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| 1 | Hepatoprotective and antioxidant properties of marine halophyte Luminetzera racemosa bark extract in CCL_4 induced hepatotoxicity显示文摘Objective:To identify the hepatoprotective and antioxidant activity of Luminetzera racemosa (L racemosa)bark extract.Methods:Wistar albino rats were divided into 6 groups:Group 1 served as control;Group 2 served as hepatotoxin(CCL4 treated) group;Group 3 served as positive control(Silymarin) treated groups;Group 4,5 and 6 served as(100,200 and 300 mg/kg bw p.o.) L racemosa bark extract treated groups.Moreover,in vitro antioxidant indexes,including DPPH, hydroxyl radical scavenging activity(HRSA),NO,ferric reducing antioxidant power(FRAP),lipid hydroperoxide(LPO) and super oxide dismutase(SOD) were also analyzed in the bark extract. Results:The results suggested that,the level of serum glutamate oxyloacetic transaminase(SCOT), serum glutamic pyruvic transaminase(SGPT),alkaline phosphatise(ALP),bilurubin,cholesterol, sugar and lactate dehydrogenase(LDH) were significantly(P<0.05) increased in hepatotoxin treated rats when compared with the control group.But,the maximum reduction of SGOT[(225.36±13.65) IU/L],SGPT[(96.85±17.36) IU/L],ALP[(315.37±17.16) IU/L],bilirubin[(2.97±0.46) mg/dL], cholesterol[(163.73±17.54) mg/dL],sugar[(127.35±27.35) mg/dL]and LDH[(1 784.00±268.36) IU/L] were observed with 300 mg/kg bw of bark extract treated rats.Histopathological scores showed that,no visible changes were observed with high dose(300 mg/kg bw) of bark extract treated rats except mild fatty changes.The in vitro antioxidant assays showed that,the IC50 values were observed as(44.17±6.87)μ/mL,(42.45±2.81)μg/mL,(62.37±3.98)μg/mL,(54.24±3.09)μg/mL, (87.25±5.90)μg/mL and(71.54±5.42)μg/mL for DPPH.HRSA,NO,FRAP,LPO and SOD radical scavenging activities,respectively.Conclusions:The hepatoprotective and antioxidant activities of the bark extract might be to the presence of unique chemical classes such as flavonoids, alkaloids and polyphenols. | Murugesan Gnanadesigan Sundaram Ravikumar Samuel Jacob Inbaneson | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 4 |
| 2 | In vitro antiplasmodial effect of ethanolic extracts of traditional medicinal plant Ocimum species against Plasmodium falciparum显示文摘Objective:To identify the possible antiplasmodial compounds from leaf,stem,root and flower extracts of Ocimum canum(O.canum),Ocimum sanctum(O.sanctum) and Ocimum basilicum (O.basilicum).Methods:The O.canum,O.sanctum and O.basilicum were collected from Ramanalhapuram District,Tamil Nadu and the extraction was carried out in ethanol.The filter sterilized extracts(100,30,23,12.5,6.23 and 3.125μg/mL) of leaf,stem,root and flower extracts of O.canum,O.sanctum and O.basilicum were tested for antiplasmodial activity against Plasmodium falciparum(P.falciparum).The potential extracts were also tested for their phytochemical constituents.Results:The leaf extract of O.sanctum showed excellent antiplasmodial activity(IC50 3538μg/mL) followed by leaf extract of O.basilicum(IC50 4341μg/mL). The leaf extract of O.canum,root extracts of O.sanctum and O.basilicum,the stem and flower extracts of all the three tested Ocimum species showed IC50 values between 50 and 100μg/mL Statistical analysis reveals that,significant antiplasmodial activity(P<0.01) was observed between the concentrations and time of exposure.The chemical injury to erythrocytes was also carried out and it shows that,there were no morphological changes in erythrocytes by the ethanolic extract of O.canum,O.sanctum and O.basilicum.The in vitro antiplasmodial activity might be due to the presence of alkaloids,glycosides,flavonoids,phenols,saponins,triterpenoids,proteins,resins, steroids and tannins in the ethanolic extracts of tested plants.Conclusions:The ethanolic leaf extracts of O.sanctum possess lead compounds for the development of antiplasmodial drugs. | Samuel Jacob Inbaneson Sundaram Ravikumar Palavesam Suganthi | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 3 |
