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| 1 | T cell–associated immunoregulation and antiviral effect of oxymatrine in hydrodynamic injection HBV mouse model显示文摘Although oxymatrine(OMT) has been shown to directly inhibit the replication of hepatitis B virus(HBV) in vitro, limited research has been done with this drug in vivo. In the present study, the antiviral effect of OMT was investigated in an immunocompetent mouse model of chronic HBV infection.The infection was achieved by tail vein injection of a large volume of DNA solution. OMT(2.2, 6.7 and20 mg/kg) was administered by daily intraperitoneal injection for 6 weeks. The efficacy of OMT was evaluated by the levels of HBV DNA, hepatitis B surface antigen(HBs Ag), hepatitis B e antigen(HBe Ag)and hepatitis B core antigen(HBc Ag). The immunoregulatory activity of OMT was evaluated by serum ELISA and flow cytometry. Results shows that OMT at 20 mg/kg inhibited HBV replication, and it was more efficient than entecavir(ETV) in the elimination of serum HBs Ag and intrahepatic HBc Ag. Inaddition, OMT accelerated the production of interferon-γ(IFN-γ) in a dose-dependent manner in CD4^+T cells. Our findings demonstrate the beneficial effects of OMT on the enhancement of immunological function and in the control of HBV antigens. The findings suggest this drug to be a good antiviral therapeutic candidate for the treatment of HBV infection. | Xiuxiu Sang Ruilin Wang Yanzhong Han Cong’en Zhang Honghui Shen Zhirui Yang Yin Xiong Huimin Liu Shijing Liu Ruisheng Li Ruichuang Yang Jiabo Wang Xuejun Wang Zhaofang Bai Xiaohe Xiao | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 20 |
| 2 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 3 | Study on stabilities and electrochemical behavior of V(V) electrolyte with acid additives for vanadium redox flow battery显示文摘Several acid compounds have been employed as additives of the V(V) electrolyte for vanadium redox flow battery(VRB) to improve its stability and electrochemical activity. Stability of the V(V) electrolyte with and without additives was investigated with ex-situ heating/cooling treatment at a wide temperature range of-5 ?C to 60 ?C. It was observed that methanesulfonic acid, boric acid, hydrochloric acid, trifluoroacetic acid,polyacrylic acid, oxalic acid, methacrylic acid and phosphotungstic acid could improve the stability of the V(V) electrolyte at a certain range of temperature. Their electrochemical behaviors in the V(V) electrolyte were further studied by cyclic voltammetry(CV), steady state polarization and electrochemical impedance spectroscopy(EIS). The results showed that the electrochemical activity, including the reversibility of electrode reaction, the diffusivity of V(V) species, the polarization resistance and the flexibility of charge transfer for the V(V) electrolyte with these additives were all improved compared with the pristine solution. | Gang Wang Jinwei Chen Xueqin Wang Jing Tian Hong Kang Xuejing Zhu Yu Zhang Xiaojiang Liu Ruilin Wang | 2014 | Journal of Energy Chemistry2014，23，1： | 10 |
| 4 | Bioaugmentation with a pyridine-degrading bacterium in a membrane bioreactor treating pharmaceutical wastewater显示文摘The bacterial strain Paracoccus denitrificans W12,which could utilize pyridine as its sole source of carbon and nitrogen,was added into a membrane bioreactor(MBR)to enhance the treatment of a pharmaceutical wastewater.The treatment efciencies investigated showed that the removal of chemical oxygen demand,total nitrogen,and total phosphorus were similar between bioaugmented and non-bioaugmented MBRs,however,significant removal of pyridine was obtained in the bioaugmented reactor.When the hydraulic retention time was 60 hr and the influent concentration of pyridine was 250–500 mg/L,the mean efuent concentration of pyridine without adding W12 was 57.2 mg/L,while the pyridine was degraded to