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| 1 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 2 | Altered Lignin Biosynthesis Improves Cellulosic Bioethanol Production in Transgenic Maize Plants Down-Regulated for Cinnamyl Alcohol Dehydrogenase显示文摘Cinnamyl 白酒脱氢酶(CAD ) 是涉及 monolignol 生合成的最后步的关键酶。木质素生产上的 CAD 下面规定的效果在玉米通过一条转基因的途径被调查。转基因的 CAD-RNAi 植物显示出在房间墙作文取决于分析织物和表演改变的酶的减小的不同的度。没有影响全部的木质素内容, CAD-RNAi 茎的细胞墙在 S-to-G 比率与细微减小包含木质素聚合物。另外,这些房间墙积累纤维素和 arabinoxylans 的高水平。相反, CAD-RNAi 中肋的房间墙在全部的木质素内容并且房间墙多糖介绍减小。,在 vitro degradability,试金显示出那到不同程度, CAD 活动的压抑导致的变化生产了中肋和比野类型的植物更可能减解的茎。在这块地里种的 CAD-RNAi 植物介绍了野类型的显型并且生产了干燥生物资源的更高的数量。有纤维质的 bioethanol 试金表明 CAD-RNAi 生物资源生产了乙醇的高水平与相比野类型,使 CAD 成为一个好目标两个都改进玉米 lignocellulosic 生物资源的营养、精力充沛的值。 | Silvia Fornale Montserrat Capellades Antonio Encina Kan Wang Sami Irara Catherine Lapierre Katia Ruel Jean-Paul Joseleaue Jordi Berenguer Pere Puigdomenech Joan Rigau David Caparros-Ruiz | 2012 | Molecular Plant2012，5，4： | 14 |
| 3 | Nitrate induction triggers different transcriptional changes in a high and a low nitrogen use efficiency maize inbred line显示文摘In higher plants, NO3 can induce its own uptake and the magnitude of this induction is positively related to the external anion concentration. This phenomenon has been characterized in both herbaceous and woody plants. Here,different adaptation strategies of roots from two maize(Zea mays L., ZmAGOs) inbred lines differing in nitrogen use efficiency(NUE) and exhibiting different timing of induction were discussed by investigating NO3 ‐induced changes in their transcriptome. Lo5 line(high NUE) showing the maximum rate of NO3 uptake 4 h after the provision of 200 mmol/L NO3 treatment modulated a higher number of transcripts relative to T250(low NUE) that peaked after 12 h. The two inbred lines share only 368 transcripts that are modulated by the treatment with NO3 and behaved differently when transcripts involved in anion uptake and assimilation were analyzed. T250 line responded to the NO3 induction modulating this group of Researchgenes as reported for several plant species. On the contrary,the Lo5 line did not exhibit during the induction changes in this set of genes. Obtained data suggest the importance of exploring the physiological and molecular variations among different maize genotypes in response to environmental clues like NO3 provision, in order to understand mechanisms underlying NUE. | Anita Zamboni Stefania Astolfi Sabrina Zuchi Youry Pii Katia Guardini Paola Tononi Zeno Varanini | 2014 | Journal of Integrative Plant Biology2014，56，11： | 6 |
| 4 | Role of Th17 cells in the pathogenesis of rheumatoid arthritis显示文摘Since early description of CD4/CD8 T cell duality, continuous discovery of functional T lymphocyte subsets and their related cytokines constitutes major progress in our understanding of the immune response. T-lymphocyte derived lymphokines and environmental cytokines are essential for both innate and antigen-specific immune responses to a wide variety of agents. Following immune battle and aggression overcome, cytokines may return against neighbored cells/organs, causing pathogenic hypersensitivity reactions, including autoimmune diseases. Due to their cytokine production, CD4+ T helper lymphocyte subsets may be considered as one the major players of the immune response. Among CD4+ T cell subsets, the identification of interleukin-17-producing cells(Th17) led to better understanding of coordinated cytokine involvement during inflammatory reactions together with the subsequent clarification of complex interactions between these mediators. In this review, we discuss Th17 cell differentiation, functions, and the role of this cell subset during rheumatoid arthritis pathogenesis together with therapeutic strategies to control these cells. | Katia Boniface Daniel Moynet M Djavad Mossalayi | 2013 | World Journal of Rheumatology2013，3，3： | 5 |
