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| 1 | Gene expression changes in spleens of the wildlife reservoir species,Eurasian wild boar(Sus scrofa),naturally infected with Brucella suis biovar 2显示文摘Brucella suis is responsible for swine brucellosis worldwide.Of the five different B.suis biovars(bv.),bv.2 appears restricted to Europe where it is frequently isolated from wild boar and hares,can infect pigs and can cause human brucellosis.In this study,the differential gene expression profile was characterized in spleens of Eurasian wild boar naturally infected with B.suis bv.2.Of the 20,201 genes analyzed in the microarray,633 and 1,373 were significantly(fold change > 1.8;P < 0.01) upregulated and downregulated,respectively,in infected wild boar.The analysis was focused on genes that were over represented after conditional test for biological process gene ontology.Upregulated genes suggested that B.suis bv.2 infection induced cell maturation,migration and/or proliferation in infected animals.The genes downregulated in infected wild boar impaired the activity of several important cellular metabolic pathways such as metabolism,cytoskeleton organization and biogenesis,immune response and lysosomal function and vesicle-mediated transport.In addition,the response to stress,sperm fertility,muscle development and apoptosis seemed to be also impaired in infected animals.These results suggested that B.suis bv.2 may use strategies similar to other smooth brucellae to facilitate intracellular multiplication and the development of chronic infections.To our knowledge,this is the first report of the analysis of gene expression profile in hosts infected with B.suis bv.2,which is important to understand the molecular mechanisms at the host-pathogen interface in the main reservoir species with possible implications in the zoonotic cycle of the pathogen. | Ruth C.Galindo Pilar M.Muoz María J.de Miguel Clara M.Marin Javier Labairu Miguel Revilla José M.Blasco Christian Gortazar José de la Fuente | 2010 | Journal of Genetics and Genomics2010，37，11： | 6 |
| 2 | Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications. | Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns | 2015 | World Journal of Gastroenterology2015，21，17： | 4 |
| 3 | Callus induction and a preliminary attempt to obtain cell suspensions from embryos and levels of Juglans regia L 显示文摘 | Rodriguez R Revilla M A Perez C | 1987 | Acta Hort (ISHS)1987，12，： | 1 |
| 4 | Contribution of autoch- thonous maize populations for adaptation to European con- ditions显示文摘 | Revilla P Boyat A lvarez A | 2006 | Euphytica2006，152，2： | 1 |
| 5 | Effect of locust bean/xanthan gum addition and replacement of pork fat with olive oil on the quality characteristicsof low-fat frankfurters显示文摘 | LURUENA-MARTINEZ M A VIVAR-QUINTANA A M REVILLA I | 2004 | Meat Science2004，68，3： | 1 |
| 6 | Insect damage to sweet corn hybrids in the south Atlantic European coast显示文摘 | Malvar R A Revilla P Velasco P | 2002 | Journal of American Society for Horticultural Science2002，127，： | 1 |
| 7 | Fx vivo ersponse to sapirin differs in stroke patients with single or recurrent events:a pilot study显示文摘 | Chamorro A Escolar G Revilla M | 1999 | J Nenrol Sci1999，171，： | 1 |
| 8 | The Relation between Firm Size and R&D Productivity in Different Technological Regimes 显示文摘 | Revilla A J Fernmdez Z | 2012 | Technovation2012，32，11： | 1 |
| 9 | Antioxidant activity of propionyl-L-carnitine in liver and heart of spontaneously hypertensive rats显示文摘 | Gomez-Amores L Mate A Revilla E | 2006 | Life Sci2006，78，17： | 1 |
| 10 | Effect of maternal diabetes on human and rat fetal development显示文摘 | POLANCO A C REVILLA M C PALOMINO M A | 2005 | Ginecol Obstet Mex2005，73，10： | 1 |
| 11 | Effect of locust bean/xanthan gum addition and replacement of pork fat with olive oil on the quality characteristics of low-fat frankfurters显示文摘 | M A Luruena-Martinez A M Vivar-Quintana I Revilla | 2004 | Meat Science2004，68，： | 1 |
| 12 | A general strategy for the isolation of mesophyll protoplasts from delicious fruit and nut tree species 显示文摘 | OCHATT S J Doughty S | 1987 | Plant Science1987，50，： | 1 |
| 13 | Isolated right-sided valvular endocarditis in non-intravenous drug users 显示文摘 | Revilla A Lopez J Villacorta E | 2008 | Rev Esp Cardiol2008，61，12： | 1 |
| 14 | Competitive Learning in Informatics: The UVa Online Judge Experience 显示文摘 | Revilla M A Manzoor S Liu Rujia | 2008 | Olympiads in Informatics2008，，2： | 1 |
| 15 | A- 174G/C polymorphism of the interleukin - 6 gene in pzitients with lacunar infarction显示文摘 | Maria'n Revilla Vl'ctor Obach A' lvaro Cervera | 2002 | Neuroscience Letters2002，324，： | 1 |
| 16 | Effect of dopaminergic medication on postural sway in advanced Parkinson' s disease显示文摘 | Revilla FJ Larsh TR Mani A | 2013 | Front Neurol2013，4，： | 1 |
| 17 | Dynamics of Haemophilus parasuis genotypes in a farm recovered from an out-break of Glasser's disease 显示文摘 | Olvera A Cerda-Cuellar M Revilla E | 2007 | Vet Microbiol2007，123，2： | 1 |
| 18 | The 174G/C pol- ymorphism of the interteukin 6 gene is a hallmark of lacunar stroke and not other ischemic stroke phenotypes显示文摘 | CHAMORRO A REVILLA M OBACH V | 2005 | Cerebrovasc Dis 20052005，9195，： | 1 |
| 19 | Effect of locust bean/xanthan gum addition and replacement of pork fat with olive oil on the quality characteristicsof low-fat frankfurters显示文摘 | Luruena m M A Vivar Q A M Revilla I | 2004 | Meat Science2004，68，3： | 1 |
| 20 | Expression of the neuronal calcium sensor protein family in the rat brain 显示文摘 | Paterlini M Revilla V Grant A L | 2000 | Neuroscience2000，99，2： | 1 |
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