an average of 10.2 mg/L with addition of W12.The bacterial community structure of activated sludge during the bioaugmented treatment was analyzed using polymerase chain reaction-denaturing gradient gel electrophoresis(PCR-DGGE).The results showed that the W12 inoculum reversed the decline of microbial community diversity,however,the similarity between bacterial community structure of the original sludge and that of the sludge after bioaugmentation decreased steadily during the wastewater treatment.Sequencing of the DNA recovered from DGGE gel indicated that Flavobacteriaceae sp.,Sphingobium sp.,Comamonas sp.,and Hyphomicrobium sp.were the dominant organisms in time sequence in the bacterial community in the bioaugmented MBR.This implied that the bioaugmentation was afected by the adjustment of whole bacterial community structure in the inhospitable environment,rather than being due solely to the degradation performance of the bacterium added. | Donghui Wen Jing Zhang Ruilin Xiong Rui Liu Lujun Chen | 2013 | Journal of Environmental Sciences2013，25，11： | 9 |
| 5 | Experimental Study on Thermal Balance of Regulated Two-Stage Turbocharged Diesel Engine at Variable Altitudes显示文摘It is significant to study thermal balance of diesel engine under different variable geometry turbocharger(VGT)vane openings at variable altitudes,which is helpful to assess the heat distribution,control the heat load and improve the heat efficiency of the diesel engine.A thermal balance test system was built to study the influence of the VGT vane opening angles on a regulated two-stage turbocharged(RTST)diesel engine’s thermal balance performance.The experiment was conducted under full load operating conditions at different altitudes(0 m,3500 m and 5500 m).Results indicated that the heat load of engine increased and the thermal efficiency decreased with the increase of altitudes under all operating conditions.As the VGT vane openings increased,the exhaust and maximum combustion temperature increased,while the maximum cylinder combustion pressure decreased.In particular,the maximum combustion temperature was more than 2000 K when the VGT vane openings were greater than 70%at the altitude of 5500 m,and the maximum combustion pressure exceeded 17 MPa when the opening of VGT vane was 70%at 0 m.The thermal efficiency of the engine decreased with the increase of VGT vane openings at the altitudes of 0 m and 5500 m,but the thermal efficiency increased and then decreased at the altitude of 3500 m.It was finally obtained that the best openings of VGT vane was 80%,60%and 50%under the engine speed of 2100 r/min at 0 m,3500 m and 5500 m,respectively. | LIU Ruilin YANG Chunhao ZHANG Zhongjie JIAO Yufei ZHOU Guangmeng | 2019 | Journal of Thermal Science2019，28，4： | 7 |
| 6 | Review of Chinese atmospheric science research over the past 70 years: Synoptic meteorology显示文摘Synoptic meteorology is a branch of meteorology that uses synoptic weather observations and charts for the diagnosis,study,and forecasting of weather.Weather refers to the specific state of the atmosphere near the Earth’s surface during a short period of time.The spatial distribution of meteorological elements in the atmosphere can be represented by a variety of transient weather phenomena,which are caused by weather systems of different spatial and temporal scales.Weather is closely related to people’s life,and its development and evolution have always been the focus of atmospheric scientific research and operation.The development of synoptic meteorology is closely related to the development of observation systems,dynamical theories and numerical models.In China,observation networks have been built since the early 1950 s.Up to now,a comprehensive meteorological observation systembased on ground,air and space has been established.In particular,the development of a new generation of dense radar networks,the