| 3 | In vitro antiplasmodial effect of ethanolic extracts of coastal medicinal plants along Palk Strait against Plasmodium falciparum显示文摘Objective:To identify the possible anliplasmodial compounds from Achyranlhes aspera(A. aspera).Acalypha indica(A.indica),Jatropha glandulifera(J.glanduUfera)and Phyllanlhus amarus(P.amarus).Methods:The A.aspera,A.indica,J.glandulifera and P.ainarus were collected along Palk Strait and the extraction was carried out in ethanol.The filter sterilized extracts(100,50,25,12.5,6.25 and 3.125μg/mL) of leaf,stem,root and flower extracts of A aspera,A. indica,J.glandulifera and P.amarus were tested for anliplasmodial activity against Plasnuxlium falciparum.The potential extracts were also tested for their phytochemical constituents.Results: Of the selected plants species parts,the stem extract of A.indica showed excellent antiplasmodial activity(IC_(50)=43.81μg/mL) followed by stem extract of J.glandulifera(IC_(50)= 49.14μg/mL).The stem extract of A.aspera,leaf and root extracts of A.indka,leaf,root and seed extracts of J. glanduUfera and leaf and stem extracts of P.amarus showed IC_(50),values between 50 and 100 μg/ mL.Statistical analysis revealed that,significant antiplasmodial activity(P<0.0l) was observed between the concentrations and time of exposure.The chemical injury to erythrocytes was also carried out and it showed that there were no morphological changes in erythrocytes by the elhanolic extract of all the tested plant extracts.The in vitro antiplasmodial activity might be due to the presence of alkaloids,glycosides,flavonoids.phenols,saponins,triterpenoids,proteins, and lannins in the elhanolic extracts of tested plants.Conclusions:The elhanolic stem extracts of P.amarus and J.glandulifera possess lead compounds for the development of antiplasmodial drugs. | Samuel Jacob Inbaneson Sundaram Ravikumar Palavesam Suganthi | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 2 |
| 4 | Is blood cardioplegia superior to crystalloid cardioplegia显示文摘 | Samuel Jacob Antonios Kallikourdis Frank Sellke | 2008 | Interact CardioVasc Thorac Surg2008，7，： | 1 |
| 5 | Catalytic oxidation of sulphide ions using a novel microporous cobalt phthalocyanine network polymer in aqueous solution显示文摘 | Saad Makhseed Faiza Al-Kharafi Jacob Samuel Badr Ateya | 2009 | Catalysis Communications2009，，9： | 1 |
| 6 | Differential effects of carotenoids on lipid peroxidation due to membrane interactions: X-ray diffraction analysis显示文摘 | Hyesun P. McNulty Jungsoo Byun Samuel F. Lockwood Robert F. Jacob R. Preston Mason | 2006 | BBA - Biomembranes2006，，1： | 1 |
| 7 | High styrene-rubber lonomers,an alternative to ther moplastic elastomers显示文摘 | JACOB SAMUEL THOMMACHAN XAVIER THOMAS KU RIAN | 2002 | Journal of Applied Polymer Science2002，85，11： | 1 |
| 8 | A Prospective Study of the Diagnostic Accuracy of PillCam ESO Esophageal Capsule Endoscopy Versus Conventional Upper Endoscopy in Patients With Chronic Gastroesophageal Reflux Diseases显示文摘 | Rami Eliakim Virender K Sharma Kamel Yassin Samuel N Adler Harold Jacob David R Cave Ritu Sachdev Roger D Mitty Dirk Hartmann Dieter Schilling Jurgen F Riemann Simon Bar-Meir Eytan Bardan Brian Fennerty Glenn Eisen Douglas Faigel Blair S Lewis David E Fle | 2005 | Journal of Clinical Gastroenterology2005，，7： | 1 |
