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| 1 | Transition-metal doped edge sites in vertically aligned MoS2 catalysts for enhanced hydrogen evolution显示文摘为象氢进化反应那样的电气化学的反应的高度活跃、便宜的催化剂(她的) 为有效精力的发展是关键的变换和存储技术。理论模拟在揭示在材料和他们的催化活动的电子结构之间的关联是有帮助的,并且指导改进催化剂的预言和发展。然而,在精确地设计需要的原子地点的困难在做在试验性、理论的结果之间的直接比较导致挑战。在瞬间 < 潜水艇 class= “ a-plus-plus ” > 2 , 而薹是惰性的,瞬间边被表明了为她活跃。用一条计算基于描述符的途径,我们预言由合并转变金属原子(Fe,公司, Ni,或 Cu ) ,薹地点应该也成为她活跃。垂直地站的、终止边的瞬间 < 潜水艇 class= “ a-plus-plus ” > 2 nanofilms 为验证这些预言提供一个明确的模型系统。转变金属做了瞬间 < 潜水艇 class= “ a-plus-plus ” > 2 nanofilms 表演交换水流密度由的增加至少双重,与理论计算一致。这个工作为由把倡导者合并到特别原子地点改进电气化学的催化剂,并且为使用明确的系统以便理解提升效果的起源开创进一步的机会。 | Haotian Wang Charlie Tsai Desheng Kong Karen Chan Frank Abild-Pedersen Jens K. Norskov Yi Cui | 2015 | Nano Research2015，8，2： | 41 |
| 2 | Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2显示文摘Receptor recognition and subsequent membrane fusion are essential for the establishment of successful infection by SARS-CoV-2.Halting these steps can cure COVID-19.Here we have identified and characterized a potent human monoclonal antibody,HB27,that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM concentrations.Remarkably,HB27 can also prevent SARS-CoV-2 membrane fusion.Consequently,a single dose of HB27 conferred effective protection against SARS-CoV-2 in two established mouse models.Rhesus macaques showed no obvious adverse events when administrated with10 times the effective dose of HB27.Cryo-EM studies on complex of SARS-CoV-2 trimeric S with HB27 Fab reveal that three Fab fragments work synergistically to occlude SARS-CoV-2 from binding to the ACE2 receptor.Binding of the antibody also restrains any further conformational changes of the receptor binding domain,possibly interfering with progression from the prefusion to the postfusion stage.These results suggest that HB27 is a promising candidate for immuno-therapies against COVID-19. | Ling Zhu Yong-Qiang Deng Rong-Rong Zhang Zhen Cui Chun-Yun Sun Chang-Fa Fan Xiaorui Xing Weijin Huang Qi Chen Na-Na Zhang Qing Ye Tian-Shu Cao Nan Wang Lei Wang Lei Cao Huiyu Wang Desheng Kong Juan Ma Chunxia Luo Yanjing Zhang Jianhui Nie Yao Sun Zhe Lv Neil Shaw Qianqian Li Xiao-Feng Li Junjie Hu Liangzhi Xie Zihe Rao Youchun Wang Xiangxi Wang Cheng-Feng Qin | 2021 | National Science Review2021，8，3： | 3 |
| 3 | Spectroscopic Analysis on the Effect of Temperature on Kunitz Domain 1 of Human Tissue Factor Pathway Inhibitor-2显示文摘Kunitz 领域 1 人的织物因素 pathwayinhibitor-2 (hTFPI-2/KD1 ) 的符合构造被 Fourier 变换学习了红外线的光谱学,圆形的二色性,和拉曼光谱学。hTFPI-2/KD1 在详细 conformational 揭示的 Fouriertransform 红外线的光谱学,圆形的二色性和拉曼光谱学观察的激烈的蛋白质改变的 25 ° C .The 包含了近似 17%alpha-helices,24% 贝它海滨, 46% 随机的卷, 13% 贝它拐弯,和二种二硫键(gggand tgt ) ,这被发现那 hTFPI-2/KDlwas 热地稳定。然而, KD1 能在高温度形成一种中间的形式,当温度被降低时,然后回到它的正常符合构造。活动试金也证明 thathTFPI-2/KDl 能在为 5min 被加热到 80 ° C 以后在胞质素上保留它的禁止的活动。 | Chenqi ZHANG Desheng KONG Xingang LIU Xiaomin YAN Linsen DAI Duan MA | 2007 | Acta Biochimica et Biophysica Sinica2007，39，6： | 3 |
| 4 | Expression and characterization of the first kunitz domain of human tissue factor pathway inhibitor-2显示文摘 | Desheng Kong Duan Ma Hao Bai Hongshen Guo Xu Cai Wei Mo Qiqun Tang Houyan Song | 2004 | Biochemical and Biophysical Research Communications2004，，4： | 1 |
| 5 | 显示文摘 | Kong Desheng Wan Lijun Chen Shenhao | 2003 | Corrosion & Protection2003，24，12： | 1 |
| 6 | 显示文摘 | Kong Desheng Chen Shenhao Wan Lijun | 2003 | Chemical Journal of Chinese Universities2003，24，10： | 1 |
| 7 | Synthesis of MoS2 and MoSe2 films with vertically aligned layers显示文摘 | KONG Desheng WANG Haotian CHA Jingjing | 2013 | Nano Lett2013，13，3： | 1 |
