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| 1 | Efficient lung cancer-targeted drug delivery via a nanoparticle/MSC system显示文摘Low targeting efficiency limits the applications of nanoparticles in cancer therapy. The fact that mesenchymal stem cells(MSC) trapped in the lung after systemic infusion is a disadvantage for cell therapy purposes. Here, we utilized MSC as lung cancer-targeted drug delivery vehicles by loading nanoparticles(NP)with anti-cancer drug. MSC showed a higher drug intake capacity than fibroblasts. In addition, MSC showed predominant lung trapping in both rabbit and monkey. IR-780 dye, a fluorescent probe used to represent docetaxel(DTX) in NP, delivered via MSC accumulated in the lung. Both in vitro MSC/A549 cell experiments and in vivo MSC/lung cancer experiments validated the intercellular transportation of NP between MSC and cancer cells. In vivo assays showed that the MSC/NP/DTX drug delivery system exerted primary tumor inhibition efficiency similar to that of a NP/DTX drug system. Collectively, the MSC/NP drug delivery system is promising for lung-targeted drug delivery for the treatment of lung cancer and other lung-related diseases. | Xusheng Wang Haiyan Chen Xiaowei Zeng Wenpeng Guo Yu Jin Shan Wang Ruiyun Tian Yanjiang Han Ling Guo Jimin Han Yaojiong Wu Lin Mei | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 4 |
| 2 | Improved Method for Intromitting Stmachic Draft tube of infants After Oromaxillo - faciai Region Surgery 显示文摘 | Sun Xiuke Guo Ruiyun Su Na | 2006 | Medical Information2006，19，3： | 1 |
| 3 | Improved Method for Intromitting Stomachic Draft Tube of infants After Oromaxillo-faciai Region Surgery显示文摘 | Guo Ruiyun Su Na | 2006 | Medical Information2006，19，3： | 1 |
| 4 | Acylated ghrelin protects hippocampal neurons in pilocarpine-induced seizures of immature rats by inhibiting cell apoptosis显示文摘 | Ruiyun Zhang Guanglu Yang Qingyi Wang Feng Guo Hua Wang | 2013 | Molecular Biology Reports2013，，1： | 1 |
| 5 | One-pot Three-component Synthesis of Functionalized Spirooxin- doles in Gluconic Acid Aqueous Solution显示文摘 | GUO Ruiyun WANG Ping WANG Guodong | 2013 | Tetrahedron2013，69，8： | 1 |
| 6 | Improved Method for Intromitting Stmachic Draft tube of infants After Oromaxillo -faciai Region Surgery 显示文摘 | Sun Xiuke Guo Ruiyun Su Na | 2006 | Medical Inforrnation2006，19，3： | 1 |
| 7 | Analysis of Imaging Characteristics and Dynamic Changes of 3 Cases of Severe Novel Coronavirus Pneumonia in Qinghai Province显示文摘Objective:To analyze the characteristics,dynamic changes,and outcomes of the first imaging manifestations of 3 patients with severe COVID-19 in our hospital.Methods:Computed tomography(CT)findings of 3 patients with severe COVID-19 who tested positive by the nucleic acid test in our hospital were selected,mainly focusing on the morphology,distribution characteristics,and dynamic changes of the first CT findings.Results:3 patients with severe pneumonia were older,with one aged 80.The first chest CT examination for all 3 patients differed.Imaging showed a leafy distribution of consolidation,primarily affecting the lower lobes of both lungs and extending subpleurally.A grid-like pattern was observed,along with changes in the consolidation and air bronchogram.These changes had slower absorption,especially in patients with underlying diseases.Conclusion:CT manifestations of severe COVID-19 have specific characteristics and the analysis of their characteristics and dynamic changes provide valuable insights for clinical treatment. | Yingfang Yu Ruiyun Zhao Changde Li Fuqiang Ma Lingyun Guo Yang Li | 2024 | Journal of Clinical and Nursing Research2024，8，3： | 0 |
| 8 | Dark energy versus modified gravity: Impacts on measuring neutrino mass显示文摘In this paper,we make a comparison for the impacts of smooth dynamical dark energy,modified gravity,and interacting dark energy on the cosmological constraints on the total mass of active neutrinos.For definiteness,we consider theΛCDM model,the w CDM model,the f(R)model,and two typical interacting vacuum energy models,i.e.,the IΛCDM1 model with Q=βHρc and the IΛCDM2 model with Q=βHρΛ.In the cosmological fits,we use the Planck 2015 temperature and polarization data,in combination with other low-redshift observations including the baryon acoustic oscillations,the type Ia supernovae,the Hubble constant measurement,and the large-scale structure observations,such as the weak lensing as well as the redshift-space distortions.Besides,the Planck lensing measurement is also employed in this work.We find that,the w CDM model favors a higher upper limit on the neutrino mass compared to theΛCDM model,while the upper limit in the f(R)model is similar with that in theΛCDM model.For the interacting vacuum energy models,the IΛCDM1 model favors a higher upper limit on neutrino mass,while the IΛCDM2 model favors an identical neutrino mass with the case ofΛCDM. | MingMing Zhao RuiYun Guo DongZe He JingFei Zhang Xin Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，3： | 0 |
| 9 | The role of surface charges in the blinking mechanisms and quantum-confined Stark effect of single colloidal quantum dots显示文摘The two frequently observed phenomena,photoluminescence(PL)blinking and quantum-confined Stark effect(QCSE)-induced spectral diffusion,are not conducive to the applications of colloidal quantum dots(QDs).It remains elusive how these two phenomena are linked to each other.Unraveling the potential link between blinking and QCSE could facilitate the adoption of appropriate strategies that can simultaneously suppress both PL blinking and spectral diffusion.In this work,we investigated the blinking mechanism and QCSE of single CdSe/CdS/ZnS QDs in the presence of positive and negative surface charges using single-dot PL spectroscopy.We found that the negative surface charges can simultaneously suppress PL blinking and spectral diffusion of single QDs.On the other hand,the positive surface charges could change the blinking mechanisms of QDs from Auger-blinking to band-edge carrier(BC)-blinking.Two types of QCSE were observed,and a significant QCSE-induced spectral broadening of 5.25 nm was measured,which could be attributed to the hopping of surface charges between different surface-trap sites.Based on these findings,several theoretical models are proposed to explain various phenomena observed. | Jialu Li Dengfeng Wang Guofeng Zhang Changgang Yang Wenli Guo Xue Han Xiuqing Bai Ruiyun Chen Chengbing Qin Jianyong Hu Liantuan Xiao Suotang Jia | 2022 | Nano Research2022，15，8： | 0 |