development of the Fengyun satellite series and the implementation of a series of large field experiments have brought our understanding of weather from large-scale environment to thermal dynamics,cloud microphysical structure and evolution characteristics of meso and micro-scale weather systems.The development of observation has also promoted the development of theory,numerical model and simulation.In the early days,China mainly used foreign numerical models.Lately,China has developed numerical model systems with independent intellectual property rights.Based on the results of high-resolution numerical simulations,in-depth understanding of the initiation and evolution mechanism and predictability of weather at different scales has been obtained.Synoptic meteorology has gradually changed from an initially independent development to a multidisciplinary approach,and the interaction between weather and the change of climate and environment has become a hot and frontier topic in atmospheric science.This paper reviews the important scientific and technological achievements made in China over the past 70 years in the fields of synoptic meteorology based on the literatures in China and abroad,from six aspects respectively including atmospheric dynamics,synoptic-scale weather,typhoon and tropical weather,severe convective weather,numerical weather prediction and data assimilation,weather and climate,atmospheric physics and atmospheric environment. | Zhiyong MENG Fuqing ZHANG Dehai LUO Zhemin TAN Juan FANG Jianhua SUN Xueshun SHEN Yunji ZHANG Shuguang WANG Wei HAN Kun ZHAO Lei ZHU Yongyun HU Huiwen XUE Yaping MA Lijuan ZHANG Ji NIE Ruilin ZHOU Sa LI Hongjun LIU Yuning ZHU | 2019 | Science China Earth Sciences2019，62，12： | 7 |
| 7 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 8 | Improving the Local Sheep in Gansu via Crossing with Introduced Sheep Breeds Dorset and Borderdale显示文摘In order to improve the meat performance of local sheep in Gansu Province,Dorset and Borderdale were introduced to crossbreed with local sheep which were Tan sheep,Small-tail Han sheep and Mongolia sheep. The offspring under different crossbreeding combinations were sampled randomly at the different growing stage to measure their growth traits so as to select optimize the crossbreeding mode. The results indicated that,for the same crossbreeding mode,the growth rate of progeny was in order F3> F2> F1; for the F3 progeny,the combinations Dorset- Borderdale- Small tail Han sheep and Dorset- Borderdale- Mongolia sheep gave a higher growth rate,with a body weight of 1. 57%,3. 17%,8. 23%,1. 15% higher in male and female individuals than the counterparts of Dorset and Tan sheep and Small tail Han sheep; for the F2 progeny,the combinations Dorset- Borderdale- Small tail Han sheep and Dorset- Borderdale- Mongolia sheep also gave a higher growth rate,with a body weight of 2. 15%,4. 53%,9. 21% and 2. 75% higher in male and female individuals than the counterparts of Dorset and Tan sheep and Small tail Han sheep; for the F1 progeny,the combination Borderdale and Small tail Han sheep assumed a higher growth rate,with a body weight of 3. 23%,6. 07%,7. 42% and 8. 66% higher in male and female individuals than the counterparts of Borderdale- Mongolia sheep and Tan sheep- Small tail Han sheep,respectively. Therefore,in the Small-tail Han sheep and Mongolia sheep producing regions,the F2 or F3progeny bred by using Dorset or Borderdale sheep as male parent to cross with local breeds,or the hybrid lambs of Small-tail Han sheep and Borderdale sheep as highly qualified commodity,would produce significant economic benefit. Moreover,the novel breeds obtained by crossing were the valuable genetic resource for breeding meat sheep. | Sun Xiaoping Liu Jianbin Zhang Wanlong Lang Xia Yang Bohui Guo Jian Feng Ruilin | 2014 | Animal Husbandry and Feed Science2014，6，5： | 3 |