| 8 | hiPSC-derived NSCs effectively promote the functional recovery of acute spinal cord injury in mice显示文摘Spinal cord injury(SCI)is a common disease that results in motor and sensory disorders and even lifelong paralysis..The transplantation of stem cells,such as embryonic stem cells(ESCs),induced pluripotent stem cells(iPSCs),mesenchymal stem cells(MSCs),or subsequently generated stem/progenitor cells,was predicted to be a promising treatment for SCI.In this study,we aimed to investigate effect of human iPSC-derived neural stem cells(hiPSC-NSCs)and umbilical cord-derived MSCs(huMSCs)in a mouse model of acute SCI.Acute SCI mice model was established and were randomly treated as phosphate-buffered saline(PBS)(control group),repaired with 1×10^(5)hiPSC-NSCs(NSC group),and 1×10^(5)huMSCs(MSC group),respectively,in a total of 54 mice.Hind limb motor function was evaluated in open-field tests using the Basso Mouse Scale(BMS)at days post operation(dpo)1,3,5,and 7 after spinal cord injury,and weekly thereafter.Spinal cord and serum samples were harvested at dpo 7,14,and 21. | Ma Jun Kong Desheng Cui Huixian | 2021 | 解剖学杂志2021，44，S01： | 1 |
| 9 | A spike-trimer protein-based tetravalent COVID-19 vaccine elicits enhanced breadth of neutralization against SARS-CoV-2 Omicron subvariants and other variants显示文摘Multivalent vaccines combining crucial mutations from phylogenetically divergent variants could be an effective approach to defend against existing and future SARS-Co V-2 variants.In this study,we developed a tetravalent COVID-19 vaccine SCTV01E,based on the trimeric Spike protein of SARS-Co V-2 variants Alpha,Beta,Delta,and Omicron BA.1,with a squalenebased oil-in-water adjuvant SCT-VA02B.In the immunogenicity studies in na?ve BALB/c and C57BL/6J mice,SCTV01E exhibited the most favorable immunogenic characteristics to induce balanced and broad-spectrum neutralizing potencies against pre-Omicron variants(D614G,Alpha,Beta,and Delta)and newly emerging Omicron subvariants(BA.1,BA.1.1,BA.2,BA.3,and BA.4/5).Booster studies in C57BL/6J mice previously immunized with D614G monovalent vaccine demonstrated superior neutralizing capacities of SCTV01E against Omicron subvariants,compared with the D614G booster regimen.Furthermore,SCTV01E vaccination elicited na?ve and central memory T cell responses to SARS-Co V-2 ancestral strain and Omicron spike peptides.Together,our comprehensive immunogenicity evaluation results indicate that SCTV01E could become an important COVID-19 vaccine platform to combat surging infections caused by the highly immune evasive BA.4/5 variants.SCTV01E is currently being studied in a head-to-head immunogenicity comparison phase 3 clinical study with inactivated and m RNA vaccines(NCT05323461). | Rui Wang Hongpeng Huang Chulin Yu Chunyun Sun Juan Ma Desheng Kong Yalong Lin Dandan Zhao Shaozheng Zhou Jianbo Lu Sai Cao Yanjing Zhang Chunxia Luo Xuefeng Li Yang Wang Liangzhi Xie | 2023 | Science China(Life Sciences)2023，66，8： | 1 |
| 10 | Skin-inspired electronics:emerging semiconductor devices and systems显示文摘Current electronics are driven by advanced microfabrication for fast and efficient information processing.In spite of high performance,these wafer-based devices are rigid,non-degradable,and unable to autonomous repair.Skin-inspired electronics have emerged as a new class of devices and systems for next-generation flexible and wearable electronics.The technology gains inspiration from the structures,properties,and sensing mechanisms of the skin,which may find a broad range of applications in cutting-edge fields such as healthcare