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| 1 | Computed tomography-guided percutaneous core needle biopsy in pancreatic tumor diagnosis显示文摘AIM: To evaluate the techniques, results, and complications related to computed tomography(CT)-guided percutaneous core needle biopsies of solid pancreatic lesions.METHODS: CT-guided percutaneous biopsies of solid pancreatic lesions performed at a cancer reference center between January 2012 and September 2013 were retrospectively analyzed. Biopsy material was collected with a 16-20 G Tru-Core needle(10-15 cm; Angiotech, Vancouver, CA) using a coaxial system and automatic biopsy gun. When direct access to the lesion was not possible, indirect(transgastric or transhepatic) access or hydrodissection and/or pneumodissection maneuvers were used. Characteristics of the patients, lesions, procedures, and histologic results were recorded using a standardized form. RESULTS: A total of 103 procedures included in the study were performed on patients with a mean age of 64.8 year(range: 39-94 year). The mean size of the pancreatic lesions was 45.5 mm(range: 15-195 mm). Most(75/103, 72.8%) procedures were performed via direct access, though hydrodissection and/or pneumodissection were used in 22.2%(23/103) of cases and indirect transhepatic or transgastric access was used in 4.8%(5/103) of cases. Histologic analysis was performed on all biopsies, and diagnoses were conclusive in 98.1%(101/103) of cases, confirming3.9%(4/103) of tumors were benign and 94.2%(97/103) were malignant; results were atypical in 1.9%(2/103) of cases, requiring a repeat biopsy to diagnose a neuroendocrine tumor, and surgical resection to confirm a primary adenocarcinoma. Only mild/moderate complications were observed in 9/103 patients(8.7%),and they were more commonly associated with biopsies of lesions located in the head/uncinate process(n =8), than of those located in the body/tail(n = 1) of the pancreas, but this difference was not significant.CONCLUSION: CT-guided biopsy of a pancreatic lesion is a safe procedure with a high success rate, and is an excellent option for minimally invasive diagnosis. | Chiang J Tyng Maria Fernanda A Almeida Paula NV Barbosa Almir GV Bitencourt José Augusto AG Berg Macello S Maciel Felipe JF Coimbra Luiz Henrique O Schiavon Maria Dirlei Begnami Marcos D Guimares Charles E Zurstrassen Rubens Chojniak | 2015 | World Journal of Gastroenterology2015，21，12： | 14 |
| 2 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 3 | 向在人的察觉到钙的受体的 allosteric 药的结构的理解显示文摘allosterically 指向人的察觉到钙的受体(CaSR ) 的药有实质的治疗学的潜力,但是当前被限制。给 CaSR 的高分辨率的结构的缺席,我们把 mutagenesis 与一条新奇分析途径并且开发 “ 的分子的建模相结合; enriched”为在 Ca 2+ 在 CaSRs 7 transmembrane (7TM ) 以内的 o 和 allosteric 调节的人领域。修改多重有约束力的地点以适应在结构上的一个扩大的洞多样的 ligands 被识别。Phenylalkylamines 绑在与通常认为的 Ca 2+ o -binding 地点并且向一个细胞外的门厅延长。相反,在结构上和 pharmacologically 不同的 AC-265347 在 7TM 领域以内更深绑。而且,不同氨基酸网络被发现调停由不同调节的人的 cooperativity。这些调查结果可以与不同、潜在地偏导小径的药理学效果便于 allosteric 调节的人的合理设计。 | Katie Leach Karen J Gregory Irina Kufareva Elham Khajehali Anna E Cook Ruben Abagyan Arthur D Conigrave Patrick M Sexton Arthur Christopoulos | 2016 | Cell Research2016，26，5： | 2 |
| 4 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 5 | Three-dimensional registration and fusion of ultrasound and MRI using major vessels as fiducial markers显示文摘 | Porter B C Rubens D J Strang J G | | 0，，04： | 1 |
| 6 | Currently available biomaterials for use in cardiopulmonary bypass显示文摘 | Belway D Rubens FD | 2006 | Expert Rev Med Devices2006，3，3： | 1 |
| 7 | Soft sensors development for on-line bioreactor state estimation显示文摘 | AJILSON J D A RUBENS M F | 2000 | Computers and Chemical Engineering2000，24，： | 1 |
| 8 | Sequence analysis of expressed sequence tags from an ABA-treated cDNA library identifies stress response genes in the moss Physcomitrella patterns显示文摘 | Machuka J Bashiardes S Ruben E Spooner K Cuming A Knight C Cove D | 1999 | Plant Cell Physiol1999，40，4： | 1 |
| 9 | Direct link between MHC polymorphism, T cell avidity, and diversity in immune defense 显示文摘 | MESSAOUDI I JOSE A G P RUBEN D | 2002 | Science2002，，298： | 1 |
| 10 | Major topics in quantitative microradiography of enamel and dentin: Parameter, mineral distribution visualization, and hyper-remineralization显示文摘 | Arends J Ruben JL lnaba D | 1997 | Adv Dent Res1997，11，4： | 1 |
| 11 | Predictors of early neurocognitive deficits in low--risk patients undergoing on--pump coronary artery bypass surgery显示文摘 | Boodhwani M Rubens F D Wozny D | 2006 | Circulation2006，114，1： | 1 |
| 12 | Fibrosing alveolitis in systemic sclerosis: indices of lung function in relation to extent of disease on computed tomography 显示文摘 | Wells AU Hansell DM Rubens MB et d | 1997 | Arthrit Rheum1997，40，7： | 1 |
| 13 | Synthesis spectral and electrochemical properties of Al(Ⅲ)and Zn (Ⅱ)complexes with flavonoids显示文摘 | RUBENS F V D S WAGNER F D G | 2005 | Spectrochimica Acta Part A2005，61，： | 1 |
| 14 | Effects of sustained mild hypothermia on neurocognitive function after coronary artery bypass surgery:a randomized,double-blind study显示文摘 | Boodhwani M Rubens F Wozny D | 2007 | J Thorac Cardiovasc Surg2007，134，6： | 1 |
| 15 | Gene expression microarrays: a 21st century tool for directed vaccine design显示文摘 | NEELAM D RUBEN B DENNIS O | 2002 | Vaccine2002，20，： | 1 |
| 16 | T-ceUlymphoproliferative disorder following mycophenolate treatment formyasthenia gravis 显示文摘 | DUBAL D B MUELLER S RUBEN B S | 2009 | Muscle Nerve2009，39，6： | 1 |
| 17 | Assessing communication competence for intercultural adaptation 显示文摘 | RUBEN B D | 1976 | Group and Organization Studies1976，，1： | 1 |
| 18 | Imaging the elastic properties of tissue: the 20 year perspective显示文摘 | Parker K J Doyley M M Rubens D J | 2012 | Physics in medicine and biology2012，57，16： | 1 |
| 19 | Are we doing everything we can to conserve blood during bypass? A national survey 显示文摘 | Belway D Rubens FD Wozny D | 2005 | Perfusion2005，20，5： | 1 |
| 20 | Three dimensional sonoelastography:Principles and practices 显示文摘 | Taylor L S Porter B C Rubens D J | 2000 | Phys Med Biol2000，45，6： | 1 |
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