| 5 | Hypertension and chronic ethanol consumption: What do we know after a century of study?显示文摘The influences of life habits on the cardiovascularsystem may have important implications for publichealth, as cardiovascular diseases are among the lead-ing causes of shorter life expectancy worldwide. A linkbetween excessive ethyl alcohol(ethanol) consumptionand arterial hypertension was first suggested early lastcentury. Since then, this proposition has received con-siderable attention. Support for the concept of ethanolas a cause of hypertension derives from several epi-demiologic studies demonstrating that in the generalpopulation, increased blood pressure is significantlycorrelated with ethanol consumption. Although thelink between ethanol consumption and hypertension iswell established, the mechanism through which etha-nol increases blood pressure remains elusive. Possiblemechanisms underlying ethanol-induced hypertensionwere proposed based on clinical and experimental ob-servations. These mechanisms include an increase insympathetic nervous system activity, stimulation of therenin-angiotensin-aldosterone system, an increase of intracellular Ca2+ in vascular smooth muscle, increased oxidative stress and endothelial dysfunction. The pres-ent report reviews the relationship between ethanol intake and hypertension and highlights some mecha-nisms underlying this response. These issues are of interest for the public health, as ethanol consumption contributes to blood pressure elevation in the population. | Katia Colombo Marchi Jaqueline Jóice Muniz Carlos Renato Tirapelli | 2014 | World Journal of Cardiology2014，6，5： | 5 |
| 6 | Knowledge management and the entrepreneur:Insights from Ikujiro Nonaka's Dynamic Knowledge Creation model(SECI)显示文摘A key goal of knowledge management(KM)is to foster innovation through the ceation of new knowledge.Surprisingly,there is little research on KM in the context of entrepre-neurship,a domain where innovation is considered essential.This paper extends estab-lished theories and frameworks for KM to the understudied context of KM in small and medium entrepreneurial firms,particularly young startups.Translating KM fr ameworks,such as the widely studied SECI model,into the entrepreneurial domain could eventually help startups in their quest for sustainability and growth.The SECI model is an aspir ational process with which to build new knowledge,including the explicit knowledge assets that startups commonly lack.However,an aspiration is only useful if the subject knows where he or she stands in relation to it.This study focuses on understanding whether entre-preneurial activities embed into,and can further enable,the'virtuous'knowledge-creation cycle.The secondary objective of this paper is to acknowledge Ikujiro Nonaka's contribution to western and eastern KM theories,and extend his seminal theories into other domains,such as small and medium enterprises.This work pilots the use of a content analysis technique largely used in psychology to analyze the connection between entrepreneurship and KM.With this method,the study highlights how the four phases of the SECI model apply to startup firms in a business incubator in the United States.It provides insights into the knowledge-creation process of entrepreneurs,and suggests how entrepreneurs can improve startup survival through greater awareness and use of KM in their business planning and operational activities. | Cesar Bandera Fazel Keshtkar Michael R.Bartolacci Shiromani Neerudu Katia Passerini | 2017 | International Journal of Innovation Studies2017，1，3： | 4 |
| 7 | Real-time multiplex PCR assay to quantify hepatitis C virus RNA in peripheral blood mononuclear cells显示文摘 | Paolo Pugnale Patrizia Latorre Christine Rossi Katia Crovatto Valerio Pazienza Andrea De Gottardi Francesco Negro | 2005 | Journal of Virological Methods2005，，2： | 3 |
| 8 | Feasibility and safety of cryoballoon ablation for atrial fibrillation inpatients with congenital heart disease显示文摘BACKGROUND The prevalence of atrial fibrillation (AF) is on the rise in the aging population with congenital heart disease (CHD). A few case series have described the feasibility and early outcomes associated with radiofrequency catheter ablation of AF centered on electrically isolating pulmonary veins (PV) in patients with CHD. In contrast, cryoballoon ablation has not previously been studied in this patient population despite its theoretical advantages, which include a favorable safety profile and shorter procedural time. AIM To assess the safety and feasibility of cryoballoon ablation for AF in an initial cohort of patients with CHD. METHODS The study population consisted of consecutive patients with CHD and cryoballoon ablation for AF at the Montreal Heart Institute between December 2012 and June 2017. Procedural complications, acute success, and 1-year freedom from recurrent AF after a single procedure with or without antiarrhythmic drugs were assessed. Procedures were performed under conscious sedation. Left atrial access was obtained via a single transseptal puncture or through an existing atrial septal defect (ASD). Cryoballoon occlusion was assessed by distal injection