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| 1 | Oncogenic role of leptin and Notch interleukin-1 leptin crosstalk outcome in cancer显示文摘Obesity is a global pandemic characterized by high levels of body fat(adiposity) and derived-cytokines(i.e., leptin). Research shows that adiposity and leptin provide insight on the link between obesity and cancer progression. Leptin's main function is to regulate energy balance. However, obese individuals routinely develop leptin resistance, which is the consequence of the breakdown in the signaling mechanism controlling satiety resulting in the accumulation of leptin. Therefore, leptin levels are often chronically elevated in human obesity. Elevated leptin levels are related to higher incidence, increased progression and poor prognosis of several human cancers. In addition to adipose tissue, cancer cells can also secrete leptin and overexpress leptin receptors. Leptin is known to act as a mitogen, inflammatory and pro-angiogenic factor that induces cancer cell proliferation and tumor angiogenesis. Moreover, leptin signaling induces cancer stem cells, which are involved in cancer recurrence and drug resistance. A novel and complex signaling crosstalk between leptin, Notch and interleukin-1(IL-1) [Notch, IL-1 and leptin crosstalk outcome(NILCO)] seems to be an important driver of leptin-induced oncogenic actions. Leptin and NILCO signaling mediate the activation of cancer stem cells that can affect drug resistance. Thus, leptin and NILCO signaling are key links between obesity and cancer progression. This review presents updated data suggesting that adiposity affects cancer incidence, progression, and response to treatment. Here we show data supporting the oncogenic role of leptin in breast, endometrial, and pancreatic cancers. | Crystal C Lipsey Adriana Harbuzariu Danielle Daley-Brown Ruben R Gonzalez-Perez | 2016 | World Journal of Methodology2016，6，1： | 8 |
| 2 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 3 | A hypothesis for treating inflammation and oxidative stress with hydrogen sulfide during age-related macular degeneration显示文摘Age-related macular degeneration(AMD) is a leading cause of blindness and is becoming a global crisis since affected people will increase to 288 million by 2040.Genetics,age,diabetes,gender,obesity,hypertension,race,hyperopia,iris-color,smoking,sun-light and pyroptosis have varying roles in AMD,but oxidative stress-induced inflammation remains a significant driver of pathobiology.Eye is a unique organ as it contains a remarkable oxygengradient that generates reactive oxygen species(ROS) which upregulates inflammatory pathways.ROS becomes a source of functional and morphological impairments in retinal pigment epithelium(RPE),endothelial cells and retinal ganglion cells.Reports demonstrated that hydrogen sulfide(H_2S) acts as a signaling molecule and that it may treat ailments.Therefore,we propose a novel hypothesis that H_2S may restore homeostasis in the eyes thereby reducing damage caused by oxidative injury and inflammation.Since H_2S has been shown to be a powerful antioxidant because of its free-radicals' inhibition properties in addition to its beneficial effects in age-relatedconditions,therefore,patients may benefit from H_2S salubrious effects not only by minimizing their oxidant and inflammatory injuries to retina but also by lowering retinal glutamate excitotoxicity. | Akash K George Mahavir Singh Rubens Petit Homme Avisek Majumder Harpal S SANDhu Suresh C Tyagi | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 3 |
