行了较深入研究,即使采用了复杂的干预措施,其作用也很有限。一个可能的解释是不依从性受多因素影响。目前药物依从性研究的范围应倾向于个体化的治疗策略,而不是标准化干预,例如临床药师干预着重于关注患者药物相关问题和依从性行为。 | Hedegaard U Kjeldsen LJ Pottegard A Henriksen JE Lambrechtsen J Hangaard J Hallas J | 2015 | 中华高血压杂志2015，23，12： | 15 |
| 2 | Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases显示文摘AIM To investigate whether immune mediated diseases(IMD) are more frequent in patients with inflammatory bowel disease(IBD).METHODS In this population based registry study,a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16,2013. Controls were randomly selected from the Danish Civil Registration System(CRS) and matched for sex,age,and municipality. We used ICD 10 codes to identify the diagnoses of the included patients. The IBD population was divided into three subgroups: Ulcerative colitis(UC),Crohn's disease(CD) and Both the latter referring to those registered with both diagnoses. Subsequently,odds-ratios(OR) and 95%CI were obtained separately for each group and their respective controls. The use of Bonferoni post-test correction adjusted the significance level to P < 0.00125. P-values were estimated using Fisher's exact test.RESULTS There were significantly more women than men in the registry,and a greater percentage of comorbidity in the IBD groups(P < 0.05). Twenty different IMDs were all significantly more frequent in the IBD group. Sixteen were associated with UC versus twelve with CD. In both UC and CD ORs were significantly increased(P < 0.00125) for primary sclerosing cholangitis(PSC),celiac disease,type 1 diabetes(T1D),sarcoidosis,asthma,iridocyclitis,psoriasis,pyoderma gangrenosum,rheumatoid arthritis,and ankylosing spondylitis. Restricted to UC(P < 0.00125) were autoimmune hepatitis,primary biliary cholangitis,Grave's disease,polymyalgia rheumatica,temporal arteritis,and atrophic gastritis. Restricted to CD(P < 0.00125) were psoriatic arthritis and episcleritis. Restricted to women with UC(P < 0.00125) were atrophic gastritis,rheumatoid arthritis,temporal arteritis,and polymyalgia rheumatica. Restricted to women with CD were episcleritis,rheumatoid arthritis,and psoriatic arthritis. The only disease restricted to men(P < 0.00125) was sarcoidosis. CONCLUSION Immune mediated diseases were significantly more frequent in patients with IBD. Our results strengthen the hypothesis that some IMDs and IBD may have overlapping pathogenic pathways. | Morten L Halling Jens Kjeldsen Torben Knudsen Jan Nielsen Lars Koch Hansen | 2017 | World Journal of Gastroenterology2017，23，33： | 9 |
| 3 | 2013 ESH/ESC Guidelines for the management of arterial hypertension显示文摘 | Giuseppe Mancia Robert Fagard Krzysztof Narkiewicz Josep Redon Alberto Zanchetti Michael B?hm Thierry Christiaens Renata Cifkova Guy De Backer Anna Dominiczak Maurizio Galderisi Diederick E. Grobbee Tiny Jaarsma Paulus Kirchhof Sverre E. Kjeldsen Stéphane | 2013 | European Heart Journal2013，，28： | 5 |
| 4 | Diagnostic Accuracy of Capsule Endoscopy for Small Bowel Crohn’s Disease Is Superior to That of MR Enterography or CT Enterography显示文摘 | Michael Dam Jensen Torben Nathan S?ren Rafael Rafaelsen Jens Kjeldsen | 2011 | Clinical Gastroenterology and Hepatology2011，，2： | 3 |
| 5 | Allocation of patients with liver cirrhosis and organ failure to intensive care: Systematic review and a proposal for clinical practice显示文摘AIM: To propose an allocation system of patients with liver cirrhosis to intensive care unit(ICU), and developed a decision tool for clinical practice. METHODS: A systematic review of the literature was performed in Pub Med, MEDLINE and EMBASE databases. The search includes studies on hospitalized patients with cirrhosis and organ failure, or acute on chronic liver failure and/or intensive care therapy. RESULTS: The initial search identified 660 potentially relevant articles. Ultimately, five articles were selected; two cohort studies and three reviews were found eligible. The literature on this topic is scarce and no studies specifically address allocation of patients with liver cirrhosis to ICU. Throughout the literature, there is consensus that selection criteria for ICU admission should be developed and validated for this group of patients and multidisciplinary approach is mandatory. Based on current available data we developed an algorithm, to determine if a patient is candidate to intensive care if needed, based on three scoring systems: premorbid Child-Pugh Score, Model of End stage Liver Disease score and the liver specific Sequential Organ Failure Assessment score.CONCLUSION: There are no established systems for allocation of patients with liver cirrhosis to the ICU and no evidence-based recommendations can be made. | Katrine Prier Lindvig Ane Sogaard Teisner Jens Kjeldsen Thomas Strom Palle Toft Valentin Furhmann Aleksander Krag | 2015 | World Journal of Gastroenterology2015，21，29： | 3 |