monitoring,human-machine interface,and soft robotics/prostheses.Practical demands have fueled the development of electronic materials with skin-like properties in terms of stretchability,self-healing capability,and biodegradability.These materials provide the basis for functional sensors with innovative and biomimetic designs.Further system-level integrations and optimizations enable new forms of electronics for real-world applications.This review summarizes recent advancements in this active area and speculates on future directions. | Zhong Ma Desheng Kong Lijia Pan Zhenan Bao | 2020 | Journal of Semiconductors2020，41，4： | 1 |
| 11 | A Printable and Conductive Yield-Stress Fluid as an Ultrastretchable Transparent Conductor显示文摘In contrast to ionically conductive liquids and gels,a new type of yield-stress fluid featuring reversible transitions between solid and liquid states is introduced in this study as a printable,ultrastretchable,and transparent conductor.The fluid is formulated by dispersing silica nanoparticles into the concentrated aqueous electrolyte.The as-printed features show solid-state appearances to allow facile encapsulation with elastomers.The transition into liquid-like behavior upon tensile deformations is the enabler for ultrahigh stretchability up to the fracture strain of the elastomer.Successful integrations of yield-stress fluid electrodes in highly stretchable strain sensors and light-emitting devices illustrate the practical suitability.The yield-stress fluid represents an attractive building block for stretchable electronic devices and systems in terms of giant deformability,high ionic conductivity,excellent optical transmittance,and compatibility with various elastomers. | Qianying Lu Yunlei Zhou Xiangfei Yin Shitai Cao Xiaoliang Wang Desheng Kong | 2021 | Research2021，，1： | 0 |
| 12 | Transplanted iPSC-derived neural stem cells for spinal cord injury显示文摘Spinal cord injury(SCI),one of the most devastating central nervous system(CNS)disorders,can lead to severe neurological disabilities,the most severe forms of which include persistent paraplegia or quadriplegia.The efficacy of induced pluripotent stem cell(iPSC)derived neural stem cells(NSC)transplantation on functional recovery following acute spinal cord injury(SCI)was detected.NSC derived from iPSC was characterized by expression of specific markers(SOX2,nestin and PAX6). | Kong Desheng Feng Baofeng Guo Ruigyun Ernest Asiamah He Jingjing Zhang Shuhan Lyu Fei Liu Xin Ma Jun Huixian Cui | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 13 | Characterization of human IgM and IgG repertoires in individuals with chronic HIV-1 infection显示文摘Advancements in high-throughput sequencing(HTS)of antibody repertoires(Ig-Seq)have unprecedentedly improved our ability to characterize the antibody repertoires on a large scale.However,currently,only a few studies explored the influence of chronic HIV-1 infection on human antibody repertoires and many of them reached contradictory conclusions,possibly limited by inadequate sequencing depth and throughput.To better understand how HIV-1 infection would impact humoral immune system,in this study,we systematically analyzed the differences between the IgM(HIV-IgM)and IgG(HIV-IgG)heavy chain repertoires of HIV-1 infected patients,as well as between antibody repertoires of HIV-1 patients and healthy donors(HH).Notably,the public unique clones accounted for only a negligible proportion between the HIV-IgM and HIV-IgG repertoires libraries,and the diversity of unique clones in HIV-IgG remarkably reduced.In aspect of somatic mutation rates of