of 50% diluted contrast into the pulmonary vein. At least one 240-second cryothermal application was performed upon obtaining complete pulmonary vein occlusion. Following ablation, patients were routinely followed at outpatient visits at 1, 3, 6, and 12 mo, and then annually. RESULTS Ten patients, median age 57.9 (interquartile range 48.2-61.7) years, 60% female, met inclusion criteria and were followed for 2.8 (interquartile range 1.4-4.5) years.Two had moderately complex CHD (sinus venosus ASD with partial anomalous pulmonary venous return;aortic coarctation with a persistent left superior vena cava), with the remainder having simple defects. AF was paroxysmal in 8 (80.0%) and persistent in 2 (20.0%) patients. The pulmonary vein anatomy was normal in 6 (60.0%) patients. Four had left common PV (n = 3) and/or 3 right PV (n = 2). Electrical pulmonary vein isolation (PVI) was acutely successful in all. One patient had transient phrenic nerve palsy that recovered during the intervention. No major complication occurred. One year after a single ablation procedure, 6 (60%) patients remained free from AF. One patient with recurrent AF had recovered pulmonary vein conduction and underwent a second PVI procedure. A second patient had ablation of an extra-pulmonary vein trigger for AF. CONCLUSION Cryoballoon ablation for AF is feasible and safe in patients with simple and moderate forms of CHD, with an excellent acute success rate and modest 1-year freedom from recurrent AF. | Sylvia Abadir Victor Waldmann Katia Dyrda Mikael Laredo Blandine Mondésert Marc Dubuc Paul Khairy | 2019 | World Journal of Cardiology2019，11，5： | 3 |
| 9 | Sharing inventory risk in supply chain: The implication of financial constraint显示文摘 | Guoming Lai Laurens G. Debo Katia Sycara | 2008 | Omega2008，，4： | 3 |
| 10 | 霉菌毒素的实际作用并不按数学公式来表现显示文摘单个霉菌毒素的影响在文献中已有了很好的捕述,但各种不同霉菌毒素的复合物又会产生怎样的作用呢?通常,会引发群体生产性能低下和/或疾病的单个霉菌毒素,其在在商业性养殖场中所表现出的作用常常低于所报道的在可控试验研究中所见到的毒性作用。 | 陈琳 Katia Pedrosa | 2012 | 国外畜牧学(猪与禽)2012，，2： | 3 |
| 11 | Estrogen receptors expression in long-lasting ulcerative pancolitis with and without dysplasia: A preliminary report显示文摘 | Mariabeatrice Principi Nicola De Tullio Maria Principia Scavo Domenico Piscitelli Andrea Marzullo Silvana Russo Francesca Albano Katia Lofano Samanta Papagni Michele Barone Enzo Ierardi Alfredo Di Leo | 2012 | Scandinavian Journal of Gastroenterology2012，，10： | 2 |
| 12 | Ionized jet deposition of antimicrobial and stem cell friendly silver-substituted tricalcium phosphate nanocoatings on titanium alloy显示文摘Orthopedic infections pose severe societal and economic burden and interfere with the capability of the implanted devices to integrate in the host bone,thus significantly increasing implants failure rate.To address infection and promote integration,here nanostructured antibacterial and bioactive thin films are proposed,obtained,for the first time,by Ionized Jet Deposition(IJD)of silver-substituted tricalcium phosphate(Ag-TCP)targets on titanium.Coatings morphology,composition and mechanical properties are characterized and proof-of-concept of biocompatibility is shown.Antimicrobial efficacy is investigated against four Gram positive and Gram negative bacterial strains and against C.albicans fungus,by investigating the modifications in planktonic bacterial growth in the absence and presence of silver.Then,for all bacterial strains,the capability of the film to inhibit bacterial adhesion is also tested.Results indicate that IJD permits a fine control over films composition and morphology and deposition of films with suitable mechanical properties.Biological studies show a good efficacy against Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Enterococcus faecalis and against fungus Candida albicans,with evidences of efficacy against planktonic growth and significant reduction of bacterial cell adhesion.No cytotoxic effects are evidenced for equine adipose tissue derived mesenchymal stem cells(ADMSCs),as no reductions are caused to cells viability and no interference is assessed in cells differentiation towards osteogenic lineage,in the presence of silver.Instead,thanks to nanostructuration and biomimetic composition,tricalcium phosphate(TCP)coatings favor cells viability,also when silver-substituted.These findings show that silver-substituted nanostructured coatings are promising for orthopedic implant applications. | Gabriela Graziani Katia Barbaro Inna V.Fadeeva Daniele Ghezzi Marco Fosca Enrico Sassoni Gianluca Vadalà Martina Cappelletti Francesco Valle Nicola Baldini Julietta V.Rau | 2021 | Bioactive Materials2021，6，8： | 2 |
