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| 1 | Polyethylene glycol microspheres loaded with irinotecan for arterially directed embolic therapy of metastatic liver cancer显示文摘AIM To study tumor response, and tolerability of arterially directed embolic therapy(ADET) with polyethylene glycol embolics loaded with irinotecan for the treatment of colorectal cancer liver metastases(CRC-LM). Secondary objectives were to monitor quality of life, time to progression and survival of patients.METHODS Patients were included in the study if they were affected by CRC-LM, refractory to systemic chemotherapy, treated with ADET using polyethylene glycol embolics, and had liver involvement < 50%. Tumor response, performance status(PS), tumor marker antigens, and quality of life(QoL) were monitored at 1, 3 and 6 mo after ADET. QoL was assessed with the Palliative Performance Scale(PPS).RESULTS We treated 50 consecutive CRC-LM patients with ADET using polyethylene glycol embolics. Their tumor response one month after ADET was: 28% of complete response(CR), 48% of partial response(PR), 8% stable disease(SD), and 16% of progression. Tumor response 3 mo after ADET was CR 24%, PR 38%, SD 19% and progression disease(PD) 19%. Tumor response 6 mo after ADET was CR 18%, PR 44%, SD 21% and PD 18%. QoL was 90% PPS at each time point. Median time to progression for patients who progressed was 2.5 mo(range 0.8-6). Median follow-up was 14 mo(0.8-25 range). ADETs were performed with no complications. Observed side effects(mild or moderate intensity) were: Pain in 32% of patients, increase of transaminase levels in 20% and fever in 14%, whereas 30% of patients did not complain any adverse event. CONCLUSION The treatment of unresectable CRC-LM with ADET using polyethylene glycol microspheres loaded with irinotecan was effective in tumor response and resulted in mild toxicity, and good QoL. | Giammaria Fiorentini Riccardo Carandina Donatella Sarti Michele Nardella Odysseas Zoras Stefano Guadagni Riccardo Inchingolo Massimiliano Nestola Alessandro Felicioli Daniel Barnes Navarro Fernando Munoz Gomez Camillo Aliberti | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 6 |
| 2 | 东营三角洲演化特征与岩性圈闭分布规律<英文>显示文摘东营三角洲是东营凹陷古近系沙河街组沙三段的主要沉积体系之一,为一大型复合三角洲。该三角训形成的浊积砂体岩性圈闭是东营凹陷沙三段重要的勘探目标,近几年平均每年发现的岩性油藏石油储量超过千万吨。为了给东营三角洲隐蔽油气藏进一步的勘探提供科学依据,运用高分辨率层序地层学理论和分析方法,在建立高频层序地层格架的基础上,研究东营三角洲演化过程、古构造坡折发育类型及不同期次三角洲与构造坡折的配置关系,分析这些因素对岩性圈闭形成的重要作用,认为在进积时期推进距离较远(三角洲进积作用大于加积作用)、退积时期湖泛规模较大条件下发育的三角洲朵叶体易形成具有一定规模的浊积扇。 | 方勇 邓宏文 Massimo SARTI 万晓樵 冯晓杰 | 2003 | 石油勘探与开发2003，30，5： | 5 |
| 3 | Multidisciplinary approach of colorectal cancer liver metastases显示文摘Large bowel cancer is a worldwide public health challenge.More than one third of patients present an advanced stage of disease at diagnosis and the liver is the most common site of metastases.Selection criteria for early diagnosis,chemotherapy and surgery have been recently expanded.The definition of resectability remains unclear.The presence of metastases is the most significant prognostic factor.For this reason the surgical resection of hepatic metastases is the leading treatment.The most appropriate resection approach remains to be defined.The two step and simultaneous resection processes of both primary and metastases have comparable survival long-term outcomes.The advent of targeted biological chemotherapeutic agents and the development of loco-regional therapies(chemoembolization,thermal ablation,arterial infusion chemotherapy) contribute to extend favorable results.Standardized evidence-based protocols are missing,hence optimal management of hepatic metastases should be single patient tailored and decided by a multidisciplinary team.This article reviews the outcomes of resection,systemic and loco-regional therapies of liver metastases originating from large bowel cancer. | Giammaria Fiorentini Donatella Sarti Camillo Aliberti Riccardo Carandina Andrea Mambrini Stefano Guadagni | 2017 | World Journal of Clinical Oncology2017，8，3： | 4 |
| 4 | Isolated limb infusion chemotherapy with or without hemofiltration for recurrent limb melanoma显示文摘AIM: To better define the efficacy and the safety of intra-arterial infusion performed with or without hemofiltration for recurrent limb melanoma. METHODS: Patients with the following characteristics were included in the study: recurrent limb melanoma not indicated for surgical resection, measurable disease in the extremity, > 18 years, performances status(Eastern Cooperative Oncology Group) was 0-1 and life expectancy of at least 6 mo. Twenty nine consecutive patients were enrolled in the study. Patients underwent fluoroscopic placement of angiographic arterial and venous catheters to infuse the drug in the artery [isolated limb infusion(ILI)], and to stop the out flow(venous). Melphalan was rapidly infused into the isolated limb via the arterial catheter after the inflation of venous balloon catheter. Then