CDR1 and CDR2,the HIV-IgG repertoire was higher than HIV-IgM.Besides,the average length of CDR3 region in HIV-IgM was significant longer than that in the HH repertoire,presumably caused by the great number of novel VDJ rearrangement patterns,especially a massive use of IGHJ6.Moreover,some of the B cell clonotypes had numerous clones,and somatic variants were detected within the clonotype lineage in HIV-IgG,indicating HIV-1 neutralizing activities.The in-depth characterization of HIV-IgG and HIV-IgM repertoires enriches our knowledge in the profound effect of HIV-1 infection on human antibody repertoires and may have practical value for the discovery of therapeutic antibodies. | Xiaolong Tian Binbin Hong Xiaoyi Zhu Desheng Kong Yumei Wen Yanling Wu Liying Ma Tianlei Ying | 2022 | Virologica Sinica2022，37，3： | 0 |
| 14 | Stretchable,breathable,and washable epidermal electrodes based on microfoam reinforced ultrathin conductive nanocomposites显示文摘Stretchable epidermal electronics allow conformal interactions with the human body for emerging applications in wearable health monitoring and therapy.Stretchable devices are commonly constructed on submillimeter-thick elastomer substrates with limited moisture permeability,thereby leading to unpleasant sensations during long-term attachment.Although the ultrathin elastomer membrane may address this problem,the mechanical robustness is essentially lost for direct manipulations and repetitive uses.Here,we report a stretchable,breathable,and washable epidermal electrode of microfoam reinforced ultrathin conductive nanocomposite(MRUCN).The new architecture involves ultrathin conductive silver nanowire nanocomposite features supported on a porous elastomeric microfoam substrate,which exhibits high moisture permeability for pleasant perceptions during epidermal applications.As-prepared epidermal electrodes show excellent electronic conductivity(8440 S·cm^(-1)),high feature resolution(~50μm),decent stretchability,and excellent durability.In addition,the MRUCN retains stable electrical properties during washing to meet the hygiene requirements for repetitive uses.The successful implementation in an integrated electronic patch demonstrates the practical suitability of MRUCN for a broad range of epidermal electronic devices and systems. | Tao Ma Yong Lin Xiaohui Ma Jiaxue Zhang Dongchan Li Desheng Kong | 2023 | Nano Research2023，16，7： | 0 |
| 15 | Fragmentation of brain apolipoprotein E(ApoE)and its relevance in late onset Alzheimer's disease显示文摘Late-onset Alzheimer's disease(LOAD)is the most common cause of dementia in the elderly.Polymorphism in apolipoprotein E(ApoE)gene(ε2,ε3,and ε4)is the greatest LOAD risk factor.The translation products are ApoE2,ApoE3,and ApoE4,respectively.ApoE fragments are present in senile plaques and neurofibillary tangles but their contributions to AD pathogenesis are not clear. | Ernest Asiamah Jingjing He Ruiyun Guo Baofeng Feng Desheng Kong Xin Liu Jun Ma Huixian Cui | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 16 | Mutation N856K in spike reduces fusogenicity and infectivity of Omicron BA.1显示文摘Dear Editor,COVID-19 lung pathology is characterized by interstitial pneumonia with cell-cell fusion-induced syncytia and extensive tissue damage.1 The correlation between viral fusogenicity and pathogenicity has been reported in SARS-CoV-2 variants.2 Compared with the previous Delta or D614G variants,Omicron BA.1 has been proven to be less fusogenic and pathogenic. | Chunyun Sun Huiyu Wang Ji Yang Desheng Kong Yuning Chen Haiyue Wang Lingling Sun Jianbo Lu Min Teng Liangzhi Xie | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 0 |