| 9 | Characterization of the target DNA sequence for the DNA-binding domain of zinc finger protein 191显示文摘抄写因素的 DNA 有约束力的性质上的研究在寻找这些因素调整的下游的基因是重要的。在现在的学习,我们在一个 Cy s2His2 类型抄写因素的 DNA 有约束力的性质上报导,锌手指蛋白质 191 (Zfpl91 ) ,它最新被发现了在老鼠起一个重要作用。由构造包含 Zfpl91 的 DNA 有约束力的域的熔化蛋白质,我们由在锌上决定蛋白质的有约束力的特性和依赖描绘了目标 DNA。数据证明 Zfpl91 的 DNA 有约束力的域能明确地绑在 TCAT 重复主题并且在目标 DNA 的多重有约束力的地点之中有合作效果。而且,有约束力的反应依赖于锌。这个工作在基因规定和开发在 Zfpl91 的角色上为进一步的研究提供一个基础。 | Haoyue Wang Ruilin Sun Guoxiang Liu Minghui Yao Jian Fei Hebai Shen | 2008 | Acta Biochimica et Biophysica Sinica2008，40，8： | 3 |
| 10 | Biomarkers in the early period of acute myocardial infarction in rat serum and protective effects of Shexiang Baoxin Pill using a metabolomic method显示文摘 | Peng Jiang Weixing Dai Shikai Yan Zhongliang Chen Ruilin Xu Jianmi Ding Li Xiang Shuping Wang Runhui Liu Weidong Zhang | 2011 | Journal of Ethnopharmacology2011，，2： | 2 |
| 11 | Solubilities of 1,2,3-trimethylbenzene and 1,2,4-trimethylbenzene and 1,3,5-trimethylbenzene in t-butyl alcohol+water mixtures and hydrophobic interaction显示文摘 | Lizhuang Zou Guanying Yang Buxing Han Ruilin Liu Haike Yan | 1999 | Science in China Series B: Chemistry1999，，4： | 1 |
| 12 | Rapid analysis of fatty acid profiles in raw and seeds by microwave-ultrasonic synergistic in situ extraction-deriatisation and gas chromatographymass spectrometry显示文摘 | LIU Ruilin SONG Shuanghong WU Wei | 2013 | Food Chemistry2013，141，4： | 1 |
| 13 | Solubilities of benzene, toluene and diphenyl in the t-butyl alcohol+water mixtures and hydrophobic interaction显示文摘 | Lizhuang Zou Guanying Yang Buxing Han Ruilin Liu Haike Yan | 1999 | Science in China Series B: Chemistry1999，，3： | 1 |
| 14 | Temperature-sensitive polymeric nanogels encapsulating withβ-cyclodextrin and ICG complex for high-resolution deep-tissue ultrasound-switchable fluorescence imaging显示文摘One of the thorny problems currently impeding the applications of the fluorescence imaging technique is the poor spatial resolution in deep tissue.Ultrasound-switchable fluorescence(USF)imaging is a novel imaging tool that has recently been explored to possibly surmount the above-mentioned bottleneck.Herein,αβ-cyclodextrin/indocyanine green(ICG)complex-encapsulated poly(N-isopropylacrylamide)(PNIPAM)nanogel was synthesized and studied for ex vivo/in vivo deep tissue/high-resolution near infrared USF(NIR-USF)imaging.To be specific,our results revealed that the average diameter of the as-prepared nanogels was significantly decreased to-32 nm from-335 nm compared to the reported ICG-PNIPAM nanoparticles.Additionally,the excitation/emission characteristics of the ICG itself in present nanogels were almost completely retained,and the resultant nanogel exhibited high physiological stability and positive biocompatibility.In particular,the signal-to-noise ratio of the USF image for the PNIPAM/P-cyclodextrin/ICG nanogel(33.01±2.42 dB)was prominently higher than that of the ICG-PNIPAM nanoparticles(18.73±0.33 dB)in 1.5-cm-thick chicken breast tissues.The NIR-USF imaging in 3.5-cm-thick chicken breast tissues was achieved using this new probe.The e x v iv o NIR-USF imaging of the mouse liver was also successfully obtained.Animal experiments showed that the present nanogels were able to be effectively accumulated into U87 tumor-bearing mice via enhanced permeability and retention effects,and the high-resolution NIR-USF imaging of in v ivo tumor was efficiently acquired.The metabolism and in vivo biodistribution of the nanogels were evaluated.Overall,the results suggest that the current nanogel is a highly promising NIR-USF probe for deep tissue and high-resolution USF imaging. | Ruilin Liu Tingfeng Yao Yang Liu Shuai Yu Liqin Ren Yi Hong Kytai T.Nguyen Baohong Yuan | 2020 | Nano Research2020，13，4： | 1 |
| 15 | Solubility of ethane int-butanol + water mixtures and a hydrophobic interaction study显示文摘 | Peixun Li Yilin Wang Buxing Han Haike Yan Ruilin Liu | 1996 | Journal of Solution Chemistry1996，，12： | 1 |