| 4 | 西班牙交通基础设施与城市体系建设显示文摘从社会和地方融合、均衡性与土地异质性、交通网等级体系和支路网与交通可持续性四个角度探讨西班牙交通基础设施网建设对土地开发和土地规划相关国家法规的影响。从城市地理学视角分析中央政府基于改善城市和区域连接度和可达性进行的高速公路网、高铁网、机场和港口等交通基础设施规划,通过1950年代以来土地开发和房价涨跌、新兴产业培育和交通状况改善刺激不同级别城市蔓延和分化的人口增长,重塑西班牙国家城市体系格局。随后,概括了蔓延的城市增长模式和房地产与交通投资泡沫破裂后带给区域增长中心的影响,对通过交通基础设施规划进行投机性投资政策进行了批评。最后建议中央政府应该避免投机投资行为,基于现有的城市体系层级改善核心城市和大城市周边的机动性,优化基础设施建设,建立新的城市与区域增长模式。 | Lois-Gonzalez Ruben C Pineira-Mantinan M J 翟炜 顾朝林 | 2016 | 地理研究2016，35，7： | 3 |
| 5 | Acidic triterpenes compromise growth and survival of astrocytoma cell lines by regulating reactive oxygen species accumulation显示文摘 | RUBEN M JULIANA C ELVIRA I | 2007 | Cancer Research2007，67，8： | 1 |
| 6 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 7 | Three-dimensional registration and fusion of ultrasound and MRI using major vessels as fiducial markers显示文摘 | Porter B C Rubens D J Strang J G | | 0，，04： | 1 |
| 8 | High doses of Ketamine- Xylazine anesthesia reduce cardiac isehemia-reperfusion injury in guinea pigs显示文摘 | Ruben C Matthew R Dorcas O | 2011 | J Am Assoe Lab Anita Sci2011，50，3： | 1 |
| 9 | Temperature sensitivity and pressure resistance of mushroom polyphenoloxidase显示文摘 | Weemaes C Rubens P De Cordt S | 1997 | J Food Science1997，62，2： | 1 |
| 10 | Acidic triterpenes compromisegrowth and survival of astrocytoma cell lines by regulating reactive oxygen species accumulation 显示文摘 | Ruben M Juliana C Elvira I | 2008 | Cancer Res2008，67，8： | 1 |
| 11 | Experimental and full scale pilot plant constructed wetlands for municipat wastewaters treatment显示文摘 | Gemma A Juan M G Ruben C and Estanistao de L | 2003 | Ecological Engineering2003，21，1： | 1 |
| 12 | Sequence analysis of expressed sequence tags from an ABA-treated cDNA library identifies stress response genes in the moss Physcomitrella patterns显示文摘 | Machuka J Bashiardes S Ruben E Spooner K Cuming A Knight C Cove D | 1999 | Plant Cell Physiol1999，40，4： | 1 |
| 13 | Quantum communication with po- larization-encoded qubit using quantum error correction 显示文摘 | Daniel B Jose C Rubens V | 2008 | IEEE Journal of Quantum Electronics2008，44，2： | 1 |
| 14 | Voltage SagsCompensation Using a Superconducting Flywheel Ener-gy Storage System 显示文摘 | Rubens A Antonio C Guilherme G | 2005 | IEEE Transactions on AppliedSuperconductivity2005，15，2： | 1 |
| 15 | Regulation of purine biosynthesis by a eukaryotic-type kinase in Streptococcus agalactiae显示文摘 | Rajagopal L Vo A Silvestroni A Rubens C E | | 0，，05： | 1 |
| 16 | A comprehensive review and evaluation of permutation flowshop heuristies显示文摘 | RUBEN R MAROTO C | 2005 | European Journal of Operational Research2005，165，2： | 1 |
| 17 | Streptococcus suis serotype 2 interactions with human brain microvascular endothelial cells显示文摘 | CHARLAND N NIZET V RUBENS C E | 2000 | Infect Immun2000，68，2： | 1 |
| 18 | The effect of intensity-modulated radiotherapy on radiation-induced second malignancies显示文摘 | Ruben JD Davis S Evans C | 2008 | Int J Radiat Oncol Biol Phys2008，70，5： | 1 |
| 19 | High-resolution transmission electron microscopy of the nanostructure of melamine-formaldehyde aerogels显示文摘 | Ruben G C Pekala R W | 1995 | JNon-Crystalline Solids1995，186，： | 1 |
| 20 | Arrhythmias ventrieular and outilow tract myocardium as a substrate for life-threatening developmental basis for elec- trophysiological heterogeneity in the ventricular arrhythmias显示文摘 | Bastiaan B Vincent C Ruben C | 2009 | Circ Res2009，104，： | 1 |
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