| 17 | A Printable and Conductive Yield-Stress Fluid as an Ultrastretchable Transparent Conductor显示文摘In contrast to ionically conductive liquids and gels,a new type of yield-stress fluid featuring reversible transitions between solid and liquid states is introduced in this study as a printable,ultrastretchable,and transparent conductor.The fluid is formulated by dispersing silica nanoparticles into the concentrated aqueous electrolyte.The as-printed features show solid-state appearances to allow facile encapsulation with elastomers.The transition into liquid-like behavior upon tensile deformations is the enabler for ultrahigh stretchability up to the fracture strain of the elastomer.Successful integrations of yield-stress fluid electrodes in highly stretchable strain sensors and light-emitting devices illustrate the practical suitability.The yield-stress fluid represents an attractive building block for stretchable electronic devices and systems in terms of giant deformability,high ionic conductivity,excellent optical transmittance,and compatibility with various elastomers. | Qianying Lu Yunlei Zhou Xiangfei Yin Shitai Cao Xiaoliang Wang Desheng Kong | 2022 | Research2022，，1： | 0 |
| 18 | Clinical efficacy and safety of mesenchymal stem cells in patients with diabetes mellitus显示文摘Diabetes mellitus(DM)as a chronic metabolic disease is threatening human health seriously.The aim of this study was to systematically review the evidence from RCTs and conduct comprehensive assessment of therapeutic efficacy and safety of mesenchymal stem cells(MSCs)in DM.PubMed,Web of Science,Ovid,the Cochrane Library and CNKI were searched until April 30,2020.Seven RCTs were eligible,including 413 participants. | He Jingjing Kong Desheng Asiamah Ernest Am ponsah Guo Ruiyun Feng Baofeng Ma Jun Timothy O'Brien Cui Huixian | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 19 | Generation of a human iPSC line from a sporadic amyotrophic lateral sclerosis patient and motor neuron differentiation显示文摘Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease that affects motor neurons in the central nervous system,which leads to muscle.atrophy and progressive paralysis.W hile mutations in several genes responsible for familial ALS have been identified,the pathogenesis of sporadic ALS,which accounts for approximately 90%of all ALS cases,remains unclear. | Feng Baofeng Asiamah Ernest Am ponsah Guo Ruiyun Kong Desheng He Jingjing Ma Jun Cui Huixian | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 20 | Establishment of amyotrophic lateral sclerosis induced pluripotent stem cells and neuronal differentiation显示文摘Amyotrophic lateral sclerosis(ALS)is a motor neuron disease that seriously threatens the health of patients.The mechanism is unclear.Most ALS disease models cannot accurately reflect the pathological characteristics of ALS.Induced pluripotent stem cells(iPSC)can best mimic lesions and is used to reveal the mechanism of ALS and develop therapeutic drugs.In the process of iPSC reprogramming,the selection of somatic cells and the optimization of conditions are critical to the progress of iPSC culture.Skin biopsies were used in this study to optimize the isolation and culture method of fibroblasts,and established a optimized somatic cell culture process with high tissue utilization rate,short culture period and high success rate. | Guo Ruiyun Feng Baofeng Kong Desheng Ernest Asiamah He Jingjing Lv Fei Ma Jun Huixian Cui | 2021 | 解剖学杂志2021，44，S01： | 0 |
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