| 9 | In vitro antiplasmodial activity of ethanolic extracts of South Indian medicinal plants against Plasmodium falciparum显示文摘 | Sundaram Ravikumar Samuel Jacob Inbaneson Palavesam Suganthi | 2012 | Asian Pacific Journal of Tropical Disease2012，，3： | 1 |
| 10 | The synthesis and characterization of zincphthalocyanines bearing functionalized bulky phenoxy substituents显示文摘 | Saad Makhseed Jacob Samuel | 2009 | Dyes and Pigments2009，82，： | 1 |
| 11 | The expanding role of rituximab and radioimmunotherapy in the treatment of B-cell lymphomas显示文摘 | SAMUEl A JACOBS KENNETH A FOON | 2007 | Expert Opin2007，7，11： | 1 |
| 12 | The expanding role of rituximab and radioimmunotherapy in the treatment of B-cell lymphomas显示文摘 | SAMUEL A JACOBS KENNETH A FOON | 2007 | Drug Evaluation2007，，11： | 1 |
| 13 | Loss of protein kinase PKR expression in human HeLa cells complements the vaccinia virus E3L deletion mutant phenotype by restoration of viral protein synthesis 显示文摘 | Zhang P Jacobs B L Samuel C E | 2008 | JVirol2008，82，2： | 1 |
| 14 | Vaccinia virusE3L interferon resistance protein inhibits the interferon-induced adenosine deaminase A-to-I editing activity 显示文摘 | Liu Y Wolff KC Jacobs BL Samuel CE | 2001 | Virology2001，289，2： | 1 |
| 15 | 入侵印刷电路板的3种方式显示文摘2018年,《彭博商业周刊》的一篇文章做出了惊人断言,声称中国间谍部门在电路板中插入了毫米级芯片,从而在为亚马逊、苹果等公司生产的服务器中制造了后门. 这一说法遭到了相关公司和美国国土安全部直接明确的驳斥.不过,电路板的确极易遭受入侵.已经有十几个系统级攻击的例子记录在案. | Samuel H.Russ Jacob Gatlin | 2020 | 科技纵览2020，，9： | 0 |
| 16 | Sulfurized-polyacrylonitrile in lithium-sulfur batteries:Interactions between undercoordinated carbons and polymer structure under low lithiation显示文摘Lithium-sulfur battery(LSB)represents an important candidate to be used in energy storage applications,due to its high specific capacities.Sulfurized-polyacrylonitrile(SPAN)is a candidate as a host material in LSB to replace graphite,due to its ability to chemisorb polysulfides(PSs).The sulfur chains attached to the polymer can reversibly form Li2S,and SPAN indicates to have a good cyclability and better performance than graphite,thus,SPAN acts partially as an active and also as a host material.In this study,we investigated the capacity of the solvent or the SPAN to lose a hydrogen atom from the backbone,to predict possible anodic reactions between solvent and host material.The simulation suggests that the photophilic salts may preferentially react with the solvent,and possibly building a cathode electrolyte interphase(CEI).We observed that an undercoordinated carbon(C_(uc))can be thermodynamically created,due to lithiation.The Cuccan react with the solvent on the polymer backbone through different mechanisms,however,the simulations indicated that the reaction should be affected by the interaction between the solvent and C_(uc),according to SPAN’s configuration.Moreover,C_(uc)reacts with long sulfur chains attached to SPAN,capturing sulfur and forming a C-S bond.A sulfur chain from one SPAN can connect to another polymer backbone,however,this process is affected by lithiation and vice-versa.Therefore,this work also investigates the formation of interconnected SPAN structures and the multiple C_(uc)effects. | Samuel Bertolini Timo Jacob | 2022 | Journal of Energy Chemistry2022，31，3： | 0 |
| 17 | Studies on Cardiac Cytoarchitectonic and Biochemical Indices in Pregnant Streptozotocin-lnduced Diabetic Rats Treated with Gliclazide and Insulin显示文摘 | Olojede Samuel Oluwaseun Lawal Sodiq Kolawole Medubi Leke Jacob Adekoya Abimbola Julius Esubi Juan Uche Dauda Feyikemi Funmilayo Buhari Muhammed Olanrewaju Osinubi Abraham Adewale | 2018 | Journal of Pharmacy and Pharmacology2018，6，1： | 0 |
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