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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Adjuvant tamoxifen and ex- emcstane in early breast cancer (TEAM) : a randomised phase 3 trial 显示文摘 | Van De Velde C J Rea D Seynaeve C et at | 2011 | Lancet2011，377，9762： | 1 |
| 3 | Physiological response of 'Larry Ann' plums to cold storage and 1-MCP treatment显示文摘 | Larrigaudi~rea C Candanb AP Ubacha D | 2009 | Postharvest Biology and Technology2009，51，1： | 1 |
| 4 | Neodymium isotopic variation in North Pacific modern silicate sediment and the insignificance of detrital REE contributions to seawater显示文摘 | Jones C E Halliday A N Rea D K | 1994 | Earth and Planetary Science Letters1994，127，： | 1 |
| 5 | Adjuvant tamoxifen and exemestane in early breast cancer (TEAM):A randomised phase 3 trial显示文摘 | van de Velde CJH Rea D Seynaeve C | 2011 | Lancet2011，377，： | 1 |
| 6 | Timing and sequence of the onset of overweight, dieting, and binge eating in overweight patients with binge eating disorder 显示文摘 | REAS D L GRILO C M | 2007 | Int J Eat Disord2007，40，2： | 1 |
| 7 | Late Miocene and mid-Pliocene enhancement of the east Asian Monsoon as viewed from land and sea显示文摘 | Zheng H Powell C Rea D | 2004 | Global and Planetary Change2004，41，： | 1 |
| 8 | Adjuvant tamoxifen and exemestane in early breast cancer (TEAM) : a randomised phase 3 trial显示文摘 | VAN DE VELDE C J REA D SEYNAEVE C | 2011 | Lancet2011，377，9762： | 1 |
| 9 | Adjuvant tamoxifen and ex- emestane in early breast cancer ( TEAM ) : a randomized phase 3 trial 显示文摘 | van de Velde CJ Rea D Seynaeve C | 2011 | Lancet2011，377，9762： | 1 |
| 10 | Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): a randomised phase 3 trial 显示文摘 | van de Velde C J Rea D Seynaeve C | 2011 | Lancet2011，377，9762： | 1 |
| 11 | Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): a randomized phase 3 trial显示文摘 | van de Velde CJ Rea D Seynaeve C | 2011 | Lancet2011，377，9762： | 1 |
| 12 | Glucocorticoids transform CD40-triggering of dendritic cells into an alternative activation pathway resulting in antigen-presenting cells that secrete IL-10显示文摘 | REA D VAN KOOTEN C VAN MEIJGAARDEN K E | 2000 | Blood2000，95，10： | 1 |
| 13 | Family-focused treatment versus individual treatment for bipolar disorder:results of a randomized clinical trial显示文摘 | Rea M M Tompson M C Miklowitz D J | 2003 | J Consult Clin Psychol2003，71，3： | 1 |
| 14 | Dissociation of oceanic methane hydrate as a cause of the carbon isotope excursion at the end of the Paleocene 显示文摘 | Dickens G R O' Neil J R Rea D C | 1995 | Paleoceanography1995，10，6： | 1 |
| 15 | Dasatinib-induced lupus 显示文摘 | REA D BERGERON A FIESCHI C | 2008 | Lancet2008，372，9640： | 1 |
| 16 | Computer simulation models of booked beach shoreline configuration显示文摘 | Rea C C Komar P D | 1975 | Sedimentary Petrology1975，，： | 1 |
| 17 | Adjuvant tamoxifen and exemestane in early breast cancer (TEAM):a randomised phase 3 trial显示文摘 | van de Velde CJ Rea D Seynaeve C | 2011 | Lancet2011，377，9762： | 1 |
| 18 | Liver transplantation with neoadjuvant chemoradiation is more effective than resection for hilar cholangiocarcinoma显示文摘 | Rea D J Heimbach J K Rosen C B | 2005 | Ann Surg2005，242，3： | 1 |
| 19 | Late Miocene and mid-Pliocene enhancement of the East Asian Monsoon as viewed from landand sea显示文摘 | Zheng H B Powell C Rea D | | Global and Planetary Change0，，： | 1 |
| 20 | Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): a randomised phase 3 trial显示文摘 | Van de velde CJ Rea D Seynaeve C | 2011 | Lancet2011，377，9762： | 1 |
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