| 13 | Prevalence and clinical significance of acquired left coronary artery fistulas after surgical myectomy in patients with hypertrophic cardiomyopathy显示文摘 | Aurelio Sgalambro Iacopo Olivotto Alessandra Rossi Stefano Nistri Katia Baldini Massimo Baldi Pierluigi Stefano David Antoniucci Francesca Garbini Franco Cecchi Magdi H. Yacoub | 2010 | The Journal of Thoracic and Cardiovascular Surgery2010，，5： | 2 |
| 14 | Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways显示文摘 | Claudio Alarcón Alexia-Ileana Zaromytidou Qiaoran Xi Sheng Gao Jianzhong Yu Sho Fujisawa Afsar Barlas Alexandria N. Miller Katia Manova-Todorova Maria J. Macias Gopal Sapkota Duojia Pan Joan Massagué | 2009 | Cell2009，，4： | 2 |
| 15 | Oxygen tension controls the expression of the monocarboxylate transporter MCT4 in cultured mouse cortical astrocytes via a hypoxia‐inducible factor‐1α‐mediated transcriptional regulation显示文摘 | Katia Rosafio Luc Pellerin | 2014 | Glia2014，，3： | 2 |
| 16 | Recent advances on the regulation of anthocyanin synthesis in reproductive organs显示文摘 | Katia Petroni Chiara Tonelli | 2011 | Plant Science2011，，3： | 2 |
| 17 | Long-Term Follow-Up After Fractional Flow Reserve–Guided Treatment Strategy in Patients With an Isolated Proximal Left Anterior Descending Coronary Artery Stenosis显示文摘 | Olivier Muller Fabio Mangiacapra Argyrios Ntalianis Katia M.C. Verhamme Catalina Trana Michalis Hamilos Jozef Bartunek Marc Vanderheyden Eric Wyffels Guy R. Heyndrickx Frank J.A. van Rooij Jacqueline C.M. Witteman Albert Hofman William Wijns Emanuele Barb | 2011 | JACC: Cardiovascular Interventions2011，，11： | 2 |
| 18 | 螺内酯与上消化道出血事件的风险:人群为基础的病例对照研究显示文摘目的确认并量化螺内酯与上消化道出血和溃疡之间的联系。设计人群为基础的病例对照研究。背景环境荷兰的初级保健信息数据库。参加者数据库中从1996年1月1日至2003年9月30日,所有年龄大于等于18岁的人。排除曾有酒精中毒或消化道肿瘤病史的患者。每个胃十二指肠溃疡或上消化道出血的病例配比十个对照,按年龄(出生年)、性别和索引日期进行匹配。主要结果评价使用条件 Logistic 回归分析,根据潜在的混杂因子对上消化道事件(出血或穿孔)的发生做出校正。结果在源人群中的306645位患者中,确认523个胃十二指肠溃疡或上消化道出血病例,与5230个对照进行配比。正在应用螺内酯治疗与消化道事件风险胜增加2.7倍相关联(95%可信区间1.2~6.0)。结论胃十二指肠溃疡或上消化道出血发生风险在使用螺内酯的患者中明显增加。 | Katia Verhamme Georgio Mosis Jeanne Dieleman Bruno Stricker Miriam Sturkenboom 史济华 | 2007 | 英国医学杂志中文版2007，10，1： | 2 |
| 19 | Buy Now and Match Later: Impact of Posterior Price Matching on Profit with Strategic Consumers显示文摘 | Guoming Lai Laurens G. Debo Katia Sycara | 2010 | Manufacturing & Service Operations Management2010，，1： | 2 |
| 20 | Role of size and pretreatment of Pd particles on their behaviour in the direct synthesis of H_2O_2显示文摘Two families of catalysts, based on Pd nanoparticles supported on ceramic asymmetric tubular alumina membranes, are studies in the direct synthesis of H_2O_2. They are prepared by depositing Pd in two ways:(i) reduction with N_2H_4 in an ultrasonic bath and(ii) by impregnation-deposition. The first preparation leads to larger particles, with average size of around 11 nm, while the second preparation leads to smaller particles, with average size around 4 nm. The catalytic membranes were tested as prepared, after thermal treatment in air and after further pre-reduction with H_2 in mild(100 ℃) conditions. Samples were characterized by TEM, CO-chemisorption monitored by DRIFTS method and TPR, while catalytic tests have been performed in a semi-batch recirculation membrane reactor. Experimental catalytic results were analysed using two kinetics models to derive the reaction constants for the parallel and consecutive reactions of the kinetic network. Smaller particles of Pd show lower selectivity due to the higher rate of parallel combustion, even if the better dispersion of Pd and thus higher metal surface area in the sample lead to a productivity in H_2O_2 similar or even higher than the sample with the larger Pd particles. Independently on the presence of smaller or larger Pd nanoparticles, an oxidation treatment leads to a significant enhancement in the productivity, although the catalyst progressively reduces during the catalytic process. The inhibition of the parallel combustion reaction(to water) induced from the calcination treatment remains after the in-situ reduction of the oxidized Pd species formed during the pre-treatment.This is likely due to the elimination of defect sites which dissociatively activate oxygen, and tentatively attributed to Pd sites able to give three- and four-fold coordination of CO. | Salvatore Abate Katia Barbera Gabriele Centi Gianfranco Giorgianni Siglinda Perathoner | 2016 | Journal of Energy Chemistry2016，25，2： | 2 |
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