| 10 | Fragmentation of brain apolipoprotein E(ApoE)and its relevance in late onset Alzheimer's disease显示文摘Late-onset Alzheimer's disease(LOAD)is the most common cause of dementia in the elderly.Polymorphism in apolipoprotein E(ApoE)gene(ε2,ε3,and ε4)is the greatest LOAD risk factor.The translation products are ApoE2,ApoE3,and ApoE4,respectively.ApoE fragments are present in senile plaques and neurofibillary tangles but their contributions to AD pathogenesis are not clear. | Ernest Asiamah Jingjing He Ruiyun Guo Baofeng Feng Desheng Kong Xin Liu Jun Ma Huixian Cui | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 11 | Recent advances in nonmetallic atom-doped metal nanocrystals:Synthesis and catalytic applications显示文摘Metal nanocrystals have been recognized as the main catalytic materials in many fields,but insufficient activity and stability,as well as high prices,have limited their large-scale potential applications.As one of the extremely promising alternatives toward metal in boosting their catalytic performance,nonmetallic atoms-doped metal nanocrystals have recently received extensive attention because of their high efficiency,chemical and structural durability,abundant reserve,and low cost.In this review,we highlight the most recent progress in this field and provide insights into their catalytic applications.The metalnonmetal nanocrystals prepared by doping metal nanocrystals with nonmetallic atoms are introduced and classified based on the types of nonmetallic atoms,including metal hydrides,borides,carbides,nitrides,oxides,phosphides,and chalcogenides.Besides,their applications in catalysis,especially in electrocatalysis and organic catalysis,have been summarized and discussed.Finally,the conclusions and perspectives are given for the catalysis-driven rational design of metal-nonmetal nanocrystals in this minireview. | Ruiyun Guo Ke Zhang Shangdong Ji Yangzi Zheng Mingshang Jin | 2021 | Chinese Chemical Letters2021，32，9： | 0 |
| 12 | Clinical efficacy and safety of mesenchymal stem cells in patients with diabetes mellitus显示文摘Diabetes mellitus(DM)as a chronic metabolic disease is threatening human health seriously.The aim of this study was to systematically review the evidence from RCTs and conduct comprehensive assessment of therapeutic efficacy and safety of mesenchymal stem cells(MSCs)in DM.PubMed,Web of Science,Ovid,the Cochrane Library and CNKI were searched until April 30,2020.Seven RCTs were eligible,including 413 participants. | He Jingjing Kong Desheng Asiamah Ernest Am ponsah Guo Ruiyun Feng Baofeng Ma Jun Timothy O'Brien Cui Huixian | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 13 | Generation of a human iPSC line from a sporadic amyotrophic lateral sclerosis patient and motor neuron differentiation显示文摘Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease that affects motor neurons in the central nervous system,which leads to muscle.atrophy and progressive paralysis.W hile mutations in several genes responsible for familial ALS have been identified,the pathogenesis of sporadic ALS,which accounts for approximately 90%of all ALS cases,remains unclear. | Feng Baofeng Asiamah Ernest Am ponsah Guo Ruiyun Kong Desheng He Jingjing Ma Jun Cui Huixian | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 14 | Establishment of amyotrophic lateral sclerosis induced pluripotent stem cells and neuronal differentiation显示文摘Amyotrophic lateral sclerosis(ALS)is a motor neuron disease that seriously threatens the health of patients.The mechanism is unclear.Most ALS disease models cannot accurately reflect the pathological characteristics of ALS.Induced pluripotent stem cells(iPSC)can best mimic lesions and is used to reveal the mechanism of ALS and develop therapeutic drugs.In the process of iPSC reprogramming,the selection of somatic cells and the optimization of conditions are critical to the progress of iPSC culture.Skin biopsies were used in this study to optimize the isolation and culture method of fibroblasts,and established a optimized somatic cell culture process with high tissue utilization rate,short culture period and high success rate. | Guo Ruiyun Feng Baofeng Kong Desheng Ernest Asiamah He Jingjing Lv Fei Ma Jun Huixian Cui | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 15 | Tunable microfluidic chip for single-cell deformation study显示文摘Microfluidic phenotyping methods have been of vital importance for cellular characterization,especially for evaluating single cells.In order to study the deformability of a single cell,we devised and tested a tunable microfluidic chip-based method.A pneumatic polymer polydimethylsiloxane(PDMS)membrane was designed and fabricated abutting a single-cell trapping structure,so the cell could be squeezed controllably in a lateral direction.Cell contour changes under increasing pressure were recorded,enabling the deformation degree of different types of single cell to be analyzed and compared using computer vision.This provides a new perspective for studying mechanical properties of cells at the single cell level. | Ruiyun Zhang Xuexin Duan Shuaihua Zhang Wenlan Guo Chen Sun Ziyu Han | 2023 | Nanotechnology and Precision Engineering2023，6，2： | 0 |
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