the circulation of the limb was completely blocked with a pneumatic cuff at the root of the limb. Haemofiltration(HF) was available only in the main center, and was performed with an extracorporeal perfusion system, in order to reduce high systemic toxic peaks of drug.RESULTS: Thirty seven ILI were done in 29 cases(31 ILI-HF and 6 ILI) between 2001 and 2014 at Ancona and Pesaro Hospitals, Italy. Clinical outcomes were monitored 30 d after treatment. Eleven patients(38%) received infusion of melphalan alone, 7(24%) melphalan associated to mitomicin C and 7(24%) melphalan associated to cisplatin, the remaining 4 were treated with cisplatin, melphalan and epirubicin or cisplatin and mitomicin C. The overall response rate was 66%, in particular, 3 patients(10%) were complete responders and 16(56%) were partial responders; whereas 7 patients(24%) had stable disease, and 3(10%) showed progressive disease. Limb toxicity was assessed adopting Wieberdink scale, with evidence of 90% of low grade(I and II) toxicity.CONCLUSION: ILI-HF and ILI are effective and safe treatments for recurrent non-resectable limb melanoma. They present evidence of favorable clinical benefit and is effective in delaying progression. | Sara Cecchini Donatella Sarti Stefano Ricci Ludovico Delle Vergini Manuela Sallei Stefano Serresi Giuseppe Ricotti Luca Mulazzani Fabrizia Lattanzio Giammaria Fiorentini | 2015 | World Journal of Clinical Oncology2015，6，4： | 2 |
| 5 | Multi-camera systems显示文摘 | Pedersini F Sarti A Tubaro S | 1999 | IEEE Signal Processing Magazine1999，16，3： | 2 |
| 6 | Antegrade scrotal sclerotherapy and varicocele显示文摘Antegrade scrotal sclerotherapy is a simple and easy technique for the treatment of varicocele.The success rate varies between87%and95%,The initlal reflux grade and the number of collateral vessels of the spermatic vein are the most important factors to predict the outcome of the technique.The postoperative complica-tion rate is about7%and the common ones are scrotal hematoma and epididymo-orchitis of slight severity.Testicular athrophy is a rare event(0.6%).This technique offers a considerable cost eduction compared to other therapeutic optione currently available for varicocele. | Vincenzo Ficarra Alessandra Sarti Giacomo Novara Walter Artibani | 2002 | Asian Journal of Andrology2002，4，3： | 2 |
| 7 | Acute inflammatory events and ischemic stroke subtypes显示文摘 | Nencini P Sarti C Innocenti R | 2003 | Cerebrovasc Dis2003，15，3： | 1 |
| 8 | The metabolic syndrome: Prevalence, CHD risk, and treatment 显示文摘 | Sarti C Gallagher J | 2006 | J Diabetes Complications2006，20，2： | 1 |
| 9 | A subjective surfaces: a method for completing missing boundaries 显示文摘 | Sarti A Malladiv R Sethian J A | 2000 | Proceedings of the National Academy of Sciences of the United States of America2000，2，97： | 1 |
| 10 | Persistent impairment of gait performances and working memory after bilateral common carotid artery occlusion in the adult Wistar rat显示文摘 | Sarti C Pantoni L Bartolini L | 2002 | Behav Brain Res2002，136，1： | 1 |
| 11 | Long-term intrathecal morphine and bupivacaine upregulate MOR gene expression in lymphocytes显示文摘 | Campana G Sarti D Spampinato S | 2010 | Int Immunopharmacol2010，10，9： | 1 |
| 12 | Are changes in mortality from stroke caused by changes in stroke event rates or case fatality? 显示文摘 | Sarti C Stegmayr B Tolonen H | 2003 | Stroke2003，，34： | 1 |
| 13 | Fast PDE approach to surface reconstruction from large cloud of points 显示文摘 | MARCON M PICCARRETA L SARTI A | 2008 | Computer Vision and Image Understanding2008，112，3： | 1 |
| 14 | Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine显示文摘 | Borgland SL Taha SA Sarti F | 2006 | Neuron2006，49，4： | 1 |
| 15 | Control of Taenia solium taeniasis/cysticercosis:From research towards implementation显示文摘 | Pawlowski Z Allan J Sarti E | 2005 | International Journal for Parasitology2005，35，1112： | 1 |
| 16 | Cretaceous oceanic red beds and land ocean interaction显示文摘 | WAN Xiao-qiao Massimo Sarti | 2005 | Cretaceous Research2005，26，1： | 1 |
| 17 | Application of molecular techniques to evaluate the methanogenic archaea and anaerobic bacteria in the presence of oxygen with different COD:Sulfate ratios in a UASB reactor显示文摘 | Julia Sumiko Hirasawa Arnaldo Sarti Nora Katia Saavedra Del Aguila Maria Bernadete A. Varesche | 2008 | Anaerobe2008，，4： | 1 |
| 18 | Thiolated hydroxyethylcellulose:synthesis and in vitro evaluation显示文摘 | Sarti F Staaf A Sakloetsakun D | 2010 | Eur J Pharm Biopharm2010，76，3： | 1 |
| 19 | Estimation and compensation of subpixel edge localization error显示文摘 | Federico Pedersini Augusto Sarti Stefano Tubaro | 1997 | IEEE Trans PAMI1997，19，10： | 1 |
| 20 | The impact of history of hy- pertension and type 2 diabetes at baseline on the incidence of stroke and stroke mortality显示文摘 | Hu G Sarti C Jousilahti P | 2005 | Stroke2005，36，12： | 1 |
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