| 16 | Structure and technology character of robot automation stamping production line 显示文摘 | He Ruilin Liu Jihui Miao Jinzhong | 2012 | Ma- chinist Metal Forming2012，，5： | 1 |
| 17 | Distribution of Upper Cenozoic carbonate-cemented sandstones,Kuche Depression,northwest China:insights from high-resolution borehole micro-resistivity imaging显示文摘 | Zhong Guangfa Ma Zaitian Liu Ruilin al et | 2003 | Journal of Sedimentary Research2003，73，2： | 1 |
| 18 | Application of the triple porosity model in well-log effectiveness estimation of the carbonate reservoir in Tarim Oilfield 显示文摘 | Liu Ruilin Li Ning Feng Qingfu | 2009 | Journal of Petroleum Science Engineering2009，68，12： | 1 |
| 19 | In-situ hydrothermal synthesized γ-Al_2O_3/O-g-C_3N_4 heterojunctions with enhanced visible-light photocatalytic activity in water splitting for hydrogen显示文摘In this work,γ-Al_2O_3 and hydrogen peroxide treated g-C_3N_4(O-g-C_3N_4) were combined through a novel in-situ hydrothermal method to form heterojunction structured photocatalysts.These photocatalysts were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FT-IR),X-ray photoelectron spectroscopy(XPS),UV–vis diffuse reflectance spectroscopy and photoluminescence spectroscopy(PL).FT-IR results indicate that oxygen functional groups can be grafted on the surface of O-g-C_3N_4 by hydrogen peroxide treatment.The visible light photocatalytic hydrogen evolution rate was investigated in 10 vol% TEOA aqueous solution.The optimal Al_2O_3 mass content is set to be 20 wt% and the corresponding hydrogen evolution rate is 1288 μmol/h/g which is approximately 6,3 folds that of pristine g-C_3N_4 and O-g-C_3N_4 respectively and 1.6 folds that of mechanical mixed composite with the same Al_2O_3 mass content.The photocurrent density–time curves were carried out under visible light illumination for four on–off cycles.The electrochemical impedance spectroscopy(EIS) measurements verified the enhanced separation efficiency of electron–hole pairs.This work raised a new method to form the heterojunction structured photocatalysts and achieved a remarkable improvement of the photocatalytic activity in water splitting for hydrogen under visible light irradiation. | Yu Wang Yaping Zeng Boqiao Li Anqi Li Ping Yang Liu Yang Gang Wang Jinwei Chen Ruilin Wang | 2016 | Journal of Energy Chemistry2016，25，4： | 1 |
| 20 | Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou,China显示文摘Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in coronavirus disease 2019(COVID-19)patients have been reported.However,the clinical outcome and pathogenesis remain unclear.In this study,we recruited 43 laboratory-confirmed COVID-19 patients.We found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients(P<0.05).The average viral shedding time in severe/critical patients was more than 50 days,and up to 100 days in some patients,after symptom onset.However,chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive,but specific antibodies appeared.Furthermore,the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred(P<0.01 and FDR<0.01)and increased when G227A occurred(P<0.05 and FDR<0.05).High IL1R1,IL1R2,and TNFRSF21 expression in the host positively correlated with viral shedding time(P<0.05 and false discovery rate<0.05).Prolonged viral RNA shedding often occurs but may not increase disease damage.Prolonged viral RNA shedding is associated with viral mutations and host factors. | Zhengtu Li Yinhu Li Ruilin Sun Shaoqiang Li Lingdan Chen Yangqing Zhan Mingzhou Xie Jiasheng Yang Yanqun Wang Airu Zhu Guoping Gu Le Yu Shuaicheng Li Tingting Liu Zhaoming Chen Wenhua Jian Qian Jiang Xiaofen Su Weili Gu Liyan Chen Jing Cheng Jincun Zhao Wenju Lu Jinping Zheng Shiyue Li Nanshan Zhong Feng Ye | 2021 | Science China(Life Sciences)2021，64，12： | 1 |
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