| 6 | Stroke is more common than myocardial infarction in hypertension:analysis based on 11 major randomized intervention trials显示文摘 | Kjeldsen SE Julius S Hedner T | | Blood Pressure0，，： | 3 |
| 7 | Interventional treatment of pulmonary arteriovenous malformations显示文摘Pulmonary arteriovenous malformations(PAVM) are congenital vascular communications in the lungs.They act as right to left shunts so that the blood running through these malformations is not oxygenated or filtered.These patients are typically hypoxaemic with exercise intolerance and are at high risk of paradoxical emboli to the brain and other organs.These malformations are most commonly seen in hereditary haemorrhagic telangiectasia(HHT)(Mb.Osler-Weber-Rendu syndrome).Nowadays,the generally accepted treatment strategy of first choice is embolization of the afferent arteries to the arteriovenous malformations.It is a minimally invasive procedure and at the same time a lung preserving treatment with a very high technical success,high effectiveness and low morbidity and mortality.Embolization prevents cerebral stroke and abscess as well as pulmonary haemorrhage and further raises the functional level.Embolization is a well-established method of treating PAVM,with a significant effect on oxygenation of the blood.Screening for PAVM in patients at risk is recommended,especially in patients with HHT. | Poul Erik Andersen Anette Drφhse Kjeldsen | 2010 | World Journal of Radiology2010，2，9： | 2 |
| 8 | Stroke is More Common than Myocardial Infarction in Hypertension: Analysis based on 11 Major Randomized Intervention Trials显示文摘 | Sverre E. Kjeldsen Stevo Julius Thomas Hedner Lennart Hansson | 2001 | Blood Pressure2001，，4： | 2 |
| 9 | Clinical and Radiological Long-Term Follow-up After Embolization of Pulmonary Arteriovenous Malformations显示文摘 | Poul Erik Andersen Anette D. Kjeldsen | 2006 | CardioVascular and Interventional Radiology2006，，1： | 2 |
| 10 | 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Giuseppe Mancia Guy De Backer Anna Dominiczak Renata Cifkova Robert Fagard Giuseppe Germano Guido Grassi Anthony M Heagerty Sverre E Kjeldsen Stephane Laurent Krzysztof Narkiewicz Luis Ruilope Andrzej Rynkiewicz Roland E Schmieder Harry AJ Struijker Boudi | 2007 | Journal of Hypertension2007，，6： | 2 |
| 11 | 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Giuseppe Mancia Guy De Backer Anna Dominiczak Renata Cifkova Robert Fagard Giuseppe Germano Guido Grassi Anthony M Heagerty Sverre E Kjeldsen Stephane Laurent Krzysztof Narkiewicz Luis Ruilope Andrzej Rynkiewicz Roland E Schmieder Harry AJ Struijker Boudi | 2007 | Journal of Hypertension2007，，6： | 2 |
| 12 | Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hyoertensinon study (LIFE) ;A randomized trial against atenolol 显示文摘 | Dahlof B Devereux RB Kjeldsen SE | 2002 | Lancet2002，359，： | 1 |
| 13 | Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine:The VALUE randomised trial显示文摘 | Julius S Kjeldsen SE Weber M | 2004 | Lancet2004，363，9426： | 1 |
| 14 | Biogeochemistry oflandfill leachate plumes 显示文摘 | Christonsen T H Kjeldsen P Sjerg P L | 2001 | Appl Geochem2001，16，67： | 1 |
| 15 | Cardiovascular morbid-ity and mortality in the Losartan Intervention For Endpoint reductionin hypertension study(LIFE):a randomised trial against atenolol显示文摘 | Dahlof B Devereux RB Kjeldsen SE | 2002 | Lancet2002，359，9311： | 1 |
| 16 | Stroke is more common than myocardial infaraction in hypertension: analysis based on 11 major randomized intervetion trials 显示文摘 | Kjeldsen SE Julius S Hedner T | 2001 | Blood Press2001，10，： | 1 |
| 17 | VALUE Study: Outcomes In 7080 Patients Treated With Monotherapy 显示文摘 | Julius S Kjeldsen SE Mclnnes G | 2005 | Presented June2005，19，： | 1 |
| 18 | Effects of deneration on sodi- um, potassium and ouabain binding in muscles of normal and potassium-depleted rats显示文摘 | Clausen T Kjeldsen K Norgaard A | 1983 | J Physiol1983，345，： | 1 |
| 19 | Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine:the VALUE randomised trial显示文摘 | Julius S Kjeldsen SE Weber M | 2004 | Lancet2004，363，： | 1 |
| 20 | Racial differences in incident heart failure during antihypertensive therapy显示文摘 | Okin PM Kjeldsen SE Dahlof B | | 0，，： | 1 |
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