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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | The Seasat Scanning Multichannel Microwave Radiometer(SMMR):Radio-metric Calibration Algorithm Development and Perfo-rmance显示文摘 | SWANSON P RILEY A L | 1980 | IEEE Journal of Oceanic Engineering1980，5，2： | 1 |
| 3 | Genetically engineered bacteriocins and their potential as the next generation of antimierobials显示文摘 | GILLOR O NIGRO L M RILEY M A | 2005 | Current Pharmaceutical Design2005，11，： | 1 |
| 4 | Decreased thin filament density and length in human atrophic soleus muscle fibers after spaceflight显示文摘 | Riley D A Bain J L Thompson J L | 2000 | J Appl Physiol2000，88，2： | 1 |
| 5 | Temporal changes in the prevalence of community-acquired anti- microbial-resistant urinary tract infection affected by Escherichia eoli clonal group composition显示文摘 | SMITH S P MANGES A R RILEY L W | 2008 | Clin In- feet Dis2008，46，： | 1 |
| 6 | Wildland fire e- missions, carbon, and climate: Seeing the forest and the trees A cross-scale assessment of wildfire and carbon dynamics in fire-prone, forested ecosystems 显示文摘 | Loehman A Reinhardt E Riley L | 2014 | Forest Ecology and Management2014，317，1： | 1 |
| 7 | Building and maintaining a library Gopher:traditional skills applied to emerging resources显示文摘 | Riley R A Shipman B L | | 0，，： | 1 |
| 8 | Ash fusion temperatures under oxidizing conditions显示文摘 | LLOYD W G RILEY J T ZHOU S RISEN M A TIBBITTS R L | 1993 | Energy Fuels1993，7，4： | 1 |
| 9 | A model for hysteretic magnetic properties under the application of noncoaxial stress and field显示文摘 | Sablik M J Rubin S W Riley L A | 1993 | Journal of Applied Physics1993，74，1： | 1 |
| 10 | Fiber-type susceptibility to eccentric contraction-induced damage of hindlimb-unloaded rat AL muscles 显示文摘 | Vijayan K Thompson J L Norenberg K M Fitts R H Riley D A | 2001 | J Appl Physiol2001，90，3： | 1 |
| 11 | Postoperative dysphagia in anterior cervical spine surgery显示文摘 | RILEY L H 3rd VACCARO A R DETTORI J R | 2010 | Spine (Phila Pa 1976)2010，35，9： | 1 |
| 12 | Evolution of the gall-forming plant parasitic nematodes (Tylenehida:Anguinidae) and their relationships with hosts as inferred from internal transcribed spacer sequences of nuclear ribosomal DNA显示文摘 | SUBBOTIN S A KRALL E L RILEY I T | | 0，，： | 1 |
| 13 | Tuberculosis in theAIDS era 显示文摘 | Sepkowitz K A Rafalli J Riley L | 1995 | Clin Microbiol Revs1995，8，2： | 1 |
| 14 | Effects of landscape and weather on winter survival of ring-necked pheasant hens显示文摘 | Perkins A L Clark W R Riley T Z | 1997 | Journal of Wildlife Management1997，61，3： | 1 |
| 15 | Ka-band MMIC beam-steered transmitter array显示文摘 | RASCOE D L RILEY A L HUANG J | 1989 | IEEE MTT1989，3702，： | 1 |
| 16 | Oxygen mobility in silicon dioxide and silicate glasses:a review显示文摘 | LAMKIN M A RILEY F L FORDHAM R J | 1992 | Journal of the European Ceramic Society1992，10，5： | 1 |
| 17 | Electrochemical effects of ALD surface modification on combustionsynthesized Mn1/3 Col/3 02 as a layered-cathode material显示文摘 | RILEY L A VAN ATTA S CAVANAGH A S | 2011 | Journal of Power Sources2011，196，6： | 1 |
| 18 | Microbiological damage of cellulose acetate RO membranes显示文摘 | Myrphy A P Moody R L Riley C D | 2001 | Journal of Membrane Science2001，193，1： | 1 |
| 19 | Micromagnetic model for biaxial stress effects on magnetic properties显示文摘 | SABLIK M J RILEY L A BURKHARDT G L | 1994 | Journal of Magnetism and Magnetic Materials1994，132，13： | 1 |
| 20 | Factors affecting mercury speciation in a 100-MW coal-fired boiler with low-NOx burners显示文摘 | KELLIE S CAO Y DUAN Y F LI L C CHU P MEHTA A CARTY R RILEY J T PAN W P | 2005 | Energy Fuels2005，19，3： | 1 |
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